The social demand of manipulative therapy has increased. but the concept, terminology, classification and system of manipulative therapy is unclear. Therefore, academic organization on manipulative therapy is needed. The aim of this study is overview the evolution of manipulative therapy and based on this, we will find out how manipulative therapy is studied in South Korea. Manipulative therapy reflects medical knowledge and trends at the time. Historically people who work as key roles in evolution of manupulative therapy are Hippocrates, Claudius Galen, Acicenna(Ibn Sīnā), Ambroise Paré, Andreas Vesalius, Pehr Henrik Ling, Florence Nightingale, Andrew Taylor Still, Daniel David Palmer, James Beaver Mennell, James Henry Cyriax, Robin Mckenzie, Freddy Kaltenborn, Brian R Mulligan, George Goodheart, Mikao Usui, Wilhelm Reich, Ida Rolf. As the result of articles search, Massage, Chiropractics, acupressure(acupuncture), Chuna, osteopathy, reflexology, CST, Mulligan techniques, Dongbang whalbub, Kaltenborn-Evjenth orthopedic manual therapy are major subject that studied in South Korea.