• 한방안이비인후피부과학회지
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• 제29권2호
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• pp.142-148
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• 2016

Objectives : The objective of this study was to report the efficacy of the Crucial Incision Acupuncture Therapy(CIAT) for removing melanocytic nevi. Methods : CIAT is penetration acupuncture to remove a lesion by sticking needles like cross-shape. We used the CIAT for treating one patient with melanocytic nevi, and then we investigated efficacy and side effect for about 5 months. Results : In 16 melanocytic nevuses treated with CIAT, one of the nevuses recurred after about 3 months. And hyperpigmentation lasted for about 2-5 months was caused after the CIAT. Conclusions : In Korean medicine, the CIAT might be used for treating melanocytic nevi. But additional studies might be needed for improvement of treatment effect.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.425-429
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• 2016

Background: Dermatoscopy can be applied to diagnose pigmented skin lesions. The aim of the present study was to compare dermatoscopic and histopathologic results in basal cell carcinoma (BCC) and melanocytic nevus of theface. Materials and Methods: In an analytical-descriptive study, 61 patients suspected of BCC or melanocytic nevi of face were randomly selected. The skin lesions of patients were evaluated with dermatoscopic method from February 2012 to February 2014 and results were compared with pathological features of samples. Results: In this study, mean age of patients was $49.5{\pm}18.9$. Some 25 (41%) were men and 36 (59%) were women. In 27 cases (44.3%) there was diagnosis of melanocytic nevus, in 28 cases (45.9%) diagnosis of BCC, and in 3 cases (4.9%) there was mixed diagnosis. The relationship between patients' gender and dermatoscopic diagnosis of the patients was statistically significant (P=0.001). For BCC the sensitivity and specificity of dermatoscopic method were 100% and 97% respectively and for melanocytic nevi 96.4% and 97%. Conclusions: Dermatoscopic study not only can be helpful in improving clinical diagnosis while guiding missed malignant lesions to pathologic evaluations, but also could be useful in evaluating further suspicious or recurrent cases.

• Neonatal Medicine
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• 제17권1호
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• pp.147-151
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• 2010

신생아에서 선천성 거대 멜라닌세포 모반은 드물게 발생하지만 악성 흑색종, 연수막멜라닌세포증, 간질과 같은 신경학적 결함의 발생 위험성이 높은 질환으로서 수술적 절제 및 장기적 추적관찰을 필요로 한다. 저자들은 출생시 부터 흉부의 선천성 거대 멜라닌세포 모반과 두경부 및 사지의 위성모반을 보인 여아 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.570-574
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• 2013

Background The elliptical excision is the standard method of removing benign skin lesions, such as congenital melanocytic nevi. This technique allows for primary closure, with little to no dog-ear deformity, but may sacrifice normal tissue adjacent to the lesion, resulting in scars which are unnecessarily long. This study was designed to compare the predicted results of elliptical excision with those resulting from our excision technique. Methods Eighty-two patients with congenital melanocytic nevus on the face were prospectively studied. Each lesion was examined and an optimal ellipse was designed and marked on the skin. After an incision on one side of the nevus margin, subcutaneous undermining was performed in the appropriate direction. The skin flap was pulled up and approximated along several vectors to minimize the occurrence of dog-ear deformity. Results Overall, the final wound length was 21.1% shorter than that achieved by elliptical excision. Only 8.5% of the patients required dog-ear repair. There was no significant distortion of critical facial structures. All of the scars were deemed aesthetically acceptable based on their Patient and Observer Scar Assessment Scale scores. Conclusions When compared to elliptical excision, our technique appears to minimize dogear deformity and decrease the final wound length. This technique should be considered an alternative method for excision of facial nevi.

• Archives of Plastic Surgery
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• 제44권6호
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• pp.523-529
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• 2017

Background Serial tissue expansion is performed to remove giant congenital melanocytic nevi. However, there have been no studies comparing the expansion rate between the subsequent and preceding expansions. In this study, we analyzed the rate of expansion in accordance with the number of surgeries, expander location, expander size, and sex. Methods A retrospective analysis was performed in pediatric patients who underwent tissue expansion for giant congenital melanocytic nevi. We tested four factors that may influence the expansion rate: The number of surgeries, expander location, expander size, and sex. The rate of expansion was calculated by dividing the 'inflation amount' by the 'expander size'. Results The expansion rate, compared with the first-time group, was 1.25 times higher in the second-or-more group (P=0.04) and 1.84 times higher in the third-or-more group (P<0.01). The expansion rate was higher at the trunk than at other sites (P<0.01). There was a tendency of lower expansion rate for larger expanders (P=0.03). Sex did not affect the expansion rate. Conclusions There was a positive correlation between the number of surgeries and the expansion rate, a positive correlation between the expander location and the expansion rate, and a negative correlation between the expander size and the expansion rate.

• Journal of Korean Neurosurgical Society
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• 제56권1호
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• pp.61-65
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• 2014

Neurocutaneous melanosis (NCM) is a rare congenital syndrome consisting of benign or malignant melanotic tumors of the central nervous system with large or numerous cutaneous melanocytic nevi. The Dandy-Walker complex (DWC) is characterized by an enlarged posterior fossa with high insertion of the tentorium, hypoplasia or aplasia of the cerebellar vermis, and cystic dilatation of the fourth ventricle. These each two conditions are rare, but NCM associated with DWC is even more rare. Most patients of NCM with DWC present neurological symptoms early in life such as intracranial hemorrhage, hydrocephalus, and malignant transformation of the melanocytes. We report a 14-year-old male patient who was finally diagnosed as NCM in association with DWC with extensive intracerebral and spinal cord involvement.

• Archives of Plastic Surgery
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• 제47권6호
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• pp.551-558
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• 2020

Background Giant congenital melanocytic nevus (GCMN) is a rare disease, for which complete surgical resection is recommended. However, the size of the lesions presents problems for the management of the condition. The most popular approach is to use a tissue expander; however, single-stage expansion in reconstructive surgery for GCMN cannot always address the entire defect. Few reports have compared tissue expansion techniques. The present study compared single and serial expansion to analyze the risk factors for complications and the surgical outcomes of the two techniques. Methods We retrospectively reviewed the medical charts of patients who underwent tissue expander reconstruction between March 2011 and July 2019. Serial expansion was indicated in cases of anatomically obvious defects after the first expansion, limited skin expansion with two more expander insertions, or capsular contracture after removal of the first expander. Results Fifty-five patients (88 cases) were analyzed, of whom 31 underwent serial expansion. The number of expanders inserted was higher in the serial-expansion group (P<0.001). The back and lower extremities were the most common locations for single and serial expansion, respectively (P =0.043). Multivariate analysis showed that sex (odds ratio [OR], 0.257; P=0.015), expander size (OR, 1.016; P=0.015), and inflation volume (OR, 0.987; P=0.015) were risk factors for complications. Conclusions Serial expansion is a good option for GCMN management. We demonstrated that large-sized expanders and large inflation volumes can lead to complications, and therefore require risk-reducing strategies. Nonetheless, serial expansion with proper management is appropriate for certain patients and can provide aesthetically satisfactory outcomes.

• Clinical and Experimental Pediatrics
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• 제49권2호
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• pp.212-216
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• 2006

신경피부멜라닌증은 피부와 중추신경계를 침범하는 드문 선천성 증후군으로 연수막에 멜라닌증 또는 흑색종과 동반하여 피부에 거대 또는 다수의 색소성 모반이 존재하며, 피부에서 악성 변화의 증거가 없고, 뇌수막 외에 다른 부위에 악성 흑색종의 증거가 없는 경우로 정의된다. 발생기전은 배아신경 외배엽의 형태발생 착오로 생기는 것으로 알려져 있다. 저자들은 복부, 흉부와 팔 전체에 검은색 모반이 덮여있고, 전신에 다양한 크기의 위성병변이 출생시부터 존재한 신생아를 경험하였다. 뇌 자기공명영상은 오른쪽 측두엽의 편도에 결절모양의 고신호 강도를 보였고, 지방억제 T1 강조영상은 연수막 주위의 고신호 강도를 보였다. 저자들은 거대 선천성 색소성 모반을 가진 신생아에서 뇌자기공명영상으로 진단받고 3차례의 소파술과 인공피부이식술을 받은 드문 선천성 증후군인 신경피부멜라닌증 환자 1례를 경험하고 문헌 고찰과 함께 보고하는 바이다.

• 대한족부족관절학회지
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• 제10권1호
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• pp.18-23
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• 2006

Purpose: We reviewed the clinical finding of malignant melanoma of the foot in korean because it's advanced stage and extended lesion at diagnosis. Materials and Methods: Retrospective study was enforced about the 11 cases who has diagnosed to malignant melanoma of the foot from February 1995 to March 2004. The mean follow up period was 61 months. In this study we used age, sex, site, depth, histology, clinical stage, precursor lesion, misdiagnosis, interval to diagnosis, survival time, survival. Results: Average age was 58 years and number of female was six. Common site of involvement were heel of plantar surface (6 cases) and subungual area (2 cases). Depths of involvement were 0.3 to 10 mm, most common histological type was acral lentiginous melanoma (7 cases), stage 5 according to classification of Clark were 5 cases and stage 2 or more according to clinical staging were 8 cases. precursor lesion were benign melanocytic nevi (2 cases) and ill defined (9 cases). Chief complaint were increasing of size, color change, pain and ulceration. Conclusion: Malignant melanoma of the foot usually arise at nonvisible area and is easy to be misdiagnosed or delayed treatment. So it is hard to early diagnosis and have poor prognosis. So we need education and effort to early detection and diagnosis.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2021년도 추계학술발표대회
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• pp.670-672
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• 2021

색소 세포성 모반과 악성 흑색종은 형태가 유사하지만 유해성의 측면에서 악성 흑색종은 암으로써 무해한 색소 세포성 모반에 비해 위험한 질환이다. 이에 기반하여 기존 연구에서 색소 세포성 모반과 악성 흑색종을 구분하기 위한 연구가 있었지만, 데이터를 취득하는 과정에서 많은 cost 가 필요하였다. 본 연구에서는 이를 개선하기 위해 두 병변의 dermatoscopic 영상을 분류 학습의 데이터로 사용하여 연구를 진행하였다. 학습을 위한 데이터는 오픈소스 dermatoscopic 데이터셋인 HAM10000을 사용하였으며 모델은 CNN 에서 개선된 MobileNetV2 를 사용하였다. 실험 결과, MobileNetV2 를 사용한 학습은 3-layer CNN 에 비해 15 분의 1 가량 적은 파라미터를 가졌으며, 검증 성능과 테스트 성능에서 93%에 근사하는 성능을 보였다. 본 연구는 이전 연구에 비해 cost 측면에서 큰 개선을 이루었으며, 상용화 가능한 분류 기법을 발견했다는 점을 시사한다.