• 제목/요약/키워드: metabolic disease

검색결과 1,412건 처리시간 0.028초

Gender difference in the association of metabolic syndrome with hs-CRP Concentration of Blood

  • Park, Se-Kwon
    • 대한임상검사과학회지
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    • 제44권2호
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    • pp.86-96
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    • 2012

  • The high sensitivity C-reactive protein (hs-CRP) as one of the typical acute phase reactants is used for predictive factor of the cardiovascular disease and diabetes mellitus. In addition, there are claims that must be included as factors of metabolic syndrome. This research examined the relationship between the concentration of hs-CRP in blood and risk factors of the metabolic syndrome by gender, and the rates of metabolic syndrome depending on the hs-CRP level based on the general public who took the comprehensive medical check-up at Chonbuk National University Hospital in the Jeonbuk province. The subjects aged 17-87 years were participated, and 2,000 people were included as the final subjects except the persons with more than 10 mg/L of the hs-CRP of blood level. The hs-CRP concentrations increased according to the number of risk factors of metabolic syndrome in both men and women. In regards to the risk ratio of metabolic syndrome based on hs-CRP level in blood according to gender, the risk ratio increased by 3.07 times in male and 4.55 times in female intermediate risk group and 3.60 times in male and 6.15 times in female high risk group compared to hs-CRP low risk group. As a result, there was a proportional relation between hs-CRP level and the occurrence of metabolic syndrome, and it occurs more frequently among women than men.

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Metabolic Bone Diseases and New Drug Developments

  • Natesan, Vijayakumar;Kim, Sung-Jin
    • Biomolecules & Therapeutics
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    • 제30권4호
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    • pp.309-319
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    • 2022

  • Metabolic bone diseases are serious health issues worldwide, since several million individuals over the age of 50 are at risk of bone damage and should be worried about their bone health. One in every two women and one in every four men will break a bone during their lifetime due to a metabolic bone disease. Early detection, raising bone health awareness, and maintaining a balanced healthy diet may reduce the risk of skeletal fractures caused by metabolic bone diseases. This review compiles information on the most common metabolic bone diseases (osteoporosis, primary hyperparathyroidism, osteomalacia, and fluorosis disease) seen in the global population, including their symptoms, mechanisms, and causes, as well as discussing their prevention and the development of new drugs for treatment. A large amount of research literature suggests that balanced nutrition and balanced periodic supplementation of calcium, phosphate, and vitamin D can improve re-absorption and the regrowth of bones, and inhibit the formation of skeletal fractures, except in the case of hereditary bone diseases. Meanwhile, new and improved drug formulations, such as raloxifene, teriparatide, sclerostin, denosumab, and abaloparatide, have been successfully developed and administered as treatments for metabolic bone diseases, while others (romososumab and odanacatib) are in various stages of clinical trials.

  • https://doi.org/10.4062/biomolther.2022.007 인용 PDF KSCI

Mucolipidosis

  • 황종희;백경훈;진동규
    • 대한유전성대사질환학회지
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    • 제2권1호
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    • pp.23-24
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    • 2002

  • 저자들은 조악한 얼굴과 관절의 구축 등 Hurler 증후군과 유사한 임상 증상을 보이면서 혈장에서 리소좀 효소 활성도의 증가를 보였던 Mucolipidosis 2례를 경험하였기에 보고하는 바이다.

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