• 대한의생명과학회지
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• 제26권4호
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• pp.296-301
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• 2020

The purpose of this study was performed to evaluate antioxidant activity of the Artemisia asiatica Nakai and Moringa oleifera Lam mixture extract. Mixture extracts were manufactured by concentration and compared with a single extract (only the Artemisia asiatica Nakai mixture and only the Moringa oleifera Lam mixture). The experiments conducted Total polyphenol measurements, Total flavonoid measurements, DPPH radical scavenging activty, ABTS radical scavenging activty and LDH assay. The LDH assay assessment shows that all extracts are cells compared to controls. The toxicity was weak. Finally, The antioxidant capacity was rated higher than mixture extract of a single extract. Also, the optimized mixture was determined AM5 (Artemisia asiatica Nakai mixture: Moringa oleifera Lam mixture = 3:1). For extracts of AM5, Total phenol and flavonoid contents were 271.769±18.087 mg/g and 45.384±5.026 mg/g. and DPPH and ABTS scavenging activity were 70.8±6.496% and 77.1±9.634%. Therefore, it is expected that the value of the extract will increase as it increases its antioxidant activity if it is manufactured according to the appropriate ratio.

• 농업과학연구
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• 제48권2호
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• pp.201-207
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• 2021

This study evaluated the influence of enzyme mixture supplementation on the growth performance, nutrient digestibility, and fecal score of growing pigs. A total of 72 pigs with an initial body weight of 20.23 ± 1.46 kg were randomly assigned to two treatments consisting of a basal diet and the basal diet supplemented with 0.5% enzyme mixture. During a 19-day trial, no significant difference was observed in the body weight (BW) and average daily feed intake (ADFI) of the pigs. However, a gradual increase in the average daily gain (ADG) was observed during the period from day 14 to day 19 and the overall period in pigs fed a diet supplemented with the 0.5% enzyme mixture (p < 0.10) as compared to the pigs that were fed the control diet. From days 4 to 14 and in the overall experiment, a gradual increase in the feed conversion ratio (FCR) (p < 0.10) was observed with the inclusion of 0.5% enzyme mixture supplementation. The nutrient digestibility of dry matter (DM), nitrogen (N), and energy were not affected by enzyme mixture supplementation. In addition, dietary supplementation with the enzyme mixture had no significant effects on the fecal score of growing pigs. In summary, supplementation with the enzyme mixture had beneficial effects on the ADG performance but failed to have a significant effect on growth performance (BW), nutrient digestibility, and fecal score.

• 한국식품과학회지
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• 제33권6호
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• pp.656-663
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• 2001

본 연구는 흡연에 의해 체내로 유입된 독성 물질들로 유발될 수 있는 폐암을 비롯한 각종 질병 기전을 in vitro 상에서 재현한 실험적 모델을 이용하여 8개의 식물로부터 추출한 phyto-extract mixture의 작용에 의하여, 체내 니코틴이 니트로사민으로의 전환되는 대사효율과 NNK의 활성화에 미치는 효과를 분석한 것이다. 이를 위해 in vitro 상에서 phyto-extract mixture에 의한 니트로소모폴린의 생성 억제와 CYP효소 활성 억제를 분석하였다. Phyto-extract mixture에 의한 니코틴으로부터 니트로소모폴린이 생성되는 대사 억제능 실험 결과, phyto-extract mixture(75%)는 비타민 C(64%)와 가루녹차(37%) 보다 우수한 억제 효능을 나타내므로서, phyto-extract mixture는 니코틴으로 부터 유독한 중간 대사물질이 생성되는 경로를 효과적으로 억제시킬 수 있음을 알 수 있었다. 또한 간에서 NNK 활성화에 관여하는 CYP 효소들에 대한 phyto-extract mixture의 효소 활성 억제능 분석 결과, phyto-extract mixture이 가루녹차보다 NNK로부터 발암물질이 생성되는 경로를 효과적으로 억제시키는 것으로 분석되었다. 결론적으로 phyto-extract mixture는 흡연으로 체내에 유입된 니코틴이 NNK와 같은 강력한 발암 물질인 니트로사민 유도체로 전환되는 경로를 효과적으로 억제함으로써 암 발생율을 효과적으로 낮출 수 있는 기능성 첨가제 혹은 식 음료로 활용될 수 있음을 in vitro 실험으로 증명하였다.

• Archives of Plastic Surgery
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• 제43권6호
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• pp.498-505
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• 2016

Background Algae have traditionally been used for promotion of hair growth. Use of hair regrowth drugs, such as minoxidil, is limited due to side effects. The aim of this study was to examine a mixture of Saccharina japonica and Undaria pinnatifida (L-U mixture) on hair growth and to compare the promoting effect of hair growth by a 3% minoxidil and a L-U mixture. Methods To evaluate the hair growth-promoting activity, saline, 50% ethanol, 3% minoxidil, and the L-U mixture were applied 2 times a day for a total of 14 days on the dorsal skin of C57BL/6 mice after depilation. Analysis was determined by using a high-resolution hair analysis system, real-time polymerase chain reaction, and H&E staining. Results On day 14, the hair growth effect of the L-U mixture was the same as that of the 3% minoxidil treatment. The L-U mixture significantly (P<0.05) stimulated hair growth-promoting genes, as vascular endothelial growth factor (VEGF) and insulin-like growth factor -1. Increase of VEGF was observed in the L-U mixture group compared with minoxidil and the negative control. In contrast, the L-U mixture suppressed the expression of transforming growth factor-${\beta}1$, which is the hair loss-related gene. In histological examination in the L-U mixture and minoxidil groups, the induction of an anagen stage of hair follicles was faster than that of control groups. Conclusions This study provides evidence that the L-U mixture can promote hair growth in mice, similar to the effect from minoxidil, and suggests that there is potential application for hair loss treatments.

• 한국도로학회논문집
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• 제19권5호
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• pp.131-141
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• 2017

PURPOSES : The main distress of asphalt pavements in monsoon climate regions are caused by water damage and plastic deformation due to repeated rain season and increased heavy vehicle traffic volume. In this study, the mechanical properties of polymer-modified warm mix asphalt (PWMA) materials are evaluated to use in monsoon climate regions such as Indonesia. METHODS : Comprehensive laboratory tests are conducted to evaluate moisture resistance and permanent deformation resistance for three different asphalt mixtures such as the Indonesian conventional hot-mix asphalt (HMA) mixture, the polymer-modified asphalt mixture, and the polymer-modified warm mix asphalt (PWMA) mixture. Dynamic immersion test and indirect tensile strength ratio test are performed to evaluate moisture resistance. The wheel tracking test is performed to evaluate rutting resistance. Additionally, the Hamburg wheel tracking test is performed to evaluate rutting and moisture resistances simultaneously. RESULTS :The dynamic immersion test results indicate that the PWMA mixture shows the highest resistance to moisture. The indirect tensile strength ratio test indicates that TSR values of PWMA mixture, Indonesian PMA mixture, and Indonesian HMA mixture show 87.2%, 84.1%, and 67.9%, respectively. The wheel tracking test results indicate that the PWMA mixture is found to be more resistant to plastic deformation than the Indonesian PMA. The dynamic stability values are 2,739 times/mm and 3,150 times/mm, respectively. Moreover, the Hamburg wheel tracking test results indicate that PWMA mixture is more resistant to plastic deformation than Indonesian PMA and HMA mixtures. CONCLUSIONS :Based on limited laboratory test results, it is concluded that rutting resistance and moisture susceptibility of the PWMA mixture is superior to Indonesian HMA and Indonesian PMA mixtures. It is postulated that PWMA mixture would be suitable for climate and traffic conditions in Indonesia.

• 한국도로학회논문집
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• 제15권4호
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• pp.107-116
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• 2013

PURPOSES: The liquid-type chemical warm-mix asphalt (WMA) additive has been developed. This study evaluates the basic properties of the additive and the mechanical properties of WMA asphalt and mixture manufactured by using the newly developed chemical additive. METHODS: First, the newly developed WMA additive was applied to the original asphalt by various composition of additive components and dosage ratio of additive. These WMA asphalt binders were evaluated in terms of penetration, softening point, rotational viscosity, and PG grade. Based on the binder test results, one best candidate was chosen to apply to the mixture and then the mechanical properties of WMA mixture were evaluated for moisture susceptibility, dynamic modulus, and rutting and fatigue resistance. RESULTS : According to the binder test, WMA asphalt binders showed the similar properties to the original asphalt binder except the penetraion index of WMA additive was a little higher than original binder. From the Superpave mix design, the optimum asphalt content and volumetric properties of WMA mixture were almost the same with those of hot mix asphalt (HMA) mixture even though the production and compaction temperatures were $30^{\circ}C$ lower for the WMA mixture. From the first set of performance evaluation, it was found that the WMA mixture would have some problem in moisture susceptibility. The additive was modified to improve the resistance to moisture and the second set of performance evaluation showed that the WMA mixture with modified chemical additive would have the similar performance to HMA mixture. CONCLUSIONS : Based on the various laboratory tests, it was concluded that the newly developed chemical WMA additve could be successfully used to produce the WMA mixture with the comparable performance to the HMA mixture. These laboratory evaluations should be confirmed by applying this additive to the field and monitoring the long-term performance of the pavement, which are scheduled in the near future.

• 대한건축학회논문집:구조계
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• 제35권8호
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• pp.169-176
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• 2019

The purpose of this study was to analyze outdoor thermal comfort of apartments planning characteristic of pedestrian height in Beijing, China. Selecting 322 apartment complexes with more than 1000 households and more than 10 buildings(including 10 buildings), mainly in Chaoyang District and Tongzhou District to select 32 basic layout types and then 12 typical layout types were select in 32 basic layout types. Finally, the simulation was conducted for the 12 typical layout types using the micro-climate model ENVI-met to evaluate the wind environment, the thermal environment and the comfort. The results of this study as follows: In the parallel arrangement, it has the best outdoor thermal comfort of Slab-East-Parallel(S/E/P). Next is Slab-South-Parallel(S/S/P), Tower-South-Parallel(T/S/P) in turn. In the stagger arrangement, Mixture-South-North and South Stagger-1(M/S/NSS-1) has the best outdoor thermal comfort and Slab-South-North and South Stagger(S/S/NSS), Tower-South-North and South Stagger(T/S/NSS), Mixture-South-North and South Stagger-3(M/S/NSS-3), Mixture-South-North and South Stagger-4(M/S/NSS-4), Mixture-South-North and South Stagger-2(M/S/NSS-2) in turn. In the cluster arrangement, Mixture-Mixture-Cluster-2(M/M/C-2) has the best outdoor thermal comfort and Mixture-Mixture-Cluster-3(M/M/C-3), Mixture-Mixture-Cluster-1(M/M/C-1) in turn. Due to the low wind speed and high air temperature, it is necessary to consider the layout types that can form the wind road at first, such as Mixture-South-North and South Stagger-1(M/S/NSS-1), Slab-South-North and South Stagger(S/S/NSS) and so on.

• 산업기술연구
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• 제22권A호
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• pp.83-87
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• 2002

Many industrial products such as paints, ink and adhesives are composed of the ingredients of a mixture. In mixture experiments, the characteristics of quality(response) depends only on the proportions of the ingredients and does not depend on the total amount of the mixture. This article discusses the constrained mixture experimental design, the data analysis, and the optimum formulation of ingredients based on the two quality characteristics - taste and flavor. It IS shown that efficient designs can be constructed from D-optimal criterion. Special cubic models were selected as the final mixture response surfaces for both reponses. The desirability function was used for the optimization of the two responses.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2004년도 Proceedings of the 4th Korea-China Joint Workshop on Nuclear Waste Management
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• pp.28-41
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• 2004

The study is aimed to assess the usefulness of the mixture design for spent resin immobilization in cement. Although a considerable amount of research has been carried out to determine the limits for the composition of an acceptable resin-cement mixture, no efficient experimental strategy exists that explores the full properties of waste form against composition relationship. In order to gain an overall view, this report introduces the method of mixture design and mixture analysis, and describes the design of experiment of the 5-component mixture with the constraint conditions. The mathematic models of 28-day compressive strength varying with the ingredients are fitted, and the main effect and interaction effect of two ingredients are identified quantitatively along with the graphical interpretation using the response trace plot and contour plots.

• 설비공학논문집
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• 제5권4호
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• pp.249-256
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• 1993

Numerical method is applied to predict the time variation behavior of flammable mixture formation in a two dimensional enclosure from the beginning of gas leak. Additionally experimental method is used to consider qualitative aspects. Characteristics of flammable mixture formation such as distribution of flow and fuel mass fraction at various locations in the enclosure are determined for the following parameters: the various locations of leak at the bottom and aspect ratio of the enclosure. In the case of gas leak with small leak velocity from the bottom of enclosure gravitational force affects the formation of flammable mixture. Aspect ratio of the enclosure also affects the formation of flammable mixture. The volume of the region of recirculating flow is dominant factor affecting the formation mixture.