• Journal of Pharmaceutical Investigation
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• v.20 no.2
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• pp.97-103
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• 1990

The metastable modification of acetaminophen was prepared in industry scale. It was found that the dissolution rate of the metastable modification was greater than that of the original powder. The metastable modification was transformed to the stable modification by grinding, but it was not transformed by compression. Starch and lactose inhibited this transformation of the metastable modification to the stable modification by grinding.

• Journal of Pharmaceutical Investigation
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• v.28 no.2
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• pp.115-119
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• 1998

Five polymorphic modifications of Cephradin were prepared by recrystallization from organic solvents. The isolated crystal forms were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray crystallography powder diffractometry. Modificaition 1 was the most stable form and decomposed at $201.3^{\circ}C$. Modification 3 and 4 were metastable. The dissolution of modification 3 and 4 was faster than that of marketed form.

• Journal of Welding and Joining
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• v.15 no.5
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• pp.25-35
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• 1997

현재, 표면개질에 주로 많이 사용되는 레이저는 세 종류로서, C $O_{2}$$laser(파장길이:10.6.\mum),$ Nd:YAG(neodymium-doped yettrium aluminum garnet) $laser(파장길이:1.06.\mum)$ 및 excimer laser(157~350nm) 등이다. 이 외에도 초기에는 ruby레이저빔이 사용되기도 하였으나, 현재는 많이 사용되고 있지 않다. 레이저 빔에 의한 표면개질에는 몇가지 장점이 있는데, 이러한 장점은 주로 급속가열과 급속냉각 효과에 기인하는 것이다. 즉, 1) 급냉효과에 의한 미세한 결정입자 형성, 2) 불안정상 (metastable phase) 또는 비정질 상 생성, 3) 열역학적 용해도 보다 높은 용해도. 4) 편석이 없는 균질한 미세조직, 5) 극히 낮은 기공도, 6) 좁은 열영향 부위, 7) 표면층과 모재 사이의 높은 결합력 등이다. 이 외에도 공정상의 장.단점들이 Ref.5, 6에 잘 요약 정리되어 있다. 지금까지 국내에서 레이저 표면개질에 대한 조사가 몇몇 있었으나, 본 조사에서는 보통 많이 다루어지지 않은 부분, 즉 충격경화 및 표면제어에 비중을 두었으며, 비용융 부분(I)과 용융부분(II)을 분리하여 정리하였다.

• Journal of Pharmaceutical Investigation
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• v.27 no.3
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• pp.233-239
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• 1997

Glibenclamide is a second generation sulfonylurea that is orally active as a hypoglycemic drug. It exists as a crystalline powder which is sparingly soluble in water. It was investigated that the potential of glibenclamide to exhibit polymorphism. Three polymorphic modifications (form 1, form 2 and form 3) and three pseudopolymorphic modifications (form 4, form 5 and form 6) were obtained by crystallization from different organic solvents. The isolated crystal forms were characterized by differential scanning calorimetry(DSC), thermogravimetric analysis(TGA) and X-ray crystallography powder diffraction studies. Form 1 was the most stable and melt at $175.4^{\circ}C$. Form 2 was metastable and melt at $151.0^{\circ}C$. Form 3 was a new polymorphic modification because it was different from form 1 and form 2 in X-ray crystallography powder diffraction data. Form 4 was a 1 : 7(toluene : glibenclamide) toluene solvate; form 5 was a 1 : 5(toluene : glibenclamide) toluene solvate; form 6 was a 3 : 8(pentanol : glibenclamide) pentanol solvate. All forms were stable in 3-month storage under 0% or 100% humidity condition. The dissolution rate of form 4 was highest; those of form 2, form 3, form 1, form 5 and form 6 followed.

• Mass Spectrometry Letters
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• v.12 no.4
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• pp.126-130
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• 2021

The mass spectrometry (MS) provides the mass-to-charge ratios of atoms, molecules, stable/metastable complexes, and their fragments. I have taken a long journey with MS to address outstanding issues and problems by experiments and theory and gain insights into underlying principles in chemistry. By looking through the mass-to-charge ratio, I have studied thermochemical problems in silicon chemistry, the infrared multiphoton dissociation spectroscopy of organometallic intermediates, unimolecular dissociations of halotoluene radical cations, and the kinetics of association/dissociation of alkali halide triple ions with Lewis bases. Various MS platforms have been used to characterize non-covalent interactions between porphyrins and fullerenes and those between the group IIB ions and trioctylchalcogenides, and to examine the binding of the group IA, IIA and porphyrin ions to G-quadruplex DNA. Recently, I have focused on mass-balanced H/D isotope dipeptide tags for MS-based quantitative proteomics, a simple chemical modification method for MS-based lipase assay, and the kinetics and dynamics of energy-variable collision-induced dissociation of chemically modified peptides. Now, I see an important role of MS in global issues in the post-COVID era, as the society demands high standards for indoor air quality to contain the airborne-pathogen transmission as well as in-situ monitoring and tracking of carbon emissions to reduce global warming.