• Title/Summary/Keyword: miR-126-3p

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Effects of a Prepared Childbirth Education on the Knowledge and Delivery Participation Levels of the Spouses of Primiparas (출산준비 교육이 초산모 배우자의 지식 및 분만참여에 미치는 효과)

  • Sung, Mi-Hae;Ju, Mi-Sook;Ju, Kyung-Sook
    • Women's Health Nursing
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    • v.9 no.3
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    • pp.213-223
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    • 2003
  • Purpose: This study was conducted to identify the effects of a prepared childbirth education on the knowledge and delivery participation levels of the spouses of primiparas. Method: The study's subjects were a convenience sample of 126 spouses, consisting of an experimental group of 74 educated for prepared childbirth for 10 hours. This study was measured by using a 41-item measurement instrument for knowledge of childbirth that was devised from Kang's(1981) instrument and a 23-item measurement instrument for measuring delivery levels which was developed through clinical experiences. The data gathered as analyzed by using SPSS WIN10.0. Result: There were no significant differences between the experimental group and the control group in homogeneity concerning the general characteristics of the spouses of primiparas. The first hypothesis, which stated that the level of knowledge of childbirth in the experimental group who received prepared childbirth education would be higher than in control group, was statistically supported by the Compared Independent Sample t-test(t=17.92, p=.000). The second hypothesis, which stated that the level of participation of delivery in the experimental group who received prepared childbirth education would be higher than in the control group, was also statistically supported (t=28.87, p=.000). The third hypothesis, which stated that there would be a correlation between the level of knowledge and the level of participation in the experimental group who received prepared childbirth education, showed a high positive correlation(r=.810, p=.000). Conclusion: The above results indicate that the increase of knowledge through prepared childbirth education in the spouses of primiparas has a high correlation with delivery partici- pation levels which engenders physical and moral support for primiparas at delivery. Additionally, a varied prepared childbirth education acts as an effective means to increase under- standing and support for primiparas couples who experience tension, anxiety and fear due to an unprepared delivery in Korea.

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Maincause of influencing oral health impact profile(OHIP) and self-esteem of orthodontic patients (교정환자의 자아존중감과 구강건강영향지수(OHIP)에 영향을 미치는 요인)

  • Park, Young-Nam;Lee, Mi-Ra
    • Journal of Korean society of Dental Hygiene
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    • v.10 no.3
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    • pp.513-522
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    • 2010
  • Objectives : This study aimed to determine self-esteem and oral health impact profile (OHIP) of orthodontic patients to get data necessary for the process of consultation, education, and treatment for those patients who hoped to get orthodontic therapy in order to see effects of orthodontic therapy on personal life in consideration of general characteristics of those patients under orthodontic therapy. methods : A self-administered questionnaire was used among 232 outpatients under orthodontic therapy from October to November 2009, obtaining the following results. Results : 1. As for general characteristics of respondents, those under 19 years of age constituted 46.6%; the unmarried comprised 85.8%; and students constituted 53.4%. 2. Most respondents were getting orthodontic therapy for beauty (41.8%) and dental health (40.5%). Family (54.3%) contributed to their decision to get orthodontic therapy; parents or siblings (62.5%) were bearing the treatment expenses. 3. Females were getting orthodontic therapy for an aesthetic purpose (50.3%), and male for the purpose of dental health (44.6%) (P<0.01). 4. OHIP was slightly higher among males ($4.10{\pm}0.61$) than among female ($4.00{\pm}0.78$), and was highest among those 19 years old and under ($4.17{\pm}0.67$); the older they were, the lower it was significantly (P<0.05). Most of them were earning 3 to 4 million won ($4.22{\pm}0.72$); the married ($4.05{\pm}0.74$) constituted higher percentage. As for occupation, students ($4.13{\pm}0.66$) comprised the highest percentage. 5. Self-esteem was higher among males ($3.83{\pm}0.47$) than among females ($3.80{\pm}0.50$), and was highest among those 25 to 29 years old ($3.92{\pm}0.46$). Most of them were earning more than 5 million won ($3.91{\pm}0.42$), which was statistically significant (P<0.01). The married ($3.91{\pm}0.54$) constituted higher percentage than the unmarried ($3.80{\pm}0.48$); office managers ($3.95{\pm}0.55$) comprised the highest percentage. 6. As for correlation between variables effecting OHIP of orthodontic patients, there was negative correlation in age (r=-0.225) and positive correlation in occupation (r=0.122). As for correlation between variables effecting self-esteem of orthodontic patients, there was negative correlation in occupation (r=-0.130) and positive correlation n income (0.126), while there was positive correlation (r=0.202) between OHIP and self-esteem of orthodontic patients. Conclusions : Younger orthodontic patients who were students showed higher OHIP, and professionals earning more showed higher self-esteem. Orthodontic patients with higher OHIP showed higher self-esteem. Therefore, it is necessary to develop a program based on OHIP and self-esteem in consulting and treating orthodontic patients; since it is considered that orthodontic therapy will improve appearance, enhance self-confidence, and have positive effects on interpersonal relationships and quality of living, researches are necessary on constant changes in psychological properties.

A Critical Evaluation of the Correlation Between Biomarkers of Folate and Vitamin $B_{12}$ in Nutritional Homocysteinemia (엽산과 비타민 $B_{12}$ 결핍에 의한 호모시스테인혈증 흰쥐의 조직내 비타민 지표간의 상관관계 분석)

  • Min, Hye-Sun;Kim, Mi-Sook
    • Journal of Nutrition and Health
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    • v.42 no.5
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    • pp.423-433
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    • 2009
  • Folate and vitamin $B_{12}$ are essential cofactors for homocysteine (Hcy) metabolism. Homocysteinemia has been related with cardiovascular and neurodegenerative disease. We examined the effect of folate and/or vitamin $B_{12}$ deficiency on biomarkers of one carbon metabolism in blood, liver and brain, and analyzed the correlation between vitamin biomarkers in mild and moderate homocysteinemia. In this study, Sprague-Dawley male rats (5 groups, n = 10) were fed folatesufficient diet (FS), folate-deficient diet (FD) with 0 or 3 g homocystine (FSH and FDH), and folate-/vitamin $B_{12}$-deficient diet with 3 g homocystine (FDHCD) for 8 weeks. The FDH diet induced mild homocysteinemia (plasma Hcy 17.41 ${\pm}$ 1.94 nmol/mL) and the FDHCD diet induced moderate homocysteinemia (plasma Hcy 44.13 ${\pm}$ 2.65 nmol/mL), respectively. Although liver and brain folate levels were significantly lower compared with those values of rats fed FS or FSH (p < 0.001, p < 0.01 respectively), there were no significant differences in folate levels in liver and brain among the rats fed FD, FDH and FDHCD diet. However, rats fed FDHCD showed higher plasma folate levels (126.5 ${\pm}$ 9.6 nmol/L) compared with rats fed FD and FDH (21.1 ${\pm}$ 1.4 nmol/L, 22.0 ${\pm}$ 2.2 nmol/L)(p < 0.001), which is the feature of "ethyl-folate trap"by vitamin $B_{12}$ deficiency. Plasma Hcy was correlated with hepatic folate (r = -0.641, p < 0.01) but not with plasma folate or brain folate in this experimental condition. However, as we eliminated FDHCD group during correlation test, plasma Hcy was correlated with plasma folate (r = -0.581, p < 0.01), hepatic folate (r = -0.684, p < 0.01) and brain folate (r = -0.321, p < 0.05). Hepatic S-adenosylmethionine (SAM) level was lower in rats fed FD, FDH and FDHCD than in rats fed FS and FSH (p < 0.001, p < 0.001 respectively) and hepatic S-adenosylhomocysteine (SAH) level was significantly higher in those groups. The SAH level in brain was also significantly increased in rats fed FDHCD (p < 0.05). However, brain SAM level was not affected by folate and/or vitamin $B_{12}$ deficiency. This result suggests that dietary folate- and vitamin B12-deficiency may inhibit methylation in brain by increasing SAH rather than decreasing SAM level, which may be closely associated with impaired cognitive function in nutritional homocysteinemia.

Association between gestational age at delivery and lymphocyte-monocyte ratio in the routine second trimester complete blood cell count

  • Cha, Hyun-Hwa;Kim, Jong Mi;Kim, Hyun Mi;Kim, Mi Ju;Chong, Gun Oh;Seong, Won Joon
    • Journal of Yeungnam Medical Science
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    • v.38 no.1
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    • pp.34-38
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    • 2021
  • Background: We aimed to determine whether routine second trimester complete blood cell (CBC) count parameters, including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR), could predict obstetric outcomes. Methods: We included singleton pregnancies for which the 50-g oral glucose tolerance test and CBC were routinely performed between 24 and 28 weeks of gestation in our outpatient clinic from January 2015 to December 2017. The subjects were divided into three groups according to their pregnancy outcomes as follows: group 1, spontaneous preterm births, including preterm labor and preterm premature rupture of membranes; group 2, indicated preterm birth due to maternal, fetal, or placental causes (hypertensive disorder, fetal growth restriction, or placental abruption); and group 3, term deliveries, regardless of the indication of delivery. We compared the CBC parameters using a bivariate correlation test. Results: The study included 356 pregnancies. Twenty-eight subjects were in group 1, 20 in group 2, and 308 in group 3. There were no significant differences between the three groups in neutrophil, monocyte, lymphocyte, and platelet counts. Although there was no significant difference in NLR, LMR, and PLR between the three groups, LMR showed a negative correlation with gestational age at delivery (r =-0.126, p =0.016). Conclusion: We found that a higher LMR in the second trimester was associated with decreased gestational age at delivery. CBC parameters in the second trimester of pregnancy could be used to predict adverse obstetric outcomes.

A Study of the Actual Conditions of the Dental Health of High School Girls Visiting Scaling Practice Rooms (스켈링 실습실에 내원한 여고생의 구강건강 실태 조사)

  • Jang, Gye-Weon;Cho, Pyeang-Kyu;Seo, Eun-Ju;Lee, Mi-Oak
    • Journal of Korean society of Dental Hygiene
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    • v.3 no.1
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    • pp.13-24
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    • 2003
  • The researcher worked with a total of 158 high school girls visiting the scaling practice room at the department of dental hygiene in Jinju Health college from November 11, 2002 to December 4, 2002, having their teeth scaled, observing their teeth and interviewing them with the aid of questionnaires. The findings can be summarized as follows. 1. The survey on the understanding of dental health and the attitudes of the subjects shows the following results : "I have never learned how to brush teeth" (65.8%: 104 girls); "I brush my teeth twice a day" (57.0%: 90 girls) : "I brush my teeth for 2 minutes"(44.3%: 70 girls): "I brush my teeth vertically and horizontally" (53.2%: 84 girls): "( brush my teeth, gum and tongue" (462%: 73 girls): "I use one brush for two months" (40.5%: 64 girls); "I don't have any floss" (582%: 92 girls): "I have never had my teeth scaled" (84.2%: 133girls) : "Smoking is bad for the teeth" (77.8%: 123 girls): "Drinking is bad for the teeth" (48.7%: 77 girls): "I have ever visited dental clinics" (92.4%: 146 girls). 2. The study on part of the teeth most exposed to caries shows the following results : Mandibular right first molar(79.8%: 126 girls): Mandibular left first molar(77.5%: 124 girls), Mandibular left second molar(70.2%: 111 girls). Mandibular right second molar(65.7%: 104 girls). Maxillary left first molar(59.5%: 94 girls): Maxillary left second molar(59.5%: 94 girls): Maxillary right first molar(58.2%: 92 girls). Maxillary right second molar(50.7%: 80 girls) 3. The statistics on the subjects' caries show the following results: DMF rate: 943%: DMFT rate: 25.61%: DMFT index: 7.17 teeth : DT rate: 4651%: FT rate: 52.25%: MT rate: 124% 4. The survey on dental caries statistics, dental health, dental health behavior, and the subjects' attitudes shows the following results: The worse the subjects' dental health was(r=-327, p<.001), the more they visited dental clinics(r=.195, p<.05), the higher DMT rate, DMFT index were; The more the subjects visited dental clinics(r =.359, p<.001), the higher DT rate was; The worse the subjects teeth went(r=-.197, p<.05), the higher MT rate was. It is necessary that systematic and substantial dental health education for high school students should be carried out in regard to plaque control, fluoride application, diet control, pit & fissure sealant as a part of developing national health policies designed for the dental health of the teenagers.

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Antioxidant and Cellular Protective Effects of Parthenocissus tricuspidata Stem Extracts Fermented by Lactobacillus pentosus (Lactobacillus pentosus 발효에 의한 담쟁이덩굴 줄기 추출물의 항산화 및 세포보호 효과)

  • Park, So Hyun;Seong, Joon Seob;Lee, Keon Soo;Park, Young Min;Xuan, Song Hua;Cha, Mi Yeon;Kang, Hee Cheol;Park, Soo Nam
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.43 no.3
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    • pp.255-263
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    • 2017
  • In this study, the antioxidant activities, cellular protective effects, and inhibitory effects on elastase of non-fermented and fermented extracts of Parthenocissus tricuspidata (P. tricuspidata) stem using Lactobacillus pentosus were investigated. The free radical scavenging activities ($FSC_{50}$) of non-fermented and fermented extracts were 42.3 and $34.5{\mu}g/mL$, respectively, in which the activity after fermentation was approximately 18.4% higher. Reactive oxygen species (ROS) scavenging activities ($OSC_{50}$) in $Fe^{3+}-EDTA/H_2O_2$ system of non-fermented and fermented extracts were 2.6 and $2.5{\mu}g/mL$, respectively. The activity after fermentation was approximately 4.2% higher. In the $^1O_2$-induced cellular damage of erythrocytes, the cellular protective effects (${\tau}_{50}$) of non-fermented and fermented extracts were 126.4 and 173.0 min at $50{\mu}g/mL$, respectively. The activity after fermentation was approximately 34.0% higher. The effect of fermented extract was 3.9 times higher than $(+)-{\alpha}$-tocopherol (${\tau}_{50}=43.4min$), known as a lipophilic antioxidant at $50{\mu}g/mL$. The inhibitory effect of elastase was investigated to predict the anti-wrinkle efficacy using Hs68 human fibroblasts cells. The elastase inhibitory activities ($IC_{50}$) of non-fermented and fermented extracts were 873.6 and $687.8{\mu}g/mL$, respectively, and the activity after fermentation was approximately 21.3% higher. These results indicated that fermented extract of P. tricuspidata stem has potentials as natural cosmetic ingredients with antioxidant and anti-wrinkle effect.

An analysis of the associated factors which influence DMFT index of the primary school children's in Pocheon city (포천시 초등학생의 주관적 구강건강인식 및 구강보건 행태와 우식경험영구치지수와의 관련성)

  • Kim, Young-Nam;Song, Yun-Sin;Choi, Eun-Jung;Kim, Young-Soo;Choi, Eun-Mi
    • Journal of Korean society of Dental Hygiene
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    • v.11 no.1
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    • pp.113-126
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    • 2011
  • Objectives : We supposed that identifying the influencing factors on DMFT index in the primary school children in Pocheon be indispensible for the primary school children's oral health program establishment in Pocheon. So, to prepare the basic materials for the primary school children's oral health program establishment in Pocheon, we analyzed the associated factors which could have an influence on the primary school children's DMFT index in Pocheon. Methods : We selected 3,676 primary school children in Pocheon, whose age were from 6 to 11, and surveyed those children by a questionnaire and the oral examination based on WHO's oral health survey method. Data were analyzed with a $x^2$-test and multiple regression analysis using SPSS $15.0^{(R)}$. Results : The results of oral survey in the primary school children in Pocheon revealed as follows: DMFT index, National Health Oral health survey of 2006 people nationwide in the results when compared to younger grade children and older grade in the low and the higher. Subjective oral health awareness, high of viscosity junk food snacks, fruit, gender, dental visits and humidity, oral health education classes, including the variable of attitude was 6(p<0.05). Their higher awareness of dental health, oral health education classes ever the more positive attitude to DMFT index was statistically significant(p<0.05). Solid in the habit of eating junk food snacks to the students of a liquid relative to student intake was higher DMFT index indices(p<0.05). Conclusions : We could reason that one's oral health recognition and behavior should have a relationship with his(her) DMFT index.

A Study on Nutrient Intakes, Glycemic Index, and Glycemic Load according to Obesity Index in Elementary School Students (남녀 초등학생의 비만도에 따른 영양소 섭취 및 Glycemic Index, Glycemic Load에 관한 연구)

  • Bae, Yun-Jung;Choi, Mi-Kyeong
    • Journal of the East Asian Society of Dietary Life
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    • v.21 no.2
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    • pp.174-184
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    • 2011
  • The purpose of this study was to evaluate nutrients intakes, glycemic index (GI), glycemic load (GL) according to obesity index in elementary school students. The study subjects included 229 elementary school students (boys=108, girls=121) who were divided into 3 groups consisting of an underweight group (obesity index<-10%, n=58), a normal weight group (10%${\leq}$ obesity index<10%, n=130) and an overweight group (obesity index${\geq}$10%, n=41) by their obesity index. The nutrient and food intakes data obtained by a 3-day food record were analyzed. Daily dietary GI and GL values were calculated from the 3-day food record. The average age of the subjects was 11.9 years. The mean daily energy intake was 2,186.8 kcal in the underweight group, 2,123.5 kcal in the normal weight group, and 2,174.2 kcal in the overweight group. The intakes of calcium and animal calcium per 1,000 kcal in the overweight group were significantly lower than in the underweight and normal weight groups (p<0.01, p<0.05), and fruit, egg and milk intakes in the overweight group were lower than those in the underweight group (p<0.05, p<0.05, p<0.05). The mean daily dietary GI of the underweight, normal weight, and overweight groups were 67.7, 68.4 and 69.5, respectively (p<0.05). The mean daily dietary GL of the underweight, normal weight, and overweight groups were 212.8, 208.1 and 213.3, respectively. The major food source of dietary GI and GL in the three groups was rice. Other major food sources of dietary GI were croquettes, hand-rolled noddle soups, instant noddles, milk, and rice cake. Dietary GI was not significantly correlated with weight, obesity or body mass index, when adjusted for energy, carbohydrate, and dietary fiber. However, GL adjusted to energy, carbohydrate and dietary fiber tended to correlate with obesity index (r=0.126, p=0.059). These results suggest that dietary GI and GL have possibility affecting obesity-related indicators in elementary school students.

Relationship between Interdental Papilla Existence & Distance from Interdental Alveolar Crest to Contact Point in the Posterior Dentition of Korean adults (한국인 구치열에서 치간유두 존재와 치아접촉점과 치간골 거리와의 관계)

  • Kim, Hyun-Chul;Jeon, Yong-Seon;Chang, Moon-Taek;Kim, Hyung-Seop;Park, Jung-Mi
    • Journal of Periodontal and Implant Science
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    • v.31 no.3
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    • pp.625-631
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    • 2001
  • The anatomic structure around interproximal area plays an important role not only in the natural teeth, but also in the implant. The loss of papilla can lead to cosmetic deformity, phonetic problem, food impaction on the anterior dentition, and masticatory problem, food impaction and proximal caries on the posterior dentition. The purpose of this study was to evaluate the relationship between interdental papilla existence and distance from contact point to alveolar crest in Korean posteior dentition. 45 Korean adult patients(31males, 14 females) participated in this study. Measurements were carreid out total 126 interproximal areas, 18 first premolar, 31 second premolar, 40 first molar, and 37 second molar areas. Papilla index was recorded as suggested by Jemt. Distance between contact point and alveolar crest measrued by Florida $probe^{R}$, after flap elevation. Each distance was measured 10 times by every 0.1mm unit. The results showed that the mean Papilla index 1.37 and mean distance between contact point and alveolar crest was 7.44mm. The correlation between the Papilla index and distance was high negative correlation(Pearson correlation=-0.47), and it was statistically significant(P=0.000) When the distance between contact point and alveolar crest was 5mm, the loss of papilla was appeared almost in half cases. When the distance was 6mm, the papilla loss was present 95%, when 7mm, the papilla loss was 100%.

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