• Archives of Pharmacal Research
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• 제20권6호
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• pp.525-528
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• 1997

Steroid $9{\alpha}$.-hydroxylase is a key enzyme system in steroid nucleus degradation in company with ${\Delta}$-dehydrogenase. To examine $9{\alpha}$-hydroxylase activity during microbial transformation of steroids, 9(11)-dehydro-$17{\alpha}$-methyl-testosterone was adopted as a stable substrate for preventing the rupture of steroid nucleus. Using Nocardia restrictus ATCC 14887 capable of introducing a $9{\alpha}$-hydroxyl group into steroids, $9{\alpha}$,$11{\alpha}$-oxido-$17{\beta}$-hydroxy-$17{\alpha}$-methyl-4-androstene-3-one and $9{\alpha}$-hydroxyl group into steroids,$9{\alpha}$,$11{\alpha}$-oxido-$17{\beta}$-hydroxy-$17{\alpha}$-methyl-1,4-androstadiene-3- one were obtained. These microbiologically transformed products could be used as reference compounds in the enzyme assay.

• Bulletin of the Korean Chemical Society
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• 제12권2호
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• pp.127-130
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• 1991

Fosfazinomycin A(1), methyl valylarginylmethylhydrazinohydroxyphosphonohydro xyacetate, has been synthesized. N-Carbobenzyloxyvalylnitroarginine(6) was reacted with methyl methylhydrazinobenzyloxyphosphonobenzyloxyacet ate(10) which has carbon-phosphorus bond, to give a coupled product of methyl N-Carbobenzyloxyvalylnitroarginylmethylhydrazinob enzyloxyphosphonobenzyloxyacetate(11). The deprotection of (11) by hydrogenation yielded Fosfazinomycin A(1).

• 식품보건융합연구
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• 제9권4호
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• pp.11-18
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• 2023

Oil was extracted from cashew nuts. The physicochemical parameters of the oil were determined. A chromatographic assay of the oil was carried out using Gas Chromatography-Mass Spectrometry. Seventeen compounds were detected: Phenol, Phenol 2-methyl-, Cyclohexene 4, 4-dimethyl-, m-Fluoro-2-diazoacetophenone 4-dimethyl-, Tetradecanoic acid, Phenol 4-octyl-, n-Hexadecanoic acid. Others are 9, 12-Octadecadienoic acid (Z, Z) - methyl ester, Hexadecanoic acid methyl ester, Methyl stearate, Dodecanoic acid methyl ester, 9, 12, 15-Octadecatrienoic acid methyl ester, 9, 12, 15-Octadecatrienoic acid (Z, Z, Z)-, Oleic acid, Octadecanoic acid, Tetracosanoic acid and 9-Octadecenoic acid methyl ester. Among the components are omega three and omega six essential free fatty acids. The rheological profiling and flow properties of cashew nut oil were determined using a Programmable Rheometer. Cashew nut oil exhibits slight dilatant behaviour at the low end of shear rate. The long chain and high molecular weight of its constituents controlled its rheology. Long-chained 9-Octadecenoic acid methyl ester, 9, 12-Octadecadienoic acid (Z, Z) - methyl ester, Tetracosanoic acid and methyl stearate, coupled with their high molecular weights are responsible for the shear thickening effect observed. Two models, Carreau-Yasuda and Ostwald-de Waele Power Law were employed to fit the rheological data. The Carreau-Yasuda model followed well the data.

• 대한화학회지
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• 제20권1호
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• pp.73-86
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• 1976

다음과 같은 새로운 4종의 N-(arylsulfonyl)benzamide 유도체와 6종의 N-(arylsulfonyl)benzimidothiophenyl ester 유도체를 합성하였다. m-methyl-N-(arylsulfonyl)benzamide, p-methyl-N-(arylsulfonyl)benzamide, m-nitro-N-(arylsulfonyl)benzamide, p-methoxy-N-(arylsulfonyl)benzamide, p-methyl-N-(arylsulfonyl)benzimidothiophenyl esters, m-methyl-N-(arylsulfonyl)benzimidothiophenyl ester, p-methoxy-N-(arylsulfonyl)benzimidothiophenyl ester, p-nitro-N-(arylsulfonyl)benzimidothiophenyl ester, m-nitro-N-(arylsulfonyl)benzimidothiophenyl ester, p-chloro-N-(arylsulfonyl)benzimidothiophenyl ester. 넓은 pH 범위에서 N-(arylsulfonyl)benzimidothiophenyl esters 유도체의 가수분해속도 상수를 자외선 분광광도법으로 측정하여 넓은 pH 범위에 적용되는 반응속도식을 구하였다. 이 속도식과 치환기효과등으로부터 N-arylsulfonylbenzimidothiophenyl esters 유도체에 대한 가수분해 반응메카니즘을 제안하였다. 즉 pH 11 이상에서는 hydroxide ion이 pH 9 이하에서는 azomethine 기에 물분자가 첨가되므로서 반응이 시작되며 pH 9∼11 사이에서는 물분자와 hydroxide ion이 경쟁적으로 반응함을 알았다.

• 한국식품영양과학회지
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• 제28권5호
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• pp.1107-1112
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• 1999

We investigated the inhibitory effects of phytol and methyl 11,14,17 eicosatrienoic acid (methyl ETA, n 3, 20 : 3) separated from perilla leaves on the growth of human cancer cells. Phytol inhibited significantly the growth of HT 29 human colon cancer cells, MG 63 osteosarcoma cells and AZ 521 gastric cancer cells. Although the activity of methyl ETA was lower than that of phytol, it was also observed to have the inhibitory effect on three human cancer cell lines. Furthermore, the DNA synthesis of the MG 63 osteosarcoma cells was markedly decreased by the addition of the phytol and methyl ETA. These results suggest that phytol and methyl ETA identified from the perilla leaves may play a role on the growth inhibition of the human cancer cells.

• 대한화장품학회지
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• 제11권1호
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• pp.13-20
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• 1985

Polyoxyethylene계 유화제를 이용한 유화계에 있어서 talc 및 $TiO_2$에 의한 methyl p-hydroxy benzoate의 흡착과 그에 따른 방부력 감소를 여러 가지 분석방법과 미생물 실험을 통하여 측정하였다. 이 유화계에 있어서 methyl p-hydroxy benzoate는 talc 및 $TiO_2$에 흡착되어 방부력이 감소함을 알 수 있으며 방부력 저하에 미치는 영향은 $TiO_2$보다 talc가 더 크고, talc에 의한 methyl p-hydroxy benzoate의 흡착량은 $20^{\circ}C$에서 다음과 같은 식으로 나타낼 수 있었다. 즉 $a=11.511C^{0.747}$

• 한국응용과학기술학회지
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• 제5권2호
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• pp.9-15
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• 1988

In order to investigate the amino acid and fatty acid content in Thuja biotae water extract treated with alkaline, it was performed. There are 16 kinds of different amino acid and 20 kinds of different fatty acid in Thuja biotae water extract. An aspartic acid was contained 52％ and proline was contained 10％, particulary, r-aminobutyric acid was analysed. Essential fatty acids; linoleic acid, linolenic acid and arachidonic acid were cotained a lot amount. There are 11 different unknown materials which were identified by GC-MS spectrum, such as N-[($4{\alpha},5{\alpha}$)-cholestan-4-yl]-acetamide; 22,26-Epithio-furost-5-en-3-ol; 2-Methyl-6-(4-methyl-3-cyclohexen-1-yl)-4-heptanone; 3,12,14-Tris(acetyloxy)-pregnane-15,20-dione;22-Methyl-26-thio-furost-5-en-3-ol; 7-Ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrene carboxyaldehyde; Methoxyiminopro-panedioic acid; 13-Methyl-13-${\beta}$-Methyl-13-vinyl-dodecaarp-7-en-3-3-ol; 22-Methyl-26-thio-furost-6-methyl-3-ol; $5{\alpha}-Androstane-2$,11-dione; 9-Methyl-heptadecanoic acid.

• 대한화학회지
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• 제25권4호
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• pp.283-290
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• 1981

N,N-디메틸포름아미드용매내 반응온도 50∼$90^{\circ}C$범위에서 과량의 슈크로오스와 라우르산, 미리스트산, 팔미트산, 스테아르산 그리고 올레산등 5종의 지방산 메틸에스테르와의 에스테르 교환반응에서 반응속도를 측정하여 반응속도정수, 활성화파라미터등을 구하여 고찰하였다. 이 반응은 본 실험범위내에서 유사 1차반응으로 진행하고 반응의 순서는 주로 메틸에스테르의 지방산기의 구조변화에 의존하면 라우르산메틸, 미리스트산메틸, 팔미트산메틸 올레산메틸 그리고 스테아르산 메틸의 순으로 반응되기 힘들어지는 엔탈피조절반응이라 생각된다. 한편 이들 각각의 활성화에너지는 9.3, 9.9, 10.3, 10.9 그리고 11.1 kcal/mole이 얻어졌다.

• Archives of Pharmacal Research
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• 제21권3호
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• pp.357-360
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• 1998

Two new 4-hydroxybenzyl alcohol derivatives (1 and 2) were isolated from the methanol extract obtained from fresh tubers of Gastrodia elata together with 4-hydroxybenzyl methyl ether, 4-hydroxybenzyl alcoho, bis(4-hydroxyphenyl)methane, 4-hydroxybenzaldehyde, $\beta$-sitosterol and plamitic acid. 1 and 2 were identified as 3-O-($4^1$-hydroxybenzyl)-$\beta$-sitosterol and 4-[$4^1$-($4^{11}$-hydroxybenzyloxy)benzyloxy]benzyl methyl ether, respectively, according to the spectroscopic data.

• Bulletin of the Korean Chemical Society
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• 제11권4호
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• pp.286-290
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• 1990

The surface enhanced Raman scatterings of Zn(Ⅱ) tetrakis (4-N-methyl pyridyl) porphyrins were studied in silver sol. Zn(Ⅱ) tetrakis (4-N-methyl pyridyl) porphyrin was found to be adsorbed on silver surface via flat-on geometry with some inhomogeneous distribution in the orientation of pyridyl groups. Both the selective enhancement of Raman modes depending on the mode character and the theoretical arguments of SERS are utilized to support the above conclusion. The surface induced substitution reaction of Mn(Ⅲ) tetrakis (4-N-methyl pyridyl) porphyrin chloride to Ag(Ⅱ) tetrakis (4-N-methyl pyridyl) porphyrin was detected via surface enhanced Raman spectrum.