• 대한임상검사과학회지
• /
• 제44권3호
• /
• pp.147-154
• /
• 2012

Metabolic syndrome and homocysteine are associated with increased independent risk factors of cardiovascular disease. We investigated the difference between the degree of obesity, metabolic syndrome risk factors, plasma homocysteine and anthropometric obesity factors. Totally 398 participated in a medical check-up program were selected for this study. Subjects were categorized into three groups according to the number of metabolic syndrome components present as defined by the NCEP-ATP III criteria; Absent (0 criteria, n=124), Pre-MetS (1-2 criteria, n=220) and MetS (${\geq}3$ criteria, n=54). Body mass index (BMI) is a measure used to distinguish between normal weight, overweight and obesity. MetS presented higher homocysteine than Absent (p<.05) and obesity higher than normal weight (p<.01). When Absent+Pre-MetS was used to classify obese or not, obesty presented higher homocysteine than non-obese (p<.05). Further homocysteine levels positively correlated with weight, BMI, waist circumference, hip circumference and waist-hip ratio (WHR). Especially WHR is not only MetS (r=0.378, p<.001) but also Absent+Pre-MetS (r=0.305, p=0.029) significantly positively correlated with homocysteine. The results of our study indicate that homocysteine is related closely to obesity. Although obesity has not been diagnosed with metabolic syndrome, obesity related with increased homocysteine.

• 디지털융복합연구
• /
• 제17권10호
• /
• pp.359-372
• /
• 2019

대사증후군은 만성질환의 위험 또는 사망률과 높은 상관성을 갖는다. 그 중 소아 청소년기의 대사증후군은 성인기로 연결되어 심혈관계 질환 등으로 이행률이 높기 때문에 소아 청소년기의 대사증후군에 대한 논의가 필요하다. 이에 본 연구는 청소년을 대상으로 고탄수화물 및 고열량 등의 식생활습관과 대사증후군 관계를 규명하며, 나아가 청소년들이 지각하는 감성요인과 대사증후군간의 관계에 대해 밝히고자 한다. 결과, 대사증후군 판별을 위한 HDL-콜레스테롤에서 영향섭취 유형에 따른 유의한 결과를 얻었으며, 청소년의 대사증후군이 스트레스와 같은 감성요인의 경험에 따라 유의한 차이가 있음을 입증하였다. 이는 청소년 대사증후군을 예방, 관리하기 위한 국가보건정책의 기초를 마련하는데 기여하였다.

• 한국직업건강간호학회지
• /
• 제28권4호
• /
• pp.262-270
• /
• 2019

Purpose: This study aims to provide preliminary data for weight management, and prevention and management of cardiovascular and cerebrovascular diseases. We examined the effect of changes in the weight of workers at a manufacturing company over three years on their metabolic syndrome and metabolic syndrome diagnosis components. Methods: Necessary data were collected from the questionnaire and the results of the Korean National Health Screening of 2015 and 2017, which included 228 workers at a manufacturing company in G region. The collected data were analyzed using the SPSS/WIN 23.0 program. ANCOVA was used to examine the differences in the metabolic syndrome diagnosis components according to weight change. In addition, multiple logistic regression analysis was used to obtain the odds ratios of metabolic syndrome and metabolic syndrome analysis component, based on the weight changes in the normal weight group and the obesity group. Results: Waist measure, systolic blood pressure, and blood pressure were found to have significant effects based on participants' weight change over three years. These factors increased with a larger increase in weight at a statistically significant level. This study analyzed the weight changes of the normal weight group and the obesity group considering the data from the National Health Screening of 2015, and found that the risk of metabolic syndrome increased at a statistically significant level as body weight increased; thus, the obesity group showed a higher risk in this regard. It was also found that waist measure, fasting blood sugar, and high-density low cholesterol increased at a statistically significant level as body weight increased. Conclusion: Health administrators need to recognize the importance of workers' weight management, select an intensive management group based on a time series analysis of weight changes, and develop and implement programs to manage the metabolic syndrome diagnosis components.

• 한국콘텐츠학회논문지
• /
• 제21권8호
• /
• pp.662-674
• /
• 2021

대사증후군은 심혈관질환과 밀접한 연관성을 가지며, 최근 대사증후군의 예측을 통한 예방에 관심이 증가하고 있다. 본 연구의 목적은 최근 한국인을 대상으로 한 대사증후군의 발병을 예측하는 논문을 수집, 분석, 종합하여 체계적 문헌고찰을 위한 것이다. 체계적 문헌고찰을 위해 자료검색은 Pubmed, WOS의 해외DB와 DBPia, KISS의 국내DB에서 검색하였으며, 'Metabolic Syndrome', 'predict', 'Korea' 세개의 키워드를 AND 조건으로 2011~2020년에 게재된 논문을 대상으로 검색하였다. 총 560편의 논문이 검색되었고 자료선정기준에 따라 최종 22편의 논문이 선별되었다. 대사증후군 예측에 가장 활용도가 높은 변수는 WHtR(AUC=0.897)이고, 가장 많이 사용된 분석방법은 로지스틱 회귀분석(63.6%), 가장 높은 정확도를 보이는 분석방법은 XGBOOST(AUC=0.879)였다. 또한 한의학적 체질 분류를 적용하는 경우 예측 정확도가 약간 향상되었다. 본 연구 결과를 토대로 한국인의 최적의 대사증후군 예측과 관리를 위한 대규모의 지속적 연구가 수반되어야 할 것으로 생각된다.

• The Korean Journal of Physiology and Pharmacology
• /
• 제27권1호
• /
• pp.49-59
• /
• 2023

Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic syndrome (pre-MetS) possesses two MetS components but does not meet the MetS diagnostic criteria. Although cardiac autonomic derangements are evident in MetS, there is little information on their status in pre-MetS subjects. In this study, we sought to examine cardiac autonomic functions in pre-MetS and to determine which MetS component is more responsible for impaired cardiac autonomic functions. A total of 182 subjects were recruited and divided into healthy controls (n=89) and pre-MetS subjects (n=93) based on inclusion and exclusion criteria. We performed biochemical profiles on fasting blood samples to detect pre-MetS. Using standardized protocols, we evaluated anthropometric data, body composition, baroreflex sensitivity (BRS), heart rate variability (HRV), and autonomic function tests (AFTs). We further examined these parameters in pre-MetS subjects for each MetS component. Compared to healthy controls, we observed a significant cardiac autonomic dysfunction (CAD) through reduced BRS, lower overall HRV, and altered AFT parameters in pre-MetS subjects, accompanied by markedly varied anthropometric, clinical and biochemical parameters. Furthermore, all examined BRS, HRV, and AFT parameters exhibited an abnormal trend and significant correlation toward hyperglycemia. This study demonstrates CAD in pre-MetS subjects with reduced BRS, lower overall HRV, and altered AFT parameters. Hyperglycemia was considered an independent determinant of alterations in all the examined BRS, HRV, and AFT parameters. Thus, hyperglycemia may contribute to CAD in pre-MetS subjects before progressing to MetS.

• 한국직업건강간호학회지
• /
• 제17권2호
• /
• pp.230-238
• /
• 2008

Purpose: This study was to investigate the lifestyle characteristics and risk of cardiovascular disease (CVD) among workers with metabolic syndrome(MS). Methods: The descriptive cross-sectional survey design was used. A total of 187 workers with MS were recruited from a university hospital. The anthropometric measures were used and blood data were reviewed from the health record. Data were analyzed using descriptive statistics and multiple logistic regressions with SPSS/WIN 12.0. Results: While 52.2% of women did not do exercise regularly, 30.5% of men did not at all. The prevalence of MS according to each component was as follows: hypertension was 92.0%, obesity was 89.8%, hyperlipidemia was 63.1%, and hyperglycemia was 61.0%. The high prevalence of each component of MS in workers with MS indicated a significantly higher risk of CVD. The odds ratio of risk of CVD was 16.04 (p=.017) in workers with hypertension, when compared to workers without hypertension. Similarly, the odds ratio of risk of CVD was 11.04 (p=.000) in workers with hyperglycemia, compared to workers without hyperglycemia. Conclusion: Increased risk of CVD was significantly associated with lifestyle characteristics and MS risk factors among Korean workers with MS.

• 성인간호학회지
• /
• 제26권2호
• /
• pp.244-252
• /
• 2014

Purpose: This study was aimed to examine the prevalence of metabolic syndrome (MetS) and cardiovascular risk factors among workers at small-sized companies having fewer than 50employees in Korea. Methods: A descriptive cross-sectional study was conducted using a secondary data analysis on workers' health examination data. Data from 21,784 employed workers were analyzed, including 16,488 males (mean age 38.7years)and 5,296 females (mean age 40.5 years). Participants were newly enrolled in annual health check-ups at a professional health clinic from 2009 to 2011. Logistic regression analysis was performed to identify age-adjusted gender specific predicting factors of MetS incidence. Results: The prevalence of MetS was 13.4% in male and 7.7% in female workers. Logistic regression analysis showed that, when age was adjusted for, family history of cardiovascular disease (CVD) was a predicting factor in both male and female workers. For male workers, heavy alcohol drinking and non-manual occupation (office workers/drivers) predicted MetS. Conclusion: Health care providers should screen for MetS periodically in small work places especially for those with a family history of CVD. Educational counseling needs to be given to male workers with sedentary occupations with an aim to reduce heavy drinking and encourage lifestyle modification.

• Clinical and Experimental Reproductive Medicine
• /
• 제42권3호
• /
• pp.86-93
• /
• 2015

Polycystic ovary syndrome (PCOS) is one of the most common hormonal endocrine disorders in women of reproductive age. It consists of a heterogeneous collection of signs and symptoms that together form a disorder spectrum. The diagnosis of PCOS is principally based on clinical and physical findings. The extent of metabolic abnormalities in women with PCOS varies with phenotype, body weight, age, and ethnicity. For general population, the prevalence of hyperandrogenism and oligomenorrhea decreases with age, while complications such as insulin resistance and other metabolic disturbances increase with age. Obese women with PCOS have a higher risk of developing oligomenorrhea, amenorrhea, hyperandrogenemia, insulin resistance, and lower luteinizing hormone (LH) to follicle stimulation hormone (FSH) ratios than non-obese women with PCOS. The LH to FSH ratio is a valuable diagnostic tool in evaluating Taiwanese women with PCOS, especially in the diagnosis of oligomenorrhea. Overweight/obesity is the major determinant of cardiovascular and metabolic disturbances in women of reproductive age.

• Journal of Preventive Medicine and Public Health
• /
• 제45권3호
• /
• pp.181-187
• /
• 2012

Objectives: Serum uric acid levels have been reported to be associated with a variety of cardiovascular conditions. However, the direct association between uric acid levels and metabolic syndrome remains controversial. Thus, we evaluated the association of serum uric acid levels and metabolic syndrome in a community-based cohort study in Korea. Methods: We performed cross-sectional analysis of baseline data of 889 males and 1491 females (aged 38 to 87) who participated in baseline examinations of the Korean Genome and Epidemiology Study: Kanghwa study. Blood samples were collected after at least an 8 hour fast. Uric acid quartiles were defined as follows: <4.8, 4.8-<5.6, 5.6-<6.5, ${\geq}6.5$ mg/dL in males; and <3.8, 3.8- <4.3, 4.3 - <5.1, ${\geq}5.1$ mg/dL in females. Metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III Criteria with adjusted waist circumference cutoffs (90 cm for males; 80 cm for females). The association between serum uric acid quartiles and metabolic syndrome was assessed using multivariate logistic regression. Results: The odds ratio for having metabolic syndrome in the highest versus lowest quartiles of serum uric acid levels was 2.67 (95% confidence interval [CI], 1.60 to 4.46) in males and 2.14 (95% CI, 1.50 to 3.05) in females after adjusting for age, smoking, alcohol intake, body mass index, total cholesterol, HbA1c, albumin, ${\gamma}$-glutamyltransferase, blood urea nitrogen, and log C-reactive protein. The number of metabolic abnormalities also increased gradually with increasing serum uric acid levels (adjusted p for trend < 0.001 in both sexes). Conclusions: Higher serum uric acid levels are positively associated with the presence of metabolic syndrome in Korean males and females.

• Journal of the Korean Data and Information Science Society
• /
• 제24권4호
• /
• pp.867-876
• /
• 2013

대사증후군은 심혈관질환의 발생을 증가시키는 주요 요인으로 알려져 왔다. 특히 만성적인 대사장애로 여러 질병이 한 개인에게서 복합되어 나타나는 대사증후군의 경우 우리나라에서도 유병률이 점차 증가하는 추세이다. 이에 본 연구는 다중인자 차원 축소 방법을 이용하여 대사증후군의 위험도를 확인하고 여러 대사증후군 진단 조합 중에서 가장 위험한 조합을 제시하는 데 목적을 둔다. 자료는 질병관리본부에서 실시한 제 5기 국민건강영양조사 1차년도 (2010년)자료를 이용하여 성인 중에서 분석방법에 적용이 가능한 3,990명을 대상자로 결정하였다. 다중인자 차원 축소 방법을 적용시킨 결과 대사증후군에 가장 위험한 단일 요인은 복부비만이었고, 복부비만을 포함한 대사증후군 진단 조합은 복부비만과 고지혈증, 고혈압이 가장 위험한 것으로 나타났다. 이것은 대사증후군의 새로운 진단 결과이다. 특히, 남성의 경우는 복부비만, 저 HDL-콜레스테롤혈증, 고혈압이 가장 위험한 조합으로 확인되었고 체질량 지수가 $25kg/m^2$이상인 사람에게서는 복부비만, 고지혈증, 고혈당의 조합이 가장 위험한 대사증후군 조합이었다.