• Korean Journal of Veterinary Research
• /
• v.8 no.1
• /
• pp.31-38
• /
• 1968

Hematological surveys using Bendixen's and Goetze's Key for bovine lymphosarcoma were made in dairy herds which have been composed of the cows imported from United States, Canada and Japan, and their calves in the area of Taegu and Chung-Nam. The results obtained were summarized as follows: 1. Of 521 cattle, 15(2.9%) were hematologically positive for lymphosarcoma; 28(5.4%) were suspect with Bendixen's Key, and 7 (1.3%) were positive; 26(5.%) were suspect with Goetze's Key. 2. Of 14 herds, 5 were involved in positive or suspect for lymphosarcoma with Bendixen's and Goetze's Key more than 5 per cent. Of the above 5 herds, 3 were involved in positive or suspect more than 30 per cent. These findings suggest that repeated hematological examinations and continuous clinical observations are required in the herds showed higher level of per cent of positive or suspect.

• Journal of Veterinary Clinics
• /
• v.3 no.2
• /
• pp.309-316
• /
• 1986

One six-year-old male Cocker spaniel with chief complaints of mandibular swelling and anorexia was referred. This dog was diagnosed into lymphosarcoma by the results of the examination with peripheral blood and fluid of the lymph nodes and bone marrow aspirated. This patient was multicentric form clinically and was cytomorphologically identified into lymphoblastic form of lymphosarcoma.

• Proceedings of the Korean Society of Veterinary Pathology Conference
• /
• 2001.09a
• /
• pp.25-25
• /
• 2001

An example of lymphoblastic lymphosarcoma was diagnosed in a 7-year-old male brown bear (Ursus arctos) that died after having a 7-month history of depression, anorexia and watery diarrhea. Grossly the mesenteric lymph nodes were enlarged to approximately 4 to 6 times their normal size and histologically diagnosed as lymphoblastic lymphosarcoma. The small intestinal mucosa was corrugated and had severe mural thickening due to infiltrated neoplastic cells. Hepatic metastasis was also noted. the mother of this bear which died at the age of 20 also had similar gross changes on necropsy, but histological examination was not performed at that time and therefore the exact type of neoplasm remained to be determined. Since the daughter also died of neoplasm, genetic factor could be suspected in this family. This is the first reported case of lymphosarcoma in Ursidae in Korea. As an incidental finding, endogenous lipid pneumonia was noted in the lung.

• Korean Journal of Veterinary Service
• /
• v.34 no.4
• /
• pp.403-407
• /
• 2011

This study describes a canine lymphosarcoma with a rapid proliferation and recurrence. A 4-year-old, male, Shih Tzu dog was examined for acute swelling mass. The mass had been identified since 3 months ago and enlarged $10{\times}7$ cm and located in the right axillary region. The surgical removal was recommended when patient visited veterinarian and the operation was conducted. The removed tumor was $11{\times}8{\times}7$ cm and firm, lobulated and white cut surface. Routine screening laboratory test was assessed with blood and radiological analysis. The metastasis sign was not detected on thoracic and abdominal radiography. Blood test revealed decreased lymphocytes. After surgical removal of the mass, microscopic histopathological examination was performed to determine the final diagnosis. Histopathologically, the tumors are characterized by the same histological features, including the presence of neoplastic cellular populations, and lymphocytes infiltration in varying proportions. Also, DNA was extracted and PCR analysis was employed to analyze the origin of tumor cells. T-cell specific nucleic acid fragments were specifically amplified by PCR. On the basis of the laboratory results, the tumor was diagnosed with canine T-cell lymphosarcoma. On the basis of our knowledge, this is the first report of canine T-cell lymphosarcoma in a Shih Tzu dog.

• Journal of the korean veterinary medical association
• /
• v.24 no.1
• /
• pp.25-29
• /
• 1988

An attempt to treat canine lymphosarcoma with the combination chemotherapy protocol consisting of cyclophosphamide, vincristine, L-asparaginase and methotrexate was made for 3 weeks. The chemotherapy to the patient showed good responses such as better cha

• Journal of Veterinary Clinics
• /
• v.11 no.2
• /
• pp.573-578
• /
• 1994

A lymphosarcoma was diagnosed in a 4-year-old female Formosan sika deer presented with persistent reproductive failure, anorexia, depression and diarrhea. Characteristic pathological findings were infiltration of neoplastic lymphoid cells and cancer emboli in the lymph nodes, heart, lung, kidney, urinary bladder, ovary, uterus and peritoneal fat tissue.

• Korean Journal of Veterinary Research
• /
• v.47 no.2
• /
• pp.187-190
• /
• 2007

A 7-year-old Jeju native boar was requested to the Veterinary Pathology Laboratory of Cheju National University with a clinical signs of anorexia, melena, lethargy and sudden death. At necropsy, four coalescing firm masses were occupied in the abdominal cavity between ventral surface of stomach and pancreas. Individual mass was a yellowish white in color and up to 6 cm in diameter. These masses were not encapsulated and bulged from the cut surface. Liver and spleen were enlarged and pale nodules were presented in these tissues. Some yellowish white nodules up to 5 mm in diameter were scattered in kidneys. Histopathologically, lymphoblastic tumor cells were occupied in the abdominal masses, multifocal areas of liver, kidneys, and spleen. Morphologically lymphoblastic tumor cells were round to oval in shape, and medium to large in size. They had round to oval nuclei, moderate amount of eosinophilic cytoplasm, and many mitotic figures. Immunohistochemistry revealed that tumor cells were CD3-positive and $CD79{\alpha}$-negative, consistent with T-cell lineage. Based on gross, microscopic findings and immunohistochemistry, this case was diagnosed as porcine multi-centric T cell lymphosarcoma. In animals, as in human, the T-cell lymphomas are generally more aggressive than B cell types and respond less well to therapy. In our best knowledge, this is the first report for porcine T cell lymphosarcoma in Korea.

• Journal of Veterinary Clinics
• /
• v.31 no.1
• /
• pp.73-76
• /
• 2014

A 10-year-old, female spayed mixed-breed dog with a history of vomiting and anorexia was examined. Abnormal findings of comlete blood count and serum chemistry included polycythemia, thrombocytopenia, hyper-globulinemia and hypoalbuminemia. Abdominal radiographs revealed severe unilateral renomegaly, and ultrasonography showed a left-sided renal mass. During the operation, left kidney was resected. Cytologial and histopathological examinations revealed neoplastic lymphoid proliferation with high mitotic figures in renal mass. Immunohistochemistry revealed tumor cells were CD3-positive and CD79${\alpha}$-negative, consistent with T-cell lineage. The renal mass of this case was diagnosed as renal T cell lymphosarcoma.

• Korean Journal of Veterinary Research
• /
• v.41 no.1
• /
• pp.85-87
• /
• 2001

A case of disseminated lymphoblastic lymphosarcoma is reported in an aborted bovine fetus 7 month in gestation. Grossly, numerous tan firm nodules, 2 to 5 mm in diameter were scattered throughout the myocardium and skeletal muscle. The corticomedullary junction of the kidney was discolored to whitish tinct. Histologically, compact sheet of monomorphic lymphoblastic lymphoid cell infiltration was noted in the myocardium and skeletal muscle. Neoplastic cell infiltration was also noted in the corticomeullary junction and deep cortical regions of the kidney, lung and the liver. This is believed to be the first reported case of lymphosarcoma in an aborted bovine fetus in Korea.

• Journal of the korean veterinary medical association
• /
• v.25 no.2
• /
• pp.86-88
• /
• 1989