• 천문학회보
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• 제44권1호
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• pp.40.1-40.1
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• 2019

We utilize times since infall of cluster galaxies obtained from Yonsei Zoom-in Cluster Simulation (YZiCS), the cosmological hydrodynamic N-body simulations, and star formation rates from the SDSS data release 10 to study how quickly late-type galaxies are quenched in the cluster environments. In particular, we confirm that the distributions of both simulated and observed galaxies in phase-space diagrams are comparable and that each location of phase-space can provide the information of times since infall and star formation rates of cluster galaxies. Then, by limiting the location of phase-space of simulated and observed galaxies, we associate their star formation rates at z ~ 0.08 with times since infall using an abundance matching technique that employs the 10 quantiles of each probability distribution. Using a flexible quenching model covering different quenching scenarios, we find the star formation history of satellite galaxies that best reproduces the obtained relationship between time since infall and star formation rate at z ~ 0.08. Based on the derived star formation history, we constrain the quenching timescale (2 - 7 Gyr) with a clear stellar mass trend and confirm that the refined model is consistent with the "delayed-then-rapid" quenching scenario: the constant delayed phase as ~ 2.3 Gyr and the quenching efficiencies (i.e., e-folding timescale) outside and inside clusters as ~ 2 - 4 Gyr (${\propto}M_*^{-1}$) and 0.5 - 1.5 Gyr (${\propto}M_*^{-2}$), Finally, we suggest: (i) ram-pressure is the main driver of quenching of satellite galaxies for the local Universe, (ii) the quenching trend on stellar mass at z > 0.5 indicates other quenching mechanisms as the main driver.

• Journal of Genetic Medicine
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• 제17권2호
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• pp.89-91
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• 2020

Charcot-Marie-Tooth (CMT) disease can be divided mainly into demyelination and axonopathy based on the results of the electrophysiological study. Mitofusin 2, encoded by MFN2 gene, has a crucial role in the fusion of mitochondria, which is known to associate with CMT type 2A as one of the axonal forms. We describe a 44-year-old man with progressive weakness on bilateral legs after noticing foot drop in his early teen. When we examined him at 45 years of age, he presented atrophy on entire legs and with distal muscle weakness on limbs. The nerve conduction study revealed severely decreased amplitude on motor nerve ranging from 0.2 to 4.5 mV, while conduction velocity remained more than 30.4 m/s. The whole-exome sequencing revealed a novel variant c.2228G>T in MFN2 by efficient genetic analysis tool, MutationDistiller. This report will not only expand the mutation spectrum of CMT2A but also introduce a time-saving genetic analysis tool.

• Bulletin of the Korean Chemical Society
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• 제11권4호
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• pp.328-331
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• 1990

Three crystal structures of dehydrated Cd(II) and Rb(I) exchanged zeolite A, $Cd_{4.0}Rb_{4.0}-A (a = 12.204(3) {\AA}), Cd_{5.0}Rb_{2.0}-A (a = 12.202(1) {\AA}),$ and $Cd_{5.95}Rb_{0.1}-A (a = 12.250(2) {\AA}),$ have been determined by single-crystal X-ray diffraction techniques. Their structures were solved and refined in the cubic space group Pm3m at $21(1)^{\circ}C.$ All crystals were ion exchanged in flowing streams of mixed $Cd(NO_3)_2·4H_2O$ and $RbNO_3$ aqueous solution with total concentration of 0.05 M. All crystals were dehydrated at ca. $450^{\circ}C$ and $2×10^{-6}$ Torr for 2 days. In all of these structures, $Cd^{2+}$ ions are found on threefold axes, each nearly at the center of a 6-oxygen ring. The first three $Rb^+$ ions per unit cell preferentially associate with 8-oxygen rings, and additional $Rb^+$ ions, if present, are found on threefold axes in the large cavity. The final $R_1$ and $R_2$ values for the three structures are 0.087 and 0.079, 0.059 and 0.067, and 0.079 and 0.095, respectively.

• 한국자기공명학회논문지
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• 제20권2호
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• pp.56-60
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• 2016

Adenylate kinase (AK) enzyme which acts as the catalyst of reversible high energy phosphorylation reaction between ATP and AMP which associate with energetic metabolism and nucleic acid synthesis and signal transmission. This enzyme has three distinct domains: Core, AMP binding domain (AMPbd) and Lid domain (LID). The primary role of AMPbd and LID is associated with conformational changes due to flexibility of two domains. Three dimensional structure of human AK1 has not been confirmed and various mutation experiments have been done to determine the active sites. In this study, AK1R138A which is changed arginine[138] of LID domain with alanine[138] was made and conducted with NMR experiments, backbone dynamics analysis and mo-lecular docking dynamic simulation to find the cause of structural change and substrate binding site. Synthetic human muscle type adenylate kinase 1 (hAK1) and its mutant (AK1R138A) were re-combinded with E. coli and expressed in M9 cell. Expressed proteins were purified and finally gained at 0.520 mM hAK1 and 0.252 mM AK1R138A. Multinuclear multidimensional NMR experiments including HNCA, HN(CO)CA, were conducted for amino acid sequence analysis and signal assignments of $^1H-^{15}N$ HSQC spectrum. Our chemical shift perturbation data is shown LID domain residues and around alanine[138] and per-turbation value(0.22ppm) of valine[179] is consid-ered as inter-communication effect with LID domain and the structural change between hAK1 and AK1R138A.

• 한국지반공학회지:지반
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• 제13권3호
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• pp.63-76
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• 1997

파쇄된 석괴댐 재료의 공학적 특성을 조사하기 위하여 대형 삼축시험을 실시하였다. 시험에 사용된 재료는 greywacke이고, 시료는 골재의 최대 치수가 각각 38.1mm, 25.4mm 및 19.1mm이며 서로 평행한 3개의 입도분포곡선을 사용하였다. 시료의 크기는 $\phi300mm\times600mm$이고, 구속응력은 5t/$m^2$에서 60t/$m^2$까지 변화시켰다. 시험결과, 석피재료의 응력-변형율 관계 및 내부마찰각에 미치는 골재의 최대치수의 영향은 무시할 수 있는 것으로 나타났다. 구속응력이 5t/$m^2$에서 60t/$m^2$으로 증가될 때, 내부마찰각은 $51.6^{\circ}$에서부터 $40.5^{\circ}$까지 감소 하였다. 석괴재료에 대한 삼축시험결과로부터 쌍곡선 모델의 매개 변수를 산정하여, 이 값들을 Duncan등(1980)의 입상재료(GW및 GP재료)에 대한 추천치와 비교하였다. 매개변수중, 석괴재료의 시험결과로부터 산정된 no 및 K치가 특히 입상재료(GW및 GP재료)에 대한 추천치와 많은 차이를 보이는 것으로 판명되었다.

• 한국멀티미디어학회논문지
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• 제12권1호
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• pp.69-84
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• 2009

본 논문에서는, 인터넷 방송을 원하는 다수의 개인들 혹은 소규모 조직들을 위한 실시간 웹캐스팅 프레임워크가 설계, 구현된다. 그리하여 콘텐츠 전달을 위한 최소한의 장비만 보유하고 있으면 누구나 손쉽게 자신의 인터넷 방송이 가능하도록 하자는 것이 제안된 프레임워크의 목적이다. 이러한 시스템은 다양한 동작 환경에 용이하게 대처할 수 있도록 유연성 있는 구조를 가져야 한다. 제안된 프레임워크는 3가지 유형의 컴포넌트를 기반으로 하는 계층 구조로 이루어져 있어, 그에 연관된 계층의 컴포넌트 변경을 통해 내부 혹은 외부의 동작 환경의 변화에 효과적으로 대처할 수 있다. 또한 상위 계층의 컴포넌트들을 하드웨어 플랫폼과 어떻게 대응시키느냐에 따라, 비용과 성능 면에서, 다양한 유형의 목적하는 시스템을 구축할 수 있다는 장점도 가지고 있다. 그리하여 제안된 프레임워크를 기반으로 인터넷 방송 시스템이 실제로 구현되고, 콘텐츠를 생성하는 제작부의 수와 시청자에 해당하는 수신부의 수의 변화에 따른 응답지연 시간이 측정된다. 그리하여 응답지연 시간은 잘 알려진 성능 모델 중 하나인 M/M/1 성능 모델을 따르고 있으며 현재 구현된 시스템은 약 16 내지 20여개 정도의 제작부를 수용할 수 있음을 보여주었다.

• Animal cells and systems
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• 제1권4호
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• pp.589-594
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• 1997

The neuronal voltage-sensitive calcium channels (VSCCs) are multisubunit complexes consisting of $\alpha_1,\;\alpha_2-\delta$ and $\beta$ subunits. Heterologous expression and biochemical studies have shown that the activity of VSCCs is regulated by their $\beta$ subunits in a $\beta$ subunit isoform-specific manner. To elucidate the $\beta$ subunit identity of the P/Q-type calcium channel encoded by an $\alpha_{1A}$ subunit, which is exclusively expressed in the Purkinje and granule cell of the cerebellum, we have examined the spatial and temporal expression patterns of $\beta$ subunits and compared them with those of $\alpha_{1A}$ subunit in the developing rat cerebellum. Reverse transcriptase- polymerase chain reaction (RT-PCR) and Northern blot analysis have shown that $\beta_4$ subunit mRNA was prominently expressed in the cerebellum and much more abundant than any other distinct $\beta$ subunits. RNase protection assay has further demonstrated that the expression of $\alpha_{1A}$ and $\beta_4$ subunits increased during cerebellar development, while the amount of $\beta_2$ and $\beta_3$ mRNAs did not significantly change. In addition, a $\beta_4$ transcript was present in cultured cerebellar granule cells, but not in astrocyte cells, and the level of $\beta_4$ mRNA expression increased gradually in vitro seen as in vivo. Based on the spatial and temporal expression patterns of $\beta_4$ subunit, we conclude that $\beta_4$ may predominantly associate, but probably not exclusively, with the $\alpha_{1A}$ subunit in rat cerebellar granule cells.

• 대한수의학회지
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• 제39권3호
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• pp.554-559
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• 1999

The purpose of this study was to evaluate effect of chitosan-oligosaccharides (CHIOL) on hydrophobicity of pathogenic E coli including a field isolate from suckling piglet with diarrhea, E coli-O157 : H7, and E coli-O149 : K88ac. E coli field isolate appeared adhesion of 100% to n-hexadecane between 0.00125% and 0.05% CHIOL. E coli-O157 : H7 occurred adhesion of 69% and 64% under the level of 0.00125% and 0.025% CHIOL, respectively. E coli-O149 : K88ac showed adhesion of 100% in higher than 0.025% CHIOL. For cationic action, the adhesion of E coli isolate and E coli-O149 : K88ac to n-hexadecane were inhibited at level of higher than 10mM $Ca^{2+}$ but did not induce any difference among the concentrations used(p < 0.01). However, the adhesion of E coli-O157 : H7 to n-hexadecane was inhibited at level of higher than 50mM $Ca^{2+}$. In a field trial, control piglets showed average mortality of up to 58% during 3 days after the onset of diarrhea. In contrast, the prevalence of E coli-induced diarrhea in CHIOL-treated groups without mortality was dropped down to average 34% on the 1st day after the treatment of CHIOL, and average 2% on the 4th day. After then, piglets with diarrhea was not present. In conclusion, the low concentrations of CHIOL were most likely to associate with the enhancement of hydrophobicity to pathogenic E coli. Calcium inhibited the hydrophobicity of E coli by CHIOL. These results suggested that CHIOL could be played an efficient and reliable role in treating enteric colibacillosis of piglets.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권5호
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• pp.364-371
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• 2002

Many chemical compopunds are converted into reactive electrophilic metabolites by the oxidative(Phase I) enzymes, which are mainly cytochrome P-450 enzyme(CYPs). Phase II conjugating enzymes, such as glutathione S-transferase(GST), usually act as inactivation of enzymes. Genetic polymorphisms have been found to be associated with increased susceptibility to cancer of the lung, bladder, breast and colorectal. Many of the polymorphic genes of carcinogen metabolism show considerably different type of cancer among different ethnic groups as well as individuals within the same group. The aim of this study is (1) to establish the frequencies of genetic polymorphisms of GSTM1 and CYP1A1 in Korean oral squamous cell carcinoma(SCC), (2) to associate oral SCC with the risk of these genetic polymorphisms. The genetic polymorphisms of the GSTM1 and the CYP1A1 genes among 50 Korean oral SCC were analyzed using polymerase chain reaction(PCR). The results suggest that the homozygote and the mutant type of CYP1A1 MspI polymorphisms may be associated with genetic susceptibility to oral SCC in Korean. A combination of the GSTM1 null type with the homozygote(m1/m1), and the mutant(m2/m2) type of CYP1A1 MspI polymorphisms showed a relatively high risk of oral SCC in Korean. In the smoking group, the GSTM1 wild genotype may be the high risk factor of oral SCC in Korean. These data coincide with the hypothesis which states that different susceptibility to cancer of genetic polymorphisms exist among different ethnic group and different types of human cancer.

• 콘크리트학회지
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• 제6권6호
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• pp.180-189
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• 1994

철근콘크리트 구조물의 손상을 진동반응특성치의 변화를 측정한 자료로부터 예측할 수 있는 실용적인 방법론이 제시되었다. 먼저, 구조물에 발생한 손상의 위치를 구조물 모드형상의 변화로부터 결정할 수 있는 알고리즘이 요약되었다. 다음으로, 실물크기 1/3 촉소 건조된 철근콘크리트 구조물을 사용한 실험에서 알고리즘을 이용하여 손상의 위치를 예측하였다. 이 실험과정에는 손상발생 전$\cdot$후의 소수의 진동반응특성치가 사용되었다. 구조물의 손상을 예측한 결과로부터 알고리즘이 손상을 정확하게 발견하는 것으로 판명되었다.