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Significance of Repeated Polymerase Chain Reaction (PCR) Testing for Diagnosis of Pulmonary Tuberculosis (폐결핵 진단 시 중합효소연쇄반응검사 반복 시행의 의의)

  • Kim, Soo-Ok;Kim, Yoon-Hee;Chi, Su-Young;Ban, Hee-Jung;Oh, In-Jae;Kwon, Yong-Soo;Kim, Kyu-Sik;Kim, Yu-Il;Lim, Sung-Chul;Kim, Young-Chul
    • Tuberculosis and Respiratory Diseases
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    • v.68 no.6
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    • pp.345-349
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    • 2010

  • Background: The polymerase chain reaction (PCR) test is important for the confirmatory diagnosis of tuberculosis (TB) caused by Mycobacterium tuberculosis. The aim of this study was to analyze the yield of repeated PCR testing in patients with confirmed pulmonary TB. Methods: The medical records of 130 patients, who had more than two consecutive PCR tests and a M. tuberculosis-positive sputum culture from August, 2006 to December, 2007, were retrospectively reviewed for the purposes of this study. A positive TB-PCR test was defined as at least one positive test result. Results: The cumulative positive PCR test rate was 80% (104/130), with gradually increasing rates of positive findings upon the first, second and third TB-PCR tests with 52.3%, 68.5% and 75.4%, respectively. However, further testing did not increase the positive rate further. Conclusion: Repeated PCR testing at least three times for M. tuberculosis is helpful for diagnosis of pulmonary TB.

  • https://doi.org/10.4046/trd.2010.68.6.345 인용 PDF KSCI

A Case of Nonspecific Interstitial Pneumonia Associated with Systemic Lupus Erythematosus (전신성 홍반성 낭창에 병발된 비특이성 간질성 폐렴 1예)

  • Lee, Ho-Moeng;Hwang, Jae-Kyung;Park, Gae-Young;Park, Jeong-Woong;Park, Jae-Kyung;Jeong, Seong-Hwan;Nam, Gui-Hyun;Lee, Jae-Woong;Ha, Seung-Yeon;Lee, Han-Kyung
    • Tuberculosis and Respiratory Diseases
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    • v.50 no.6
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    • pp.732-739
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    • 2001

  • Systemic lupus erythematosus frequently has thoracic involvement among connective tissue diseases. One of the pleuropulmonary manifestations is diffuse interstitial lung disease including nonspecific interstitial pneumonia(NSIP). NSIP is a newly classified disease among interstitial lung diseases. Systemic lupus erythematosus has a better prognosis than usual interstitial peumonia(UIP) and responds well to steroids. In this report, a 34 year-old woman who complained of a dry cough, and exertional dyspnea for 2 months is described. The chest X-ray showed fine reticular opacities and a mild honeycomb appearance in both basal lungs. High resolution computed tomography(HRCT) showed bilateral patchy areas of ground-glass attenuation and a mild honeycomb appearance in the subpleural of both the lower and the middle portion of the lung fields. An open lung biopsy showed prominent lymphocytic interstitial inflammation and fibrosis with small areas with a honeycomb appearance. This case was diagnosed as NSIP associated with systemic lupus erythematosus and was managed with oral steroids. Here we report a case of nonspecific interstitial pneumonia associated with systemic lupus erythematosus confirmed by HRCT and an open lung biopsy with a review of the relevant literature.

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A Case of Benign Metastasizing Leiomyoma in the Lung (양성 전이성 폐 평활근종 1예)

  • Hwang, Jae-Kyung;Park, Kae-Young;Park, Jeong-Woong;Park, Jae-Kyung;Jeong, Seong-Hwan;Suh, Jun-Bum;Lee, Han-Kyung;Lee, Jae-Woong;Oh, Young-Ha;Nam, Gui-Hyun
    • Tuberculosis and Respiratory Diseases
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    • v.49 no.2
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    • pp.231-236
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    • 2000

  • Benign metastasizing leiomyoma usually occurs in women and is associated with a past hysterectomy in 80% of the cases, which is a rare entity. The patient was a 39-year-old woman who complained of cough and sputum. She underwent hysterectomy because of benign leiomyoma ten years ago. Chest X-ray showed nodular lesion in the left lung field. Chest CT showed a 3cm sized round well defined mass at left hilum with mild indentation of segmental bronchi of left upper lobe and a small tiny nodule in right lower lung field. Nodular lesion of left upper 1000 was resected by thoracotomy. Pathological evaluation showed benign spindle-like cells having nuclei without cytotic atypia similar to those of benign leiomyoma. Immunohistochernical stainings for desmin and smooth muscle actin were positive. Therefore these nodules are considered as benign metastasizing leiomyoma from a uterine leiomyoma. We report this case with the review of literature.

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