• The Korean Journal of Physiology
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• 제30권2호
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• pp.279-288
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• 1996

Chronic exposure to cadmium impairs various renal tubular functions, including organic acid (anion) secretion. To investigate the mechanism of cadmium-induced alterations in the organic anion transport system, kinetics of p-aminohippurate (PAH) uptake was studied in renal cortical basolateral membrane vesicles (BLMV) isolated from cadmium-intoxicated rats (adult male Sprague-Dawley). Cadmium intoxication was induced by subcutaneous injections of $CdCl_{2}$ (2 mg Cd/kg per day) for 3 weeks. The renal plasma membrane vesicles were prepared by Percoll gradient centrifugation. The vesicular uptake of $^{14}C$-PAH was determined by rapid filtration technique using Millipore filter. Cadmium intoxication resulted in a marked attenuation of $Na^{+}$-dependent, ${\alpha}$-ketoglutarate (${\alpha}$KG)-driven PAH uptake with no changes in $Na^{+}$ and ${\alpha}$KG-independent transport component. Kinetic analysis indicated that Vmax, but not Km, of the $Na^{+}$-dependent, ${\alpha}$KG-driven component was reduced. A similar reduction of $Na^{+}$-dependent, ${\alpha}$KG-driven PAH uptake was observed in normal membrane vesicles directly exposed to inorganic cadmium in vitro, and this was accompanied by an inhibition of both $Na^{+}$-dependent ${\alpha}$KG uptake and ${\alpha}$KG-PAH exchange activity. These results indicate that during chronic exposure to cadmium, free cadmium ions liberated in the proximal tubular cytoplasm directly interact with the basolateral membrane and impair the active transport capacity for organic anions, most likely due to an inhibition of both $Na^{+}$-dicarboxylate cotransporter and dicarboxylate-organic anion antiporter activities.

• 지역사회간호학회지
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• 제19권2호
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• pp.157-166
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• 2008

This study was conducted with whole home care nurses nationwide to provide secondary analyzed data to understand on their usage of medical equipments and their need of them for a month. This study found that treatments given by home care nurses were nelaton catheterization, bladder washing/urethral washing, newborn care, exchange and care for nasogastric tube and suction in that order of frequency. Second, instruments and equipments used for home care were reported to be stethoscope, patient monitor, blood pressure measuring equipment, air flotation mattresses, beds for patients, mattresses, suctioning device sets, enteral feeding equipment and dressing set in that oder of frequency. Moreover, need assessment of medical instruments and equipments showed renal dialysis was most needed and patient monitor, blood pressure measuring equipment, enteral feeding equipment, solution and other supplies for renal dialysis and beds for patient were necessary in that order. In conclusion, the results of this study investigating special treatments and medical instruments and equipments used for home care patients and analyzing patients' need, were expected to be useful for expansion of application of long-term care insurance for the elderly and health insurance as well as for quality control of home care and development of medial instruments and equipments used at home.

• IMMUNE NETWORK
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• 제4권2호
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• pp.94-99
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• 2004

Background: We previously reported that ginsan, a polysaccharide extracted from Panax ginseng had an immunostimulatory activity such as mitogenic activity, activation of macrophages and killer cells, and production of a variety of cytokines which resulted in antitumor and antiseptic effects. We further purified $\alpha$-(1$\longrightarrow$6)-glucan and $\beta$-(2$\longrightarrow$6)-fructan from the ginsan with size exclusion and ion-exchange column chromatography successively. In this study, we performed the structure-based activity of ginsan by comparison with known polysacchrides such as $\beta$-glucan, curdlan, laminarin, levan, dextran, lentinan and OK-432. Methods: To investigate the immunostimulatory activity of several polysaccharide compounds, we investigated the stimulation of lymphocytes proliferation, the generation of activated killer cells and the secretion of nitrites from activated macrophages. Results: Of polysaccharides tested, curdlan and ginsan stimulated lymphocyte proliferation, suggesting that the molecular weight and composition of polysaccharide are dependent on the mitogenic activity. The production of nitric oxide was significantly increased in curdlan, levan, ginsan and its fraction, indicating that fructan has also capacity to activate macrophages and may devote to kill pathogens. In addition, the activation of macrophages was seemed to be independent of molecular weight of polysaccharide. The generation of AK cells was exhibited in order of curdlan, OK-432> F1, ginsan, F3> levan> etc. The AK activity may be dependent on molecular weight and composition of polysaccharides. Conclusion: Unfortunately, purified polysaccharide from ginsan were less active on immunostimulatory activity than mixed compounds of polysaccharides. From the viewpoint of structure and activity relationships, we found several characteristic features.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제5권10호
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• pp.1830-1840
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• 2011

CDISC (Clinical Data Interchanging Standards Consortium) standards are to support the acquisition, exchange, submission and archival of clinical trial and research data. SDTM (Study Data Tabulation Model) for Case Report Forms (CRFs) was recommended for U.S. Food and Drug Administration (FDA) regulatory submissions since 2004. Although the SDTM Implementation Guide gives a standardized and predefined collection of submission metadata 'domains' containing extensive variable collections, transforming CRFs to SDTM files for FDA submission is still a very hard and time-consuming task. For addressing this issue, we developed metadata based SDTM mapping rules. Using these mapping rules, we also developed a semi-automatic tool, named CDISC Transformer, for transforming clinical trial data to CDISC standard compliant data. The performance of CDISC Transformer with or without MDR support was evaluated using CDISC blank CRF as the 'gold standard'. Both MDR and user inquiry-supported transformation substantially improved the accuracy of our transformation rules. CDISC Transformer will greatly reduce the workloads and enhance standardized data entry and integration for clinical trial and research in various healthcare domains.

• 해운물류연구
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• 제34권4호
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• pp.677-694
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• 2018

해양은 도시와 연계되어 교류의 공간으로 활용되고 유기적 관계를 형성하며 인간과 친수 공간을 구성한다. 해양치유산업은 의료와 웰빙으로 삶의 질을 개선하는 융합 부분으로 부가가치를 창출하고 의료산업과 결합 되어가는 미래 산업이다. 해양치유산업의 정책 분석결과는 다음과 같다. 첫째, 해양치유산업 운영이 가장 높다. 종합 중요도는 제1순위가 해양친수공간에 해양치유산업 운영의 부분의 전문의료서비스 병원형이다. 해양치유시설 개발과 산림치유 연결성을 강화하는 내용으로 구성하고 의료기술의 고도의 전문화된 전문의료서비스 개발이 필요하다. 둘째, 제2순위는 해양치유산업 특성화에서 가치창조성이다. 해양치유효과에 대한 새로운 가치창조성을 위하여 의 신약학 연구개발 등 통합적이고 체계적인 정책이 진행되어야 한다. 셋째, 해양치유산업의 정책 개발을 위하여서는 세분화된 시장의 가능성을 탐색 할 필요가 있으며 본 연구는 세부항목에 관한 구체적 정책제안에 한계를 가지고 있다.

• 대한장애인치과학회지
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• 제9권1호
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• pp.56-65
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• 2013

I participated in Academic Exchange Program(Action plan II) between KADH(Korean Association for Disability and Oral Health) and JSDH(Japanses Society for Disability and Oral Health) for 2 months from 3rd July 2012 to 2nd september 2012 in the Department of Hygiene and Oral Health, School of Dentistry, Showa University at Tokyo, Japan. I have observed their operation process and learned what dysphagia is and how it is consulted and taken care of as a therapy for patients with eating and swallowing disorders for two months in The department of special needs dentistry at Showa University Dental Hospital, Jonan Branch of Tokyo Metropolitan Kita Medical Rehabilitation Center for the Disabled, Smile Nakano Center, Tokyo metropolitan center for persons with disabilities in Lidabashi for one week, Eating and swallowing functional therapy workshop for disabled children, Tokyo metropolitan Tobu medical center for Persons with Developmental/Multiple Disabilities located in Minamisunamitchi for one week and on The 17-18th JSDR(Japanese Society of Dysphagia rehabilitation) in Sapporo. Through Action Plan II program, I learned how precious eating, drinking and swallowing with ease are and observed how they do and what they do as a dentist or a dental hygienist in Japan for dysphagia patients. Therefore, I want to present the dental approaches of children with dysphagia in Japan, based on my experience for two months.

• Parasites, Hosts and Diseases
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• 제56권2호
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• pp.199-203
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• 2018

The cutaneous myiasis has been rarely reported in the Republic of Korea. We intended to describe here a case of furuncular cutaneous myiasis caused by Cordylobia anthropophaga larvae in a Korean traveler returned from Central Africa. A patient, 55-year-old man, had traveled to Equatorial Guinea, in Central Africa for a month and just returned to Korea. Physical examinations showed 2 tender erythematous nodules with small central ulceration on the left buttock and thigh. During skin biopsy, 2 larvae came out from the lesion. C. anthropophaga was identified by paired mouth hooks (toothed, spade-like, oral hooklets) and 2 posterior spiracles, which lack a distinct chitinous rim. Although rarely described in Korea until now, cutaneous myiasis may be encountered more frequently with increasing international travel and exchange workers to tropical areas.

• 한국실내디자인학회논문집
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• 제22권4호
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• pp.158-166
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• 2013

The purpose of this study is to suggest a direction for eco-friendly healing space design for healthcare facilities in the future. Theoretical review and case study on the concept of sustainable design, spatial expression and behavioral affordance were used as research method. Through these reviews, the 3 elements of the total healing environment -physical, psychological and social- have correspondence with elements of spatial expression; Refuge, Flow, Prospect and Void. And these are related to the eight kinds of Behavioral affordance which are subdivided into WORK&STUDY, REST, CIRCULATION, VISUAL SEQUENCE, SOCIAL EXCHANGE, REFRESHMENT, COMMUNITY and MEDITATION. And the concept of sustainable design consists of 6 principles ; Natural system, People, Place, The cycle of life, Energy & natural resources and Process. Through correlation analysis of behavioral affordance and 6 principles, the result of this study presents that the physical elements of the total healing space was mainly associated with the principles of people, place and the cycle of life. Psychological element was related to principle of natural system, human, place and process. And social element was associated with the principles of human, place and process. According to this analysis, the case study of four low-rise eco-friendly medical facilities was undertaken. Sustainability was evaluated in total healing environmental through this case study.

• Tuberculosis and Respiratory Diseases
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• 제59권1호
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• pp.5-13
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• 2005

COPD는 비가역적인 기류제한을 특징으로 하는 질병의 상태이다. 이러한 기류제한은 유해입자나 가스등에 대한 폐의 비정상적인 염증반응과 관련되어 있고 자연경과 중 지속적으로 진행하는 양상을 띤다. 비정상적인 염증반응 및 단백분해효소와 항단백분해효소간의 불균형과 산화 스트레스 등의 기전에 의해 점액의 과분비, 섬모의 기능장애, 소기도의 섬유화와 협착, 폐실질의 파괴, 폐혈관손상 등이 발생한다. 이러한 병리학적 변화에 의해 기류제한이 발생하고 가스교환 장애, 폐고혈압, 폐성심, 전신적인 염증이나 골격근의 기능장애 등이 유발된다. COPD 환자의 일반적인 증상인 기침, 객담, 호흡곤란 등은 이러한 병태생리학적 변화로 설명할 수 있다.

• 대한디지털의료영상학회논문지
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• 제7권1호
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• pp.33-38
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• 2005

Modern hospitals have been greatly facilitated with information technology (IT) such as hospital information system (HIS). One of the most prominent achievements is medical imaging and image data management so-called Picture Archiving and Communication Systems (PACS). Due to inevitable use of diagnostic images (such as X-ray, CT, MRI), PACS made tremendous impact not only on radiology department but also nearly all clinical departments for exchange and sharing image related clinical information. There is no doubt that better use of PACS leads to highly efficient clinical administration and hospital management. However, due to rapid and widespread acceptance of PACS storage and management of digitized image data in hospital introduces overhead and bottleneck when transferring images among clinical departments within and/or across hospitals. Despite numerous technical difficulties, financing for installing PACS is a major hindrance to overcome. In addition, a mirroring or a clustering backup can be used to maximize security and efficiency, which may not be considered as cost-effective approach because of extra hardware expenses. In this study therefore we have developed a new based on grid of distributed PACS in order to balance between the cost and network performance among multiple hospitals.