• 한국축산식품학회지
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• 제39권1호
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• pp.114-120
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• 2019

Response surface methodology (RSM) is a useful set of statistical techniques for modeling and optimizing responses in research studies of food science. As a design for a response surface experiment, a central composite design (CCD) with multiple runs at the center point is frequently used. However, sometimes there exist situations where some among the responses at the center point are outliers and these outliers are overlooked. Since the responses from center runs are those from the same experimental conditions, there should be no outliers at the center point. Outliers at the center point ruin statistical analysis. Thus, the responses at the center point need to be looked at, and if outliers are observed, they have to be examined. If the reasons for the outliers are not errors in measuring or typing, such outliers need to be deleted. If the outliers are due to such errors, they have to be corrected. Through a re-analysis of a dataset published in the Korean Journal for Food Science of Animal Resources, we have shown that outlier elimination resulted in the increase of the maximum possible R-square that the modeling of the data can obtain, which enables us to improve the quality of response surface analysis.

• Journal of Power Electronics
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• 제11권4호
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• pp.449-455
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• 2011

Electric drive vehicles (EDV) have received much attention recently because of their environmental and energy benefits. In an EDV, the motor drive system directly influences the performance of the propulsion system. However, the available DC voltage is limited, which limits the maximum speed of the motors. At high speeds, the inverter voltage increases if the square wave (SW) voltage (six-step operation) is used. Although conventional direct torque control (DTC) has several advantages, it cannot work in the six-step mode required in high-speed applications. In this paper, a single-mode seamless DTC for AC motors is proposed. In this scheme, the trajectory of the reference flux changes continuously between circular and hexagonal paths. Therefore, the armature voltage changes smoothly from a high-frequency switching pattern to a square wave pattern without torque discontinuity. In addition, because multi-mode controllers are not used, implementation is more straightforward. Simulation results show the voltage pattern changes smoothly when the motor speed changes, and consequently, torque control without torque discontinuity is possible in the field weakening area even with a six-step voltage pattern.

• Structural Engineering and Mechanics
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• 제85권5호
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• pp.635-644
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• 2023

The design of honeycomb sandwich structures is often challenging because these structures can be tailored from a variety of possible cores and face sheets configurations, therefore, the design of sandwich structures is characterized as a time-consuming and complex task. A data-driven computational approach that integrates the analytical method and Artificial Neural Network (ANN) is developed by the authors to rapidly predict the design of sandwich structures for a targeted maximum structural deflection. The elaborated ANN reverse design approach is applied to obtain the thickness of the sandwich core, the thickness of the laminated face sheets, and safety factors for composite sandwich structure. The required data for building ANN model were obtained using the governing equations of sandwich components in conjunction with the Monte Carlo Method. Then, the functional relationship between the input and output features was created using the neural network Backpropagation (BP) algorithm. The input variables were the dimensions of the sandwich structure, the applied load, the core density, and the maximum deflection, which was the reverse input given by the designer. The outstanding performance of reverse ANN model revealed through a low value of mean square error (MSE) together with the coefficient of determination (R2) close to the unity. Furthermore, the output of the model was in good agreement with the analytical solution with a maximum error 4.7%. The combination of reverse concept and ANN may provide a potentially novel approach in designing of sandwich structures. The main added value of this study is the elaboration of a reverse ANN model, which provides a low computational technique as well as savestime in the design or redesign of sandwich structures compared to analytical and finite element approaches.

• Biomolecules & Therapeutics
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• 제6권3호
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• pp.289-295
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• 1998

The bioequivalence of two nilvadipine products was evaluated in 16 normal male volunteers (age 22-32 yr, body weight 57-80 kg) following sidle oral dose. Test product was Overca $l_{R}$ tablet (Choong-Wae Pharm. Corp., Korea) and reference product was Nivadi $l_{R}$ tablet (Hyundai Pharm. Corp., Korea). Both products contain 4 mg of nilvadipine. One tablet of the test or the reference product was administered to the volunteers, respectively, by randomized two period cross-over study (2$\times$2 Latin square method). The determination of nilvadipine was accomplished using a validated capillary column GC with electron-capture detection. As a result of the assay validation, the quantiflcation of nilvadipine in human plasma by this technique was possible down to 0.5 ng/ml using 1 ml of plasma. Absolute overall recovery from five replicate analyses of nilvadipine-spiked sample were 88.4$\pm$ 10.24% (mean$\pm$ 5.D.) for human plasma of 10 ng/ml. The coefficients of variation (C.V.) were less than 20% and the actual concentration of nilvadipine measured by GC ranged from 80 to 99% in all plasma. Average drug concentrations at each sampling time and pharmacokinetic parameters calculated were not significantly different between two products (p>0.05); the area under the curve from time zero to 8 hr (AUCo-$_{8 hr}$) (22.8$\pm$5.90 vs 22.2$\pm$6.10 ng . hr/ml), maximum plasma concentration ( $C_{max}$) (10.0$\pm$2.85 vs 9.3$\pm$3.28 ng/ml) and time to reach maximum plasma concentration ( $T_{max}$) (1.2$\pm$0.31 vs 1.3 $\pm$0.47 hr). The differences of mean AU $Co_{8hr}$ $C_{max}$, and $T_{max}$ between the two products (2.25, 7.65, and 10.30%, respectively) were less than 20%. The power (1-$\beta$) and treaeent difference (7) for AU $Co_{8hr}$, and $C_{max}$ were more than 0.8 and less than 0.2, respectively. Although the power for Tmax was under 0.8, Tm\ulcorner of the two products was not significantly different from each other (p>0. 05). These results suggest that the bioavailability of Overeat tablet is not significantly different from that of Nivadil tablet. Therefore, two products are bioequivalent based on the current results.sults.lts.lts.lts.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제22권4호
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• pp.37-45
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• 2016

Purpose: The purpose of this paper is to analyze a sample of single corridor, pod type and composite type of ICUs in terms of patient visibility, spatial configurations and nurse walking distance focused on Korean cases. Methods: The measures of static visibility were used to quantify the patient visibility (upper third part of the patient bed) from the nurse station. The measure of space programme and area distribution (patient zone percentage, staff zone percentage, circulation zone percentage, corridor length per bed, distance from nurse station (NS) to patient bed and departmental gross square meter (DGSM) per patient bed) were calculated by using AutoCAD and MS Excel programs. In the second step of analysis the values of space distribution were compared among the three type of ICUs as well as the nurse walking distance, DGSM per bed and gross factor. in the third step of analysis regression analysis was conducted for the possible correlation between visibility and space programme and area distribution factors as well as nurse walking distance factors. Results: (1) It was found that on average composite type unit offer highest value of patient visibility followed by pod type, while single corridor type unit offers the minimum value of patient visibility among the three plan typologies. (2) Average patient visibility and DGSM per bed shows a strong positive correlation ($r^2=0.75$) and p=0.026. (3) Average patient visibility and average distance from NS has a strong negative correlation ($r^2=0.78$), and P=0.02. (4) On average composite type unit offer the minimum walking distance from NS (7.22 meter) followed by pod type unit (8.35 meter) and single corridor (9.76 meter). (5) Maximum distance from NS was noted in single corridor (18.19 meter) followed by pod type unit (15.14 meter) and Composite type unit (11.1 meter). Implications: This study may contribute to the visibility analysis of existing and future ICU design in Korea to achieve maximum patient visibility and reduced nurse walking distance.

• Biomolecules & Therapeutics
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• 제6권2호
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• pp.219-224
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• 1998

The bioequivalence of two clarithromvcin products was evaluated with 16 normal male volunteers (age 23-28 yr, body weight 57.5-75.517g) following single oral dose. Test product was ReYon Clarithromycin tablets (ReYon Pharm. Corp., Korea) and reference product was Klarici $d_{R}$ tablets (Abbott Korea). Both products contain 250 mg of clarithromucin. One tablet of the test or the reference product was administered to the volunteers, respectively, by randomized two period cross-over study (2$\times$2 Latin square method). The determination of clarithromycin was accomplished using a modified agar well diffusion bioassay. As a result of the assay validation, the quantification of clarithromycin in human serum by this technique was possible down to 0.03$\mu$g/ml using 100$\mu$l of serum. The coefficient of variation (C.V.) was less than 10%. Average drug concentrations at each sampling time and pharmacokinetic parameters calculated were not significantly different between two products P>0.05); the area under the curve to last sampling time (24 hr) (AU $Co_{24hr}$ (8.10$\pm$ 1.26 vs 8.22$\pm$ 1.627g . hr/ml), AUC from time zero to infinite (AU $Co_{\infty}$) (8.61 $\pm$ 1.28 vs 8.84$\pm$ 1.71 $\mu$g . hr/ml), maximum plasma concentration ( $C_{msx}$) (0.87$\pm$0.22 vs 0.88$\pm$0.19 $\mu$g/ml) and time to maximum plasma concentration ( $T_{max}$) (2.69 $\pm$0.48 vs 2.56$\pm$ 0.51 hr). The differences of mean AU $Co_{24h}$, $C_{msx}$ and $T_{msx}$ between the two products (1.44, 1.39, and 4.65%, respectively) were less than 20%. The power (1-$\beta$) and treatment difference ($\Delta$) for AU $Co_{24hr}$, and $C_{max}$ were more than 0.8 and less than 0.2, respectivly. Although the power for $T_{max}$ was under 0.8, $T_{max}$. of the two products was not significantly different each other (p>0.05). These results suggest that the bioavailability of ReYon Clarithromycin tablets is not significantly different from that of Klarici $d_{R}$ tablets. Therefore, two products are bioequivalent based on the current results. results.sults.sults.s.s.s.s.s.s.s.

• 핵의학기술
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• 제27권2호
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• pp.99-109
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• 2023

Purpose: CT scan makes up for the weak point of the nuclear medicine image having a low resolution and also were used for attenuation correction on image reconstruction. Recently, many studies try to make use of CT images additionally, one of them is to measure the bone mineral density(BMD) using Quantitative CT(QCT) software. BMD exams are performed to scan lumbar and femur with DXA(Dual-Energy X-Ray Absorptiometry) in order to diagnose bone disease such as osteopenia, osteoporosis. The purpose of this study is to identify the usefulness of QCT_BMD analyzed with low dose CT images on L-spine Bone SPECT/CT comparing with DXA_BMD. Materials and Methods: Fifty five women over 50 years old (mean 66.4 ± 9.1) who took the both examinations(L-spine Bone SPECT/CT with SIEMENS Intevo 16 and DXA scan with GE Lunar prodigy advance) within 90 days from April 2017 to July 2022, BMD, T-score and disease classification were analyzed. Three-dimensional BMD was analyzed with low dose CT images acquired on L-spine Bone SPECT/CT scan on Mindways QCT PRO^TM software and two-dimensional BMD was analyzed on DXA scan. Basically, Lumbar 1-4 were analyzed and the patients who has lesion or spine implants on L-spine were excluded for this study. Pearson's correlation analysis was performed in BMD and T-score, chi-square test was performed in disease classification between QCT and DXA. Results: On 55 patients, the minimum of QCT_BMD was 18.10, maximum was 166.50, average was 82.71 ± 31.5 mg/cm³. And the minimum of DXA-BMD was 0.540, maximum was 1.302, average was 0.902 ± 0.201 g/cm², respectively. The result shows a strong statistical correlation between QCT_BMD and DXA_BMD(p<0.001, r=0.76). The minimum of QCT_T-score was -5.7, maximum was -0.1, average was -3.2 ± 1.3 and the minimum of DXA_T-score was -5.0, maximum was 1.7, average was -2.0 ± 1.3, respectively. The result shows a statistical correlation between QCT T-score and DXA T-score (p<0.001, r=0.66). On the disease classification, normal was 5, osteopenia was 25, osteoporosis was 25 in QCT and normal was 10, osteopenia was 25, osteoporosis was 20 in DXA. There was under-estimation of bone decrease relatively on DXA than QCT, but there was no significant differences statistically by chi-square test between QCT and DXA. Conclusion: Through this study, we could identify that the QCT measurement with low dose CT images QCT from L-Spine Bone SPECT/CT was reliable because of a strong statistical correlation between QCT_BMD and DXA_BMD. Bone SPECT/CT scan can provide three-dimensional information also BMD measurement with CT images. In the future, rather than various exams such as CT, BMD, Bone scan are performed, it will be possible to provide multipurpose information via only SPECT/CT scan. In addition, it will be very helpful clinically in the sense that we can provide a diagnosis of potential osteoporosis, especially in middle-aged patients.

• International Journal of Computer Science & Network Security
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• 제22권11호
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• pp.308-318
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• 2022

Noise is a serious issue. While sending images via electronic communication, Impulse noise, which is created by unsteady voltage, is one of the most common noises in digital communication. During the acquisition process, pictures were collected. It is possible to obtain accurate diagnosis images by removing these noises without affecting the edges and tiny features. The New Average High Noise Density Median Filter. (HNDMF) was proposed in this paper, and it operates in two steps for each pixel. Filter can decide whether the test pixels is degraded by SPN. In the first stage, a detector identifies corrupted pixels, in the second stage, an algorithm replaced by noise free processed pixel, the New average suggested Filter produced for this window. The paper examines the performance of Gaussian Filter (GF), Adaptive Median Filter (AMF), and PHDNF. In this paper the comparison of known image denoising is discussed and a new decision based weighted median filter used to remove impulse noise. Using Mean Square Error (MSE), Peak Signal to Noise Ratio (PSNR), and Structure Similarity Index Method (SSIM) metrics, the paper examines the performance of Gaussian Filter (GF), Adaptive Median Filter (AMF), and PHDNF. A detailed simulation process is performed to ensure the betterment of the presented model on the Mini-MIAS dataset. The obtained experimental values stated that the HNDMF model has reached to a better performance with the maximum picture quality. images affected by various amounts of pretend salt and paper noise, as well as speckle noise, are calculated and provided as experimental results. According to quality metrics, the HNDMF Method produces a superior result than the existing filter method. Accurately detect and replace salt and pepper noise pixel values with mean and median value in images. The proposed method is to improve the median filter with a significant change.