• Molecular & Cellular Toxicology
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• 제4권3호
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• pp.218-223
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• 2008

Oxidative stress is believed to contribute to the neuronal damage induced by cerebral ischemia/reperfusion injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of hydroxyfullerene (a radical absorbing cage molecule) against neuronal death in hippocampal CA1 neurons following transient global cerebral ischemia in the rat. Transient global cerebral ischemia was induced in male Wistar rats by four vessel- occlusion (4VO) for 10 min. Lipid peroxidation in brain tissues was determined by measuring the concentrations of thiobarbituric acid-reactive substances (TBARS). Furthermore, the apoptotic effects of ${H_2}{O_2}$ on PC12 cells were also investigated. Cell viabilities were measured using MTT [3-(4,5-dimethylthiazolyl-2)-2,-5-diphenyltetrazolium bromide] assays. Hydroxyfullerene, when administered to rats at 0.3-3 mg/kg i.p. at 0 and 90 minutes after 4-VO was found to significantly reduce CA1 neuron death by 72.4% on hippocampal CA1 neurons. Our findings suggest that hydroxyfullerene protects neurons from transient global cerebral injury in the rat hippocampus by reducing oxidative stress and lipid peroxidation levels, which contribute to apoptotic cell death.

• Journal of Korean Neurosurgical Society
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• 제48권1호
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• pp.53-58
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• 2010

Objective : The purpose of this study was to review the safety and durability of aneurysms treated with stent-assisted coiling of ruptured anterior communicating artery aneurysms with small parent vessels (< 2.0 mm). Methods : Retrospective review of all ruptured aneurysm treated with stent assisted endovascular coiling between March 2005 and March 2009 at our institution was conducted. We report 11 cases of the Neuroform stent placement into cerebral vessels measuring less than 2.0 mm in diameter (range, 1.3-1.9 mm) in anterior cerebral artery. Clinical follow-up ranged from 3 to 12 months and imaging follow-up was performed with cerebral angiography at 6 months and 12 months after discharge. Results : Complete occlusion was achieved in 10 patients, and a remnant neck was evident in one. No stent displacement or no dislodgement occurred during stent placement. There was no evidence of thromboembolic complication, arterial dissection and spasm during procedure. We performed follow-up angiography in all patients at 6 months and/or 12 months from the first procedure. The follow-up angiographic data showed successfully results except one in-stent stenosis case. All patients improved clinical performances except one patient with severe vasospasm who showed poor clinical condition initially. Conclusion : We have safely and successfully treated 11 vessels smaller than 2.0 mm in diameter with self-expanding stents with good short and intermediate term results. More clinical data with longer follow-ups are needed to establish the role of stent-assisted coiling in ruptured aneurysms with small parent vessels.

• Nuclear Engineering and Technology
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• 제33권5호
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• pp.526-538
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• 2001

Fatigue tests in air and in room temperature water were performed to obtain comparable data and stable crack measuring conditions. In air environment, fatigue crack growth rate was increased with increasing temperature due to an increase in crack tip oxidation rate. In room temperature water, the fatigue crack growth rate was faster than in air and crack path varied on loading conditions. In simulated light water reactor (LWR) conditions, there was little environmental effect on the fatigue crack growth rate (FCGR) at low dissolved oxygen or at high loading frequency conditions. While the FCGR was enhanced at high oxygen condition, and the enhancement of crack growth rate increased as loading frequency decreased to a critical value. In fractography, environmentally assisted cracks, such as semi-cleavage and secondary intergranular crack, were found near sulfide inclusions only at high dissolved oxygen and low loading frequency condition. The high crack growth rate was related to environmentally assisted crack. These results indicated that environmentally assisted crack could be formed by the Electrochemical effect in specific loading condition.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2017년도 공동학술발표회
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• pp.255-255
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• 2017

본 연구에서는 고속으로 활주하는 선박의 승선감 향상 및 운항성능 특성 연구를 위해 30ton급 세관감시정의 측정위치에 따른 멀미도 해석을 수행하였다. 특히, 관공선내의 선원들은 유사시에 신속 정확한 판단이 요구되므로 측정위치에 따른 멀미도의 영향에 대한 연구가 필요할 것으로 판단하였다. 멀미도 평가는 ISO 2631-3(1985)을 기준으로 하였다. 평가 기준은 30분, 2시간, 8시간 이후 성인 100명 중 10명이 멀미를 한다는 국제표준 지표이며 조우주파수와 수직가속도 성분으로 나타난다. 멀미도 해석은 Maxsurf Motion 모듈을 이용하였다. 30ton급 세관감시정은 고속활주형 선박의 특성을 갖기 때문에 선속에 따른 트림변화를 고려하였다. 입사각은 선체 전 방향에서의 영향을 고려한 범위로 선정하였다. 선속의 경우 선박 운용상태(정박, 저속, 고속)을 고려하여 적용하였다. 측정위치의 경우 선원들의 주 활동 구역을 고려하여 선정하였다. 해석결과 멀미도의 영향은 30knot, $180^{\circ}$의 경우에 가장 크게 분석되었다.

• 대한조선학회논문집
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• 제56권2호
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• pp.117-127
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• 2019

Vessel's ice speed performances will be verified in ice sea trial but environmental conditions of ice fields are changeable according to the weather condition of ice trial area. Speed performance has to correct in the no wind, wave and current etc. after sea trial. Especially finding ice fields which is exact the same as owner's ice thickness and strength requirements is not easy. Therefore speed correction according to environment condition has to be done after sea trial measurements. Correction methods for ice thickness, ice strength, wave, wind and ship draft, trim, ice drift etc. are checked in ice sea trial based on literature review such as ISO standard, ITTC recommendation, journal papers and proceedings of conferences. Possibility of application for current and ice drift correction in ice field are discussed and measuring schemes and procedures of correction methods are described in this paper. All of correction schemes are calculated for 'Araon' which is ice breaking research vessel with Arctic and Antarctic ice field test results. Analyzed results shows that Araon is satisfied with her official ice speed performance of 3 knots with 10MW power at 1m ice thickness, 570kPa ice flexural strength.

• 대한본초학회지
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• 제28권2호
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• pp.1-7
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• 2013

Objectives : Sesamin, a major lignan in sesame seeds, has been reported to have neuroprotective effects against in vitro ischemia and in vivo MCAo-reperfusion cerebral ischemia model, however, there is no reports in an in vivo global cerebral ischemia model. The purpose of the study was to investigate the neuroprotective effect of sesamin in global cerebral ischemia induced by four-vessel occlusion (4-VO) in rats through inhibition of microglial activation in this model. Methods : The neuroprotective effects were investigated using a 10 min of 4-VO ischemia rat model by measuring intact pyramidal neurons in the CA1 region of the hippocampus using Nissle staining. The antiinflammatory or reducing neurotoxicity effect was investigated using immunohistochemisty, RT-PCR and western blot analysis of inflammatory or neurotoxic mediators. Results : Intraperitoneal injection of sesamin at doses of 0.3, 1.0, 3.0, and 10.0 mg/kg at 0 min and 90 min after ischemia conferred 26.6%, 30.1%, 42.5%, and 30.5% neuroprotection, respectively, compared to the vehicle-treated control group. A 3.0 mg/kg dose of sesamin inhibited microglia activation and consequently, cyclooxygenase-2, inducible nitric oxide, and interleukine-$1{\beta}$ expressions at 48 h after reperfusion. Conclusions : Sesamin protects neuronal cell death through inhibition of microglial activation or the production of neurotoxic metabolites and proinflammatory mediators by microglia such as COX-2, iNOS and IL-$1{\beta}$ in global cerebral ischemia.

• 한국의학물리학회지:의학물리
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• 제8권1호
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• pp.75-82
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• 1997

인체의 생리기관의 운동은 매우 복잡하고 불규칙적인 운동을 보이고 있다. 특히 말초 혈관의 운동은 매우 민감하고 복잡한 운동특성을 보이고 있다. 그중에서도 당 (glucose)에 의한 운동은 매우 민감한 변화의 운동을 반응한다. 이런 운동을 분석하기에는 기존의 선형적인 분석방법으로 복잡한 혈류운동을 분석하고 예측하기에는 많은 문제점을 가지고 있다. 그래서 비선형적 운동계의 분석방법인 카오스이론의 시계열분석방법으로 분석하는 것이 적합하다. 이런 맥락으로 본 연구는 당의 주입에 의한 토끼의 말초혈류량의 스칼라적 데이터를 획득하여 시계열분석방법으로 다차원의 벡터로 재정의하여 말초혈관의 혈류운동이 카오스적 운동임을 재확인하고 비선형적분석방법의 적합성을 확인하고자 하였다. 그 결과 당 주입에 따른 혈당치의 변화에 따라 기존의 주파수분석 및 평균치분석에서 차이가 나타나지 않았지만 비선형적분석방법으로 분석한 결과 그 차이를 확인할수 있었고, 말초 혈류의운동이 카오스적현상을 보임을 확인하였다.

• Archives of Plastic Surgery
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• 제40권6호
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• pp.761-765
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• 2013

Background Partially resecting ribs of the recipient site to facilitate easy anastomosis of the internal mammary vessels to free flaps during breast reconstruction can cause chest wall pain or deformities. To avoid this, the intercostal perforating branches of the internal mammary vessels can be used for anastomosis. The purpose of this study was to investigate the location and size of the internal mammary perforator vessels based on clinical intraoperative findings and to determine their reliability as recipient vessels for breast reconstruction with microsurgical free tissue transfer. Methods Twelve patients were preoperatively screened for the presence of internal mammary perforators using Doppler tracing. After modified radical mastectomy was performed by a general surgeon, the location and size of the internal mammary perforator vessels were microscopically investigated. The external diameter was examined using a vessel-measuring gauge from a mechanical coupling device, and the distance from the mid-sternal line to the perforator was also measured. Results The largest arterial perforator averaged 1.5 mm, and the largest venous perforator averaged 2.2 mm. Perforators emerging from the second intercostal space had the largest average external diameter; the second intercostal space also had the largest number of perforators arising from it. The average distance from the mid-sternal line to the perforator was 20.2 mm. Conclusions Internal mammary perforators presented consistent and reliable anatomy in this study. Based on these results, the internal mammary perforators appear to have a suitable diameter for microvascular anastomosis and should be considered as an alternative recipient vessel to the internal mammary vessel.

• 한국항해항만학회지
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• 제26권2호
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• pp.221-226
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• 2002

표류지점 추정 모델의 환경 입력자료를 확보하기 위해 부산항 연근해에서 표류실험을 실시하였다. 실험에는 크기가 다른 4척의 선박(10, 20, 50, 90톤급)이 사용되었다. 그중 50톤급 선박에는 해류, 바람, 위치를 자동적으로 기록하는 계기들을 장착하였고, 나머지 선박들에서는 분산각 추정 연구를 위해 위치자료만 기록하였다. 각 선박들의 위치는 DGPS와 자동위치발신기(APRS)를 사용하여 기록하였다. 실험은 풍속 2~10m/s, 유속 0.5~1.5m/s의 환경에서 행하여졌으며, leeway는 선박 표류속도에서 표층의 유속성분을 제거하여 구하였다. 50톤급 선박의 leeway rate는 풍속의 약 3.6%인 것으로 분석되었으며, leeway 방정식은 $U_L$ =0.042W -0.034로 표현되었고 leeway angle은 $-30^{\circ}$~$40^{\circ}$의 범위였다.

• 한국생산제조학회지
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• 제21권5호
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• pp.726-732
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• 2012

Pipe and Pressure Vessels that is used in power plant and chemical industry have many Internal Defects that is corrosion caused by the flow of fluid. These Internal Defects that have possibility of explosion are very dangerous because it can not see from the outside. This days many companys using NDT method to find an Internal Defect. Most of the NDT methods have limitations that are constraint of shape and materials. But Sheargoraphy have many advantages compared conventional NDT method. It has very fast measuring speed, non-destructive and non contacting measurement. As well as it hasn't constraint of shape and materials. As a paper on the analysis of measurement of error, the important factors were the Shearing Amount and pressure, and discovered measurement of the Internal Defect of the object by using shearography. The optimal Shearing Amount and pressure was discovered and utilized.