• 생약학회지
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• 제30권2호
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• pp.226-230
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• 1999

We have isolated a sesquiterpene lactone, cumambrin A from the dried flowers of Chrysanthemum boreale Makino and reported its chemical structure. The aim of the present study was to investigate whether the exogenous administration of cumambrin A has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In vitro studies: Relaxative response induced by cumainbrin A was increased with dose-dependent manner and showed maximizing response at a concentration of $5{\times}10^{-4}M$. Further, this relaxative response was significantly increased at a condition of endothelium present than that of endothelium denuded. In vivo studies: The normalizing effect of cumambrin A on blood pressure was also increased with time-dependent manner and then gradually recovered to normal condition at approximately 4 hrs after cumambrin A treatment.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 1999년도 특별강연 및 추계학술발표대회 개요집
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• pp.142-145
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• 1999

The dynamic resistance monitoring is one of the important issues in that in-process and real time quality assurance of resistance spot weld is needed to increase the product reliability. Secondary dynamic resistance patterns, as a real manner, are hard to adapt those factors in real time and in-plant system. In the present study, a new dynamic resistance detecting method is presented as a practical manner of weld quality assurance at the primary circuit. By the correlation analysis, it is found that the primary dynamic resistance patterns are basically similar to those of the secondary. Various dynamic resistance indices are characterized with the primary curve. And quality of the weld, like the tensile shear strength, is estimated using adaptive neuro-fuzzy estimation system which is consisted of the Sugeno fuzzy algorithm. Through the fuzzy clustering and parameter optimization, real time weld quality assurance system with less efforts is proposed.

• 산업공학
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• 제17권2호
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• pp.142-148
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• 2004

The objective of bridge construction cost allocation is to distribute in a fair and rational manner the bridge construction costs among those vehicles using the bridge. In most bridge construction cost allocation studies, bridge construction costs are mainly distributed according to traffic load(gross vehicle weight), without any consideration of bridge capacity requirements(the number of lanes). In this paper, a bridge cost allocation method for considering both traffic capacity and traffic loads is developed. The proposed method is based on cooperative game theory, particularly two concepts known as the Aumann-Shapley (A-S) value and Shapley value. This method can help to analyze the impact of traffic capacity costs. By applying the proposed method to an example, traffic capacity cost is found to be high so that traffic capacity should be considered to allocate the bridge construction costs to vehicle classes in a more equitable manner.

• 지식경영연구
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• 제9권4호
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• pp.51-63
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• 2008

Effective energy consumption now becomes one of the area of knowledge management which potentially gives global impact. It is considerable for the energy management to optimize the usage of energy, rather than decreasing energy consumption at any cases. To resolve these challenges, an intelligent and personalized system which helps the individuals control their own behaviors in an optimal and timely manner is needed. So far, however, since the legacy energy management systems are nation-wide or organizational, individual-level energy management is nearly impossible. Moreover, most estimating methods of energy consumption are based on forecasting techniques which tend to risky or analysis models which may not be provided in a timely manner. Hence, the purpose of this paper is to propose a novel individual-level energy management system which aims to realize timely and personalized energy management based on context-aware computing approach. To do so, an index model for energy consumption is proposed with a corresponding service framework.

• 한국항만학회지
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• 제14권1호
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• pp.47-55
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• 2000

In order to cope with the changes of container terminal situation in these days, many simulation studies for container terminal have been accomplished. But previous simulation studies using simulation language have limitations in model representation and difficulties in modeling of large scaled container terminal system. To make these problems better, this paper addresses an object-oriented simulation of container terminal system using a DEVS formalism. The DEVS(Discrete Event System Specification) formalism, developed by Zeigler, supports specification of discrete event system in a hierarchical and modular manner. The formalism provides a mathematical basis for studying discrete event systems with better understood and sounder semantics. In a step of system modeling, a DEVS formalism aims at the exact system modeling that has a basis of semantics and utilizing the object-oriented manner can flexibly cope with the changes of system environment. In this study a model is developed and verified through the simulation of some alternatives.

• 대한의생명과학회지
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• 제22권4호
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• pp.211-214
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• 2016

House dust mite is an essential allergen in the pathogenesis of allergic diseases. Abnormal regulation of neutrophil apoptosis is an important pathogenic process in allergic diseases. In the present study, we investigated the effects of house dust mites on spontaneous apoptosis of neutrophils and its associated mechanisms. Extract of Dermatophagoides pteronissinus (DP) inhibited neutrophil apoptosis in a time-dependent manner. Cycloheximide (CHX), an inhibitor of translation, increased apoptosis of DP-treated neutrophils as well as control cells. The pro-apoptotic effect of CHX was blocked by DP in neutrophils. In addition, DP increased the phosphorylation of Bad in a time-dependent manner, indicating that it exerted an inhibitory effect on the function of Bad. These results suggest that DP has anti-apoptotic effects of neutrophils and may regulate protein synthesis and activation of Bad. Moreover, these findings may shed light on elucidation of allergy pathogenesis due to house dust mites.

• 한국생활과학회지
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• 제13권6호
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• pp.875-889
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• 2004

The purpose of this study Is to analyze the homepage contents of an auction site on the Internet. This study collected 459 cases of purchasing and selling notes, and classified them into three types. The finding showed that some of the most frequently-occurring consumer problems are concerned with delivery and return, and sellers manner. On the other hand, consumers' manner is important to sellers. The auction site itself has problems with consultation and its own system.

• Journal of Microbiology and Biotechnology
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• 제19권9호
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• pp.946-950
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• 2009

In the course of screening for apoptotic substances that induce apoptosis in human leukemia U937 cells, a fungal strain, F000487, which exhibits potent inducible activity, was selected. The active compound was purified from an ethyl acetate extract of the microorganism by Sep-pak $C_{18}$ column chromatography and HPLC, and was identified as atromentin by spectroscopic methods. This compound induced caspase-3 processing in human leukemia U937 cells. The caspase-3 and poly (ADP-ribose) polymerase (PARP) were induced by atromentin in a dose-dependent manner. Furthermore, DNA fragmentation was also induced by this compound in a dose-dependent manner. These results show that atromentin potently induces apoptosis in U937 cells and that atromentin-induced apoptosis is related to the selective activation of caspases.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2007년도 추계 종합학술대회 논문집
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• pp.652-656
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• 2007

만화는 종이 매체를 기반으로 출간되는 전형적인 만화형태와 인터넷 환경을 기반으로 서비스되는 만화로 크게 구분할 수 있다. 이는 출판만화와 디지털만화로 명명할 수 있으나 기존의 종이에 인쇄된 내용이 단순히 컴퓨터 모니터를 통해 본다는 출력의 상이함 외에는 디지털의 특징을 부각한 것은 아직 미비한 실정이다. 이에 디지털 콘텐츠의 핵심인 "인터랙티비티"를 적용한 만화 연출을 통해 디지털 코믹의 새로운 가능성을 알아본다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2004년도 추계 학술대회 및 정기총회
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• pp.7-11
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• 2004

We previously reported that ginseng inhibited NMDA receptors in cultured hippocampal neurons. Here, we further examined the detailed mechanism of ginseng-mediated inhibition using its main active ingredient, ginsenoside Rg$_3$. Co-application of ginsenoside Rg$_3$ with increasing concentrations of NMDA did not change the EC$_{50}$ of NMDA to the receptor, suggesting ginsenoside Rg$_3$ inhibits NMDA receptors without competing with the NMDA-binding site. Ginsenoside Rg$_3$-mediated inhibition also occurred in a distinctive manner from the well-characterized NMDA receptor open channel blocker, MK-801, However, ginsenoside Rg$_3$ produced its effect in a glycine concentration-dependent manner and shifted the glycine concentration-response curve to the right without changing the maximal response, suggesting the role of ginsenoside Rg$_3$ as a competitive NMDA receptor antagonist. We also demonstrated that ginsenoside Rg$_3$ significantly protected neurons against NMDA insults. Therefore, these results suggest that ginsenoside Rg$_3$ protects NMDA-induced neuronal death via a competitive interaction with the glycine-binding site of NMDA receptors in cultured hippocampal neurons.