• Journal of Chest Surgery
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• 제50권3호
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• pp.190-196
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• 2017

Background: The feasibility of single-port video-assisted thoracic surgery (SPVATS) for primary lung cancer is not well understood. In this study, we compared SP and multi-port (MP) VATS for the surgical treatment of patients with primary lung cancer. Methods: Surgical treatment was performed in 181 patients with primary lung cancer at Inje University Haeundae Paik Hospital between June 2012 and December 2015. A propensity-matched analysis was used to compare the postoperative outcomes and to evaluate the comparative feasibility and safety of SPVATS and MPVATS. Results: There were 37 patients in the SPVATS group and 67 patients in the MPVATS group. Propensity matching produced 32 pairs. The operation time (210 minutes versus 200 minutes, p=0.11), volume of the estimated blood loss (170 mL versus 160 mL, p=0.19), duration of chest tube drainage (5 days versus 6 days, p=0.66), and length of hospital stay (9 days versus 10 days, p=0.89) were similar between the 2 groups. Conclusion: In our study, SPVATS for primary lung cancer was safe and feasible in well selected patients. A prospective, randomized study with a large group and long-term follow-up is necessary to evaluate the clinical feasibility and the advantages of SPVATS for primary lung cancer.

• Safety and Health at Work
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• 제5권4호
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• pp.234-237
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• 2014

Background: Inhalation of asbestos fibers can lead to adverse health effects on the lungs. This study describes lung function profiles among individuals with nonmalignant asbestos-related disorders (ARDs). Methods: The study population was from the Workers' Compensation (Dust Diseases) Board of New South Wales, Sydney, Australia. Lung function measurements were conducted in males with asbestosis (n = 26), diffuse pleural thickening (DPT; n = 129), asbestosis and DPT (n = 14), pleural plaques only (n = 160) and also apparently healthy individuals with a history of asbestos exposure (n = 248). Standardized spirometric and single-breath diffusing capacity for carbon monoxide ($DL_{CO}$) measurements were used. Results: Mean age [standard deviation (SD)] was 66.7 (10.3) years for all participants. Current and ex-smokers among all participants comprised about 9.0% and 54.8%, respectively. Median pack-years (SD) of smoking for ex- and current-smokers were 22.7 (19.9). Overall 222 participants (38.6%) and 139 participants (24.2%) had forced expiratory volume in 1 second ($FEV_1$) and forced vital capacity (FVC) measurements < 80% predicted, and 217 participants (37.7%) had $FEV_1/FVC$ results < 70%. A total of 249 individuals (43.8%) had DLCO values < 80% predicted and only 75 (13.2%) had DLCO/VA results < 80% predicted. A total of 147 participants (25.6%) had peak expiratory flow (PEF) measurements < 80% predicted. The presence of ARDs lowered the lung function measurements compared to those of healthy individuals exposed to asbestos. Conclusion: Lung function measurement differs in individuals with different ARDs. Monitoring of lung function among asbestos-exposed populations is a simple means of facilitating earlier interventions.

• 대한통합의학회지
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• 제9권4호
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• pp.11-18
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• 2021

Purpose : The purpose of this study was to investigate the effect on lung capacity of healthy men and women in their twenties by performing an intervention using the chest extension exercise and the bridge exercise, which are respiratory muscle strengthening exercises. Methods : Thirty adult men and women in their 20s participated in this study. All subjects participated in the study after hearing the explanation of the purpose and method of the study, filling out a consent form. All subjects were randomly assigned to the chest extension exercise (CEE) group and the bridge exercise (BE) group of fifteen each. Each exercise was performed twice a week for 4 weeks. Lung capacity was measured by forced vital capacity (FVC) and forced expiratory volume in one second (FEV₁) using spirometry. Lung capacity was measured before and after exercise. The measured data were compared through the dependent t-test and the independent t-test. The statistical significance level was set at .05. Results : After the intervention, the CEE group showed a significant increase in FVC and FEV₁ compared to before the intervention (p<.05). After the intervention, the BE group also had a significant increase in FVC and FEV₁ compared to before the intervention (p<.05). However, there was no difference in FVC and FEV₁ between groups before and after the intervention (p>.05). Conclusion : There was no difference between groups in lung capacity after exercise. However, both the chest extension exercise and the bridge exercise increased FVC and FEV1, which was thought to be because both exercise methods were effective in increasing lung capacity. Therefore, both chest extension exercises and bridge exercises can be effectively applied as a way to increase lung capacity.

• Journal of Chest Surgery
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• 제39권11호
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• pp.844-849
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• 2006

배경: 미만성 침윤성 폐질환의 확진을 위해서는 외과적 폐생검이 필요하다. 개흉 폐생검과 흉강경 폐생검 방법을 비교하고 외과적 폐생검이 미만성 간질성 폐질환의 진단에 미치는 영향을 알아보고자 하였다. 대상 및 방법: 2000년 3월부터 2005년 12월까지 영남대학교의료원 흉부외과에서 폐생검을 시행한 환자를 후향적 조사를 하였다. 외과적 폐생검 후 조직학적 진단과 치료방침의 변화를 분석하고 소개흉술을 실시한 군(OLB)과 비디오 흉강경수술을 실시한 군(TLB)으로 나누어 비교 분석하였다. 결과: 전체 환자는 36명이었고 기침이 가장 많은 술 전 증상이었다. OLB군과 TLB군 사이에 수술시간, 마취시간, 재원기간, 흉관거치 기간, 채취한 조직의 용적, 합병증 발생률에는 유의한 차이가 없었다. 전 예에서 술 후 조직학적 진단이 가능하였다. 술 후 33%에서 치료 방침의 변화가 있었고 두 군 간유의한 차이는 없었다. 술 후 사망은 1예가 있었고 술 전 호흡부전이 있었던 환자에서 발생하였다. 결론: 외과적 폐생검은 미만성 침윤성 폐질환을 확진할 수 있는 진단방법이고 술 후 치료 방침의 결정에 많은 도움을 준다. 흉강경 폐생검은 개흉 폐생검에 비해 덜 침습적이고 동일한 조직학적 진단율을 보이므로 외과적 폐생검의 기본 수술술기라 할 수 있다.

• 대한핵의학회지
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• 제19권2호
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• pp.43-50
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• 1985

With the improvement of hemodialysis, the course of the disease in patient with endstage renal disease has been clearly improved. Nevertheless, among several shortcomings to our present mode of renal replacement therapy, cardiovascular complications have been the leading cause of morbidity and mortality. Several factors such as anemia, arteriovenous shunting of blood, intermittent extracorporeal circulation and hypertension may be contributing. But little is known about the quantitative cardiac hemodynamic characteristics occurred during hemodialysis. The purpose of this study is to observe the sequential hemodynamic changes before, during and after the hemodialysis and to investigate reliable parameters in the detection of ventricular dysfunction. In the present study, equilibrium radionuclide cardiac angiography was performed and left and right ventricular volume indices, ejection phase indices of both ventricular, performance were measured in the 16 stable patients with chronic renal failure treated with maintenance hemodialysis sequentially i.e. before, during (early and late phase) and after the hemodialysis. The results obtained were as follows; 1) The indices of the left ventricular function were not changed during the hemodialysis but increased after the hemodialysis. 2) The indices of the right ventricular function(EF, SVI) were significantly decreased in the early phase (15, 30 minutes after starting extracorporeal circulation) but recovered after the hemodialysis. 3) The ratio of right ventricular to left ventricular ejection fraction was significantly decreased in the early phase and the lung volume indices were significantly increased at the same phase. As a conclusion, hemodialysis improves left ventricular function maybe due to increased contractility, and effects on the right ventricular function maybe due to the increased lung volume in the early phase of hemodialysis.

• 한국콘텐츠학회논문지
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• 제19권8호
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• pp.284-292
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• 2019

소아 흉부 CT 검사 시 방사선 피폭을 최소화 하면서 진단적으로 가치가 높은 영상을 얻기 위해서 Helical mode, High-pitch mode, Volume Axial mode를 적용하여서 선량, 검사시간, 화질을 비교하여 유용성을 평가하고자 한다. Revolution(GE Healthcare, Wisconsin USA)을 이용하여 PBU-70팬텀을 Helical mode, High-pitch mode, Volume Axial mode로 각각의 그룹으로 나누어서 관전압 80kVp, 조건으로 30회 검사를 실시하였다. 영상을 획득 한 후에 각각의 영상에 심장(Heart), 뼈(Bone), 폐(Lung), Back-ground air에 ROI를 설정하고 CT number(HU)와 noise(SD)값을 측정하여 평균값을 구하고 SNR과 CNR을 측정하였고, 장비에서 직접 제공하는 DLP값 비교하였다. 통계적인 유의성을 확인해보기 통계 분석은 SPSS 21.0을 사용하여 ONE-WAY-ANAOVA를 시행하였다. 본 실험을 통해 검사 시 volume axial mode 사용 시 가장 적은 선량으로 영상의 화질 저하 없이 빠른 시간에 검사가 가능하였다. 16cm의 detector coverage 가 모든 소아 흉부 CT검사에 적용하기에 제한점이 있으나 가능한 소아환자에 있어 적극적인 활용을 추천하며 volume axial mode의 다른 검사부위 적용에 대한 지속적인 연구가 필요하리라 사료된다.

• 한국정보전자통신기술학회논문지
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• 제6권1호
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• pp.37-44
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• 2013

본 논문에서는 voxel classification을 이용한 폐 결절 자동 검출 시스템을 제안한다. 제안하는 폐 영상 분석 방법은 크게 세 단계로 구성된다. 첫 번째 단계에서는 분석 대상 폐 영역을 분할한다. 그리고 두 번째 단계는 분할된 폐 영역 내에서 폐 구조물을 분할한다. 마지막으로 두 번째 과정에서 분할된 폐결절후보와 폐혈관 voxel을 대상으로 log-polar sampling을 이용한 특징 벡터를 만들고, 특징벡터를 입력 값으로 하여 support vector machine classifier를 이용하여 분석대상 voxel을 폐 결절 voxel과 비결절 voxel로 구분하여 폐 결절을 검출한다.

• 대한물리의학회지
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• 제6권4호
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• pp.407-414
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• 2011

Purpose : The aim of this study was to clarify the lung capacity, maximal insufflation capacity, and peak cough flow when a mechanical insufflation-exsufflation(MIE) method was used to increase Duchenne muscular dystrophy patients' lung function. Methods : The subjects of the study were 21 patients with Duchenne muscular dystrophy. They were randomly selected from patients within the boundaries of the selection criteria, and divided into two groups; The subject group(n=11) used the mechanical insufflation-exsufflation method with traditional therapeutic exercise. The control group(n=10) used only traditional therapeutic exercise. Results :The results indicated that maximal insufflation capacity, unassisted peak cough flow and assisted peak cough flow significantly increased in the subject group(p<.05). By contrast, in the control group, the results didn't indicate the significant differences from the variable. There were significant differences in maximal insufflation capacity and assisted peak cough flow between the subject group and the control group before and after the application of the mechanical insufflation-exsufflation method. Conclusion : A mechanical insufflation-exsufflation method has positive effects on the improvements of cough functions and that of pulmonary functions such as lung volume, lung elasticity in patients with Duchenne muscular dystrophy.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1703-1706
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• 2013

Lung cancer remains a deadly disease with unsatisfactory overall survival. Resveratrol (Res) has the potential to inhibit growth of several types of cancer such as prostate and colorectal examples. In the current study, we evaluated in vitro and in vivo anticancer efficiency of Res in a xenograft model with A549 cells. Cell inhibition effects of Res were measured by MTT assay. Apoptotis of A549 cells was assessed with reference to caspase-3 activity and growth curves of tumor volume and bodyweight of the mice were measured every two days. In vitro cytotoxicity evaluation indicated Res to exert dose-dependent cell inhibition effects against A549 cells with activation of caspase-3. In vivo evaluation showed Res to effectively inhibit the growth of lung cancer in a dose-dependent manner in nude mice. Therefore, we believe that Res might be a promising phytomedicine for cancer therapy and further efforts are needed to explore this potential therapeutic strategy.

• Tuberculosis and Respiratory Diseases
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• 제71권5호
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• pp.341-348
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• 2011

Background: The aim of this study was to investigate annual changes in pulmonary function in workers who were exposed to inorganic dust. Methods: The subjects were 2,922 male patients who had been diagnosed with pneumoconiosis more than twice during 6 years from 2005 to 2010. Results: Of the 2,922 cases, forced vital capacity (FVC) decreased by 54 mL in 1 year. In contrast, the annual change of forced expiratory volume in one second ($FEV_1$) decreased by 56 mL. Conclusion: This is the first study that has investigated the annual change in pulmonary function in workers exposed to inorganic dust. The results will help estimate the pulmonary condition of patients who are unable to perform a pulmonary function test due to age or a disorder.