• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 추계학술대회
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• pp.344-346
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• 2016

HL7의 차세대 버전인 FHIR는 의료 환경에서 메시지 교환의 표준으로 이벤트 발생시점부터 데이터 교환을 손쉽게 할 수 있도록 지원하는 프로토콜이다. 응급실 등 심전도 기기로부터 환자의 자동 판독 결과를 FHIR 메시지로 생성하고, 생성된 메시지를 EMR 등 병원정보시스템에 전달하고 스마트 폰을 통해 해당 결과를 실시간으로 알려 줄 수 있음으로 다양한 의료기관에서 사용 될 것으로 생각한다. 또한, 향후 SMART on FHIR로 확대되어, 순환기내과, 흉부외과 병동에서 실시간 원격모니터링에도 활용 될 것으로 생각한다.

• Investigative Magnetic Resonance Imaging
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• 제26권2호
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• pp.83-95
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• 2022

The purpose of this study was to establish and provide guidelines for the standardized acquisition and interpretation of diffusion-weighted magnetic resonance imaging (DW-MRI) to improve the image quality and reduce the variability of the results interpretation. The standardized protocol includes the use of high-resolution DW-MRI with advanced techniques and post-processing. The aim of the protocol is to increase the effectiveness of the medical image information exchange involved in the construction, activation, and exchange of clinical information for healthcare use. An organized interpretation form could make DW-MRIs' interpretation easier and more familiar. Herein, the authors briefly review the basic principles, optimized image acquisition, standardized interpretation guidelines, false negative and false positive cases of DW-MRI, and provide a standard interpretation form and examples of various cases to help users become more familiar with the DW-MRI.

• The Korean Journal of Physiology and Pharmacology
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• 제9권2호
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• pp.95-101
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• 2005

In the heart, $Na^{+}-Ca^{2+}$ exchange (NCX) is the major $Ca^{2+}$ extrusion mechanism. NCX has been considered as a relaxation mechanism, as it reduces global $[Ca^{2+}]_i$ raised during activation. However, if NCX locates in the close proximity to the ryanodine receptor, then NCX would curtail $Ca^{2+}$ before its diffusion to global $Ca^{2+}_i$ This will result in a global $[Ca^{2+}]_i$ decrease especially during its ascending phase rather than descending phase. Therefore, NCX would decrease the myocardial contractility rather than inducing relaxation in the heart. This possibility was examined in this study by comparing NCX-induced extrusion of $Ca^{2+}$ after its release from SR in the presence and absence of global $Ca^{2+}_i$ transient in the isolated single rat ventricular myocytes by using patch-clamp technique in a whole-cell configuration. Global $Ca^{2+}_i$ transient was controlled by an internal dialysis with different concentrations of BAPTA added in the pipette. During stimulation with a ramp pulse from +100 mV to -100 mV for 200 ms, global $Ca^{2+}_i$ transient was suppressed only mildly, and completely at 1 mmol/L, and 10 mmol/L BAPTA, respectively. In these situations, ryanodine-sensitive inward NCX current was compared using $100{\mu}mol/L$ ryanodine, $Na^+$ depletion, 5 mmol/L $NaCl_2$ and $1{\mu}mol/L$ nifedipine. Surprisingly, the result showed that the ryanodine-sensitive inward NCX current was well preserved after 10 mmol/L BAPTA to 91 % of that obtained after 1 mmol/L BAPTA. From this result, it is concluded that most of the NCX-induced $Ca^{2+}$ extrusion occurs before the $Ca^{2+}$ diffuses to global $Ca^{2+})i$ in the rat ventricular myocyte.

• 정보과학회 논문지
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• 제44권3호
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• pp.323-331
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• 2017

다양한 스마트기기들의 발달로, 최근 들어 스마트기기를 이용한 U-헬스케어 관련 서비스들이 증가하고 있다. 하지만 U-헬스케어 서비스는 민감한 개인의 건강 정보를 다루는 것이기 때문에 정보보안이 매우 중요하다. 정보보안 이슈를 해결하기 위해서는 의료정보에 대한 암호화 기능이 기본적으로 제공되어야 하며, 이를 위한 암호키 교환 방법이 필요하다. 따라서 본 논문에서는 스마트 기기들을 활용하여 안전한 U-헬스케어 서비스를 위한 키 교환 프로토콜을 제안한다. 제안하는 프로토콜은 스마트 기기들에 적합하도록 비교적 짧은 키 길이로 높은 보안성을 제공하는 타원곡선 기반의 공개키 암호방식을 기반으로 설계 되었다. 또한, 키 교환 프로토콜을 수행할 때, 스마트워치를 보조 기기로 활용함으로써 사용자 인증을 강화하고 보안성을 높였다.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.30-30
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• 2003

Without a definitive resolution of stoichiometry of cardiac Na$^{+}$-Ca$^{2+}$exchange (NCX), we cannot proceed to any quantitative analysis of exchange function as well as cardiac excitation-contraction coupling. The stoichiometry of cardiac NCX, however, is presently in doubt because reversal potentials determined by various groups range between those expected for a 3-to-1 and a 4-to-1 flux coupling. For a new perspective on this problem, we have used ion-selective microelectrodes to quantify directly exchanger-mediated fluxes of $Ca^{2+}$and Na$^{+}$in giant membrane patches. $Ca^{2+}$- and Na$^{+}$-selective microelectrodes, fabricated from quartz capillaries, are placed inside of the patch pipettes to detect extracellular ion transients associated with exchange activity. Ion changes are monitored at various distances from the membrane, and the absolute ion fluxes through NCX are determined via simulations of ion diffusion and compared with standard ion fluxes (Ca$^{2+}$ fluxes mediated by $Ca^{2+}$ ionophore, and Na$^{+}$ fluxes through gramicidin channels and Na$^{+}$/K$^{+}$pumps). Both guinea pig myocytes and NCX1-expressing BHK cells were employed, and for both systems the calculated stoichiometries for inward and outward exchange currents range between 3.2- and 3.4-to-1. The coupling ratios do not change significantly when currents are varied by changing cytoplasmic [Ca$^{2+}$] or by adding cytoplasmic Na$^{+}$. The exchanger reversal potentials, measured in both systems under several ionic conditions, range from 3.1- to 3.3-to-1. Taken together, a clear discrepancy from a NCX stoichiometry of 3-to-1 was obtained. Further definitive experiments are required to acquire a fixed number, and the present working hypothesis is that NCX current has an extra current via ‘conduction mode’.ent via ‘conduction mode’.

• Healthcare Informatics Research
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• 제24권4호
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• pp.359-370
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• 2018

Objectives: We assessed the public acceptance of a health information exchange (HIE) and examined factors that influenced the acceptance and associations among constructs of the Technology Acceptance Model (TAM). Methods: We collected data from a survey of 1,000 individuals in Korea, which was administered through a structured questionnaire. We assessed the validity and reliability of the survey instrument with exploratory factor analysis and Cronbach's alpha coefficients. We computed descriptive statistics to assess the acceptance and performed regression analyses with a structural equation model to estimate the magnitude and significance of influences among constructs of TAM. Results: Eighty-seven percent of the respondents were willing to use the technology, and the average level of agreement with the need for the technology was 4.16 on a 5-point Likert scale. The perception of ease of use of the technology significantly influenced perceptions of usefulness and attitudes about the need for HIE. Perceptions of usefulness influenced attitude and behavioral intention to use HIE, and attitude influenced intention. Age showed a wide range of influences throughout the model, and experience with offline-based information exchange and health status also showed noteworthy influences. Conclusions: The public acceptance of HIE was high, and influences posited by TAM were mostly confirmed by the study results. The study findings indicated a need for an education and communication strategy tailored by population age, health status, and prior experience with offline-based exchange to gain public buy-in for a successful introduction of the technology.

• Tuberculosis and Respiratory Diseases
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• 제45권4호
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• pp.896-901
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• 1998

Pulmonary arteriovenous malformation(PAVM) is an uncommon congenital anomaly. As pulmonary arteriovenous malformation is a direct communication between the branches of pulmonary artery and vein which originated from the malformation of capillary development, major disturbances in gas exchange can result. This malformation results in the several symptoms such as dyspnea, hemopyssis, cyanosis, and severe neurologic complaints. However, the most of patients are usually asymptomatic. Selective pulmonary angiography is well known the helpful diagnostic method. Recently, therapeutic embolization has been advocated as the treatment of choice for pulmonary arteriovenous malformations. We report a case of multiple pulmonary arteriovenous malformation, which was detected on the simple chest X-ray and successfully treated with coil embolization in a 19-year-old asymptomatic woman.

• 한국의사학회지
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• 제20권1호
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• pp.41-61
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• 2007

In 1607 a delegation was dispatched from Chosun to Japan (under the condition that prisoners of war were returned) to restore the destroyed relationship between the nations due to a war and to restore economic profits. This delegation later on became a delegation representing faith in each other. It contributed greatly to the Korea-Japan cultural exchanges in the 17th and 18th centuries. It was also a cornerstone for the exchange of Korea's distinguished studies as well as medical technology and Japan's results of international trade such as sweet potatoes, pepper, and tobacco. This thesis is one that discusses the study of documents produced during this process.

• Clinical and Experimental Pediatrics
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• 제54권7호
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• pp.310-312
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• 2011

A preterm female infant born at 27 weeks of gestation with a birth weight of 990 g developed acute hypotonia, apnea, hypotension and bradycardia mimicking septic shock syndrome at 14h after birth. Laboratory tests indicated a severe hypermagnesemia of 45 mg/dL. The renal function, complete blood count and maternal blood concentrations of magnesium were normal, and the blood cultures were negative. The patient recovered with treatment including exchange transfusion. However, the etiology of the severe hypermagnesemia remains unknown.

• 한국인터넷방송통신학회논문지
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• 제10권2호
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• pp.167-172
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• 2010

최근 병원에서는 전반적으로 의료정보시스템의 전산화가 진행되고 있으며, 시스템 간에 효율적인 정보 교환을 위하여 HL7, DICOM 등의 의료 표준이 존재한다. 그러나 병원별로 이질적으로 구축된 시스템으로 인해 환자의 의료정보의 데이터 구조가 다르므로 서로 다른 병원 간에 정보를 공유하기 어렵다. 본 논문에서는 XML을 기반으로 하여 다양한 의료정보를 단일 구조로 결합하고, 병원마다 독립적으로 관리되고 있는 의료정보시스템을 일괄적으로 관리하는 통합의료정보 시스템을 제안하였다. 따라서 제안 시스템은 타 병원의 내부 시스템에 따라 별도의 구조를 고려하지 않는 효과적인 정보 공유가 가능하다. 이로 인하여 의료기관들은 환자들에게 시간과 비용의 절감과 함께 정확한 진료를 제공할 수 있게 된다.