• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 춘계학술대회
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• pp.134-137
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• 2016

빅 데이터 분석은 기존 데이터베이스 관리 도구로부터 데이터를 수집, 저장, 관리, 분석할 수 있는 역량을 말한다. 또한, 대량의 정형 또는 비정형 데이터 집합으로부터 가치를 추출하고 결과를 분석하는 기술을 의미한다. 따라서 메타분석은 여러 실증연구의 정량적인 결과를 통합과 분석을 통해 전체 결과를 조망할 수 있는 기회를 제공하는 통계적 통합 방법이다. 또한 분석을 위한 분석이라고도 말한다. 우리나라 학술지에 게재된 대사증후군 위험요인에 콩 식품 중재에 관련된 연구들을 계량적으로 통합하고 검토해보기 위해 진행하였다. 본 연구는 대사증후군 위험요인에 대한 문헌적 고찰을 통해 선행연구를 살펴보고 열거된 요인에 관한 실증 분석된 연구들을 메타분석하기 위해 2000년-2016년 국내 학술지에 게재된 연구논문을 대상으로 하였다. 따라서 분석결과를 바탕으로 연구의 한계와 시사점을 제시하고자 한다.

• 한국컴퓨터정보학회논문지
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• 제29권5호
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• pp.101-110
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• 2024

이 연구의 목적은 웨어러블 디바이스를 활용한 걷기 활동에 대한 모니터링과 피드백이 중년 여성의 체성분 및 대사증후군 지표 변화에 미치는 영향을 분석하고자 실시하였다. 연구 대상자는 6개월간 모바일 연동 웨어러블 디바이스를 사용하였으며, 지원하는 모바일 앱을 통해 자동 전송된 보행 수 및 활동량 정보를 모니터링을 통해 피드백을 제공하였다. 연구 결과 체중, 골격근량, 그리고 체지방률에서 통계적으로 유의한 차이가 나타났다(p<.001). 대사증후군 지표 변화는 수축기 혈압(p<.05), 공복 혈당(p<.01), 복부둘레(p<.001)에서 유의한 차이가 나타났고, TC(p<.001)와 LDL-C(p<.05)에서 유의한 차이가 나타났다. 따라서 쉽고 편리하게 적용 가능한 웨어러블 디바이스는 좌업적인 생활습관을 가진자들의 신체활동량 증가와 대사증후군 예방을 위한 효과적인 도구로 볼 수 있다.

• 한국식품영양학회지
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• 제34권1호
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• pp.88-95
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• 2021

This study compared the lifestyle patterns, dietary patterns, and health care practices of Korean middle-aged people by household type, and ultimately analyzed their relationship with different risk factors for the prevalence and severity of metabolic syndrome. We analyzed the data from 4,755 subjects who were from 40 to 64 years old, and gathered our sample from participants of the Korea National Health and Nutrition Examination Survey from 2013 to 2015. Our results showed that single-person households had lower economic income levels, lower subjective health statuses, and higher levels of food instability than households with two or more individuals. The incidence of metabolic syndrome was 1.64 times higher in single-person households than in households with two or more individuals. After adjusting for potential confounding factors (sex, age, education, household income, smoking status, health status, and dietary factors), single-person households showed 1.75 times higher hypertriglyceridemia ORs than non-single-person households. In the conclusion of our study, we suggest that middle-aged people in single-person households may be at greater risk for metabolic syndrome and hypertriglyceridemia.

• 대한의생명과학회지
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• 제23권3호
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• pp.166-174
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• 2017

The bacterial cells located within the gastrointestinal tract (GIT) outnumber the host's cells by a factor of ten. These human digestive-tract microbes are referred to as the gut microbiota. During the last ten years, our understanding of gut microbiota composition and its relation with intra- and extra-intestinal diseases including risk factors of cardiovascular diseases (CVD) such as atherosclerosis and metabolic syndrome, have greatly increased. A question which frequently arises in the research community is whether one can modulate the gut microbial environment to 'control' risk factors in CVD. In this review, we summarized promising intervention methods, based on our current knowledge of intestinal microbiota in modulating CVD. Furthermore, we explore how gut microbiota can be therapeutically exploited by targeting their metabolic program to control pathologic factors of CVD.

• 농촌의학ㆍ지역보건
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• 제35권1호
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• pp.36-45
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• 2010

대사증후군으로 확진된 65세 이상 농촌지역 노인의 2년 후 대사증후군 위험인자와 건강생활습관행태의 변화를 보고자 2006년 7월 1일부터 8월31일까지 J군 보건소에서 건강검진을 받았던 134명 중에서 대사증후군에 해당된 65명을 선정하여 이 가운데 2년 후 재방문한 62명의 노인을 최종분석 대상으로 하였다. 본 연구 결과 2006년 대사증후군 62명이 2008년에는 53명으로 감소되어 대사증후군 유병률은 전체적으로 14.5%가 감소하였다. 2년 동안 대상자의 대사증후군 변화 양상을 보면 1차 조사 시 비정상 기준치에서 2차 조사 시 정상으로 변화된 대상자는 허리둘레 8.1%, 수축기혈압 6.5%, 공복혈당 4.8%, 총콜레스테롤 3.2%, 이완기혈압 1.5%순이었다. 이에 반해 2년 전 정상 기준치이었으나 2년 후 비정상 기준치를 보인 대상자는 공복혈당6.4%, 허리둘레 4.8%, 총콜레스테롤 1.6% 순이었다. 교육수준($X^2$=12.691, p=.002), 흡연($X^2$=9.074, p=.001), 운동습관($X^2$=8.880, p=.012), 과거병력($X^2$=7.669, p=.010)에 따라 대사증후군의 차이가 있는 것으로 나타났다. 따라서 대사증후군 예방을 위해서는 향후 교육수준이 낮은 그룹의 행동위험인자를 규명할 것을 제안하며, 대상자의 학력수준별 맞춤식 교육 및 상담이 필요할 것으로 판단된다. 또한 흡연군, 비운동군, 과거병력이 있는 군에게 집중적으로 대사증후군 예방을 위한 정기검진을 강화하고, 스스로 관심을 갖도록 교육과 개별상담이 필요할 것으로 여겨진다.

• Journal of Nutrition and Health
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• 제38권4호
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• pp.267-278
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• 2005

Postmenopausal women or ovariectomized rats are associated with increased cholesterol levels, which are risk factors of metabolic syndrome and cardiovascular diseases. Increased prevalence of metabolic syndrome after menopause might be associated with estradiol deficiency. Harmful effect of estradiol hampers the casual usage of hormone to prevent the metabolic syndrome. Soy protein has been reported to show several beneficial effects on health, however it is unclear which components of soy protein is responsible for anti-obesity and hypocholesterolemic effects. Soy isoflavones, gem-stein and daizein, are suggested to have anti-obesity and hypocholesterolemic effects but with inconsistency. The present study investigated the effect of supplementation of genistein (experiment I) and soy protein containing isoflavones (experiment II) to high fat diet on body weight gain, food intake, liver and fat tissue weight and the lipid levels in ovariectomized rats. Plasma and hepatic lipid contents and the mRNA levels of genes encoding lipid metabolism related proteins, such as CPT1 and HMGR were measured. Ovariectomy increased body weight, fat tissue weight and plasma and hepatic lipid levels which increase the risk of metabolic syndrome. Soy protein could improve plasma and hepatic lipids levels. Soy protein also increased hepatic CPT1 and HMGR mRNA levels. Plasma and hepatic lipids levels could not be decreased by dietary genistein alone. In contrast, lipids levels could be decreased by isoflavone-fortified soy protein, suggesting that the ingestion of soy protein enriched with isoflavone gives more benefit for protecting postmenopausal women from metabolic syndrome.

• 비만대사연구학술지
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• 제2권2호
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• pp.37-44
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• 2023

Weight gain is defined as the increase in body weight, increasing the prevalence of obesity, and results in metabolic diseases. Weight gain was reportedly caused by the interaction between the obesogenic environmental factors and individual metabolic factors. Sociodemographic and environmental factors (demographic factors, lifestyle/behavioral factors, food/nutritional factors, socioeconomic factors), drug-related secondary causes (some of the corticosteroids, antihyperglycemics, antihypertensives, antidepressants, etc.), and metabolic factors (aging and hormonal changes, menopause and decreased sex hormones, decreased adipocyte degradation, decreased fibroblast growth factor 21, central sympathetic nervous system hyperactivity, decreased sympathetic-adrenomedullary system activity) are significant factors related to weight gain. It is crucial to prevent weight gain and maintain an ideal weight, but studies on the risk factors of weight gain are insufficient. Therefore, this study evaluated the factors associated with weight gain to find strategies for preventing unnecessary weight gain.

• Endocrinology and Metabolism
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• 제33권4호
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• pp.447-458
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• 2018

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive-age women. Its metabolic features often overlap with those associated with metabolic syndrome (MS) and insulin resistance syndrome (IRS). The objective of this study was to determine the prevalence and predictors of MS and IRS in infertile Vietnamese women with PCOS. Methods: A cross-sectional study was conducted at a tertiary fertility centre at Hue University Hospital from June 2016 to November 2017. A total of 441 infertile women diagnosed with PCOS based on the revised 2003 Rotterdam consensus criteria were enrolled. MS and IRS were defined based on the National Heart, Lung, and Blood Institute/American Heart Association Adult Treatment Panel III 2005 and American College of Endocrinology IRS 2003 criteria, respectively. Complete clinical and biochemical measurements of 318 women were available for analysis. Independent predictors of MS and IRS were identified using multivariate logistic regression. Results: The overall prevalence of MS and IRS in women with PCOS was 10.4% and 27.0%, respectively. We identified older age (>30 years) and obesity as independent predictors of MS and IRS. Elevated anti-$M{\ddot{u}}llerian$ hormone levels increased the risk of IRS, but not that of MS. Conclusion: MS and IRS are prevalent disorders among infertile Vietnamese women with PCOS. PCOS is not solely a reproductive problem. Screening and early intervention for MS and/or IRS based on anthropometric, metabolic, and reproductive hormone risk factors should be an integral part of fertility care.

• 대한지역사회영양학회지
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• 제13권1호
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• pp.91-99
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• 2008

The present study was conducted to examine metabolic risk factors and total antioxidant capacity (TAC) of Korean females living in Seoul and to investigate the relationship between the metabolic risk factors and serum TAC. A total of 353 females aged between 20 and 64 participated in the study. Obesity indicators, blood pressure, serum lipid profile and fasting blood glucose were measured as metabolic risk factors. Ferric reducing antioxidant power (FRAP) assay was employed to determine serum TAC of subjects. Obesity indicators such as body mass index, waist circumference and waist-hip ratio were significantly higher in the participants aged $\geq$ 50 y (older group) than in the participants aged 20-49 y (younger group) (p < 0.001). Blood pressure, serum total cholesterol (TC), triglyceride (TG) and fasting blood glucose were also significantly higher in the older group than in the younger group (p < 0.001), demonstrating significant positive correlations between age and MS risk factors. The association between FRAP and MS risk factors were also investigated. FRAP values showed significant positive correlations with age (p = 0.001), serum TG (p = 0.002) and TC (p = 0.03). A tendency of positive association between FRAP and waist circumference was observed without any significant difference (p = 0.06). Increased serum FRAP with central obesity and serum lipids may be interpreted as results of activation of antioxidant defense system against oxidative stress induced by metabolic syndrome (MS) constituent factors. However, to verify the function of FRAP as a potential biomarker of susceptibility to MS various contributors to the plasma antioxidant capacity and their biological relevance related to MS should be elucidated further.

• 동아시아식생활학회지
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• 제23권3호
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• pp.282-296
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• 2013

The study classified 83 obese adults by constitution and had them follow a strict diet according to their constitution in order to see if the Yin-Yang method would be effective on the metabolic syndrome, which is one of the main causes of death in Korea. Overall, the application of both Yin and Yang methods improved the following factors: weight, body fat percentage, systolic blood pressure, diastolic pressure, neutral fats and total cholesterol. In particular, the Yin constitution group of men showed more improvements than the Yang constitution group. Furthermore, waist circumference and the prevalence rate of systolic blood pressure, diastolic pressure, total cholesterol and metabolic syndrome were decreased noticeably. Total energy intake was increased in both men and women after the constitutional diet, along with the increase of nutrient intake, such as dietary fiber, vitamins and minerals, among others. Among various nutrients, vitamin A, vitamin C, thiamine, vitamin B6, folic acid, calcium, phosphorus, potassium, magnesium and iron intake were increased noticeably after the constitutional diet. In addition, subjects' intake of all nutrients, except for magnesium, satisfied the nutrition intake standards. Further, the nutrients adequacy ratio (NAR) and the mean adequacy ratio (MAR) improved for both men and women. The intake of potatoes, starch, greens and mushrooms increased noticeably, whereas the intake of meat, dairy, drinks and alcohol decreased after the constitutional diet. For the Yin constitution, the intake of Yin foods noticeably decreased, where as the intake of Yang foods decreased for the Yang constitution. In conclusion, the constitutional diet effectively improves the metabolic syndrome. Among many nutrients, the intake of dietary fiber, vitamins A, C and E, potassium and magnesium is positively associated with the improvement of metabolic syndrome biomarkers.