• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1419-1426
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• 2008

Fulminant hepatic failure is a clinical syndrome associated with a high mortality rate. Orthotopic liver transplantation is the only clinically proven effective treatment for patients with end-stage liver disease who do not respond to medical management. A major limitation of this treatment modality is the scarcity of donor organs available, resulting in patients dying while waiting for a donor liver. An extracorporeal bioartificial liver (BAL) device containing viable hepatocytes has the potential to provide temporary hepatic support to liver failure patients, serving as a bridge to transplantation while awaiting a suitable donor. In some patients, providing temporary hepatic support may be sufficient to allow adequate regeneration of the host liver, thereby eliminating the need for a liver transplant. Although the BAL device is a promising technology for the treatment of liver failure, there are several technical challenges that must be overcome in order to develop systems with sufficient processing capacity and of manageable size. In this overview, the authors describe the critical issues involved in developing a BAL device. They also discuss their experiences in hepatocyte culture optimization within the context of a microchannel flat-plate BAL device.

• Journal of Astronomy and Space Sciences
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• 제19권4호
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• pp.273-282
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• 2002

과학위성 1호의 주탑재체인 원자외선 분광기의 검출기 전자부에 대한 특성을 분석하였다. FIMS (Far-ultraviolet Imaging Spectrograph)는 교차 지연선 양극을 가진 MCP(micro-channel plate)를 사용하여 입사된 원자외선 광자의 위치를 검출한다. MCP에 입사하는 광자는 MCP을 통해 전자형태로 변환되고 증폭된다. 증폭된 전하운의 중심은 양분되어 연결된 지연선을 통해 양단으로 나가게 되고, 지연선의 양단에서 전하운의 도착시간 차이를 구하여 입사된 광자의 위치를 판독한다. FIMS의 경우 2개의 MCP 검출기를 갖고 있으며, 각각 25mm$\times$25mm의 유효 크기를 갖고있다. 또 신호처리계는 1채널의 신호처리 회로계를 통해 2개의 검출기에 대한 영상검출이 가능하도록 함으로써 신호처리계의 복잡성을 피하고 아울러 전력과 무게 비용을 줄였다. 이 시스템을 통해 높은 시간 및 공간 분해능(<$35{\times}75$ps FWHM)을 얻었으며, 6W 이하의 저전력 시스템을 구현하였다.

• Nuclear Engineering and Technology
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• 제53권7호
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• pp.2364-2370
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• 2021

The ⁿMCP (Neutron sensitive microchannel plate) combined with advanced readout electronics is widely used in energy selective neutron imaging because of its good spatial and timing resolution. Neutron detection efficiency is a crucial parameter for the ⁿMCP. In this paper, a mathematical model based on the oblique cylindrical channel and elliptical pore was established to calculate the neutron absorption probability, the escape probability of charged particles and overall detection efficiency of ⁿMCP and analyze the effects of neutron incident position, pore diameter, wall thickness and bias angle. It was shown that when the doping concentration of the ⁿMCP was 10 mol%, the thickness of ⁿMCP was 0.6 mm, the detection efficiency could reach maximum value, about 24% for thermal neutrons if the pore diameter was 6 ㎛, the wall thickness was 2 ㎛ and the bias angle was 3 or 6°. The calculated results are of great significance for evaluating the detection efficiency of the ⁿMCP. In a subsequent companion paper, the mathematical model would be extended to the case of the spatial resolution and detection efficiency optimization of the coating ⁿMCP.