• Title/Summary/Keyword: mass-scale production

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Effect of Cutting Conditions on Surface Roughness in CNC Lathe C-axis Milling Cutting (CNC선반 C축 밀링가공에서 표면 거칠기에 미치는 절삭조건의 영향)

  • Shin, Kuk-Sik
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.11 no.3
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    • pp.110-115
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    • 2012
  • For domestic aircraft industry, not mass production of components is limited, small production scale of the order is made by part because many kinds of hundreds of thousands of kinds of small quantity batch production system are taking. But the high reliability and stability are required during the processing because they require high precision parts are required. It is found that when C-axis rotation speed was increased, the diameter of the cutting tool decreased with increasing surface roughness, while the turn-mail feed rate was increased with increasing the surface roughness.

Mass Production and Identification of Anthocyanin in Cell Cultures of Euphorbia splendens Bojer (꽃기린 (Euphorbia splendens Bojer) 배양세포로부터 화청소의 대량생산 및 동정)

  • 선정훈;정재동
    • Korean Journal of Plant Tissue Culture
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    • v.21 no.2
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    • pp.77-84
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    • 1994
  • To assess the feasibility of anthocyanin production in cell cultures of Euphorbia splendens Bojer the role of sucrose in pigment production was investigated and pilot scale cultures were attempted to establish mass production system. And also, several instrumental analyses were conducted to identify the pigment extracted from cultured rolls. Anthocyanin production was promoted prominently with concenetrations of sucrose ranging from 3% to 9% while cell growth was maximized at 3% of sucrose . This suggested that high osmolarity of sucrose enhance pigment production. When cells were cultured in two types of bioreactor better cell growth was achieved with draft-type air lift bioreactor than impeller type bioreactor and the pigment productivity was reached to 2.2 mg/L/day. The major pigment extracted from cultured cells was characterized as cyanidin-3-glucoside.

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Optimization of Medium Components for Cell Mass Production of Saccharomyces cerevisiae JUL3 using Response Surface Methodology (반응표면분석법을 이용하여 Sacharomyces cerevisaeJUL3의 균체량 생산을 위한 배지조성 최적화)

  • Kim, Young-Hwan;Kang, Seong-Woo;Lee, Jong-Ho;Chang, Hyo-Ihl;Yun, Cheol-Won;Paik, Hyun-Dong;Kang, Chang-Won;Kim, Seung-Wook
    • KSBB Journal
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    • v.21 no.6 s.101
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    • pp.479-483
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    • 2006
  • [ ${\beta}-Glucan$ ], one of the cell wall components, is most plentiful polysaccharides in cell wall and has several advantages in immune system. In yeast ${\beta}-glucan$ is mainly contained in the yeast cell wall, and thus it is important to produce high levels of cell mass for the mass production of yeast ${\beta}-glucan$. The best carbon and nitrogen sources on cell mass production were high fructose syrup and yeast extract. Response surface methodology (RSM) was very potential tool for the optimization of process factor and medium component. It was applied to estimate the effects of medium components on the production of cell mass. Optimal concentrations of high fructose syrup and yeast extract by response surface methodology were 8.0% (v/v) and 5.2% (w/v), respectively and the cell mass predicted was $17.0\;g/{\ell}$ at 20 h of cultivation.

이송물체의 질량 측정 속도 및 정밀도 향상 모사 연구

  • 이우갑;정진완;김광표
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 1992.10a
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    • pp.161-165
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    • 1992
  • The important properties of industrial scale or weighing machine operated in production lines are quickness and precision. This paper presents an algorithm which meets the importance. The algorithm of Recursive Least Squares Regression is described for the weighing system simulated as a dynamic model of the second order. Using the model and the algorithm, model parameters and then the mass being weighed can be determined from the step input. The performance of the algorithm is illustrated in digital simulation. Discussions have been extended to the development of fast converging algorithm. It turns out that the algorithm shows several desirable features suitable for microcomputer assisted realtime signal processing.

Establishment of Scale-up Criterion for the Mass Production of $\beta$-D-Glucan

  • 곽중기;구재근;박성우;조만기
    • Proceedings of the Korean Society of Fisheries Technology Conference
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    • 2001.05a
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    • pp.207-208
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    • 2001
  • $\beta$-D-Glucan은 곡류(Fincher et al., 1975) 및 효모류(Machova et al., 1995)의 세포 구성성분으로 함암, 항균, 항바이러스 활성을 지닌 다당류이다(Trowell et al., 1976). 또한 면역활성 증강 및 식이 섬유 등의 생리적 활성이 우수하여 기능성 식품 소재로 활용 가능함이 보고되고 있고 현재 어류의 비특이 면역활성도 촉진시키므로 양식업계에서 주목받고 있는 물질이다(Sung et al., 1994). (중략)

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Strain Improvement and Bioprocess Optimization for Enhanced Production of Haluronic Acid(HA) in Bioreactor Cultures of Streptococcus zooepidemicus (히알루론산 생산성 향상을 위한 Streptococcus zooepidemicus 균주 개량 및 발효조 배양공정 최적화)

  • Kim, Soo Yeon;Chun, Gie-Taek
    • Microbiology and Biotechnology Letters
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    • v.48 no.3
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    • pp.344-357
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    • 2020
  • Strain improvement and bioprocess development were undertaken to enhance hyaluronic acid(HA) production by Streptococcus zooepidemicus cells. Using a high-yielding mutant strain, statistical medium optimization was carried out in shake flask cultures, resulting in 52% increase in HA production (5.38 g/l) at the optimal medium composition relative to the parallel control cultures. For sufficient supply of dissolved oxygen (DO), which turned out to be crucial for enhanced production of HA, agitation system and speed were intensively investigated in 5 L bioreactor cultures. Increase in oxygen mass transfer coefficient (kLa) through increment of agitation speed (rpm) and 35% expansion of diameter of the newly-designed impellers showed significantly positive effects on HA production. By installing an expanded Rushton-turbine impeller for efficient break-down of sparged air, and an extended marine impeller above the Rushton-turbine impeller for efficient mixing of the air-born viscous fermentation broth, maximum amount of HA (9.79 g/l) was obtained at 450 rpm, 1.8 times higher level than that of the corresponding flask culture. Subsequently, the possibility of bioprocess scale-up to a 50 L bioreactor was investigated. Despite almost identical maximum HA production (9.11 vs 9.25 g/l), the average HA volumetric productivity (rp) of the 50 L culture turned out only 74% compared to the corresponding 5 L culture during the exponential phase, possibly caused by shear damages imposed on the producing cells at the high stirring in the 50 L culture. The scale-up process could be successfully achieved if a scale-up criterion of constant oxygen mass transfer coefficient (kLa) is applied to the 50 L pilot-scale bioreactor system.

An assessment of responses to egg production and liver health of Japanese quails subjected to different levels of metabolizable energy

  • Diana Maryuri Correa, Castiblanco;Michele Bernardino, de Lima;Silvana Martinez Baraldi, Artoni;Erikson Kadoshe de Morais, Raimundo;Daniel Silva, Santos;Lizia Cordeiro, de Carvalho;Edney Pereira, da Silva
    • Animal Bioscience
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    • v.36 no.1
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    • pp.98-107
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    • 2023
  • Objective: Current quail production is configured as an economic activity in scale. Advancements in quail nutrition have been limited to areas such as breeding and, automation of facilities and ambience. The objective of this study was to evaluate the performance responses, liver and oviduct morphometry, and liver histology of Japanese laying quails subjected to different levels of nitrogen-corrected apparent metabolizable energy (MEn). Methods: A completely random design was used that consisted of nine levels of MEn, six replicates, and five hens per cage with a total of 270 quails. The experimental period lasted for 10 weeks. The variables of performance were subjected to analysis of variance and then regression analysis using the broken-line model. The morphometric and histological variables were subjected to multivariate exploratory techniques. Results: The MEn levels influenced the responses to zootechnical performance. The broken-line model estimated the maximum responses for feed intake, egg production, egg weight, and egg mass as 3,040, 2,820, 1,802, and 2,960 kcal of MEn per kg of diet, respectively. Multivariate analysis revealed that the occurrence of hepatic steatosis and increased levels of Kupffer cells were not related to MEn levels. Conclusion: The level of 2,960 kcal/kg of MEn meets performance variable requirements without compromising hepatic physiology.

A Study on the Environmental Impact of Biological Production Facilities (대규모 생물생산 시설의 환경 영향 연구)

  • 남상운
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.38 no.5
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    • pp.106-115
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    • 1996
  • This study was carried out to provide fundamental data for reuse of resources and prevention of environmental pollution Actual states of environmental pollution by biological production facilities were investigated. Various pollution loads and quantity of wastes from greenhouse and animal housings estimated. In greenhouse contents of investigation were wastes of plastic cover, noise of heater and fan, air pollutant of heater, and wastes of soilless culture system, etc. In animal housings, those were actual state of livestock waste treatment and reuse, pollutant mass unit discharge, noise pollution, and malodorant, etc. The main pollutants discharged from greenhouses were wastes of plastic cover, rockwool, and waste fluid of nutrient solution. Developments of waste disposal methods for plastic cover and rockwool are required. And recycle technique of nutrient solution for soilless culture should be developed and propagated. With the buildup of legal control, pollutant mass discharged from livestock wastes are, on the decrease. The other side, reuse of livestock excreta increased. Most animal housings are located near the dwelling house. Malodorant and noise from animal housings have bad effects on the rural living conditions. So developments of integrated complex for small scale livestock farms are required.

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Recent Trends of the Development of Photobioreactors to Cultivate Microalgae (미세조류 배양을 위한 광생물반응기 개발의 기술동향)

  • Kim, Jong-Tye;Ahn, Dong-Gyu;Park, Jong-Rak;Park, Jeong-Woo;Jeong, Sang-Hwa
    • Journal of the Korean Society for Precision Engineering
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    • v.28 no.2
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    • pp.125-132
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    • 2011
  • This paper describes current status and future prospects of the mass production of microalgae biomass. Microalgae have attracted considerable attention since they not only effectively fix $CO_2$ gas during their metabolic process but also have the great potential to be utilized for producing valuable substances as a kind of efficient light-harvesting cell factories. In this review, we outline various types of photobioreactors employed for mass production of biomass by culturing microalgae in a well controlled way and give an overview about the present state of affairs, both domestic and international, in the field of the microalgal culturing technologies.

Comparative Analyses of Mass Marketing and Target Marketing Based on Price Elasticity and Production Cost (가격탄력성과 생산비용에 기초한 대량 마케팅과 표적시장 마케팅의 비교 분석)

  • Won, Jee Sung
    • Journal of Distribution Science
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    • v.11 no.4
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    • pp.61-72
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    • 2013
  • Purpose - It is widely accepted that the process of developing marketing strategy is composed of three steps: market segmentation, target market selection and positioning. However, mass marketing strategy based on cost reduction through economies of scale and standardized products, can be also an effective strategic option. Many marketing scholars including Theodore Levitt emphasize the importance of applying the mass production concept to various industries including service industries. Especially, in times of economic downturn, the capability of providing consumers with low-priced, value products can be an important source of competitive advantage, as well as the ability of providing high-priced premium products. Marketers should decide whether they will implement mass marketing strategy or target marketing strategy. The present study theoretically shows that firms should understand the target customers' price elasticity as well as the firm's cost structure in order to make such a strategic decision. Research design, data, and methodology - Instead of implementing an empirical study, this study provides a theoretical(mathematical) investigation on the effect of consumers' price elasticity on a firm's optimal price level, profit, sales volume, revenue, and cost. The results are mostly deduced from derivative calculations and several graphs are utilized to represent the results on the relationships between the variables under study. Results - The analytical results suggest that it is more profitable for a firm to adopt the segment/target marketing strategy (more specifically the differentiation strategy) when the degree of consumers' heterogeneity is high and the proportion of the fixed cost in the total cost is low. On the other hand, if the degree of consumers' heterogeneity is low and the fixed cost is high, it is better to adopt the mass marketing strategy or the cost leadership strategy. The strategy of concentrating on a single target market will be effective when consumers' needs are highly heterogeneous but the fixed cost is high. Any of the three types of generic strategies proposed my Porter(1980, 1985) can be applied when both the consumers' heterogeneity and the fixed cost are low. This study also proposes the contribution-margin-based method for developing the optimal pricing strategy. Conclusions - One of the primary roles of marketers is to find a proper compromise between the two conflicting goals of maximizing customer satisfaction and minimizing cost. In order to do so, he or she should understand the characteristics of the target customers as well as the cost structure of the firm. In addition to the theoretical analyses, this study discusses several business cases and explains how superior companies find the optimal compromise position between these two goals and dominate the market. One of the radical changes recently taking place in business arena is the reduction of production and distribution costs of both physical goods and information due to the advancement and the wide diffusion of information technology. The cost reduction combined with lowered priced elasticity incurred by customized products and services, will enable many firms to adopt the mass customization strategy.

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