• 한국식품과학회지
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• 제33권5호
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• pp.514-520
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• 2001

표백제 규제 대상인 한약재 28종 101건을 재배 현장에서 채취하여 수세, 건조 후 천연유래 이산화황 함유량을 모니어-월리암스 변법과 산증류-이온 크로마토그래피법으로 조사하고 그 출처를 규명하였다. 모니어-윌리암스 변법으로 측정한 한약재의 천연유래의 이산화황 함유량은 0.6-4.7ppm으로 의이인(0.6ppm)이 가장 낮았으며 황기(4.7ppm)가 가장 높았으나 산증류-이온 크로마토그래피법에 의해 측정한 천연유래 이산화황 함유량은 0.31-3.20ppm으로 택사(0.31ppm)가 가장 낮고 고본(3.3ppm)이 가장 높은 함유량을 보였다. 시험법에 따른 측정값의 차이 및 이산화황의 출처를 규명하기 위하여 GC-MS로 휘발성분을 분석한 결과, 측정값의 차이는 모니어-윌리암스 변법에서 휘발성 유기화합물에 의한 false positive response로 일어났으며, 한약재에서 측정되는 천연유래 이산화황은 한약재가 함유하고 있는 휘발성 황화합물에 기인함을 확인하였다.

• 대한한의학방제학회지
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• 제20권2호
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• pp.187-197
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• 2012

Objectives : The purpose of this study is to find a reasonable solution to a current status of drug classification between the drugs of western conventional (allopathic) medicine and Korean medicine. A clear and distinct concept on the drugs of allopathic medicine and Korean medicine based on reasonable concepts and broad consensus is a pressing issue in Korea, and will facilitate the development of herbal medicinal products and pharmaceutical industry. Methods : Considering the issue of drug classification from domestic and international regulations, we reviewed the current Drug Law of Korea and China, Guidance for Industry, Botanical Drug Products of USA, Directive 2004/24/EC of the European parliament and of the council. Results : In Korea, the drug classification of allopathic medicine and Korean medicine is quite vague even though differential licensure system is enforced for the clinicians of allopathic medicine and Korean medicine field. According to the definition in the Drug Law, the scope of Korean medicine drug is so broad that even a drug made of single-compound material, as well as herbal extract of crude mixture, is regarded as a drug of Korean medicine, as long as the material may be separated from medicinal herbs, animal tissues, or mineral resources. Only new compound not found in natural resources are outside of the scope of Korean medicine drug. In USA and EU, medicinal products manufactured from herbs are approved by separate regulations for the herbs with special waivers. In China, the category of new medicine and the definition of allopathic medicine and traditional chinese medicine are clearly specified and classified. Conclusions : As medicines are validated therapeutic materials for efficacy and toxicity, we suggest that generally the concept of conventional medicines is based on a single compound that has been synthesized and individually validated and that of Korean medicines is based on a compound extracted from natural materials or a complex of compounds that has been validated as a whole in its totality.

• 동의생리병리학회지
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• 제32권3호
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• pp.149-156
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• 2018

Traditional medicines (TM) in Korea, China, and Japan share most of the theories and therapeutic tools, but there are also differences due to their unique histories and cultures. Here, we aim to identify the differences in the utilization of TM theory between three countries by analyzing herb usage data in terms of the related traditional theories. Herb usage data of each country was collected from "Investigation of Korean medicine use and herbal medicine consumption survey" (Korea), "Analytical report on circulation of key Chinese medicinal materials" (China), and "Survey report on raw material crude drug usage" (Japan). Fifty five herbs with sixty features belonging to five theoretical categories (four properties, five tastes, targeting meridians, treatment strategies, and herbal parts) were selected and analyzed. Weight Sum Model (WSM) and Network-Based Group Features (NBGF) were used to compare the theoretical characteristics of TM between three countries. For the statistical evaluation, we developed and applied Herb Set Enrichment Analysis (HSEA) for WSM and NBGF results. HSEA for WSM results revealed the kidney meridian were targeted more in Korea than Japan, while the spleen meridian were targeted more in Japan than Korea. Herbs with sour taste were used more in Japan than China. HSEA for NBGF results found that NBGF including warm, neutral, sweet, and tonifying features were more dominant in Korea and than Japan, while NBGF including cold, bitter, heat-clearing features were more dominant in Japan than the others. These results suggest that TM in Korea, China, and Japan have unique aspects of practice patterns and theoretical utilization.