• 제목/요약/키워드: mark

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PDGFC, MARK3 and BCL2 Polymorphisms are Associated with Left Ventricular Hypertrophy in Korean Population

  • Jeon, Tae-Eun;Jin, Hyun-Soek
    • 대한의생명과학회지
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    • 제25권3호
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    • pp.237-246
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    • 2019
  • Left ventricular hypertrophy (LVH) refers to the expansion and the enlarged myocardium due to the increased resistance to ejection from the left ventricle to the aorta and/or the periphery, or the long-term burden imposed by the blood increase. Hypertension is a major risk factor that accounts for more than 50% of the causes of cardiovascular disease. If hypertension endure in the long term, the myocardium responds to abnormal heartbeat in the heart. Therefore, the prevalence of left ventricular hypertrophy also increases. As a result of genome-wide association study (GWAS) analysis for European people, PDGFC, MARK3, and BCL2 were related to blood pressures. In this study, the genetic polymorphisms of PDGFC, MARK3, and BCL2 were extracted and selected based on Korean genomic and epidemiologic data, and then logistic regression analysis was performed on LVH. As a result, one SNP (rs9307953) in PDGFC gene, four SNPs (rs6575983, rs17679475, rs2273703 and rs10141388) in MARK3 gene and two SNPs (rs17756073 and rs17070739) in BCL2 gene were statistically significant. The rs6575983 of the MARK3 gene showed the highest significance level ($P=7.2{\times}10^{-3}$) among the SNPs and the relative risk of 1.08 (95% confidence interval: 1.06 to 1.45). These results suggest that the polymorphisms of PDGFC, MARK3, and BCL2 not only affect European blood pressures but also correlate with LVH in Korean. These results suggest that increased understanding of the genetic correlations of the pathogenesis of LVH.

가사전담 남편을 위한 육아 TV채널의 브랜드마크 및 스테이션 아이덴티피케이션 제안 (Brand Mark and Station Identification for TV Channel Specializing in Childcare for House Husbands)

  • 천은영;최장섭;백진경
    • 디자인융복합연구
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    • 제15권3호
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    • pp.103-116
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    • 2016
  • 본 연구는 사회발전으로 인한 성별분업 체계의 변화와 가사전담 남편의 비율이 증가함에 따라 이들의 육아를 다루는 프로그램에 대한 필요성에 주목하여 가사전담 남편을 주요 대상으로 육아채널 개설 시 필요한 브랜드마크와 스테이션 아이디를 디자인하여 제안하는데 목적이 있다. 선행연구와 현황분석을 통해 브랜드마크와 응용브랜드마크를 제작하여 생후 6개월~37개월까지의 아이를 육아하는 부모 55명을 대상으로 채널 필요성과 선호도 및 인지도 관련 수용자 의식조사를 2차에 나누어 실시하였다. 1차 조사 결과, 부모들의 육아에 대한 걱정과 두려움의 심리와 육아채널의 필요성을 확인하였고, 브랜드마크와 응용브랜드마크 형태와 색채 선호도 및 인지도 평가를 통해 부정적 결과를 얻은 응용브랜드마크의 문제점을 도출하고 이에 대한 개선안을 제안하여 2차 설문조사를 실시하였다. 그 결과, 아이를 연상시킬 수 있는 형태가 인지도와 적합성이 높았으며, 고채도의 남색 계열 색채 사용이 긍정적임을 확인하였다.

치과내원 환자의 올리어리(O'Leary) 지수와 개별치아의 치면세균막 지수에 관한 연구 (A study on the O'Leary index and dental plague index of dental patients)

  • 박성숙;조평규
    • 한국치위생학회지
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    • 제9권3호
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    • pp.426-438
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    • 2009
  • The purpose of this study was to examine the relationship of the general characteristics of dental patients to their total O'Leary index and individual plaque indexes in a bid to check the oral hygiene state of citizens and evaluate their plaque management ability. The subjects in this study were 288 patients at dental hospitals and clinics in Busan and South Gyeongsang Province. A survey was conducted from September to November 2008. The findings of the study were as follows: 1. Overall, the O'Leary index of the patients investigated stood at 72 percent. By age and gender, the O'Leary index was highest among those in their 30s(83%) and among the women(75%)(p<.05). As to the influence of toothbrushing frequency, the patients who did it twice or more a day had the highest O'Leary index(75%)(p<.001). By the use of oral hygiene supplies, the patients who used oral hygiene supplies had a higher O'Leary index(76%) than the others who didn't(p<.01). 2. As for plaque index for each tooth, 28 percent of their teeth were given zero point, and 52 percent were given one mark. 13 percent were given two marks, and 6.3 percent were given three marks. Thus, the teeth that were given one mark were largest in number(p<.001). 3. As for plaque index for labial posterior mandibular, 43 percent of their teeth were given one point, and 36 percent were given zero mark. 14 percent were given three mark, and 5 percent were given three marks(p<.01). 4. As for plaque index for buccal posterior maxilla, 57 percent of their teeth were given one point, and 20 percent were given zero mark. 16 percent were given two mark, and 6.3 percent were given three marks(p<.01). 5. As for plaque index for lingual posterior mandibular, 56 percent of their teeth were given one point, and 27.8 percent were given zero mark. 9 percent were given three mark and 6 percent were given three mark(p<.001).

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릴레이 회로의 확장된 마크흐름선도 변환 (The Relay Circuits Translation to EMFGs)

  • 여정모;백형구
    • 제어로봇시스템학회논문지
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    • 제9권11호
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    • pp.952-957
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    • 2003
  • We propose how to translate relay circuits to the EMFGs(Extended Mark Flow Graphs) formally and analyze the original one by using the mark flow of it. Firstly, the concepts of the output condition, the output-on condition and the output-off condition are introduced in the relay circuits. These can be used to find the structure and the operation of respective relay outputs but the sequential operations of them cannot be obtained from these. Secondly, a relay circuit is translated to the corresponding EMFG as the all output-on conditions and all output-off conditions of it are translated to EMFGs. For the adequate translation, the condition arc and the concepts of the generation transition and the degeneration transition are introduced, and the duality for the simplification of the result. Thirdly, we analyze the operation of the original circuit by analyzing the mark flow of the resulting EMFG. We can achieve easy and fast analysis based on the EMFG's operation algorithm. Finally, we apply these to the relay circuit for an electric furnace and analyze its operation with the mark flow of the resulting EMFG. The formal translation from relay circuits to EMFGs makes the analysis easy so that these results can be used to design, modelling, the fault detection and the maintenance.

혼합형 감성공학에 의한 CI 심벌마크의 설계 및 평가 (Design and Evaluation of Corporate Identity Symbol Marks by Hybrid Kansei Engineering)

  • 장인성;박용주
    • 지능정보연구
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    • 제7권2호
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    • pp.129-141
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    • 2001
  • 본 연구에서는 기업의 경영이념이나 특성 등을 시각적 이미지로 표현하는 CI(Corporate Identity) 심벌마크의 설계 및 평가를 위해 혼합형(Hybrid) 감성공학기법을 적용하였다. 먼저, CI 심벌마크에 내재된 기업의 시각적 이미지를 분석하기 위하여 SD평가를 실시하였으며 CI 심벌마크의 디자인 요소와 기업이미지와의 상관관계를 분석하기 위하여 정통적인 감성공학적 접근방식에 해당하는 순향성 감성공학기법을 적용하였다. 최종적으로는 CI 심벌마크의 디자인 요소로부터 기업이미지에 대한 고객의 감성을 자동으로 평가할 수 있는 시스템을 개발하기 위하여 역향적 감성공학기법을 적용하였다. 구축된 시스템은 CI 심벌마크의 설계를 지원함으로써 설계에 소요되는 시간과 비용을 효과적으로 줄일 수 있는 유용한 도구로 장차 이용되리라 기대된다.

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Development of Automatic Mark Welding Robot

  • Ryu, Sin-Wook;Kim, Ho-Gu;Lee, Jae-Chang;Kim, Se-Hwan
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 2005년도 ICCAS
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    • pp.643-648
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    • 2005
  • Generally, ships have marks of various shapes on outside of the hull. Among them, so called "Draft Mark" indicates the distance from the bottom of the keel to the waterline. Draft marks are used to determine the displacement and other properties of the ship for stability and control purposes. These marks are made up of welding bead or sticking the steel plate on outside of the hull. To improve the confidence level of the ship owner, quality and accuracy of the draft mark is very important. So the automatic mark welding robot is used to enable a high quality and accurate manufacturing line. To improve the system portability, the system is divided into two distinct parts, namely mechanical part and control part. Mechanical part is robust, a lightweight, and easy to dismantle. The control part consists of an in-house developed controller, which is based on embedded Linux. Also, the control part consists of power line communication module to ensure the applicability of the controller in manufacturing line. In this paper, the methodologies of control and configuration of the robot are discussed.

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마크 로드코의 색면추상에 표현된 색의 확장성 연구 (A Study on the Color Extendability in Mark Rothko's Color-Field Abstract)

  • 김선영
    • 한국실내디자인학회논문집
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    • 제22권1호
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    • pp.239-246
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    • 2013
  • This study is aimed at understanding the color extendibility of color-field abstract through Mark Rothko's paintings. Color extendibility is a structure applied by Mark Rothko. He simplifies it and by pursuing autonomy and immediacy of the color itself, including surface color and the front of color-field, Rothko creates value through motions in his square paintings of non-fixed shapes. Chapter 2 revisits the meaning of color in abstract expressionism and explains the principle of color-field by applying the concept of ergon and parergon. In chapter 3, the principle, processes, methods, techniques of expression were studied as a basis to understand color extendibility and color-field abstract. In chapter 4, the works of Mark Rothko were analyzed based on his multiform paintings(1946-1948), number and untitled(1949-1957), and black paintings(1958-1970) in order to identify, in the final chapter, the features of color extendibility in Rothko's works. According to the above research, the thesis successfully concludes that the artist's reconstruction of reality and readjustment of transcendent reality are reproduced via color extendibility, the movement of color-field.

표지방류 조사를 통한 거제 외포 주변해역 대구(Gadus macrocephalus) 자원량과 어획사망률 추정 (Estimating the Abundance and Fishing Mortality of Pacific Cod Gadus macrocephalus during the Spawning Season in Jinhae Bay, Korea, Using a Mark-Recapture Method)

  • 황강석;최일수;정석근
    • 한국수산과학회지
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    • 제45권5호
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    • pp.499-506
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    • 2012
  • We estimated the population size and fishing mortality of Pacific cod Gadus macrocephalus during the spawning season in waters off Woipo, Geoje Island, Korea, using a mark-recapture method. We marked and released 51 cod>50 cm in total length; six were recaptured by local fishermen during the period from December 15 to 31, 2009. The estimated population size was ca. 180,000 and the fishing mortality of the exploitable cod was 26%. Although we could assume a closed population due to the short survey period, we evaluated the uncertainty in the estimates by applying bootstrap resampling because the sample size was small. The estimated 95% confidence interval was 94,000-568,000 for the population size and 8-49% for fishing mortality. Our study demonstrated that the application of mark-recapture methods and bootstrap resampling can be useful in stock assessment for fisheries management in Korea, but requires a larger sample size, spatially extensive coverage, and sophisticated mark-recapture models based on a refined sampling design for reliable stock assessment and biological reference points in sustainable cod management.