• Korean Journal of Radiology
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• v.22 no.11
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• pp.1764-1776
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• 2021

Objective: This study aimed to validate a deep learning-based fully automatic calcium scoring (coronary artery calcium [CAC]_auto) system using previously published cardiac computed tomography (CT) cohort data with the manually segmented coronary calcium scoring (CAC_hand) system as the reference standard. Materials and Methods: We developed the CAC_auto system using 100 co-registered, non-enhanced and contrast-enhanced CT scans. For the validation of the CAC_auto system, three previously published CT cohorts (n = 2985) were chosen to represent different clinical scenarios (i.e., 2647 asymptomatic, 220 symptomatic, 118 valve disease) and four CT models. The performance of the CAC_auto system in detecting coronary calcium was determined. The reliability of the system in measuring the Agatston score as compared with CAC_hand was also evaluated per vessel and per patient using intraclass correlation coefficients (ICCs) and Bland-Altman analysis. The agreement between CAC_auto and CAC_hand based on the cardiovascular risk stratification categories (Agatston score: 0, 1-10, 11-100, 101-400, > 400) was evaluated. Results: In 2985 patients, 6218 coronary calcium lesions were identified using CAC_hand. The per-lesion sensitivity and false-positive rate of the CAC_auto system in detecting coronary calcium were 93.3% (5800 of 6218) and 0.11 false-positive lesions per patient, respectively. The CAC_auto system, in measuring the Agatston score, yielded ICCs of 0.99 for all the vessels (left main 0.91, left anterior descending 0.99, left circumflex 0.96, right coronary 0.99). The limits of agreement between CAC_auto and CAC_hand were 1.6 ± 52.2. The linearly weighted kappa value for the Agatston score categorization was 0.94. The main causes of false-positive results were image noise (29.1%, 97/333 lesions), aortic wall calcification (25.5%, 85/333 lesions), and pericardial calcification (24.3%, 81/333 lesions). Conclusion: The atlas-based CAC_auto empowered by deep learning provided accurate calcium score measurement as compared with manual method and risk category classification, which could potentially streamline CAC imaging workflows.

• Journal of Environmental Science International
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• v.17 no.4
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• pp.397-403
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• 2008

The purpose of this study is to investigate weighted compaction density according to a leading density in truck, a compaction density of solid waste and composition ratios of solid waste fur calculation of a capacity of the landfill sites. The experiments for calculations of in-place density at landfill site have been conducted in S landfill site at B City. The size of vessel for measuring the compaction density was $1m^3(1m{\times}1m{\times}1m)$. The experiment tests have been carried out methods (1 time for bulldozer and 4 times for compactor) that do contain all of specification at the landfill site. Average of the loading density at the landfill site was $0.264\;ton/m^3$ ($0.113{\sim}0.487\;ton/m^3$). When the loading density for each compositions was compared, the composition of the highest average loading density ($0.474\;ton/m^3$) was miscellaneous wastes. The composition of the lowest average loading density ($0.120 ton/m^3$) was general solid waste. The reported results indicated that the compaction density at the landfill site was $0.538\;ton/m^3$, which was calculated with weighted incoming ratios of compositions. The ranges of the density for each composition were from $0.021\;ton/m^3$ to $0.221\;ton/m^3$. When the compaction density for each composition was compared, the composition with the highest average compaction density ($0.221\;ton/m^3$) was miscellaneous wastes. The composition with the lowest average compaction density ($0.021\;ton/m^3$) was general solid wastes.

• Journal of the Korean Society for Nondestructive Testing
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• v.25 no.4
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• pp.304-310
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• 2005

The techniques in order to measure the depth of defect in weldment and structure accurately have been developed. Many researches have made efforts to develop the methods for the accurate depth sizing of defect. TOFD is known as the most accurate method of various methods for measuring depth sizing. However, there is a possibility to miss defects because of the limitation of beam coverage for the ultrasound incident angle. In this study, the results for detectability and depth sizing using phased array ultrasonic technique for thick body were compared with those of conventional TOFD technique. It was experimentally confirmed that the phased array ultrasonic TOFD technique gives good detectability and accurate depth measurement for the various types of defects. The phased array ultrasonic TOFD technique developed in this study will contribute to increase the inspection reliability in thick component such as the pressure vessel of power generation industry.

• The Journal of Internal Korean Medicine
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• v.17 no.1
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• pp.34-50
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• 1996

The present experiment was desinged to investigate the effects of Tongdosan water extracts on the Cardiovascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral admini- stration. Measurment of Mortality rate was observed for measuring the effect of Tongdosan water extract. Tongdosan water extract against pulmonary thrombo- embolism induced by collagen the mixture(0.1ml/10g, 2mg/kg B.W) plus serotonin(5mg/kg B.W) in mouse. The effect of Tongdosan water extract was examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as followings. 1. Tongdosan dropped the blood pressure in spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which was led to thromboembo- lism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug reduced the fibrinogen lyses time of rat ex vivo assay and lyses area was increased. 8. Tongdosan reduced fibrinogen lyses time of rat in vitro assay. According to the above mentioned results, Tongdosan increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin acivity, inhibited the platelet aggregation.

• Journal of Sensor Science and Technology
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• v.20 no.5
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• pp.343-350
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• 2011

The compliance and stiffness of artery are closely related with disease of arteries. Pulse wave velocity(PWV) in the blood vessel is a basic and common parameter in the hemodynamics of blood pressure and blood flow wave traveling in arteries because the PWV is affected directly by the conditions of blood vessels. However, there is no standardized method to measure the PWV and it is difficult to measure. The conventional PWV measurement has being done by manual calculation of the pulse wave transmission time between coronary arterial proximal and distal points on a strip chart on which the pulse wave and ECG signal are recorded. In this study, a pressure sensor consisting of strain gauges is used to measure the blood pressure of arteries in invasive method and regular ECG electrodes are used to record the ECG signal. The R-peak point of ECG is extracted by using a reference level and time windowing technique and the ascending starting point of blood pressure is determined by using differentiation of the blood pressure signal and time windowing technique. The algorithm proposed in this study, which can measure PWV automatically, shows robust and good results in the extraction of feature points and calculation of PWV.

• The Journal of Internal Korean Medicine
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• v.18 no.1
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• pp.97-113
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• 1997

The present experiment was designed to investigate the effects of Sambutang water extracts on the serum cholesterol levels and the cardiovascular system in the experimental animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurment of Mortality rate was observed for measuring the effect of Sambutang water extract. Sambutang water extract against pulmonary thromboembolism induced by collagen the mixture(0.1 ml/10 g, 2 mg/kg) plus serotonin(5 mg/kg) in mouse. The effect of Sambutang water extract was examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as follows. 1. Sambutang decreased the serum cholesterol levels in rats. 2. Sambutang dropped the blood pressure in spontaneous hypertensive rat. 3. The drug increased the auricular blood flow in rabbit. 4. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 5. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 6. The drug inhibited the platelet aggregation in rat. 7. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 8. The drug increased the antithrombin activity in rat and the fibrinogen lysis time was reduced and lysis area was increased. 9. Sambutang reduced fibrinogen lysis time of rat in vitro assay. According to the above mentioned results. Sambutang increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin activity, inhibited the platelet aggregation.

• Ocean Systems Engineering
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• v.6 no.2
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• pp.143-159
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• 2016

Cargo, such as a Tension Leg Platform (TLP), Semi-submersible platform (Semi), Spar or a circular Floating Production Storage and Offloading (FPSO), are frequently dry-transported on a Heavy Lift Vessel (HLV) from the point of construction to the point of installation. The voyage can span months and the overhanging portions of the hull can be subject to frequent wave slamming events in rough weather. Tie-downs or sea-fastening are usually provided to ensure the safety of the cargo during the voyage and to keep the extreme responses of the cargo, primarily for the installed equipment and facilities, within the design limits. The proper design of the tie-down is dependent on the accurate prediction of the wave slamming loads the cargo will experience during the voyage. This is a difficult task and model testing is a widely accepted and adopted method to obtain reliable sea-fastening loads and extreme accelerations. However, it is crucial to realize the difference in the inherent stiffness of the instrument that is used to measure the tri-axial sea fastening loads and the prototype design of the tie-downs. It is practically not possible to scale the tri-axial load measuring instrument stiffness to reflect the real tie-down stiffness during tests. A correlation method is required to systematically and consistently account for the stiffness differences and correct the measured results. Direct application of the measured load tends to be conservative and lead to over-design that can reflect on the overall cost and schedule of the project. The objective here is to employ the established correlation method to provide proper high-frequency responses to topsides and hull design teams. In addition, guidance for optimizing tie-down design to avoid damage to the installed equipment, facilities and structural members can be provided.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.16 no.3
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• pp.290-301
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• 2006

A push pull hood system is frequently applied to control contaminants evaporated from an open surface tank. Efficiency of push pull hood system is affected by various parameters, such as, cross draft, vessel shapes, tank surface area, liquid temperature. A previous work assisted by flow visualization technique qualitatively showed that a strong cross draft blown from the pull hood to push slot could destroy a stable wall-jet on the surface of tank, resulting in the abrupt escape of smoke from the surface. In this study, the tracer gas method was applied to determine the effect of cross-draft on the capture efficiency qualitatively. A new concept of capture efficiency was introduced, that is, linear efficiency. This can be determined by measuring the mass of tracer gas in the duct of pull hood while the linear tracer source is in between push slot and pull hood. By traversing the linear tracer source from the push slot to the pull hood, it can be found where the contaminant is escaped from the tank. Total capture efficiency can be determined by averaging the linear efficiencies. Under the condition of cross-draft velocities of 0, 0.4, 0.75, 1.05 and 1.47m/s, total capture efficiencies were measured as 97.6, 95.4, 94.6, 92.7 and 70.5% respectively. The abrupt reduction of efficiency with cross-draft velocity of 1.47m/s was due to the destruction of tank surface wall-jet by the counter-current cross-draft. The same phenomenon was observed in the previous flow visualization study. As an alternative to overcome this abrupt efficiency drop, the 20% increase of hood flow rates was tested, resulting in 20% efficiency increase.

• The Journal of Internal Korean Medicine
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• v.16 no.1
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• pp.197-213
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• 1995

The present experiment was desinged to investigate the effects of Sopungtang water extracts on the Cardiovascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurments of Mortality rate were observed for measuring the effect of Sopungtang water extract. Sopungtang water extract against pulmonary thromboembolism induced by collagen the mixture(0.1ml/10g, 2mg/kg B.W) plus serotonin(5mg/kg B.W) in mouse. The effects of Sopungtang water extract were examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as followings. 1. Sopungtang dropped the blood pressure in spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug increased the antithrombin activity in rat and the fibrinogen lyses time was reduced and lyses area was increased. 8. Sopungtang reduced fibrinogen lyses time of rat in vitro assay. According to the above mentioned results, Sopungtang increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin acivity, inhibited the platelet aggregation.

• The Korea Journal of Herbology
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• v.21 no.4
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• pp.189-195
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• 2006

Objectives : It has been reported previously that the roots of Scutellaria baicalensis (known as Huang-Gum in Korean, henceforth referred to as S. baicalensis) could prevent neuronal cell death after global cerebral ischemia. In Genuine Korean medicine, S. baicalensis is known to relieve fever in upper body, and it was thus thought to be able to alleviate deteriorations in brain function. Methods : The protective effects of S. baicalensis against post-stroke memory retardation using 4-vessel occlusion model were examined in the present study. Results : S. baicalensis was shown to significantly alleviate the deficits in learning and memory by increasing the fraction of time spent in the quadrant in which the platform was initially placed ($34.9\;{\pm}\;3.2%$, p < 0.05) compared to that of the ischemia group ($28.0\;{\pm}\;2.5%$). The cytoprotective effect of S. baicalensis on CA1 hippocampal neurons was evaluated by measuring the neuronal cell density. Neuronal cell density in S. baicalensis extracts-treated ischemia group ($138.0\;{\pm}\;13.6\;cells/mm^2$) was significantly increased compared to saline-treated ischemia group ($22.1 \;{\pm}\;9.3\;cells/mm^2$, p < 0.05). In the study of OX-42 immunohistochemistry, S. baicalensis could decrease the micrgial activation in hippocampus after brain ischemia. Conclusion : These results may provide experimental support for the use of S. baicalensis in treating post-stroke memory impairment.