• Proceedings of the Optical Society of Korea Conference
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• 2006.07a
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• pp.489-489
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• 2006

• Journal of Yeungnam Medical Science
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• v.21 no.2
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• pp.207-214
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• 2004

Purpose: This study was carried out to evaluate the efficacy of intravaginal pelvic floor electrical stimulation (FES) therapy on bladder irritability symptoms in stress urinary incontinent women. Materials and Methods: The evaluation before and after treatment included the Blaivas's female Bladder Questionnaire, the quality of life questionnaires and the overall satisfaction with present voiding state using visual analogue test (VAT). All patient were treated for 20 minutes, twice a week for 6 weeks, using a new intravaginal electrical stimulator with microchip (PIC16C74). Results: After the FES therapy, the overall success rate of the SUI was 50.4.% at 9 months. The bladder irritability symptoms such as frequency, nocturia, urgency, residual urine sensation and lower abdominal discomfort were improved. In particular, the symptoms of frequency, urge incontinence, dysuria were significantly improved after the FES therapy at 9 months. The VAT score of the overall satisfaction with the present voiding state was significantly lower after the FES therapy. 73.7% of patients were satisfied with the FES therapy and complications such as hemorrhage, vaginitis, urinary tract infection and pain were not encountered. Conclusion: These results suggest that FES therapy with microchip improves some bladder irritability in SUI women. Therefore, electrical stimulation therapy should be considered as a first line therapy in SUI women with bladder irritability symptoms.

• Proceedings of the KIEE Conference
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• 2006.07c
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• pp.1629-1630
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• 2006

This paper describes a micro total analysis system ($\mu$ TAS) for detecting and digesting the target protein which includes a bead based temperature controllable microchip and computer based controllers for temperature and valve actuation. We firstly combined the temperature control function with a bead based microchip and realized the on-chip sequential reactions using two kinds of beads. The PEG-grafted bead, on which RNA aptamer was immobilized, was used for capturing and releasing the target protein. The target protein can be chosen by the type of RNA aptamer. In this paper, we used the RNA aptamer of HCV replicase. The trypsin coated bead was used for digesting the released protein prior to the matrix assisted laser desorption ionization time of flight mass spectrometer (MALDI TOF MS). Heat is applied for release of the captured protein binding on the bead, thermal denaturation and trypsin digestion. PDMS microchannel and PDMS micro pneumatic valves were also combined for the small volume liquid handling. The entire procedures for the detection and the digestion of the target protein were successfully carried out on a microchip without any other chemical treatment or off-chip handling using $20\;{\mu}l$ protein mixture within 20 min. We could acquire six matched peaks (7% sequence coverage) of HCV replicase.

• Journal of the Korean Chemical Society
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• v.48 no.5
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• pp.483-490
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• 2004

We have developed a novel polymerase chain reaction (PCR)-microchip gel electrophoresis (MGE) method based on the sieving gel mixture of commercially available poly(vinylpyrrolidone) (PVP) and hydroxy ethyl cellulose (HEC) for the rapid detection and diagnosis of the orf virus (ORFV) from Korean indigenous goat. After amplification of 594-bp DNA fragment from the B2L gene of ORF virus, the amplicon was analyzed by the MGE separation. The glass microfluidic chip (64 mm total length (36 mm effective length)${\times}$90 ${\mu}$m width${\times}$20 ${\mu}$m depth) allowed the fast detection and diagnosis of ORFV in the mixture of 1.0% PVP ($M_r$ 360,000) and 1.0% HEC ($M_r$250,000) as a sieving matrix with better resolution and reproducibility of DNA fragments. Under the electric field of 277.8 V/cm, the 594-bp DNA was analyzed within 4 min. Compared to traditional slab gel electrophoresis, the PCR-MGE method was twenty times faster and an effective clinical method for the quantitative analysis of ORFV.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.2
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• pp.54-63
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• 2004

무칩 태그(chipless tag)란 마이크로 칩(microchip)을 포함하지 않는 것으로 저가(low cost)의 RFID (Radio Frequency IDentification) 태그이다. '저가 RFID'라는 용어가 사용되기 시작한 것은 비교적 최근으로, 태그의 정보를 인식할 수 있는 거리가 1 m 이하인 경우는 $1 이하, 그 이상의 거리에서는 $5 이하인 경우를 일반적으로 저가 RFID라고 한다.(중략)

• Bulletin of the Korean Chemical Society
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• v.26 no.6
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• pp.979-982
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• 2005

• Journal of the Korea Society of Computer and Information
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• v.18 no.6
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• pp.1-8
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• 2013

In this paper, we design and implement a firmware for low-cost small PCR devices. To minimize machine code size, the proposed firmware controls real-time tasks simultaneously only with support of the hardware interrupt, but without support of the operating system program. The proposed firmware has the host-local structure in which the firmware receives operation commands from PC and sends operation results to PC through usb communication. We implement a low-cost small PCR device with the proposed firmware loaded on microchip PIC18F4550 chip, and verify that the implemented PCR device significantly reduces cost and volume size of existing commercial PCR devices with a similar performance.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.1
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• pp.103-109
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• 2021

Fine chips generated by machining have an impact on machine failure and quality of machined products, it is necessary to remove the chips, so the microchip collection and removal device by rotating conveyor belt with neodymium permanent magnets was developed. In this research, to solve the problem for reducing the existing microchips in the tank, a micro-chip removal device by rotating conveyor belt with neodymium permanent magnets developed. In the development of micro-chip removal device, 3D CATIA modeling was used, and the flow analysis and the electromagnetic force analysis were performed with COMSOL Multiphysics program. To evaluate the performance of the prototypes produced, design of experiments (DOE) is used to obtain the effect of neodymium conveyor movement speed on chip removal for the ANOVA analysis of recovered powders. An experiment was conducted to investigate the effect of the conveyor feed rate on the chip removal performance in detail. As a result of the experiment, it was confirmed that the slower the feeding speed of the fine chip removing device, the more efficient the chip removal.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.717-720
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• 2003

A chromogenic biosensor employing microfluidics on a chip has been developed for the determination of high-density lipoprotein (HDL) cholesterol (HDL-C) in human serum. We have investigated a plain and effective method to immobilize enzymes within the microchip without chemically modifying micro-channel or technically micro-fabricating column reactor and fluid channel network. In assessing risk factors of coronary heart disease, a micro-chip system would minimize requirements of instrument and reagent handling.

• Proceedings of the Optical Society of Korea Conference
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• 2002.07a
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• pp.72-73
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• 2002

매우 작은 이득 매질 안에 높은 농도의 레이저 이온을 도핑하여 공진기의 길이를 수 3m 이내로 대폭 축소하였으면서도 기존의 고체 레이저보다 효율적이며, 소형화된 마이크로 칩 레이저에 관한 연구는 최근 여러 연구진에 의해 활발하게 진행되고 있다. 기존의 YAG는 열 전달 계수가 크며, 역학적, 광학적, 화학적 성질이 모두 매우 우수한 레이저 매질로 평가되어왔으나 대표적인 레이저 이온인 Nd이온과 비교하여 Yttrium이온의 크기가 커서 도핑 농도를 높이는데 한계를 가지고 있다. (중략)