• 대한인간공학회지
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• 제36권5호
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• pp.559-568
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• 2017

Objective: The aim of this study is to investigate the effective managerial factors influencing dose reduction of the nozzle dam installation and removal tasks ranking within top 3 in viewpoint of average collective dose of nuclear power plant maintenance job. Background: International Commission on Radiation Protection (ICRP) recommended to reduce unnecessary dose and to minimize the necessary dose on the participants of maintenance job in radiation fields. Method: Seven sessions of nozzle dam installation and removal task logs yielded a multiple regression model with collective dose as a dependent variable and work time, number of participants, space doses before and after shield as independent variables. From the sessions in which a significant reduction in collective dose occurred, the effective managerial factors were elicited. Results: Work time was the most important factor contributing to collective dose reduction of nozzle dam installation and removal task. Introduction of new technology in nozzle dam design or maintenance job is the most important factor for work time reduction. Conclusion: With extended task logs and big data processing technique, the more accurate prediction model illustrating the relationship between collective dose reduction and effective managerial factors would be developed. Application: The effective managerial factors will be useful to reduce collective dose of decommissioning tasks as well as regular preventive maintenance tasks for a nuclear power plant.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권3호
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• pp.186-192
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• 2016

Purpose: To evaluate the correlation between colon transit time (CTT) test value and initial maintenance dose of polyethylene glycol (PEG) 4000 or lactulose. Methods: Of 415 children with chronic functional constipation, 190 were enrolled based on exclusion criteria using the CTT test, defecation diary, and clinical chart. The CTT test was performed with prior disimpaction. The laxative dose for maintenance was determined on the basis of the defecation diary and clinical chart. The Shapiro-Wilk test and Pearson's and Spearman's correlations were used for statistical analysis. Results: The overall group median value and interquartile range of the CTT test was 43.8 (31.8) hours. The average PEG 4000 dose for maintenance in the overall group was $0.68{\pm}0.18g/kg/d$; according to age, the dose was $0.73{\pm}0.16g/kg/d$ (<8 years), $0.53{\pm}0.12g/kg/d$ (8 to <12 years), and $0.36{\pm}0.05g/kg/d$ (12 to 15 years). The dose of lactulose was $1.99{\pm}0.43mL/kg/d$ (<8 years) or $1.26{\pm}0.25mL/kg/d$ (8 to <12 years). There was no significant correlation between CTT test value and initial dose of laxative, irrespective of the subgroup (encopresis, abnormal CTT test subtype) for either laxative. Even in the largest group (overall, n=109, younger than 8 years and on PEG 4000), the correlation was weak (Pearson's correlation coefficient [R]=0.268, p=0.005). Within the abnormal transit group, subgroup (n=73, younger than 8 years and on PEG 4000) correlation was weak (R=0.267, p=0.022). Conclusion: CTT test value cannot predict the initial maintenance dose of PEG 4000 or lactulose with linear correlation.

• 한국임상약학회지
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• 제32권3호
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• pp.238-250
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• 2022

Objective: The aim of this study was to examine the impact of ATP-binding cassette subfamily B member 1 (ABCB1) C3435T polymorphism on the treatment response of patients to vitamin K antagonists (VKAs). Methods: In this systematic review and meta-analysis, the PubMed/Medline, Embase, and Cochrane Library databases were searched for eligible articles for the period up to November 2020. Articles that reported treatment response to VKAs according to the ABCB1 C3435T polymorphism were included in this study. Results: A total of 13 and 9 articles were included in the systematic review and meta-analysis, respectively. The weekly maintenance dose of warfarin was significantly lower in patients with the ABCB1 3435CT or TT polymorphism type than in those with the ABCB1 3435CC type (weighted mean difference [WMD], -2.53 mg/week; 95% confidence interval [CI], -3.64 to -1.43, p<0.001). However, the weekly maintenance dose of acenocoumarol was not significantly associated with the ABCB1 C3435T polymorphism (WMD, 1.02; 95% CI, -0.61 to 2.65, p=0.22). Conclusion: The ABCB1 C3435T polymorphism was significantly associated with the weekly maintenance dose of warfarin. Further research is needed to confirm the association between the ABCB1 C3435T polymorphism and the incidence rate of bleeding events.

• Journal of Radiation Protection and Research
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• 제28권2호
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• pp.137-143
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• 2003

Annual radiation dose limit to radiation worker was substantially lowered in Korea by the adoption of 1990 recommendations of the International Commission on Radiation Protection (ICRP 60) in its legislation. On the other hand, radiation management environment in nuclear power plants is getting more worse because of the accumulation of radiation sources inside the system and the frequent need for maintenance according as the operation years of nuclear power plants increase. Therefore, Korea Hydro & Nuclear power Co., Ltd. (KHNP) has established a long-term 10 years plan from 2001 to 2010 for the reduction of radiation dose to workers. The plan is aimed for the reduction of annual dose per unit averaged over 5 years from 0.9 man-Sv in 2001 to 0.75 man-Sv in 2010 by radiation source reduction, equipment/tool improvement or new equipment development for easy maintenance, and the improvement of administration and system.

• 방사성폐기물학회지
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• 제19권2호
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• pp.243-253
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• 2021

In the dismantling process of a reactor coolant system (RCS) piping, a radiation protection plan should be established to minimize the radiation exposure doses of dismantling workers. Hence, it is necessary to estimate the individual effective dose in the RCS piping dismantling process when decommissioning a nuclear power plant. In this study, the radiation exposure doses of the dismantling workers at different positions was estimated using the MicroShield dose assessment program based on the NUREG/CR-1595 report. The individual effective dose, which is the sum of the effective dose to each tissue considering the working time, was used to estimate the radiation exposure dose. The estimations of the simulation results for all RCS piping dismantling tasks satisfied the dose limits prescribed by the ICRP-60 report. In dismantling the RCS piping of the Kori-1 or Wolsong-1 units in South Korea, the estimation and reduction method for the radiation exposure dose, and the simulated results of this study can be used to implement the radiation safety for optimal dismantling by providing information on the radiation exposure doses of the dismantling workers.

• Nuclear Engineering and Technology
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• 제55권5호
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• pp.1935-1945
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• 2023

The radiological safety of workers in a newly developed microwave-based spent resin treatment facility was assessed based on work location and operational scenarios. The results show that the remote-operation room worker was exposed to maximum annual dose of 3.19E+00 mSv, which is 15.9% of the dose limit, thereby confirming radiological safety. Inside the pathway, annual doses in the range of 7.87E-02-2.07E-01 mSv were measured initially at the mock-up tank and later at the point between the spent resin separation and treatment parts. The dose of emergency maintenance workers was below the dose limit (4.08E-03-4.99E+00 mSv); however, before treatment (separation and microwave), the dose of maintenance and repair workers exceeded the dose limit. The doses of the effluent removal workers at the zeolite and activated carbon storage tank and spent resin storage tank were the lowest at 2.79E-01-2.87E-01 mSv and 9.27E-01 mSv in "1 h" and "4-5 h of operation", respectively. The immediately lower and upper layers of the facility room exhibited the highest annual doses of 1.84E+00 and 3.22E+00 mSv, respectively. Through this study, a scenario that can minimize the dose considering the movement of spent resin through the facility can be developed.

• Journal of Radiation Protection and Research
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• 제35권2호
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• pp.57-62
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• 2010

원전 계획예방정비기간 증기발생기 수실작업, 가압기 전열관교체 또는 압력관피더 제거작업 지역 등은 높은 방사선량률을 보이는 지역으로, 짧은 시간 동안의 작업으로 작업종사자는 높은 피폭을 받을 가능성이 있다. 특히, 방사성물질과 접촉하는 손 부위는 높은 피폭이 일어날 수 있다. 이런 점을 고려하여 국내 가압경수로원전과 가압중수로원전의 계획 예방정비기간 중 증기발생기 수실 노즐댐 설치와 제거작업, 원자로 냉각재펌프 보수작업, 원자로헤드 보수 및 검사작업 등과 같은 고피폭 접촉작업에서 방사선작업종사자의 말단선량을 측정하기위한 현장시험을 실시하였다. 여기에 참여한 작업종사자는 가슴과 등 부위에 일상적인 절차에 따른 복수선량계를 패용한 것 이외에 손목에 개인선량계를 추가로 패용하였고, 손가락 부위에는 말단선량계 (Extremity dosimeter)를 패용하였다. 그 결과, 손가락이 받는 등가선량은 각각 손목이 받는 등가선량 및 가슴 또는 등 부위가 받는 등가선량과 일정한 비율로 평가됨을 확인하였다.

• Nuclear Engineering and Technology
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• 제30권4호
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• pp.308-317
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• 1998

Ensuring occupational radiation exposure(ORE) as low as is reasonably achievable(ALARA) has been one of very important requirements in a nuclear power plant. It is well known that about 70 percent of occupational dose has incurred from maintenance jobs in the outage period. To reduce occupational dose effectively, the high-dose jobs in the outage period should be identified with their dose reduction potentials and methods. In this study, a PC-based ORE database program, INSTORE, is developed to evaluate ORE doses in individual jobs, and the ORE data of Kori Units 3 and 4 are assembled to the database. Based on customary job classification, radiation work is classified into 26 main jobs which comprise 61 detailed jobs, and occupational doses are assessed according to each detailed job. As a result, high-dose jobs are identified with dose reduction priority in terms of collective ORE dose. It is recommended that adeqaute dose reduction methods for these jobs should be prepared to improve their working conditions and procedures.

• 방사선산업학회지
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• 제11권3호
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• pp.123-130
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• 2017

Concerns about high radiation exposure to the hands of radiation workers who may contact with radioactive contamination on surfaces in a nuclear power plant (NPP) had been raised, and the Korean regulatory body required the extremity dose estimation during contact tasks with radioactive materials. Korean NPPs conducted field tests to identify the incident radiation to the hands of radiation workers who may contact with radioactive contamination during maintenance periods. The results showed that the radiation fields for contact tasks are dominated by high energy photons. It was also found that the radiation doses to the hands of radiation workers in Korean NPPs were much less than the annual dose limits for extremities. This approach can be applicable to measure and estimate the extremity dose to the hands of medical workers who handle the radioactive materials in a hospital.

• 생물정신의학
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• 제28권2호
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• pp.50-57
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• 2021

Objectives Clozapine is the most effective atypical antipsychotic agent for the treatment-resistant schizophrenia (TRS), however, only 40%-70% of TRS patients respond to clozapine. Moreover, TRS encompasses various symptom dimensions. Therefore, augmentation with other medications for clozapine is frequently applied. However, the prescription pattern of clozapine and combined medications in Korea is yet to be examined. This study aims to investigate the maintenance treatment pattern of clozapine and augmentation agents in one Korean tertiary hospital. Methods The patients with schizophrenia spectrum disorders under clozapine maintenance, defined as one-year clozapine continuation, were subjected for analysis. Medication data at one-year time-point after clozapine initiation was extracted and analyzed. Results Among total 2897 patients having clozapine prescription experience from January 2000 to December 2018, 1011 patients were on clozapine maintenance. The mean age of clozapine initiation was 30.2 ± 11.3 years, and the maintenance dose of clozapine was 217.8 ± 124.3 mg/day. Combination rate of antipsychotics, mood stabilizers, and antidepressants were 43.5%, 25.3%, 38.6%, respectively. Most frequently prescribed drugs in each category were aripiprazole, valproate, and sertraline. Olanzapine equivalent dose of combined antipsychotics was 10.4 ± 7.7 mg/day. Male patients were prescribed higher dose of combined antipsychotics and higher rate of antidepressants. Female patients had later onset of clozapine prescription. Patients with two or more combined antipsychotics were prescribed higher dose of clozapine and higher rate of antidepressants compared to patients with one combined antipsychotic. Conclusions Taken together, among the patients taking clozapine, a substantial rate of patients were under polypharmacy. The present findings based on the real-world prescription pattern could provide the valuable clinical information on the treatment of TRS-related conditions.