• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2777-2783
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• 2014

The purpose of this study was to explore the expression of ATAD2 in ovarian tumor tissue as well as its relationship with degree of malignancy. Tumor tissue from 110 cases of ovarian cancer was collected in accordance with the Declaration of Helsinki for evaluation of ATAD2 expression iimmunohistochemistry, quantitative PCR (qPCR) and Western blotting. The correlation between the ATAD2 expression and and the prognosis of ovarian cancer was evaluated by Cox regression model. In addition, HO-8910 and OVCAR-3 cells were transfected with two siRNAs targeting ATAD2. Cell viability was evaluated with MTT assay, and cell migration by transwell migration assay. ATAD2 was shown to be highly expressed in 65.5% (72/110) of ovarian cancer cases, both at transcriptional and protein levels. Moreover, highly expression was positively correlated with degree of malignancy. Knock-down of ATAD2 in HO-8910 and OVCAR-3 cells was found to reduce cell migration. In addition, follow-up visits of the patients demonstrated that the 5-year survival rate was lower in patients with high expression of ATAD2. Our study suggested that ovarian tumor tissue may have highly expressed ATAD2, which is associated with tumor stage, omentum-metastasis, ascites and CA-125. Increased ATAD2 may play important roles in tumor proliferation and migration. ATAD2 could serve in particular as a prognostic marker and a therapeutic target for ovarian cancer.

• Journal of Family Resource Management and Policy Review
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• v.14 no.2
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• pp.153-176
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• 2010

The purpose of this study was to investigate the relationship between marriage migration females' acculturative stress and marital adjustment, especially the mediating and moderating effects of ego-resilience. The structural equation models were tested by setting marriage migration females' acculturative stress as a prediction variable, their marital adjustment as an outcome variable and their ego-resilience as mediator and moderator variables. The sample consisted of 172 marriage migration females from Busan. I analyzed the data using correlation analysis in order to discover the correlation coefficient of those variables among acculturative stress, ego-resilience and marital adjustment. I used the structural equation model (SEM) for investigating the relationship among acculturative stress, ego-resilience and marital adjustment and for investigating the mediating effects of ego-resilience. I also used multiple group analysis and two way ANOVA to investigate the moderating effects of ego-resilience. The results of structural equation modeling were as follows: first, it was proved that ego-resilience was exerted as a mediating variable, because acculturative stress appeared to affect marital adjustment in relation to ego-resilience. Therefore, marital adjustment was evident when ego-resilience was low. Second, it was proved that ego-resilience was exerted as a moderating variable, because those with low ego-resilience experienced high acculturative stress and low marital adjustment, and those with high ego-resilience experienced low acculturative stress and high marital adjustment. Such findings point out the importance of considering personal characteristics, like ego-resilience, in the relationship between acculturative stress and marital adjustment.

• Journal of the Korea Society of Computer and Information
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• v.12 no.5
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• pp.57-64
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• 2007

Mobile Agent has been known that it is an efficient communication paradigm for distributed applications and that a mobile agent provides higher flexibility and performance than existing communication paradigms. Despite these benefits, mobile agent is not used widely in the market because it is very vulnerable to a variety of attacks. To be applied to develop distributed applications, a mobile agent paradigm must consider both security and performance. In this paper, we propose and evaluate an improving method of a migration performance for a mobile agent model using ISM(Integrated Security Manager), which provides high-level security services and travel plan guide. In the proposed method. ISM offers the travel plan guide service which replies the accumulated results when a mobile agent has executed all migration plans related the trusted domain to be managed by ISM. Our method improved about $33{\sim}82%$ of total execution time than the existing method.

• Journal of Acupuncture Research
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• v.22 no.2
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• pp.171-180
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• 2005

Background & Objective : Angiogenesis consists of the proliferation, migration, and differentiation of endothelial cells, and angiogenic factors and matrix protein interactions modulate this process. The aim of this study was to determine whether Puerariae radix could induce angiogenic activity in human umbilical vein endothelial cells (HUVECs). Methods: The angiogenic activity of Puerariae radix were evaluated by using BrdU assay, chemotactic migration assay, tube formation assay, measurement of bFGF in HUVECs, and Matrigel plug assay in mice. Results : Puerariae radix significantly increased HUVECs proliferation in a dose-dependent manner. In addition, Puerariae radix increased migration and tube-like formation in HUVECs. Interestingly,the expression of basic fibroblast growth factor (bFGF), an angiogenesis-stimulating growth factor, was dose-dependently increased by Puerariae radix. The angiogenic activity of Puerariae radix was confirmed using an in vivo Matrigel angiogenesis model, showing promotion of blood vessel formation. Conclusion : Puerariae radix significantly induces angiogenesis in vitro and in vivo. These results suggest that Puerariae radix is a potent angiogenic agent, and a promising drug, for the induction of neovascularization.

• The KIPS Transactions:PartD
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• v.11D no.2
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• pp.351-360
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• 2004

Most mobile agents are migrated to many mobile agent systems by the sequential node migration method. However. in this case, if some problems such as host's fault or obstacle etc. happened, mobile agent falls infinity walt or orphan states. Therefore, it is difficult to get an expectation effect as use of other distribution technologies because the required time for networking between nodes increases. And so, many researches have been performed to solve this problems. However, most of methods decide node migration based on passive routing table or detour hosts which have some problems. Actually, the researches for reducing the total required time for networking are insufficient yet. In this paper, to reduce the required time for networking of mobile agent we design an active routing table based on the information of implemented objects which are registered in the meta-table of naming agent. And also, for user's keyword, we propose an replication model that replicates many agent object according to the information and number of object references corresponding to meta-table. Replicated objects are migrated to mobile agent systems in parallel and it provides minimized required time for networking.

• Ecology and Resilient Infrastructure
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• v.5 no.4
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• pp.276-284
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• 2018

In order to analyze sediment transport characteristics of knickpoint migration, sediment transport length, and sediment transport weight through the under-flow type vertical lift gate, the hydraulic model experiment and dimensional analysis were performed. The correlations between Froude number and sediment transport characteristics were schematized. The multiple regression formulae for sediment transport characteristics with non-dimensional parameters were suggested. The determination coefficients of multiple regression equations appeared high as 0.618 for knickpoint migration, 0.632 for sediment transport length, and 0.866 for sediment transport weight. In order to evaluate the applicability of the developed hydraulic characteristic equations, 95% prediction interval analysis was conducted on the measured and the calculated by multiple regression equations, and it was determined that NSE (Nash-Sutcliffe Efficiency), RMSE (root mean square), and MAPE (mean absolute percentage error) are appropriate, for the accuracy analysis related to the prediction on sediment transport characteristics of kickpoint migration, sediment transport length and weight.

• Journal of the Korean Regional Science Association
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• v.35 no.2
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• pp.49-57
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• 2019

The young generation in life cycle that social position is rapidly changing is play an important role in a regional development because they can increase social and natural population in the region. This study analyzed the relationship between the movement of young generation and the regional characteristics including housing market characteristics in Seoul. As the results, the movement of young generation was influenced by commuting distance and location of jobs as the gravity model has suggested. In addition, housing supply and housing price (or Jeonse price) is an important factor for the movement of young generation. It can be inferred that the more price gap such as Jeonse price and housing supply gap are increased, the more out-migration of young generation in Seoul is increased. However, the housing demand of young generation in employment centers will be increased because jobs contribute to increasing the inflow of young people. Therefore, the policies of central and Seoul government that supply housing in job rich and high accessibility areas are needed for young generation. In addition, if public housing and affordable housing are supplied in the other areas, it can contribute to reduce the out-migration of young people in Seoul.

• Journal of Radiation Protection and Research
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• v.46 no.2
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• pp.58-65
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• 2021

Background: The evaluation of skyshine distribution, release of airborne radioactive nuclides, and soil activation and groundwater migration were required for radiological assessment of the impact on the environment surrounding In-Flight (IF)-system facility of the RAON (Rare isotope Accelerator complex for ON-line experiment) accelerator complex. Materials and Methods: Monte Carlo simulation by MCNPX code was used for evaluation of skyshine and activation analysis for air and soil. The concentration model was applied in the estimation of the groundwater migration of radionuclides in soil. Results and Discussion: The skyshine dose rates at 1 km from the facility were evaluated as 1.62 × 10^-3 μSv·hr^-1. The annual releases of ³H and ¹⁴C were calculated as 9.62 × 10^-5 mg and 1.19 × 10^-1 mg, respectively. The concentrations of ³H and ²²Na in drinking water were estimated as 1.22 × 10^-1 Bq·cm^-3 and 8.25 × 10^-3 Bq·cm^-3, respectively. Conclusion: Radiological assessment of environmental impact on the IF-facility of RAON was performed through evaluation of skyshine dose distribution, evaluation of annual emission of long-lived radionuclides in the air and estimation of soil activation and groundwater migration of radionuclides. As a result, much lower exposure than the limit value for the public, 1 mSv·yr^-1, is expected during operation of the IF-facility.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.5
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• pp.347-355
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• 2022

Abdominal aortic aneurysm (AAA) is a life-threatening disorder worldwide. Fibroblast growth factor 21 (FGF21) was shown to display a high level in the plasma of patients with AAA; however, its detailed functions underlying AAA pathogenesis are unclear. An in vitro AAA model was established in human aortic vascular smooth muscle cells (HASMCs) by angiotensin II (Ang-II) stimulation. Cell counting kit-8, wound healing, and Transwell assays were utilized for measuring cell proliferation and migration. RT-qPCR was used for detecting mRNA expression of FGF21 and activating transcription factor 4 (ATF4). Western blotting was utilized for assessing protein levels of FGF21, ATF4, and markers for the contractile phenotype of HASMCs. ChIP and luciferase reporter assays were implemented for identifying the binding relation between AFT4 and FGF21 promoters. FGF21 and ATF4 were both upregulated in Ang-II-treated HASMCs. Knocking down FGF21 attenuated Ang-II-induced proliferation, migration, and phenotype switch of HASMCs. ATF4 activated FGF21 transcription by binding to its promoter. FGF21 overexpression reversed AFT4 silencing-mediated inhibition of cell proliferation, migration, and phenotype switch. ATF4 transcriptionally upregulates FGF21 to promote the proliferation, migration, and phenotype switch of Ang-II-treated HASMCs.

• Nutrition Research and Practice
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• v.4 no.5
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• pp.362-368
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• 2010

Oral administration of royal jelly (RJ) promotes wound healing in diabetic mice. Concerns have arisen regarding the efficacy of RJ on the wound healing process of normal skin cells. In this study, a wound was created by scratching normal human dermal fibroblasts, one of the major cells involved in the wound healing process. The area was promptly treated with RJ at varying concentrations of 0.1, 1.0, or 5 mg/ml for up to 48 hrs and migration was analyzed by evaluating closure of the wound margins. Furthermore, altered levels of lipids, which were recently reported to participate in the wound healing process, were analyzed by HPTLC and HPLC. Migration of fibroblasts peaked at 24 hrs after wounding. RJ treatment significantly accelerated the migration of fibroblasts in a dose-dependent manner at 8 hrs. Although RJ also accelerated the migration of fibroblasts at both 20 hrs and 24 hrs after wounding, the efficacy was less potent than at 8 hrs. Among various lipid classes within fibroblasts, the level of cholesterol was significantly decreased at 8 hrs following administration of both 0.1 ug/ml and 5 mg/ml RJ. Despite a dose-dependent increase in sphinganines, the levels of sphingosines, ceramides, and glucosylceramides were not altered with any concentration of RJ. We demonstrated that RJ enhances the migration of fibroblasts and alters the levels of various lipids involved in the wound healing process.