• 생명과학회지
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• 제33권9호
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• pp.730-735
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• 2023

지난 10년 동안 인공지능의 도움으로 노화를 정량화하기 위한 수많은 연구가 수행되었다. DNA 메틸화 데이터를 사용하여 다양한 모델이 개발되었으며 흔히 후성유전학적 시계라고 불린다. 후성유전학적 나이 가속화는 일반적으로 질병 상태와도 주로 연관이 있어 보인다. 조현병은 가속 노화 가설과 관련있는 정신질병으로 심각한 정신적, 신체적 스트레스를 동반한다. 다른 심리 질환과 비교했을 때 이 질병은 젊은 사람들에서 높은 사망률과 질병률을 유발한다. 과거 연구에서는 이 질병이 가속 노화 가설과 연관있다고 알려져 있었다. 이번 연구에서는 조현병 환자의 후성유전학적 나이 가속도 변화를 통해 질병에 대한 후성유전학적 통찰을 얻고자 하였다. 후성유전학적 나이 가속화를 측정하기 위해 두 가지 다른 DNA 메틸화 시계 모델을 사용했으며 이는 범조직 모델인 Horvath clock과 Epi clock을 사용하였다. 우리는 Horvath clock과 Epi clock이 모두 호환되는 450k 어레이 데이터를 사용하였다. 그 결과, Epi clock을 사용했을 때 환자샘플에서 후성유전학적 나이 가속화가 더 느리다는 것을 발견했다. Epi clock이 질병으로 인한 DNA 메틸화 변화를 잘 감지해낼 수 있음을 알아내었다. 또한 Epi clock에서 대조군과 환자군에서 차등적으로 메틸화된 CpG 부위를 분석하고 경로 농축 분석을 수행한 결과, 대부분의 CpG가 신경 세포 과정에 관여한다는 사실을 발견했다.

• 한국지식정보기술학회논문지
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• 제13권2호
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• pp.273-286
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• 2018

지금까지 우리나라는 다양한 인구정책을 펴고 있지만 인구 통계학적 결과에 따르면 급속히 고령화가 이어지고 있고 앞으로도 더 심화 될 것으로 예상된다. 또한 많은 노인들은 열악한 경제적인 여건과 체계적이지 못한 건강관리에 노출이 되어있고 대 부분 정신적인 질환과 만성질환에 항상 시달리고 있는 상태이다. 특히 기존에 도시의 노인들은 대가족 구조에서 소가족으로 바뀌면서 가족의 소외감과 혼자 거주하는 노인 인구가 늘어나면서 이에 따른 여러 가지 사회문제가 대두되고 있다. 현재 혼자 주거하는 노인들의 건강관리는 더욱 더 이루어지지 않고 있고 또한 신체적으로나 정신적으로 매우 빈약한 관리아래 있다고 볼 수 있다. 인간은 누구나 노년기를 거쳐야 되며 우리는 노년의 과정을 신체적으로나 정신적으로 건강하게 보내게 하는데 목적이 있다. 노인의 기본적인 연령이 늘어나면서 그에 따른 복지정책과 의료정책 등 여러 측면에서 고려하여야 될 것이다. 본 연구에서는 65세 이상의 100명의 노인 인구를 대상으로 경제학적인 상황과 신체적인 건강 상태와 정신적인 건강상태를 살펴보았으며 특히 심각한 소외감과 고독감 그리고 정서적인 상황을 분석하여 보다 효과적으로 이를 해결하고자 최신 디지털 기술을 적용하기 위하여 일명 "도시형 시니어 멀티 케어존"이 실제 실효성이 있는지에 대하여 연구하였으며 이는 노인의 맞춤형 건강관리를 통하여 도움을 줄 수 있는 방향을 찾고자 연구하였다.

• 대한임상독성학회지
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• 제12권1호
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• pp.14-21
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• 2014

Purpose: The objective of this study was to develop a new scoring tool that is comprehensively applicable and predicts fatality within 24 h of intoxication. Methods: This was a cohort study conducted in two emergency medical centers from 2011 to 2012. We identified factors associated with severe/fatality. Through a discriminant analysis, we devised the aBIG (age, Base deficit, Infection, and Glasgow coma scale) score. To compare the ability of aBIG to predict intoxication severity with that of previous scoring systems such as APACHE II, MODS, SAPS IIe, and SOFA, we determined the receiver operating characteristic curves of each variable in predicting severe-to-fatal toxicity. Results: Compared with the mild/moderate toxicity group (n=211), the severe/fatal group (n=143) had higher incidences of metabolic acidosis, infection, serious mental change, QTc prolongation and hepato-renal failure. Age, base deficit, infection-WBC count, and Glasgow Coma Scale were independently associated with severe/fatal poisoning. These variables were combined into the poisoning "aBIG" score [$0.28{\times}$Age group+$0.38{\times}WBC$ count/$10^3+0.52{\times}$Base deficit+$0.64{\times}$(15-GCS)], which were each calculated to have an area under the curve of 0.904 (95% confidence interval: 0.868-0.933). The aBIG poisoning score had an equivalent level of severity predictability as APACHE II and a superior than MODS, SOFA, and SAPS IIe. Conclusion: We developed a simplified scoring system using the four variables of age, base deficit, infected leukocytosis, and GCS. The poisoning aBIG score was a simple method that could be performed rapidly on admission to evaluate severity of illness and predict fatal severity in patients with acute intoxications.

• 부모자녀건강학회지
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• 제12권1호
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• pp.61-76
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• 2009

Purpose: The purpose of this study was to develop child's health assessment tools for children in child care centers. Methods: Based on the literature review and several types of workshops participated with the child health nursing professors, doctoral students, nurses in pediatric units and pediatric psychiatric units from July to December 2006, the standards of child health assessment tools were developed. Graduate students and 4th grade students in nursing were trained for health assessment and used these assessment tools to validate the content and reliability of said tools. Results: Some record forms were newly developed, including demographic characteristics, past history, present health status, behavioral problems, and appropriate developmental screening tests in child care centers were selected. For systematic health care management in child care centers, daily care report, illness log, and referral sheet were also developed. Conclusion: In the face of growing utilization of daycare and their association with increased risk of various diseases, assessment and control measures are indispensable to the promotion of child health. Children's physical and mental health and developmental problems can be assessed using this assessment tools. They can be used for establishing the direction for developing a health care service system for young children.

• 대한간호학회지
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• 제10권1호
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• pp.57-64
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• 1980

The purpose of the study was to find out the relationship between experienced stressful events and its coping behavior within mentally wellness and illness, and to define the effective coping method under the stressful situation. By doing so, during the period of April, 1978- to March, 1979 the objects of this study were 100 persons who were under the psychiatric facilities in their first hospitalization, and who were registered in psychiatric out patient department in the form general hospitals located at Seoul selected as a experimental group. As a control group 100 persons who never experienced psychiatric treatment who were not under the current medical treatment, and who were tarring appropriate social roles in their community were selected, and in both groups utilized questimaires for Social Readjustment Pating Scale and Coping Scale. This study was tested by X$^2$ examinationand by F-ratio（analysis of variance). Results were as follows : Hypothesis 1. The actually experienced life events were expected to be higher in the experimental group than in the control group, but they did not show the significant difference between the groups.（ p >0.05) Thus hypothesis 1 was rejected. Hypothesis : 2. The stress scores were expected to be higher in the experimental group than in the control group, and also did show the significant difference between the groups ( p< 0.05）. Therefore hypothesis 2 was supported. Hypothesis 3. The non-effective coping behavior were expected to be higher in the experimental group than in the control group, and also did show the significant difference between the two groups(p < 0.001). Also hypothesis 3 was supported. Hypothesis 4 . The higher stress score groups (above 250 LCU ) were expected to utilize non.effective coping method more frequently than in the lower stress score groups (below 249 LCU ), and not only they showed high in utilizing non-effective coping method but also showed high in utililzing effective coping method. Thus hyphothesis 4 was partially supported. (p < 0.001) The following are drawn out based on the result of this study that the stress scores were higher, and more utilized non-effective coping method in the emotionally disturbances than in the emtionally healthies.

• 한국병원경영학회지
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• 제21권1호
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• pp.14-31
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• 2016

Obesity of adolescents causes mental and physical problems as well as social problems, which need prevention and management. Although a number of systematic reviews and meta-analyses on obesity programs for adolescents were conducted, there is no study evaluating the programs based on CCM(Chronic Care Model), an organizing framework for improving chronic illness care. This study was conducted to review the features of studies in obesity management programs and interventions of the selected studies were evaluated in terms of inclusion of components of the Chronic Care Model. 4 databases were searched for relevant studies in obesity management programs, which were published from 1994 to 2014 in Korea. Results were analyzed in a qualitative way. 14 studies were satisfied inclusion criteria. The interventions most frequently utilized the elements of self-management support(66.7%) and only 1 of the studies included more than three components of CCM. This study presents the direction of health policies about managements of metabolic syndrome, which means that we identified effective process of the obesity management programs for adolescents in Korea and also this study will be used as a basic information for the development of obesity management program.

• 한국치위생학회지
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• 제12권5호
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• pp.973-985
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• 2012

Objectives : The aim of this study is to investigate the possible impact factors on adults' self-reports of dry mouth and to develop strategies to improve oral health education policy. Methods : This study was conducted on a total of 622 self-administered questionnaires adult above 20 and under 65 years of age living in Seoul and Gyeonggi provinces. The final participants consisted of 443 adults without chronic illness, taking medications and wearing dentures. The Hierarchical Multiple Regression model with three stages was used to assess the association for exposure of interest, such as socio-demographics, health-related behavior, mental health and self-reported of dry mouth. Results : The participants reported mean score of dry mouth($6.32{\pm}4.47$), of which 191 were male($6.81{\pm}4.56$) and 252 were female($5.94{\pm}4.37$). Hierarchical Multiple Regression revealed that the score of dry mouth was shown to be significantly higher for the following people: Males, who were employed, unemployed, negative self-perceived general health, perceived stress, and participants who had no experience awareness of distress in two weeks. The explanatory power was 21.9%. The most powerful impact factor regarding to employment was shown to be negatively associated to dry mouth, and self-perceived general health, experiencing awareness of distressful in two weeks was also important factors. Conclusions : Based on these results in order to develop oral health education policy strategies for the prevention and management of dry mouth, there need to be considered for the employee.

• 종양간호연구
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• 제4권2호
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• pp.143-153
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• 2004

Death of spouse is the most heartbreaking stressful and inevitable tragic life event. In middle aged men who belong to the social middle class and accomplished their occupational success, experiences of spousal bereavement are great shock. The aim of this study was to find out how they overcome their mental and physical pain and to obtain the basic materials to develop suitable nursing care programs for them. The methodological approach of this study is Giorgi's phenomenological analysis meaning unit. This method also makes theme focal meaning, situated structural description and create general structural description grasped by participator's experience through situated structure description. This study performed from November 2002 to May 2004, and participators were four men. Data collected through in-depth personal interviews. which had been tapped and analysed the Giorgi's method. Finally, the five focal meaning below have been abstracted. Theme 1. Physical symptom loss of appetite, fatigue, insomnia. outbreak of illness, weight loss. Theme 2. life of spiritless lack of desire, sense of emptiness, unstableness, prosaic life. wandering. indifference of appearances, avoidance of meeting people. Theme 3. life of retrospction reflection for his wife, yearning, grief, muttering to himself, never-to-be forgotten wife, leading a lonely life. Theme 4. negative emotion reproaching, feeling hurt, marriage of daughter, feeling heavy, getting angry, sexual desire, awareness of his sinfulness. loneliness Theme 5. social support and adjustment getting his wife off his mind, curring favor with children, support and consolation by his daughter-in-law, appreciation for hospice nurse, considering remarriage, taking care of himself, good relation with his children. The result of this study showed that middle aged men bereaved of their wife by cancer need other's concern. And we have to study further to understand their experience. Until now hospice nursing is concentrated on cancer patients But from now we have to provide their families suitable nursing care programs to adjust themselves to social life before and after death of patients.

• 한국콘텐츠학회논문지
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• 제17권8호
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• pp.454-462
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• 2017

본 연구는 노인 고독사 현상에 대한 이해를 목적으로 미디어 자료를 사용하여 고독사 사례를 살펴보고자 하였다. 질적 연구방법으로 사례분석 방법을 적용하였다. 고독사 사례는 2007년부터 2017년 초까지 보도된 미디어 자료를 사용하였다. 자료 수집은 인터넷 검색 엔진을 사용하여 수행하였으며, 총 47사례가 최종 분석에 사용되었다. 60대 21사례, 70대 17사례, 80대 이상 9사례를 분석에 사용하였다. 성별은 남성 22사례, 여성 17사례, 성별미상 사례 8사례로 나타났다. 분석 결과, 고독사 사례에서 나타난 주요 위험요인으로는 빈곤과 경제적 곤경, 만성질환, 정신건강 문제, 사회적 고립, 가족 및 이웃과의 관계 절연, 실업, 1인 가구, 독신 혹은 이혼, 그리고 대도시 거주 등으로 파악되었다. 연구 결과를 바탕으로 향후 예방 전략에 대한 논의를 제기하였다.

• 한국산학기술학회논문지
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• 제14권8호
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• pp.3715-3723
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• 2013

본 연구의 목적은 요양시설 입소노인의 중증질환자와 명리학적 선천성질환의 상관관계, 스트레스 충격척도, 정서적 탈진척도 요인을 분석하고자 한다. 연구대상은 서울시에 소재하는 요양시설에 입소한 노인들 중에서 4대 중증질환자의 147명을 대상으로 2013년 3월 15일부터 5월 31일까지 실시하였다. 연구방법은 빈도분석, 상관분석, 단순회귀분석, t-test, 일원변량분석 등을 실시하였고, 실증분석은 모두 유의수준 5%에서 검증하였다. 분석결과 및 결론은 중증질환 자와 명리학적 선천성질환의 상관관계가 높게 나타났으며, 중증질환 판정시 스트레스척도가 높게 나타났다. 그리고 스트레스 척도가 높을수록 정서적 탈진척도도 높게 나타났다.