• 제목/요약/키워드: miR-20a

검색결과 541건 처리시간 0.044초

우주분야 연구개발 및 산업동향 (Current Status and Outlook of the Space Economy)

  • 최수미
    • 항공우주산업기술동향
    • /
    • 제6권1호
    • /
    • pp.3-13
    • /
    • 2008
  • 우주분야에서의 2007년은 역사적으로 기념할 만한 해였다. 구소련의 스푸트니크가 1957년 10월 4일 발사되어 50주년을 맞이하였고, UN이 우주의 평화적 이용을 선언한지 40주년이 되는 해이기도 하다. 그리고 2007년과 2008년 초에는 일본과 중국의 달 탐사위성 발사 성공, 유럽과 일본의 국제우주정거장 실험모듈 조립성공, 중국의 위성요격시험 시도, 그리고 한국 최초의 우주인 배출사업 성공 등 다양한 변화들이 돋보인 한 해였다. 2007년 주요국 정부의 우주개발 예산은 총 783억불로 전년 대비 36% 증가하였으며, 탐사분야에서는 세계 탐사 전략과 협력 프레임워크가 발표되면서 달탐사에 대한 전 세계 14개국의 국제협력 방향이 마련되었다. 우주산업 매출은 2006년 1,061억불 규모로 전년 대비 20% 증가하였으며, 2007년 매출은 1,739억불로 예상되고 있다. 본 논문에서는 특히 지구관측위성 연구개발과 제도, 이로 인해 파생되는 영상데이터 및 서비스 시장의 동향과 전망을 자세히 분석하였다. 우리나라의 2008년 우주개발 예산은 3,164억원이며, 2007년 우주산업 생산규모는 1억불이다. 다목적실용위성 3, 3A, 5호, 통신해양기상위성의 개발과 소형위성발사체 개발 등의 연구사업이 진행 중이며, 올 해 완공되는 나로 우주센터에서 과학기술위성2호가 탑재된 소형위성발사체를 연내 발사할 예정이다.

  • PDF

월경전증후군에 대한 한약 치료의 효과 : 체계적 문헌 고찰과 메타 분석 (Herbal Medicine for Premenstrual Syndrome: A Systematic Review and Meta-analysis)

  • 서지인;이윤재;고서림;김누리;김정훈;손미주;김영은;김안나;이은희
    • 대한한방부인과학회지
    • /
    • 제36권4호
    • /
    • pp.96-120
    • /
    • 2023
  • Objectives: This study reports the findings that support the efficacy of herbal medicine (HM) for premenstrual syndrome (PMS). Methods: We conducted meta-analysis of findings from randomized controlled trials (RCTs) for PMS treated with HM. The articles were published before July 2022, located using 9 databases (Pubmed, EMBASE, Cochrane Library, CINAHL, CNKI, CiNii, SCIENCE ON, KoreaMed, OASIS). Results: We observed 2,034 studies, of which 23 RCTs met our inclusion criteria. The risk of bias in the included studies was relatively unclear or high. Meta-analysis of 3 RCTs showed that HM group had a significantly higher total effective rate than the western medicine group (RR 1.20 [95% CI 1.06, 1.36, p=0.004]). Meta-analysis of 1 RCT showed that HM group had a significantly lower symptom score (MD -3.04 [95% CI -5.36, -0.72, p=0.01]), while there was no significant difference in daily record of severity of problems scale (MD -20.52 [95% CI -49.33, 8.29, p=0.16]). Conclusions: HM significantly improved PMS symptoms than general treatment and no serious adverse events were reported. However, the evidence on the effectiveness and safety of HM for PMS was not enough to provide reliable results due to the small number and low quality of included studies. We believe that rigorous RCTs will lead to more reliable evidence of the intervention.

국내산 팥의 품종별 종실 및 수분흡수 특성 (Seed and water absorption characteristics of red bean cultivars in Korea)

  • 오선민;조영제;천아름;곽지은;오유근;김미정;송석보;최인덕
    • 한국식품과학회지
    • /
    • 제53권5호
    • /
    • pp.607-612
    • /
    • 2021
  • 본 연구에서는 국내산 팥 품종별 종실 특성과 수분흡수율 및 수분흡수 kinetics를 분석하였으며 수분흡수 속도와 팥의 종실 특성 변수들 간의 상관관계를 조사하였다. 팥의전체 종실의 길이는 품종간 유의적인 차이를 보였지만(7.74-8.99 mm), 전체 종실의 너비에는 유의적인 차이가 없었으며(5.33-5.54 mm), 배꼽의 경우 길이는 3.21-4.01 mm, 너비는 0.58-0.73 mm의 범위를 가졌다. 주사 전자 현미경을 통해 종피는 39.18-50.01 ㎛로 나타났다, 수침 동안 초기 수분함량이 <14%인 팥은 30시간에 도달함에 따라 모든 품종 팥에서 130% 이상 수분을 함유하고 있었으며 수침 초기에는 수분에 큰 변화가 없는 lag phase를 갖는 것으로 나타났다. 흰나래의 경우 다른 품종들에 비해 lag phase로 도달하는 시간이 빨랐으며 평형수분 함량의 50%까지 도달하는 시간인 τ (h)의 경우 모델식에 적용하여 도출할 수 있는데 이때, 흰나래가 4.40 h로 가장 빨랐고 다른 품종의 경우 도달시간이 9-10 h였다. 모델식으로부터 품종별 수분흡수 속도를 계산한 결과, 흰나래가 가장 빠르게 수분흡수가 이루어졌으며 검구슬, 연두채, 홍진, 아라리 순서로 나타났다. 수분흡수 속도와 종실 특성 지표와의 상관관계에서 수분흡수 속도는 전체 종실의 길이나 너비, 배꼽의 길이 보다는 배꼽의 너비(r=0.7858*)와 종피의 두께(r= -0.9954***)와 더 높은 상관성이 있어, 이 두가지가 팥의 수분흡수율에 영향을 주는 주요 요인임을 알 수 있다. 본 연구에서 흰나래는 가장 긴 배꼽 너비(0.73 mm)와 가장 얇은 종피(39.18 ㎛)를 가져 다른 품종들보다 눈에 띄는 수분흡수 속도를 보여 경제적이고 효율적인 품종으로서 산업적 적용을 기대할 수 있다. 또한, 본 연구를 통해 팥의 수분 거동은 S형 방정식에 모델링하는 것이 적절하며 모델링을 하여 수분거동을 예측함으로써 수분침지 시간과 수분흡수율을 제어하고 용도에 맞게 가공시스템을 설정할 수 있을 것으로 생각된다.

등속성 에르고미터 운동을 이용한 수정된 생리적 부담 지수와 산소소비량 변화량과의 상관성 (Relationship Between Modified Physiological Cost Index for Isokinetic Ergometer Exercise Test and Oxygen Consumption)

  • 박호준;조상현;이충휘;박정미
    • 한국전문물리치료학회지
    • /
    • 제7권2호
    • /
    • pp.20-34
    • /
    • 2000
  • The purpose of this study was to establish modified physiological cost index (PCI) for predicting energy consumption by heart rate (HR) at isokinetic ergometer exercise testing. The subjects were twenty-eight healthy men in their twenties. All of them performed upper and lower extremity isokinetic ergometer exercise tests which had six loads (400, 500, 600, 700, 800, and 900 kg-m/min) and five loads (400, 500, 600, 700, and 800 kg-m/min) respectively. The exercise sessions were finished when HR was in plateau. HR and oxygen consumption were determined during the final minute. Resting heart rate and oxygen consumption were used for calculating heart rate, oxygen consumption changes and modified PCI. Regression analysis established the relationship between each variable to work load, HR and oxygen consumption. The results were as follows: 1) In the lower extremity ergometer exercise test, oxygen consumption increased continuously as work load increased, but in the upper extremity ergometer test, oxygen consumption only increased until work load was 700 kg-m/min. 2) HR increased as work load increased in both exercise tests, but in the upper extremity ergometer test, HR decreased from the 700 kg-m/min. 3) The modified PCI increased as work load mcreased until the 700 kg-m/min point in the lower extremity ergometer test and until the 500 kg-m/min point in the upper extremity ergometer test when it started to decrease in both tests. 4) In the lower extremity ergometer exercise test, regression analysis established the relation as $dVO_2$ = -.0215HR - .2141 where $dVO_2$ is given in l/min and HR in beat/min ($R^2$ = .2677, p = .000). ln the upper extremity ergometer exercise test. regression analysis established the relation as $dVO_2$ = -.0115HR + .2746 ($R^2$ = .1308, p = .000). The results of this study were similar to previous studies but were different under high work load conditions. So modified PCI should be used with only low intensity work load testing. Subjects for upper extremity ergometer exercise testing should complete a prescribed training course prior to testing, and only low intensity work load should be used for safety considerations.

  • PDF

rmIL-5로 유도된 호산구의 활성화 및 성장에서 중루의 천식반응 억제효과 (Inhibitory effects of Paridis Rhizoma in the activation and proliferation of eosinophils: implications on its regulatory roles for asthma)

  • 신미경;길기정;이영철;김진숙;서영배;노성수
    • 대한본초학회지
    • /
    • 제20권2호
    • /
    • pp.159-169
    • /
    • 2005
  • Objectives : This study was carried out for the purpose of knowing the effect from anti-arthma action of the abstraction from a extract of Paridis Rhizoma(EPR). In order to know what the effect of controlling an abstraction from Paridis Rhizoma. and about the expression of B cells and Ig E cells, mast cells it was necessary for it to be activated by ovalbumin. Methods : In order to know what the effect was on the organization of cytokine gene expression from The increase and divorce of the B cells and allergic acting by EPR, we found it necessary to examine the BALF. At the same time, as we examined the histamine release by ELISA method, we also examined the effect of EPR. Results : EPR at $100\;{\mu}g/ml$, the highest concentration examined did not have any cytotoxic effects on mLFCs. In FACS analysis, number of granulocyte/lymphocyte, $CD3e^+/CCR3^+,\;CD4^+\;and\;CD23^+/B220^+$ in asthma-induced lung cells were significantly decreased by EPR treatment compared to the control group. In RT-PCR analysis, mRNA expression for CCR3, eotaxin and histamine in asthma-induced lung cells, which was induced by rIL-3 plus rmIL-5 treatments, was significantly decreased by EPR treatment. In ELISA analysis, production levels of IL-4, IL-13 and histamine in asthma-induced lung cells, which were induced by rIL-3 plus rmIL-5 co-treatment, were significantly decreased by EPR treatment. EPR treatments significantly inhibited the proliferation of eosinohils prepared from asthma-induced mouse lung tissues compared to the non-EPR treated control cells. Immunohistochemical analysis revealed that EPR treatment significantly decreased the levels of eosipnphil activation compared to non-treated cells. Conclusion : The present data suggested that Paridis Rhizoma may have an effects on the inhibition of parameters associated with asthma responses in eosinpophils, and thus implicate the possibility for the clinical application of Paridis Rhizoma.

  • PDF

농업용 저수지의 수질 예측 모델을 위한 PSO(Particle Swarm Optimization) 알고리즘의 적용 (Application of Particle Swarm Optimization(PSO) for Prediction of Water Quality in Agricultural Reservoirs of Korea)

  • 권용수;배미정;황순진;박영석
    • 생태와환경
    • /
    • 제41권spc호
    • /
    • pp.11-20
    • /
    • 2008
  • 본 연구에서는 농림부와 환경부의 전국수질측정망 자료를 이용하여 2002년 9월 전후에 조사된 전국 290개 농업용 저수지의 Chl-${\alpha}$ 농도를 예측하였다. 우리나라 290개 농업용 저수지의 9월 전후 영양상태를 분류한 결과, 부영양 상태 이상을 나타내는 저수지가 $TSI_{CHL}\;64.1%,\;TSI_{TP}\;75.5%$로 대부분의 저수지가 높은 부영양화 상태를 보였다. 이렇게 분류된 저수지의 영양 상태를 환경특성에 따라 판별분석을 실시하였다. 그 결과 전체 판별적중률은 약 60%를 보였다. 판별분석의 결과에 정준분석을 실시한 결과, 각 그룹은 영양상태에 따라 구분이 되었으며, COD, DO, TP등이 중요한 인자로 나타났다. 또한 MLP-PSO 모델을 이용하여 부영양화에 따른 저수지 수질을 예측한 결과 높은 예측력을 보였으며 (r=0.831, p<0.05), 민감도 분석 결과 COD와 TP가 상대적으로 가장 중요한 요인으로 작용하였으며, 고도 및 제방 높이는 음의 영향을 미치는 것으로 나타났다.

암환자들의 식행동과 건강식품 섭취실태에 관한 연구 (Dietary Behaviors and Consumption of Health Food among the Cancer Patients)

  • 김용신;김상연;정경아;권순형;장유경;박미현;황성주
    • 동아시아식생활학회지
    • /
    • 제15권5
    • /
    • pp.516-523
    • /
    • 2005
  • This study was performed to investigate dietary behaviors and consumption of health food in cancer patients. The subjects were 163 cancer patients recruited from the general hospital in Seoul, Korea. The data were obtained by the structured self administered questionnaire. The mean age of subjects was 51 years. Most of subjects didn't eat the visual fat of meat and chicken skin. The mealtime of the subjects was generally regular and most of subjects had breakfast. The subjects of this survey liked to eat foods with sweet taste but disliked to eat hot, salty and sour taste ones. The preference for fish, marine products and vegetables was high but that for instant foods and frying foods was very low. Most of subjects consumed the foods that is generally known as anticancer foods such as vegetables and fruits. On the other hand, most of subjects didn't intake butter, margarine, and frying foods that is known as risk factors of cancer. The majority of subjects$(84.7\%)$ consumed the health food The main reasons for taking health foods by subjects were to cure disease$(58.0\%)$, to prevent disease$(45.3\%)$, to supply nutrients$(39.3\%)$, to maintain the mental state$(12.7\%)$ and to recover fatigue$(10.7\%)$. Majority of subjects$(66.0\%)$ spent money more than 200,000 won/month to buy health foods. The purchasing channels of health foods by subjects were recommendation by family or friend$(64.0\%)$, by physician/pharmacist$(18.0\%)$ and by nutritionist or dietician(6.0), and advertisement through TV or radio$(12.0\%)$. The types of taking health foods of the subjects were vegetable extracted food$(60.0\%)$, mushrooms$(51.3\%)$, Lactobacillus food$(25.3\%)$, enzyme food$(22.6\%)$ calcium containing food$(20.0\%)$ and so on. The results of the current study show that although many cancer patients already practice healthy dietary behaviors, there is a substantial proportion who do not and most of cancer patients consume health foods.' Further intervention is needed to explore the effect of health foods in cancer patients

  • PDF

Serum anti-M$\ddot{u}$llerian hormone levels as a predictor of the ovarian response and IVF outcomes

  • Choi, Min-Hye;Yoo, Ji-Hee;Kim, Hye-Ok;Cha, Sun-Hwa;Park, Chan-Woo;Yang, Kwang-Moon;Song, In-Ok;Koong, Mi-Kyoung;Kang, Inn-Soo
    • Clinical and Experimental Reproductive Medicine
    • /
    • 제38권3호
    • /
    • pp.153-158
    • /
    • 2011
  • Objective: The aim of this study was to investigate whether anti-M$\ddot{u}$llerian hormone (AMH) levels could be predict ovarian poor/hyper response and IVF cycle outcome. Methods: Between May 2010 and January 2011, serum AMH levels were evaluated with retrospective analysis. Three hundred seventy infertile women undergoing 461 IVF cycles between the ages of 20 and 42 were studied. We defined the poor response as the number of oocytes retrieved was equal or less than 3, and the hyper response as more than 25 oocytes retrieved. Serum AMH was measured by commercial enzymelinked immunoassay. Results: The number of oocytes retrieved was more correlated with the serum AMH level (r=0.781, $p$ <0.01) than serum FSH (r=-0.412, $p$ <0.01). The cut-off value of serum AMH levels for poor response was 1.05 ng/mL (receiver operating characteristic [ROC] curves/area under the curve [AUC], $ROC_{AUC}$=0.85, sensitivity 74%, specificity 87%). Hyper response cut-off value was 3.55 ng/mL $ROC_{AUC}$=0.91, sensitivity 94%, specificity 81%). When the study group was divided according to the serum AMH levels (low: <1.05 ng/mL, middle: 1.05 ng/mL - 3.55 ng/mL, high: >3.55 ng/mL), the groups showed no statistical differences in mature oocyte rates (71.6% vs. 76.5% vs. 74.8%) or fertilization rates (76.9% vs. 76.6% vs. 73.8%), but showed significant differences in clinical pregnancy rates (21.7% vs. 24.1% vs. 40.8%, $p$=0.017). Conclusion: The serum AMH level can be used to predict the number of oocytes retrieved in patients, distinguishing poor and high responders.

벼의 저온발아성에 관한 유전분석 (Genetic Analysis of Low Temperature Germinability of Rice)

  • 강종래;고미석;김호영;임상종;김순철
    • 한국작물학회지
    • /
    • 제42권6호
    • /
    • pp.766-777
    • /
    • 1997
  • 수도 저하발아성에 대한 유전 양상을 구명하여 저온발아성 품종 육성의 기초 자료를 얻고자 숙기가 다른 세 그룹에서 10품종을 선정 '94년에 15일 간격 4시기로 파종 및 이앙을 실시하여 수량한 종자를 '95년 4~5월에 13$^{\circ}C$ 항온 실내 시험과, 건답 직파의 포장 시험으로 저온발아성을 조사하고, 저온발아성 고 1품종, 저 1품종, 중 4품종을 선정 '94 하계에 절영법에 의한 정역이면교잡을 실시하여 얻어진 F$_1$ 교배입을 '95년 5월에 13$^{\circ}C$ 항온에서 저온발아 시험을 실시하여 얻은 결과를 요약하면 다음과 같다. 1. 재배 시기를 달리하여 수량된 종자의 실내 및 포장에서의 저온발아성 분산분석 결과 품종에 따라 재배시기간에 고도의 유의차가 인정되었다. 2. 실내 13$^{\circ}C$ 항온 저온발아계수와 포장의 자연상태 건답직파에서의 출아계수와의 상관분석 결과 고도의 유의한 상관(r=0.5111)이 인정되었다. 3. 조합능력 분석 결과 일반조합능력 및 특정조합능력 모두 고도의 유의성이 인정되었으며, 일반조합능력이 특정조합능력보다 커서 상가적작용이 상위성 작용보다 더 크게 나타났다. 4. 정역차이 분산분석 결과 정역간에 고도의 유의차가 인정되었다. 5. 부친열 공분산/모친열 공분산 Graph에서 6개의 교배열 모두가 모본 효과를 보였으며, Alpha와 Beta 유전 분석 결과, 저온발아성의 정역간 차이는 Alpha 유전의 효과로 나타났다. 6. 평균우성도 분석 결과, 30개 조합 중 17개 조합에서 초월분리를 보였으며, 그 중 9개 조합이 저온발아성이 낮은 쪽으로 초월분리를 보였다.

  • PDF

내관 자침 시 염전 횟수가 심박 변이도에 미치는 영향: 예비연구 (Influence of Rotation Number in the Effect of PC6 on the Heart Rate: A Pilot Study)

  • 이봉효;정재환;손지국;허정현;박지하;김희영;이상남;이영준;김미려;임성철;김재수;이윤규;이현종;정현정;정태영
    • Korean Journal of Acupuncture
    • /
    • 제30권2호
    • /
    • pp.88-96
    • /
    • 2013
  • Objectives : In the acupuncture treatment of Korean Medicine, the Tonifying or Purging depending on how many times the needle is rotated has been used widely. However, there is little evidence about the optimal number of rotation. This study, therefore, was aimed to investigate the optimal number of rotation. Methods : Heart rate variation was measured before and after exercise in 20 healthy adults. Acupuncture was performed at PC6 immediately after exercise according to the protocol of each group without remaining. Pre-exercise and post-exercise measurements were compared and the rotation number that produced statistically significant difference was investigated. Results : Significant differences were found in the heart rate variation and R-R interval Average, between non-rotation group (control) and both of 15 times rotation group of tonifying and 6 times rotation group of purging. Conclusions : Significantly effective number of rotation in the effect of PC6 on the HR and RRAv was 15 times in the tonifying and 6 in the purging respectively.