• The Journal of Advanced Prosthodontics
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• 제2권3호
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• pp.111-115
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• 2010

PURPOSE. This study was conducted to evaluate clinical validity of a zirconia full-coverage crown by comparing zirconia's wear capacity over antagonistic teeth with that of feldspathic dental porcelain. MATERIALS AND METHODS. The subject groups were divided into three groups: the polished feldspathic dental porcelain group (Group 1), the polished zirconia group (Group 2), and the polished zirconia with glazing group (Group 3). Twenty specimens were prepared from each group. Each procedure such as plasticity, condensation, and glazing was conducted according to the manufacturer's manual. A wear test was conducted with 240,000 chewing cycles using a dual-axis chewing simulator. The degree of wear of the antagonistic teeth was calculated by measuring the volume loss using a three-dimensional profiling system and ANSUR 3D software. The statistical significance of the measured degree of wear was tested with a significant level of 5% using one-way ANOVA and the Tukey test. RESULTS. The degrees of wear of the antagonistic teeth were $0.119{\pm}0.059\;mm^3$ in Group 1, $0.078{\pm}0.063\;mm^3$ in Group 3, and $0.031{\pm}0.033\;mm^3$ in Group 2. Statistical significance was found between Group 1 and Groups 2 and between Group 2 and 3, whereas no statistical significance was found between Group 1 and Group 3. CONCLUSION. Despite the limitations of this study on the evaluation of antagonistic teeth wear, the degree of antagonistic tooth wear was less in zirconia than feldspathic dental porcelain, representing that the zirconia may be more beneficial in terms of antagonistic tooth wear.

• Molecules and Cells
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• 제40권3호
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• pp.186-194
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• 2017

A brain-enriched secreting signal peptide, NELL2, has been suggested to play multiple roles in the development, survival, and activity of neurons in mammal. We investigated here a possible involvement of central NELL2 in regulating feeding behavior and metabolism. In situ hybridization and an immunohistochemical approach were used to determine expression of NELL2 as well as its colocalization with proopiomelanocortin (POMC) and neuropeptide Y (NPY) in the rat hypothalamus. To investigate the effect of NELL2 on feeding behavior, 2 nmole of antisense NELL2 oligodeoxynucleotide was administered into the lateral ventricle of adult male rat brains for 6 consecutive days, and changes in daily body weight, food, and water intake were monitored. Metabolic state-dependent NELL2 expression in the hypothalamus was tested in vivo using a fasting model. NELL2 was noticeably expressed in the hypothalamic nuclei controlling feeding behavior. Furthermore, all arcuatic POMC and NPY positive neurons produced NELL2. The NELL2 gene expression in the hypothalamus was up-regulated by fasting. However, NELL2 did not affect POMC and NPY gene expression in the hypothalamus. A blockade of NELL2 production in the hypothalamus led to a reduction in daily food intake, followed by a loss in body weight without a change in daily water intake in normal diet condition. NELL2 did not affect short-term hunger dependent appetite behavior. Our data suggests that hypothalamic NELL2 is associated with appetite behavior, and thus central NELL2 could be a new therapeutic target for obesity.

• 한국재료학회지
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• 제13권7호
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• pp.453-459
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• 2003

In this paper the effect of interstitial heat treatment on the microstructure and mechanical properties was examined both in the 0.15C-6Mn steels and 0.15C-6Mn steels added with Nb or Ti. This result will be applied into the development of a steel which has the properties of high strength and high ductility resulted from the transformation induced plasticity. The strength-elongation combination was increased as the holding time was increased when the temperature is at $625^{\circ}C$. However, the strength-elongation combination was decreased sharply as the holding time was increased when the temperature is at $675^{\circ}C$. The tensile strength and elongation of a reverse transformed steels added with Ti or Nb was 93 kg/$\textrm{mm}^2$ and 40%, respectively. This steel shows higher strength more than 10% of the 0.15C-6Mn steel without loss of ductility. The autenite formed from the reverse transformed treatment has a fine lath type, which has the width size of 0.1-0.3 $\mu\textrm{m}$. The TRIP sequence normally transforms the austenite to martensite, however, some of the sequence will produce retained austenite \longrightarrow deformation twin \longrightarrow martensite

• 소성∙가공
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• 제24권1호
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• pp.37-43
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• 2015

The purpose of the current study is to improve the clinching joint strength of aluminum and fiber metal laminates (FMLs) comprised of three layers. The joining of FML and Al 5052 by a conventional clinching joint has some disadvantages such as necking of the upper sheet, lack of interlocking, defects caused by the vertical load, and especially loss of strength of the composite material due to the low ductility. In the current study, a tapered-hole clinching method is proposed as an alternative for the joining of Al 5052 and FMLs. A hole with a tapered shape is formed before the joining process. The design parameters were evaluated using the Taguchi method for the geometry of the tapered hole in order to determine the maximum separation load. The diameter of the punch corner, clearance, punch stroke and the tapered length were used as the main variables in the Taguchi method. In conclusion, the contribution ratio for each of the fours variable examined was 35.07%, 22.44%, 21.32% and 14.11%, respectively. In addition, the appropriate combination of the design parameters can make a 5% improvement in the vertical direction joint strength.

• Restorative Dentistry and Endodontics
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• 제46권1호
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• pp.2.1-2.8
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• 2021

Objectives: New premixed bioceramic root repair materials require moisture for setting. Using micro-computed tomography (micro-CT), this study evaluated the filling ability and volumetric changes of calcium silicate-based repair materials (mineral trioxide aggregate repair high-plasticity [MTA HP] and Bio-C Repair, Angelus), in comparison with a zinc oxide and eugenol-based material (intermediate restorative material [IRM]; Dentsply DeTrey). Materials and Methods: Gypsum models with cavities 3 mm deep and 1 mm in diameter were manufactured and scanned using micro-CT (SkyScan 1272. Bruker). The cavities were filled with the cements and scanned again to evaluate their filling capacity. Another scan was performed after immersing the samples in distilled water for 7 days to assess the volumetric changes of the cements. The statistical significance of differences in the data was evaluated using analysis of variance and the Tukey test with a 5% significance level. Results: Bio-C Repair had a greater filling ability than MTA HP (p < 0.05). IRM was similar to Bio-C and MTA HP (p > 0.05). MTA HP presented the largest volumetric change (p < 0.05), showing more volume loss than Bio-C and IRM, which were similar (p > 0.05). Conclusions: Bio-C Repair is a new endodontic material with excellent filling capacity and low volumetric change. The gypsum model proposed for evaluating filling ability and volumetric changes by micro-CT had appropriate and reproducible results. This model may enhance the physicochemical evaluation of premixed bioceramic materials, which need moisture for setting.

• Animal Bioscience
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• 제37권2_spc호
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• pp.396-403
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• 2024

Objective: Monofluoroacetate (MFA) is a potent toxin that blocks ATP production via the Krebs cycle and causes acute toxicity in ruminants consuming MFA-containing plants. The rumen bacterium, Cloacibacillus porcorum strain MFA1 belongs to the phylum Synergistota and can produce fluoride and acetate from MFA as the end-products of dehalorespiration. The aim of this study was to identify the genomic basis for the metabolism of MFA by this bacterium. Methods: A draft genome sequence for C. porcorum strain MFA1 was assembled and quantitative transcriptomic analysis was performed thus highlighting a candidate operon encoding four proteins that are responsible for the carbon-fluorine bond cleavage. Comparative genome analysis of this operon was undertaken with three other species of closely related Synergistota bacteria. Results: Two of the genes in this operon are related to the substrate-binding components of the glycine reductase protein B (GrdB) complex. Glycine shares a similar structure to MFA suggesting a role for these proteins in binding MFA. The remaining two genes in the operon, an antiporter family protein and an oxidoreductase belonging to the radical S-adenosyl methionine superfamily, are hypothesised to transport and activate the GrdB-like protein respectively. Similar operons were identified in a small number of other Synergistota bacteria including type strains of Cloacibacillus porcorum, C. evryensis, and Pyramidobacter piscolens, suggesting lateral transfer of the operon as these genera belong to separate families. We confirmed that all three species can degrade MFA, however, substrate degradation in P. piscolens was notably reduced compared to Cloacibacillus isolates possibly reflecting the loss of the oxidoreductase and antiporter in the P. piscolens operon. Conclusion: Identification of this unusual anaerobic fluoroacetate metabolism extends the known substrates for dehalorespiration and indicates the potential for substrate plasticity in amino acid-reducing enzymes to include xenobiotics.

• 소성∙가공
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• 제25권1호
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• pp.36-42
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• 2016

Fiber metal laminates (FMLs) are well known for improved fatigue strength, better impact resistance, superior damage tolerance and slow crack growth rate compared to traditional metallic materials. However, defects and loss of strength of a composite material can occur due to the vertical load from the punch during the joining with a dissimilar material using a conventional clinching method. In the current study, tapered-hole clinching was an alternative process used to join Al 5052 and FMLs. The tapered hole was formed in the FML before the joining. For the better understanding of static and dynamic characteristics, a clinched joining followed by a tensile-shear test was numerically simulated using the finite element analysis. The design parameters were also evaluated for the geometry of the tapered hole by the Taguchi method in order to improve and compare the lateral joining strength of the clinched joint. The influence of the neck thickness and the undercut were evaluated and the contribution of each design parameter was determined. Then, actual experiments for the joining and tensile-shear test were conducted to verify the results of the numerical simulations. In conclusion, the appropriate combination of the design parameters can improve the joining strength and the cross-sections of the tapered-hole clinched joint formed in the actual experiments were in good agreement with the results of the numerical simulations.

• 한국산학기술학회논문지
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• 제16권9호
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• pp.6385-6390
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• 2015

수평 곡선 I-형 거더에는 초기곡률이라는 기하학적 특성으로 인해 휨 모멘트와 더불어 비틀림 모멘트가 작용하게 된다. 이러한 휨 비틀림 거동은 서로 상호 작용을 일으켜 약축방향으로 2차 휨거동을 유발하게 된다. 휨과 비틀림 간의 상호 작용은 곡선 거더를 조기에 비선형 상태 및 소성 상태로 유도하여 내하력의 저하를 야기하게 되고, 차량의 이동 위치에 따른 편심 하중은 비틀림을 더욱 증대시킬 수 있다. 그러나 기존에 연구되어왔던 직선 거더에 대한 휨 비틀림 상호관계식은 곡선 거더가 가지고 있는 거동 특성이 고려되지 않았기 때문에 수직하중을 받는 수평 곡선 I-형 거더의 극한 강도가 과대평가 될 수 있다. 따라서 이에 대한 보다 명확하고 합리적인 제안식의 적용이 곡선 거더의 설계 시에 필요하다. 본 연구에서는 유한요소해석을 통하여 편심하중이 작용하는 수평 곡선 I형 거더의 휨 비틀림 상호작용 특성을 파악하고 거동분석을 수행하였다.

• 한국건설순환자원학회논문집
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• 제6권3호
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• pp.53-60
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• 2011

건설폐기물이 매년 증가함에 따라 제도적으로 건설폐기물을 재활용한 순환골재의 사용을 촉진하게 되었고, 이에 따라 현장에 순환골재의 사용이 증가되었다. 그러나 순환골재의 알카리수 용출에 의한 환경적 문제가 발생하게 되었고, 이를 저감시킬 방안에 대한 연구가 요구되었다. 본 연구는 순환골재의 알카리저감을 위한 방안으로 촉진탄산화 반응을 이용한 알카리 저감장치를 제작하여 순환골재 생산현장에 설치하고, 대량의 순환골재를 대상으로 알카리저감효과 및 품질의 영향을 분석하였다. 그 결과, 탄산화 반응시간 30초, 반응압력 -50 kPa에서 100 kPa까지 3싸이클의 압력변화를 주는 조건에서, 순환골재 pH는 9.33에서 9.8의 범위 내를 유지하였다. 또한 순환골재의 물리적 품질은 탄산화 반응 전보다 반응 후의 소성지수, 수정 CBR, 마모감량, 모래당량, 액성한계, 입도분포, 밀도 및 흡수율이 개선되는 것으로 나타났다.

• 한국터널지하공간학회 논문집
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• 제8권2호
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• pp.87-100
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• 2006

본 연구에서는 화강암의 3차원 거동을 예측 분석할 수 있는 구성방정식을 마이크로플레인 모델을 이용하여 Westerly 화강암과 Bonnet 화강암의 시험데이터와 최적을 이루도록 개발하였다. 개발된 마이크로플레인 모델은 화강암의 일축압축 및 삼축압축 거동을 잘 예측하였다. 그리고 개발된 화강암의 마이크로플레인 모델을 유한요소법에 적용하여 암반 굴착시의 발파 모사를 통해 화강암의 비선형 거동을 효과적으로 해석하였다. 발파 응력파의 감쇠계수, 파쇄 영역 그리고 여굴을 방지할 수 있는 화약 장전조건 등이 연구되었다. 마이크로플레인 모델에서는 암석의 비선형 거동 및 균열발생으로 인한 에너지 감소가 잘 반영되었으며 발파 응력파의 감쇠계수는 선형탄성모델보다 크게 계산되었다. 또한 마이크로플레인 모델에서는 발파 응력파 진행에 따른 최대 주변형율을 이용하여 파쇄 영역을 직접적으로 계산할 수 있었다.