• Journal of Korean Society of Disaster and Security
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• v.13 no.2
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• pp.39-51
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• 2020

Recently, flood damage has been increasing in Korea due to frequent local torrential rains caused by abnormal weather conditions. According to the calculation of the recurrence period of torrential rain that occurred in North Chungcheong Province on July 16, 2017, it was estimated that the rainfall frequency in the upper are of Goessan Dam was around 1,524 years, and the highest level of Goesan Dam rose to EL.137.60 meters, leaving only 5 cm of margin until the height of the dam floor (EL.137.65 meters). The Goesan Dam, which operated for 62 years since 1957, needs to be prepared to cope with the increase of floodgate volume in the basin, the development of a single purpose dam for power generation only, and there are no measurement facilities for flood control, so efficient operation methods are needed to secure the safety of residents in upper and lower regions. In this study, a method of dam operation was proposed by constructing a rain matrix for quick decision making in flood prediction, calculating the highest level of dam for each condition in advance, and preparing a survey table, and quickly finding the level corresponding to the conditions in case of a situation.

• Journal of Gastric Cancer
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• v.20 no.3
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• pp.277-289
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• 2020

Purpose: To evaluate the feasibility and safety of intracorporeal overlapping gastrogastrostomy between the proximal anterior wall and antrum posterior wall (PAAP; PAAP anastomosis) of the stomach in minimally invasive pylorus-preserving gastrectomy (PPG) for early gastric cancer (EGC). Materials and Methods: From December 2016 to December 2019, 17 patients underwent minimally invasive PPG with PAAP anastomosis for EGC in the high body and posterior wall of the stomach. Intraoperative gastroscopy was performed with the rotation maneuver during proximal transection. A longer antral cuff (>4-5 cm) was created for PAAP than for conventional PPG (≤3 cm) at the point where a safe distal margin and good vascular perfusion were secured. Because the posterior wall of the proximal remnant stomach was insufficient for intracorporeal anastomosis, the anterior wall was used to create an overlapping anastomosis with the posterior wall of the remnant antrum. The surgical and oncological outcomes were analyzed, and the stomach volume was measured in patients who completed the 6-month follow-up. The results were compared to those after conventional PPG (n=11 each). Results: PAAP anastomosis was successfully performed in 17 patients. The proximal and distal resection margins were 2.4±1.9 cm and 4.0±2.6 cm, respectively. No postoperative complications were observed during the 1-year follow-up esophagogastroduodenoscopy (n=10). The postoperative remnant stomach (n=11) was significantly larger with PAAP than with conventional PPG (225.6±118.3 vs. 99.1±63.2 mL; P=0.001). The stomach length from the anastomosis to the pylorus was 4.9±2.4 cm after PAAP. Conclusions: PAAP anastomosis is a feasible alternative for intracorporeal anastomosis in minimally invasive PPG for highly posteriorly located EGC.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.70-81
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• 2000

DA-5018 is a synthetic capsaicin derivative under development as a non-narcotic a analgesic ag$\varepsilon$nt. DA-50 18 showed a potent analgesic activity against acute and chronic pain m model(Tablel, 2.), but it had a narrow margin of safety. DA-5018 did not bind to opioid(${\kappa}, {\delta}, {\mu}$), NKl, CGRP receptors in vitro and its analgesic effect was not antagonized by naloxone, a and it did not develop analgesic tolerance. In addition DA-5018 had no inhibitory effects against c cyclooxygenase and 5-lipooxygenase activities. DA-5018 significantly increased the relcase of substance P from the slices of the rat spinal cord. These results suggest that DA-50 18 is not a narcotic nor aspirin-like analgesic and the release of substance P is one of analgesic mechanism of action of DA-5018. We found that DA-5018 was almost ten times more potent and was at l least IOO-times less irritable compared to capsaicin. Accordingly development of topical formula was adopted. Topical formula was desiged and screened by flux test of DA-5018 using hairless mouse skin and several formulas were selected. With these topical formulas we a assessed the analgesic efficacy and carried out the toxicity, skin irritation and pharmacokinetic studies. In streptozotocin-induced hyperalgesic rat and 50 % galactose-fed hyperalgesic rat as diabetic pain models, DA-5018 cream increased the pain thresh이ds up to 77.0% and 24.4% respectively, while Zostrix-HP(capsaicin cream) incr$\varepsilon$as cd by 65.9% and 21.0%. DA-5018 c cream showed a good analgesic effect as welI in FCA-induced arthritic rat. DA-5018 cream did not show any toxicological signs in acute and chronic toxicity test and had little skin irritation in car swclIing and scratching t$\varepsilon$st. Pharmacokinetics of DA-50 18 were studied after topical application of ${14}^C$-Iabelled or unlabelIed DA-5018 cream. Plasma and skin concentrations c except applied skin wcre below the dctection limit and after 7-day cummulative application, plasma concentrations were also below detection limit DA-50 18 may have an advantag$\varepsilon$ ov$\varepsilon$r c capsaicin and is now being developed as a topical agent for the treatment of pains. DA-50 18 cream was approved for Korean IND and is now under a Phase II clinical study for arthritic pain a after finising Phase I study. DA-50 18 was also liscensed out to Stiefel Company in America in

• Journal of the Korean Geotechnical Society
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• v.22 no.11
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• pp.123-131
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• 2006

Liquefaction-induced lateral spreading has been the most extensive damage to pile foundations during earthquakes. Several cases of pile failures were reported despite the fact that a large margin of safety factor was employed in their design. In this study, 1-g shaking table tests were performed in order to analyze the failure behavior of piles embedded in liquefied soil deposits by buckling instability. As a result, it can be concluded that the pile subjected to excessive axial loads $(near\;P_{cr})$ can fail easily by buckling instability during liquefaction. When lateral spreading took place in sloping grounds, it was found that lateral loading due to lateral spreading increased lateral deflection of pile and reduced the buckling load. In addition, from the buckling shape of pile, difference between Euler's buckling and pile buckling vat observed. In the case of pile buckling, hinge formed at the middle point of the pile, not at the bottom. And in sloping grounds, location of hinge formation got lower compared with level ground because of the soil movements.

• The Transactions of the Korea Information Processing Society
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• v.3 no.2
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• pp.283-294
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• 1996

To operate the automatic devices of manufacturing process more effectively and to solve the needs of the resource sharing, network technology is applied to the unit control devices located in common manufacturing zone and operated by connecting them. This paper introduces deign and test operation of cell system for the management of multivendor PLC by applying to wall paper process based on the manufacturing standardization of CIM. The analysis of designed multivendor PLC group is performed by selecting the parameters such as variation of data packet size and node number of PLC ladder logic program and variation by analyzing the corresponding variation values of token rotation time and waiting time for the system operation. For the method of the analysis,the equation is considering the overhead such as indicated packet service time and transmission safety margin for PLC network connection in M/G/1 queue model,and it is applied to the cell system and PLC group manage-ment for operation .Through the experiment,it is found that the realtime processing is possible with expanded and better result than the resuit obtained by Jayasumana.Browaka with PLC scan time considered,response lower limit of 10-20 msec. data packet size not more than 50 bytes.and the number of nodes less than 40.

• Environmental Analysis Health and Toxicology
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• v.15 no.1_2
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• pp.31-37
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• 2000

Acetanilide may be released into the environment through air and wastewater from its production and use sites and exposed to human. Acetanilide is known to produce an analgesic effect and may pose adverse effects on human health by overly exposure. According to the EUSES system, acetanilide showed a high MOS (Margin of safety) value exceeding 6$\times$10$^4$ on a regional exposure, which is safe enough for public health. Whereas the lowest MOS value in dermal exposure was estimated as 3$\times$10$^{-4}$ on a local basis (workplace), the risk could be partly counteracted by taking preventive measures such as using mask and globes and good ventilation in the work places. Acetanilide may pose a potential risk for workers by dust inhalation. For the sake of health protection in the work places, additional data should be accumulated with respect to repeated dose toxicity, reproduction toxicity and developmental toxicity, etc. It is, therefore, recommended that acetanilide should be a candidate for further work to supplement the lacking data until it is proved to be safe in the occupational health aspects.

• Journal of the Korean Geotechnical Society
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• v.31 no.10
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• pp.5-16
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• 2015

Considering the conversion of the Korea Construction Standards to Limit State Design (LSD), we analyzed the resistance bias factor for pullout resistance, as a part of the development of the Load and Resistance Factor Design (LRFD) for soil nailing; very few studies have been conducted on soil nailing. In order to reflect the local characteristics of soil nailing, such as the design and construction level, we collected statistics on pullout tests conducted on slopes and excavation construction sites around the country. In this study a database was built based on the geotechnical properties, soil nailing specifications, and pullout test results. The resistance bias factors are calculated to determine the resistance factor of the pullout resistance for gravity and pressurized grouting method, which are the most commonly used methods in Korea; moreover, we have relatively sufficient data on these methods. We found the resistance bias factors to be 1.144 and 1.325, which are relatively conservative values for predicting the actual ultimate pullout resistance. It showed that our designs are safer than those found in a research case in the United States (NCHRP Report); however, there was an uncertainty, $COV_R$, of 0.27-0.43 in the pullout resistance, which is relatively high. In addition, the pressurized grouting method has a greater margin of safety than the gravity grouting method, and the actual ultimate pullout resistance determined using the pressurized grouting method has low uncertainty.

• Journal of the Korea Concrete Institute
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• v.17 no.4 s.88
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• pp.505-511
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• 2005

This experimental investigation was conducted to examine the seismic performance of reinforced concrete bridge columns. The columns were subjected to a constant axial load and a cyclic horizontal load-inducing reversed bending moment. The variables studied in this research were the volumetric ratios of transverse reinforcement (ps=0.96, 1.44 percent) and axial load ratios (P/Po=0.05, 0.1, 0.2) and concrete strengths (35, 60MPa). Test results showed that bridge columns with $44\%$ higher amounts of transverse reinforcement than that required by seismic provisions of ACI 318-02 showed ductile behavior. For bridge columns with axial load ratio(P/Po) less than 0.2, the ratio of $M_{max}\;over\;M_{ACI}$, nominal moment capacity predicted by ACI 318-02 provisions, was consistently greater than 1 with approximately a $20\%$ margin of safety.

• Korean Journal of Plant Resources
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• v.23 no.5
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• pp.399-405
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• 2010

Rosa rugosa has been used as a folk medicine with various pharmacological properties for a long time in Asia. Recently, it has been reported that the extract of fractions from different parts of Rosa rugosa have various pharmacological effects on diverse diseases including diabetes, inflammatory diseases and tumor. We investigated effects of fructus extracts of Rosa rugosa(RRF) and semen extracts of this herb(RRS) on macrophage to evaluate the possibilities as a biological response modifier. We showed increased effects on tumoricidal activity, phagocytic activity, TNF-$\alpha$ and NO production in RRF-treated groups without direct tumor cell cytotoxicity. RRS-treated groups increased direct tumor cell cytotoxicity at high dose without tumoricial activity except increasing of TNF-$\alpha$ release. These results provide further possibilities for the beneficial immunomodulating effects of RRF on immune system with relatively larger safety margin rather than RRS.

• Journal of the Korea Computer Graphics Society
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• v.29 no.5
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• pp.21-30
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• 2023

Accurate segmentation of the kidney tumor is necessary to identify shape, location and safety margin of tumor in abdominal CT images for surgical planning before renal partial nephrectomy. However, kidney tumor segmentation is challenging task due to the various sizes and locations of the tumor for each patient and signal intensity similarity to surrounding organs such as intestine and spleen. In this paper, we propose a semi-supervised learning-based mean teacher network that utilizes both labeled and unlabeled data using a kidney local guided map including kidney local information to segment small-sized kidney tumors occurring at various locations in the kidney, and analyze the performance according to the kidney tumor size. As a result of the study, the proposed method showed an F1-score of 75.24% by considering local information of the kidney using a kidney local guide map to locate the tumor existing around the kidney. In particular, under-segmentation of small-sized tumors which are difficult to segment was improved, and showed a 13.9%p higher F1-score even though it used a smaller amount of labeled data than nnU-Net.