• Nuclear Engineering and Technology
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• 제54권3호
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• pp.940-947
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• 2022

Meta-heuristic algorithms have found their place in optimization problems. Henry gas solubility optimization (HGSO) is one of the newest population-based algorithms. This algorithm is inspired by Henry's law of physics. To evaluate the performance of a new algorithm, it must be used in various problems. On the other hand, the optimization of the proportional-integral-derivative (PID) gains for load-following of a nuclear power plant (NPP) is a good challenge to assess the performance of HGSO. Accordingly, the power control of a pressurized water reactor (PWR) is targeted, based on the point kinetics model with six groups of delayed-neutron precursors. In any optimization problem based on meta-heuristic algorithms, an efficient objective function is required. Therefore, the integral of the time-weighted square error (ITSE) performance index is utilized as the objective (cost) function of HGSO, which is constrained by a stability criterion in steady-state operations. A Lyapunov approach guarantees this stability. The results show that this method provides superior results compared to an empirically tuned PID controller with the least error. It also achieves good accuracy compared to an established GA-tuned PID controller.

• 동력기계공학회지
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• 제7권2호
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• pp.44-50
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• 2003

The power steering hose is a kind of high-pressure hose with reinforced braids in rubber material. It is usually manufactured through the swaging process. In this paper, the deformation characteristics of a power steering hose during the swaging process were analyzed using the nonlinear finite element method. The material properties were obtained on experiments, and the contact conditions were used in consideration of real manufacturing process. Investigations were focused on the stress and strain values of the hose and meta] components at the maximum jaw stroke and at the completion of the process. Especially, the results of inner rubber component were interpreted in detail, because of its important role in the hose efficiency.

• 한국정보통신학회논문지
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• 제20권6호
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• pp.1074-1080
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• 2016

빅데이터 분석은 기존 데이터베이스 관리 도구로부터 데이터를 수집, 저장, 관리, 분석할 수 있는 역량을 말한다. 따라서 메타분석은 여러 실증연구의 정량적인 결과를 통합과 분석을 통해 전체 결과를 조망할 수 있는 기회를 제공하는 통계적 통합 방법이다. 일반적으로 대사증후군 위험요인을 허리둘레, 수축기혈압, 이완기혈압, 공복혈당, 중성지방 그리고 고밀도지단백콜레스테롤 요인으로 정의한다. 메타분석 결과 공복혈당 사전 사후 경로에서 가장 큰 효과크기(r = -.324)인 것으로 나타났다. 따라서 콩 식품의 중재효과는 10%의 설명력을 확인할 수 있었다. 두 번째 큰 효과크기는 허리둘레 사전 사후 경로(r = .256)인 것으로 나타났다. 그런데 콩 식품의 습취는 허리둘레 (복부비만) 개선효과가 없는 것을 확인할 수 있었다. 이러한 결과를 바탕으로 학문적 실무적 의의를 논의하였다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제10권5호
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• pp.425-431
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• 2005

The systems-level analysis of microbes with myriad of heterologous data generated by omics technologies has been applied to improve our understanding of cellular function and physiology and consequently to enhance production of various bioproducts. At the heart of this revolution resides in silico genome-scale metabolic model, In order to fully exploit the power of genome-scale model, a systematic approach employing user-friendly software is required. Metabolic flux analysis of genome-scale metabolic network is becoming widely employed to quantify the flux distribution and validate model-driven hypotheses. Here we describe the development of an upgraded MetaFluxNet which allows (1) construction of metabolic models connected to metabolic databases, (2) calculation of fluxes by metabolic flux analysis, (3) comparative flux analysis with flux-profile visualization, (4) the use of metabolic flux analysis markup language to enable models to be exchanged efficiently, and (5) the exporting of data from constraints-based flux analysis into various formats. MetaFluxNet also allows cellular physiology to be predicted and strategies for strain improvement to be developed from genome-based information on flux distributions. This integrated software environment promises to enhance our understanding on metabolic network at a whole organism level and to establish novel strategies for improving the properties of organisms for various biotechnological applications.

• 한국공간정보시스템학회 논문지
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• 제6권2호
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• pp.39-49
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• 2004

이동통신 환경의 분산 응용에서는 사용자나 단말기의 위치 이동을 파악하여 서비스를 지속할 수 있는 모바일 기술이 요구된다. 이 문제를 해결하기 위해 상황 인식 미들웨어를 이용해 모바일 네트워크 상에서 사용자 혹은 사용자 디바이스의 CPU속도, 메모리 그리고 가용배터리의 변화를 적절히 지원하기 위한 연구가 많이 진행되고 있다. 여기에는 사용자와 디바이스에 대한 프로파일, 상황의 메타데이터가 필수적이다. 본 논문에서는 상황인식의 동적 반영을 지원하는 미들웨어 서비스에 필요한 메타서버를 모델링하고 구축했다. 메타데이터는 프로파일, 정책, 사용자 선호도로 구성되며, 메타 서버는 미들웨어의 요청에 따라 서비스 가능한가를 판별 후, 결과를 돌려준다. 멀티미디어 스트림을 제공하는 이동동신 환경에서 사용자나 통신 단말기의 상황이 변동되는 시나리오에 적용해 보았다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8093-8100
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• 2016

Background: Genetic and environmental factors play important roles in pathogenesis of digestive tract cancers like those in the esophagus, stomach and colorectum. Folate deficiency and methylenetetrahydrofolate reductase (MTHFR) as an important enzyme of folate and methionine metabolism are considered crucial for DNA synthesis and methylation. MTHFR variants may cause genomic hypomethylation, which may lead to the development of cancer, and MTHFR gene polymorphisms (especially C677T and A1298C) are known to influence predispositions for cancer development. Several case control association studies of MTHFR C677T polymorphisms and colorectal cancer (CRC) have been reported in different populations with contrasting results, possibly reflecting inadequate statistical power. Aim: The present meta-analysis was conducted to investigate the association between the C677T polymorphism and the risk of colorectal cancer. Materials and Methods: A literature search of the PubMed, Google Scholar, Springer link and Elsevier databases was carried out for potential relevant articles. Pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) was calculated to assess the association of MTHFR C677T with the susceptibility to CRC. Cochran's Q statistic and the inconsistency index (I2) were used to check study heterogeneity. Egger's test and funnel plots were applied to assess publication bias. All statistical analyses were conducted by with MetaAnalyst and MIX version 1.7. Results: Thirty four case-control studies involving a total of 9,143 cases and 11,357 controls were retrieved according to the inclusion criteria. Overall, no significant association was found between the MTHFR C677T polymorphism and colorectal cancer in Asian populations (for T vs. C: OR=1.03; 95% CI= 0.92-1.5; p= 0.64; for TT vs CC: OR=0.88; 95%CI= 0.74-1.04; p= 0.04; for CT vs. CC: OR = 1.02; 95%CI= 0.93-1.12; p=0.59; for TT+ CT vs. CC: OR=1.07; 95%CI= 0.94-1.22; p=0.87). Conclusions: Evidence from the current meta-analysis indicated that the C677T polymorphism is not associated with CRC risk in Asian populations. Further investigations are needed to offer better insight into any role of this polymorphism in colorectal carcinogenesis.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5655-5661
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• 2015

Purpose: To assess the role of two adjuvant chemotherapy regimens, anthracycline-based and CMF on disease free survival and overall survival breast cancer patients by meta-analysis approach in Eastern Mediterranean and Asian countries to determine which is more effective and evaluate the appropriateness and efficiency of two different proposed statistical models. Materials and Methods: Survival curves were digitized and the survival proportions and times were extracted and modeled to appropriate covariates by two multivariate mixed effects models. Studies which reported disease free survival and overall survival curves for anthracycline-based or CMF as adjuvant chemotherapy that were published in English in the Eastern Mediterranean region and Asia were included in this systematic review. The two transformations of survival probabilities (Ln (-Ln(S)) and Ln(S/ (1-S))) as dependent variables were modeled by a multivariate mixed model to same covariates in order to have precise estimations with high power and appropriate interpretation of covariate effects. The analysis was carried out with SAS Proc MIXED and STATA software. Results: A total of 32 studies from the published literature were analysed, covering 4,092 patients who received anthracycline-based and 2,501 treated with CMF for the disease free survival and in order to analyze the overall survival, 13 studies reported the overall survival curves in which 2,050 cases were treated with anthracycline-based and 1,282 with CMF regimens. Conclusions: The findings illustrated that the model with dependent variable Ln (-Ln(S)) had more precise estimations of the covariate effects and showed significant difference between the effects of two adjuvant chemotherapy regimens. Anthracycline-based treatment gave better disease free survival and overall survival. As an IPD meta-analysis in the Italy the results of Angelo et al in 2011 also confirmed that anthracycline-based regimens were more effective for survival of breast cancer patients. The findings of Zare et al 2012 on disease free survival curves in Asia also provided similar evidence.

• 디지털융복합연구
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• 제17권11호
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• pp.149-156
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• 2019

정보기술의 활용이 보편화되면서 대중과 연구자 모두 정보 프라이버시 문제에 대한 관심이 높아지고 있다. 이러한 문제에 대한 연구가 기하급수적으로 증가하면서 연구결과에 대한 전반적인 이해가 어려워졌다. 이에 따라 과거연구에 대한 체계적인 검토가 요구된다. 본 연구는 정보 프라이버시 연구에 핵심적인 네 가지 연구개념을 두 가지 연구모형으로 설정하고 기존 연구에서 수집된 데이터를 이용하여 실증 분석하였다. TSSEM이라는 정량적 메타분석 기법이 적용되었는데, 이 기법은 MASEM의 한 가지로서 구조방정식모형과 메타분석 기법을 통합하여 분석하는 기능을 제공한다. 분석결과는 위험 중심적 모형이 염려 중심적 모형과 비교하여 보다 높은 모형 적합도를 나타내었다. 본 연구의 결과는 전통적인 염려 중심적 모형의 설명력에 의문을 제시하며, 사용자의 프라이버시 정보 제공의도를 설명하기 위하여 위험 중심적 모형을 고려할 필요가 있다는 점을 시사한다.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2004년도 춘계공동학술대회 논문집
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• pp.409-412
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• 2004

Today, meta-heuristic algorithms have been much attention by researcher because they have the power of solving combinational optimization problems efficiently. As the result, many variants of a meta-heuristic algorithm (e.g., simulated annealing) have been proposed for specific application domains. However, there are few efforts to classify them into a unified software framework, which is believed to provide the users with the reusability of the software, thereby significantly reducing the development time of algorithms. In this paper, we present an object-oriented framework to be used as a general tool for efficiently developing variants of simulated annealing algorithm. The interface classes in the framework achieve the modulization of the algorithm, and the users are allowed to specialize some of the classes appropriate for solving their problems. The core of the framework is Algorithm Configuration Pattern (ACP) which facilitates creating user-specific variants flexibly. Finally, we summarize our experiences and discuss future research topics.

• Journal of Electrical Engineering and Technology
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• 제12권4호
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• pp.1417-1426
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• 2017

Power system analysis, Non-Convex Economic Dispatch (NED) is considered as an open and demanding optimization problem. Despite the fact that realistic ED problems have non-convex cost functions with equality and inequality constraints, conventional search methods have not been able to effectively find the global answers. Considering the great potential of meta-heuristic optimization techniques, many researchers have started applying these techniques in order to solve NED problems. In this paper, a new and efficient approach is proposed based on imperialist competitive algorithm (ICA). The proposed algorithm which is named multi-operator ICA (MuICA) merges three operators with the original ICA in order to simultaneously avoid the premature convergence and achieve the global optimum answer. In this study, the proposed algorithm has been applied to different test systems and the results have been compared with other optimization methods, tending to study the performance of the MuICA. Simulation results are the confirmation of superior performance of MuICA in solving NED problems.