• 암석학회지
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• 제26권2호
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• pp.127-141
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• 2017

거창지역의 쥬라기 화강암에 대하여 결의 특성에 대한 분석을 실시하였다. 박편의 확대사진(${\times}6.7$) 및 간격-누적빈도 도표에서 도출한 미세균열의 간격과 관련된 파라미터를 통하여 여섯 방향의 결에 대한 다기준 평가를 실시하였다. 결에 대한 이들 간격의 파라미터의 대표 값에 대한 분석 결과를 요약하면 다음과 같다. 첫째로, 여섯 도표 사이의 배열순을 지시하는 주요 파라미터의 도출을 위한 분석을 수행하였다. 위의 분석을 위하여 여섯 방향의 결에 대한 5개 파라미터의 값에 대하여 증가 또는 감소하는 순으로 배열하였다. 주요 파라미터(평균 간격-중앙 간격, $S_{mean}-S_{median}$) 및 평균 간격의 값이 감소하는 순은 H1, H2, G1, G2, R1 그리고 R2 방향의 순과 상호 부합한다. 여섯 방향의 결의 이러한 순차적인 배열은 간격과 관련된 여섯 도표의 순차적인 배열에 대한 근거를 제공할 수 있다. 둘째로, 위의 주요 파라미터 그리고 다양한 파라미터 사이의 9개 상관도를 상관계수($R^2$)가 감소하는 순으로 배열하였다. 이들 관련도는 공통적으로 멱법칙함수의 높은 상관성을 보여 준다. 평균 간격, 밀도 및 선 oa의 길이의 값은 주요 파라미터의 값과 정비례하지만, 반면에 상수(a), 지수(${\lambda}$), 간격의 빈도수(N), 선 oa'의 길이, 지수 직선의 기울기(${\theta}$) 및 총 길이($1mm{\geq}$)는 반비례한다. 셋째로, 3개 면에 대한 파라미터의 값 그리고 3개 결에 대한 파라미터의 값 사이의 상관성 분석의 결과는 다음과 같다. 3개 면 및 3개 결에 대한 빈도수, 총 간격, 상수, 지수, 기울기, 선 oa' 길이의 값은 R' < G' < H' 및 H < G < R의 순을 각각 보여 준다. 반면에, 3개 면 및 3개 결에 대한 평균 간격, (평균 간격 - 중앙 간격), 밀도 및 선 oa의 길이의 값은 H' < G' < R' 및 R < G < H의 순을 각각 보여 준다. 3개 결 및 3개 면 사이의 파라미터의 값의 상호 역순의 상관성이 도출될 수 있다. 이러한 유형의 상관성 분석은 3개 채석면의 판별에 유용하다.

• 기술사
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• 제20권3호
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• pp.15-25
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• 1987

Statistical control charts are useful tools to monitor and control the manufacturing processes and are widely used in most Korean industries. Many Korean companies, however, do not always obtain desired results from the traditional control charts by Shewhart such as the X-chart, X-chart, X-chart, etc. This is partly because the quality charterstics of the process are not distributed normally but are skewed due to the intermittent production, small lot size, etc. In Shewhart X-chart, which is the most widely used one in Korea, such skewed distributions make the plots to be inclined below or above the central line or outside the control limits although no assignable causes can be found. To overcome such shortcomings in nonnormally distributed processes, a distribution-free type of confidence interval can be used, which should be based on order statistics. This thesis is concerned with the design of control chart based on a sample median which is easy to use in practical situation and therefore properties for nonnormal distributions may be easily analyzed. Control limits and central lines are given for tile more famous nonnormal distributions, such as Gamma, Beta, Lognormal, Weibull, Pareto, Truncated-normal distributions. Robustness of the proposed median control chart is compared with that of the X-chart, the former tends to be superior to the latter as the probability distribution of the process becomes more skewed. The average run length to detect the assignable cause is also compared when the process has a Normal or a Gamma distribution for which the properties of X are easy to verify, the proposed chart is slightly worse than the X-chart for the normally distributed product but much better for Gamma-distributed products. Average Run Lengths of the other distributions are also computed. To use the proposed control chart, the probability distribution of the process should be known or estimated. If it is not possible, the results of comparison of the robustness force us to use the proposed median control chart based on a normal distribution. To estimate the distribution of the process, Sturge's formula is used to graph the histogram and the method of probability plotting, $X^2$-goodness of fit test and Kolmogorov-Smirnov test, are discussed with real case examples. A comparison of the propose4 median chart and the X chart was also performed with these examples and the median chart turned out to be superior to the X-chart.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.4127-4131
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• 2015

Background: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. Materials and Methods: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy. Efficacy and toxicity results were evaluated retrospectively. Results: The median age of patients was 46 (range 27-67). Fourteen patients (26%) had metastases at the time of diagnosis. All of the patients had received trastuzumab in an adjuvant or metastatic setting, while 16 (30%) had received two lines of trastuzumab. All patients had received lapatinib plus capecitabine. The median chemotherapy line for the metastatic setting was 2 (range 1-7). Cranial metastases were identified in 27 (50%) patients. 53 patients received trastuzumab-based chemotherapy following lapatinib progression while one patient received trastuzumab monotherapy. Combination chemotherapy consisted of navelbin (n=33), taxane (n=10), gemcitabine (n=2), platinum (n=2) and platinum with taxane (n=6). The median treatment cycle was 5 (range 1-44). Among 49 patients assessed for response 2 (4%) showed CR, 12 (25%) PR, 11 (22%) SD and 24 (49%) disease progression. Asymptomatic cardiotoxicity was reported in 2 (4%) of the patients. At a median follow-up of 9 months (1-39), median progression-free survival was 5 months (95% CI 4.1-5.9) and median overall survival was 10 months (95% CI 6.9-13.0). PFS and OS were not affected by the absence/presence of cranial metastases. Conclusions: Retreatment with trastuzumab-based therapy after lapatinib progression showed efficacy in heavily treated MBC patients.

• 산업경영시스템학회지
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• 제10권16호
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• pp.101-106
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• 1987

Statistical control charts are useful tools to monitor and control the manufacturing processes and are widely used in most Korean industries. Many Korean companies, however, do not always obtain desired results from the traditional control charts by Shewhart such as the $\bar{X}$-chart, $\bar{X}$-chart, $\bar{X}$-chart, etc. This is partly because the quality charterstics of the process are not distributed normally but are skewed due to the intermittent production, small lot size, etc. In Shewhart $\bar{X}$-chart. which is the most widely used one in Kora, such skewed distributions make the plots to be inclined below or above the central line or outside the control limits although no assignable causes can be found. To overcome such shortcomings in nonnormally distributed processes, a distribution-free type of confidence interval can be used, which should be based on order statistics. This thesis is concerned with the design of control chart based on a sample median which is easy to use in practical situation and therefore properties for nonnormal distributions may be easily analyzed. Control limits and central lines are given for the more famous nonnormal distributions, such as Gamma, Beta, Lognormal, Weibull, Pareto, Truncated-normal distributions. Robustness of the proposed median control chart is compared with that of the $\bar{X}$-chart; the former tends to be superior to the latter as the probability distribution of the process becomes more skewed. The average run length to detect the assignable cause is also compared when the process has a Normal or a Gamma distribution for which the properties of X are easy to verify, the proposed chart is slightly worse than the $\bar{X}$-chart for the normally distributed product but much better for Gamma-distributed products. Average Run Lengths of the other distributions are also computed. To use the proposed control chart, the probability distribution of the process should be known or estimated. If it is not possible, the results of comparison of the robustness force us to use the proposed median control chart based oh a normal distribution. To estimate the distribution of the process, Sturge's formula is used to graph the histogram and the method of probability plotting, $\chi$$^2$-goodness of fit test and Kolmogorov-Smirnov test, are discussed with real case examples. A comparison of the proposed median chart and the $\bar{X}$ chart was also performed with these examples and the median chart turned out to be superior to the $\bar{X}$-chart.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7171-7177
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• 2013

Purpose: To compare the safety and efficacy of first-line chemotherapy regimen with or without doxorubicin in treating patients with advanced soft tissue sarcoma (STS). Patients and Methods: We retrospectively analyzed a cohort of 56 patients histologically confirmed with STS who were treated at Jiangsu Cancer Hospital and Research Institute from July 2011 to June 2012.The basic element of first line chemotherapy contained epirubicin in group B and lacked epirubicin in group A. Response was assessed using RECIST criteria. The Kaplan-Meier method was used to estimate progress free survival (PFS). Results: According to RECIST criteria, patients in group treated by chemotherapy without epirubicin, the objective response (OR) ratio was 6.5 % (CR0%+PR6.5%). Disease control rate (DCR=CR+PR+SD) was 25.8% with a median follow-up of 14.6 months, including 2 patients achieving a partial response (PR 6.5%) and a stable response (SD 19.4%) in 6. In group B with epirubicin based regimens, no patient had complete response, PR (28 %) was observed in 7 and SD (24 %) in 6. DCR was observed in 13 patients (52%). By Fisher's exact test, the DCR difference between the two groups was statistically significant (p=0.046). In group A, median PFS was 3.0 months (95%CI:2.1-3.8), compared with 4.0 months (95% CI:3.03-4.97) in group B (p=0.0397 by log-rank test). Epirubicin based chemotherapy and ECOG performance status 0-1 were identified as favorable factors for progression in our cohort of patients. Differences of nonhematologic and hematologic toxicities were not statistically significant between the two groups, and the addition of epirobicin was not associated with cardiac toxicity (p=0.446). Conclusion: Our study demonstrates that epirubicin-based chemotherapy is effective and well tolerated, and is superior to chemotherapy without epirubicin regarding efficacy. Therefore it is recommended that epirubicin-based chemotherapy should be considered as first line for patients with advanced STS.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.339.2-339.2
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• 2016

본 연구에서는 Ti/Al/Ti 금속 배선의 Electro-Migration(EM) 현상을 분석했다. Van der Pauw, Greek Cross bridge, Straight line linear line bridge를 결합한 패턴을 제작하여, 온도 변화에 따른 EM의 발생 시간(Failure Time)을 측정했다. 측정 조건은 W/L=3.5/300 um 소자에 전류 밀도(current density)를 $J=10^4A/cm^2$로 고정하고, 온도를 300 K, 350 K, 400 K로 가변 시켰다. 측정된 Cumulative Failure의 50 % 되는 지점(Median Time To Failure; MTTF)은 각각 22.3시간, 18.46시간, 15.4시간으로 온도가 300 K에서 400 K로 증가함에 따라 MTTF가 6.9시간 감소했다. 이 결과를 통해 Black방정식에서 온도 변수가 $t_{50}$에 영향을 주는 것을 확인했다. 온도가 증가함에 따라 더 많은 전자들이 원자에 충돌하면서 운동량을 전달하고, 더 많은 원자들이 이주되면서 EM 발생 시간이 감소했다.

• 대한한의학회지
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• 제20권2호
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• pp.157-164
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• 1999

This study focused on the method of interpreting Moire's topography. There has been no standard of interpretation which informed, this study, The conclusions arc as follows: Miore's image closed contour lines which is consisted of points. These points in one contour have the same distances from the screen to the patient's back. Moire's index means the number of contour gaps from symmetrical point of a specific point with the axis of central line. The number of contours which pass the median line means the degree of antero-posterior curvature.

• 한국의류학회지
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• 제18권5호
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• pp.628-636
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• 1994

One vertical (medianus) and six horizontal (chest, bust, below bust, waist, abdomen and hip) sections of nine healthy pregnant women were examined every month by siliding gauge method during the period from 3rd to loth monthes of pregnancy. In the body changes along the passing months of pregnancy, which were observed by a follow·up measurement, there was little change on the posterior line when viewed using a vertical cross section. On the contrary, there was a great deal of increase on the anterior median line. Particularly, the degree of protrusion was great in the waist and ubilicus area due to pregnancy. At early pregnancy the distance from front to back is much shorter than side to side, however, as pregnancy progressed the front to back distance, on a horizontal cross section, is almost equal to the side to side distance.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1999년도 제14차 학술회의논문집
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• pp.194-197
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• 1999

Automatic weld bead removal system is consisted of bead removal tool, bead profile measurement system and tool motion control system. In this paper, design of weld bead profile measurement system which is used for automatic weld bead removal system is described. The system measures the weld bead position, normal vector of the auto-body and weld bead profile. The optical sensor with structured laser beam is used as a sensor and comparison of the sensor that can be used for this purpose is discussed in detail. The measurement process and the related software developed for this purpose are also described. A median filter, average filter and long line filters are used and their effects in bead profile measurement are discussed. The measurement system is integrated into automatic bead removal system and is used to remove weld bead in rear pillar of automotive body. The whole system operates well in automotive body assembly line and thus the system is proved to be good for this purpose.

• 한국항공운항학회지
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• 제17권1호
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• pp.46-51
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• 2009

This paper presents results from field studies carried out to monitor off-target droplet movement of endosulfan insecticide applied to the Korea chestnut tree area. As a results, mean airborne drift values were recorded 25m as average from downwind of a single flight line(sample line) in mountain terrain and mean effective swath width was recorded 19.5m as average in a plain. In terms of characteristics of geography of Korea aerial application is mainly carried out in mountain terrain. The equipment, weather conditions, and appropriate aerial spray technic are required for effective aerial application. In particular, the pilot can get effective results when he only sprays with consideration of environment factors since there is much turbulence in mountain terrain. Eventually, the most effective factor of droplets drift is to estimate the local weather conditions exactly.