• Polymer(Korea)
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• v.26 no.3
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• pp.293-299
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• 2002

By the reaction of m-cresol as a microbicide with acryloyl chloride m-cresyl acrylate (CA) was synthesized, and polymers with the moiety of m-cresol were prepared by the radical terpolymerization of CA -methylmethacrylate -acrylic acid. The contents of CA unit in the polymers were found to be 4.7 mol% and 10.1 mol% from their nuclear magnetic resonance spectra. The number -average molecular weights of the polymers were in the range of 12000 to 15000. Through the hydrolysis of the polymers m-cresol was released. The release rate of the microbicide increased with increasing PH of the release medium. This result can be attributed to enhanced proton dissociation of carboxyl group of the acrylic acid unit in the polymers. These polymers showed microbicidal activities for S. aureus as a positive microbe and E. coli as a negative microbe.

• Polymer(Korea)
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• v.27 no.5
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• pp.443-448
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• 2003

2-Biphenylyl acrylate (BPA) was synthesized by the reaction of 2-phenylphenol as a microbicide with acryloyl chloride, and copolymers with the moiety of 2-phenylphenol were prepared by the radical terpolymerization of BPA-methylmethacrylate-acrylic acid. The contents of BPA unit in the poly mers were found to be 4.2 mol% and 9.1 mol% from their nuclear magnetic resonance spectra. The number average molecular weights of the polymers were in the range of 15000 to 16000. 2-Phenylphenol was released through the hydrolysis of the polymers. The release rate of the microbicide increased with increasing pH of the release medium. The released solution showed higher microbicidal activity for E. coli as a negative microbe than S. aureus as a positive microbe.

• Journal of Microbiology and Biotechnology
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• v.28 no.8
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• pp.1367-1375
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• 2018

Silver nanoparticles have been widely applied for biomedical areas owing to their potent antiviral and antibacterial activities. Synthesis of silver nanoparticles using biomacromolecules is more efficient, environment-friendly, and cost-saving compared with the traditional approach. In this paper, a novel approach was developed to establish a reaction system with $Ag^+-BH4^--sericin$ to synthesize silver nanoparticles conjugated to sericin (AgNPs-Sericin). Sericin could be as a good dispersant and stabilizing agent, which is able to modify nanoscaled AgNPs, the average diameter of which was only $3.78{\pm}1.14nm$ prepared in a 0.3 mg/ml sericin solution. The characterizations of the AgNPs-Sericin were determined by FTIR, thermogravimetry, and XRD analyses. The results showed that the synthesized AgNPs conjugated with sericin as organic phase. Via SAED and XRD analysis, we showed that these AgNPs formed polycrystalline powder with a face-centered cubic structure of bulk metals. Moreover, we investigated the antiviral and antibacterial activities of AgNPs-Sericin, and the results showed that AgNPs-Sericin exhibited potent anti-HIV-1 activity against CCR5-tropic and CXCR4-tropic strains, but no significant cytotoxicity was found toward human genital epithelial cells compared with free silver ions, which are accepted as a commonly used potent antimicrobial agent. Moreover, its antibacterial activity was determined via flow cytometry. The results showed that AgNPs-Sericin could suppress gram-negative (E. coli) and gram-positive (S. aureus) bacteria, but more was potent for the gram-negative one. We concluded that our AgNPs-Sericin could be a potential candidate as a microbicide or antimicrobial agent to prevent sexually transmitted infections.

• Polymer(Korea)
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• v.30 no.1
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• pp.80-84
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• 2006

2-Biphenylyl acrylate(BPA) was synthesized by the reaction of acryloyl chloride with 2-phenylphenol (2PP). Hydrophilic copolymers with the moiety of the microbicide, 2PP, were prepared by the radical copolymerization of BPA and methacrylic acid (MA). From the compositions of the BPA unit and the MA unit in the copolymers, the monomer reactivity ratios were determined to be 0.86 for BPA and 1.21 for MA by means of Kelen-Tudos plot. This result indicates that the copolymers have a random structure. The amount of 2PP released through the hydrolysis of the copolymers was examined by UV spectrometry. The result showed that the release of 2PP increased with an increase in the hydrophilic MA content in the copolymers and with an increase in the pH of the release medium. Therefore, these results indicate that the hydrophilic polymers bearing 2-phenylphenol moiety can be controlled release microbicides.