• 제목/요약/키워드: loss curves

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Prognostic Value of Restaging F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography to Predict 3-Year Post-Recurrence Survival in Patients with Recurrent Gastric Cancer after Curative Resection

  • Sung Hoon Kim;Bong-Il Song;Hae Won Kim;Kyoung Sook Won;Young-Gil Son;Seung Wan Ryu
    • Korean Journal of Radiology
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    • v.21 no.7
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    • pp.829-837
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    • 2020
  • Objective: The aim of this study was to investigate the prognostic value of the maximum standardized uptake value (SUVmax) measured while restaging with F-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) to predict the 3-year post-recurrence survival (PRS) in patients with recurrent gastric cancer after curative surgical resection. Materials and Methods: In total, 47 patients with recurrent gastric cancer after curative resection who underwent restaging with 18F-FDG PET/CT were included. For the semiquantitative analysis, SUVmax was measured over the visually discernable 18F-FDG-avid recurrent lesions. Cox proportional-hazards regression models were used to predict the 3-year PRS. Differences in 3-year PRS were assessed with the Kaplan-Meier analysis. Results: Thirty-nine of the 47 patients (83%) expired within 3 years after recurrence in the median follow-up period of 30.3 months. In the multivariate analysis, SUVmax (p = 0.012), weight loss (p = 0.025), and neutrophil count (p = 0.006) were significant prognostic factors for 3-year PRS. The Kaplan-Meier curves demonstrated significantly poor 3-year PRS in patients with SUVmax > 5.1 than in those with SUVmax ≤ 5.1 (3-year PRS rate, 3.5% vs. 38.9%, p < 0.001). Conclusion: High SUVmax on restaging with 18F-FDG PET/CT is a poor prognostic factor for 3-year PRS. It may strengthen the role of 18F-FDG PET/CT in further stratifying the prognosis of recurrent gastric cancer.

A comparative experimental study on the mechanical properties of cast-in-place and precast concrete-frozen soil interfaces

  • Guo Zheng;Ke Xue;Jian Hu;Mingli Zhang;Desheng Li;Ping Yang;Jun Xie
    • Geomechanics and Engineering
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    • v.36 no.2
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    • pp.145-156
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    • 2024
  • The mechanical properties of the concrete-frozen soil interface play a significant role in the stability and service performance of construction projects in cold regions. Current research mainly focuses on the precast concrete-frozen soil interface, with limited consideration for the more realistic cast-in-place concrete-frozen soil interface. The two construction methods result in completely different contact surface morphologies and exhibit significant differences in mechanical properties. Therefore, this study selects silty clay as the research object and conducts direct shear tests on the concrete-frozen soil interface under conditions of initial water content ranging from 12% to 24%, normal stress from 50 kPa to 300 kPa, and freezing temperature of -3℃. The results indicate that (1) both interface shear stress-displacement curves can be divided into three stages: rapid growth of shear stress, softening of shear stress after peak, and residual stability; (2) the peak strength of both interfaces increases initially and then decreases with an increase in water content, while residual strength is relatively less affected by water content; (3) peak strength and residual strength are linearly positively correlated with normal stress, and the strength of ice bonding is less affected by normal stress; (4) the mechanical properties of the cast-in-place concrete-frozen soil interface are significantly better than those of the precast concrete-frozen soil interface. However, when the water content is high, the former's mechanical performance deteriorates much more than the latter, leading to severe strength loss. Therefore, in practical engineering, cast-in-place concrete construction is preferred in cases of higher negative temperatures and lower water content, while precast concrete construction is considered in cases of lower negative temperatures and higher water content. This study provides reference for the construction of frozen soil-structure interface in cold regions and basic data support for improving the stability and service performance of cold region engineering.

Fire resistance assessment of high strength segment concrete depending on PET fiber amount under fire curves (화재곡선과 PET섬유 혼입량에 따른 고강도 세그먼트 콘크리트의 화재저항성 평가에 대한 연구)

  • Choi, Soon-Wook;Lee, Gyu-Phil;Chang, Soo-Ho;Park, Young-Taek;Bae, Gyu-Jin
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.16 no.3
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    • pp.311-320
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    • 2014
  • High strength concrete is not only vulnerable to the occurrence of spalling which generates the loss of cross-section in concrete structures but produces faster degradation in its mechanical properties than normal strength concrete in the event of fire. This study aims to evaluate fire resistance of high strength segment concrete with PET fibers mixed to prevent spalling under ISO834 (2hr) and RABT fire curve. As results, the samples without PET fibers show the concrete loss up to the depth of about 8 cm and 9.5 cm from the surface exposed to fire under ISO834 and RABT fire curve respectively. The samples mixed with PET fiber of 0.1% show no spalling under ISO834 fire curve and the spalled thickness of 6.5 cm under RABT fire curve after the fire tests. Finally, the sample mixed with PET fiber of 0.2% shows no spalling under RABT fire curve. The results indicate that the suitable amounts of PET fiber for securing fire resistance performance of this high strength segment concrete are 0.1% under ISO834 fire curve and 0.2% under RABT fire curve. However, even though spalling does not occur, it is necessary to repair the deterioration of concrete up to 4 cm from the surface exposed to fire after fire.

Radiation Effects on the Ignition and Flame Extinction of High-temperature Fuel (고온연료의 점화 및 화염 소화특성에 미치는 복사효과)

  • Kim, Yu Jeong;Oh, Chang Bo;Choi, Byung Il;Han, Yong Shik
    • Fire Science and Engineering
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    • v.27 no.6
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    • pp.50-56
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    • 2013
  • The radiation effects on the auto-ignition and extinction characteristics of a non-premixed fuel-air counterflow field were numerically investigated. A detailed reaction mechanism of GRI-v3.0 was used for the calculation of chemical reactions and the optically-thin radiation model was adopted in the simulations. The flame-controlling continuation method was also used in the simulation to predict the auto-ignition point and extinction limits precisely. As a result, it was found that the maximum H radical concentration, $(Y_H)_{max}$, rather than the maximum temperature was suitable to understand the ignition and extinction behaviors. S-, C- and O-curves, which were well known from the previous theory, were identified by investigating the $(Y_H)_{max}$. The radiative heat loss fraction ($f_r$) and spatially-integrated heat release rate (IHRR) were introduced to grasp each extinction mechanism. It was also found that the $f_r$ was the highest at the radiative extinction limit. At the flame stretch extinction limit, the flame was extinguished due to the conductive heat loss which attributed to the high strain rate although the heat release rate was the highest. The radiation affected on the radiative extinction limit and auto-ignition point considerably, however the effect on the flame stretch extinction limit was negligible. A stable flame regime defined by the region between each extinction limit became wide with increasing the fuel temperature.

Preliminary Estimation of Earthquake Losses Based on HAZUS in a Coastal Facility Area with Blocks Applying Site Classification (블록별 부지분류 적용 해안시설 영역에서의 HAZUS 기반 지진피해 추정)

  • Sun, Chang-Guk;Chun, Sung-Ho
    • Journal of the Korean Association of Geographic Information Studies
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    • v.17 no.4
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    • pp.10-27
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    • 2014
  • HAZUS-MH is a GIS-based computer program that estimates potential losses from multi-hazard phenomena: earthquakes, floods and hurricanes. With respect to seismic disaster, characteristics of a hypothetical or actual earthquake are entered into HAZUS. Then HAZUS estimates the intensity of ground shaking and calculates the correspondent losses. In this study, HAZUS was used as a part of the preparations of the future seismic events at a coastal plant facility area. To reliably characterize the target facility area, many geotechnical characteristics data were synthesized from the existing site investigation reports. And the buildings and facilities were sorted by analyzing their material and structural characteristics. In particular, the study area was divided into 17 blocks taking into account the situation of both land development and facility distribution. The ground conditions of blocks were categorized according to the site classification scheme for earthquake-resistant design. Moreover, seismic fragility curves of a main facilities were derived based on the numerical modeling and were incorporated into the database in HAZUS. The results estimated in the study area using HAZUS showed various seismic damage and loss potentials depending on site conditions and structural categories. This case study verified the usefulness of the HAZUS for estimating earthquake losses in coastal facility areas.

Development of Vibration and Impact Noise Damping Wood-Based Composites -Synthesis of the Polymer Showing a Broad Damping Peak (진동·충격음 흡수성 목질계 복합재료의 개발 -폭 넓은 감쇠곡선을 나타내는 고분자의 합성-)

  • Lee, Hyun-Jong
    • Journal of the Korean Wood Science and Technology
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    • v.27 no.2
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    • pp.15-22
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    • 1999
  • Polymeric meterials that are used for noise and vibration damper in wood/polymer/wood sandwich composites, must have a high loss factor(tan ${\delta}$), and at the same time the storage modulus(E) of $5{\times}10^7$ to $10^9$ dyne/$cm^2$ must withstand over a wide temperature and frequency ranges. In this study, the series of epoxy resinlpolyacrylate interpenetrating polymer networks(IPNs) were synthesized by simultaneous polymerization. Their dynamic tensile properties were measured at 110Hz using Rheovibron instrument. Composite damping factor(tan ${\delta}_c$) and dynamic bending modulus($E_c,\;E_^{\prime\prime}c$) of wood/polymer/wood sandwich composites were measured at 110Hz using a Rheovibron in bending mode of vibration. These dynamic tensile studies indicated that cured epoxy resin/polyacrylates IPNs were semicompatible in the sense that both the shifting of T($E^{\prime\prime}_{max}$) or T(tan ${\delta}_{max}$) and the broadening of glass transition temperature range were observed. Especially, the cured Epikote871/P(n-BMA) IPNs of composition 70/30 to 50/50 showed a relatively high tan a and appropriate E' value over a wide temperature range; consequently the tan a e curves of wood/IPNs/wood sandwich composites was broadened over a wide temperature range.

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Establishment of a Murine Model for Radiation-induced Bone Loss in Growing C3H/HeN Mice (성장기 마우스에서 방사선 유도 골소실 동물모델 확립)

  • Jang, Jong-Sik;Moon, Changjong;Kim, Jong-Choon;Bae, Chun-Sik;Kang, Seong-Soo;Jung, Uhee;Jo, Sung-Kee;Kim, Sung-Ho
    • Journal of Radiation Protection and Research
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    • v.40 no.1
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    • pp.10-16
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    • 2015
  • Bone changes are common sequela of irradiation in growing animal. The purpose of this study was to establish an experimental model of radiation-induced bone loss in growing mice using micro-computed tomography (${\mu}CT$). The extent of changes following 2 Gy gamma irradiation ($2Gy{\cdot}min^{-1}$) was studied at 4, 8 or 12 weeks after exposure. Mice that received 0.5, 1.0, 2.0 or 4.0 Gy of gamma-rays were examined 8 weeks after irradiation. Tibiae were analyzed using ${\mu}CT$. Serum alkaline phosphatase (ALP) and biomechanical properties were measured and the osteoclast surface was examined. A significant loss of trabecular bone in tibiae was evident 8 weeks after exposure. Measurements performed after irradiation showed a dose-related decrease in trabecular bone volume fraction (BV/TV) and bone mineral density (BMD), respectively. The best-fitting dose-response curves were linear-quadratic. Taking the controls into accounts, the lines of best fit were as follows: BV/TV (%) = $0.9584D^2-6.0168D+20.377$ ($r^2$ = 0.946, D = dose in Gy) and BMD ($mg{\cdot}cm^{-3}$) = $8.8115D^2-56.197D+194.41$ ($r^2$ = 0.999, D = dose in Gy). Body weight did not differ among the groups. No dose-dependent differences were apparent among the groups with regard to mechanical and anatomical properties of tibia, serum ALP and osteoclast activity. The findings provide the basis required for better understanding of the results that will be obtained in any further studies of radiation-induced bone responses.

CCD Photometric Observations and Light Curve Synthesis of the Near-Contact Binary XZ Canis Minoris (근접촉쌍성 XZ CMi의 CCD 측광관측과 광도곡선 분석)

  • Kim, Chun-Hwey;Park, Jang-Ho;Lee, Jae-Woo;Jeong, Jang-Hae;Oh, Jun-Young
    • Journal of Astronomy and Space Sciences
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    • v.26 no.2
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    • pp.141-156
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    • 2009
  • Through the photometric observations of the near-contact binary, XZ CMi, new BV light curves were secured and seven times of minimum light were determined. An intensive period study with all published timings, including ours, confirms that the period of XZ CMi has varied in a cyclic period variation superposed on a secular period decrease over last 70 years. Assuming the cyclic change of period to occur by a light-time effect due to a third-body, the light-time orbit with a semi-amplitude of 0.0056d, a period of 29y and an eccentricity of 0.71 was calculated. The observed secular period decrease of $-5.26{\times}10^{-11}d/P$ was interpreted as a result of simultaneous occurrence of both a period decrease of $-8.20{\times}10^{-11}d/P$ by angular momentum loss (AML) due to a magnetic braking stellar wind and a period increase of $2.94{\times}10^{-11}d/P$ by a mass transfer from the less massive secondary to the primary components in the system. In this line the decreasing rate of period due to AML is about 3 times larger than the increasing one by a mass transfer in their absolute values. The latter implies a mass transfer of $\dot{M}_s=3.21{\times}10^{-8}M_{\odot}y^{-1}$ from the less massive secondary to the primary. The BV light curves with the latest Wilson-Devinney binary code were analyzed for two separate models of 8200K and 7000K as the photospheric temperature of the primary component. Both models confirm that XZ CMi is truly a near-contact binary with a less massive secondary completely filling Roche lobe and a primary inside the inner Roche lobe and there is a third-light corresponding to about 15-17% of the total system light. However, the third-light source can not be the same as the third-body suggested from the period study. At the present, however, we can not determine which one between two models is better fitted to the observations because of a negligible difference of $\sum(O-C)^2$ between them. The diversity of mass ratios, with which previous investigators were in disagreement, still remains to be one of unsolved problems in XZ CMi system. Spectroscopic observations for a radial velocity curve and high-resolution spectra as well as a high-precision photometry are needed to resolve some of remaining problems.

Thermal Stability and Cure Behavior of Waterborne Phenol-Formaldehyde Resin (수용성 페놀-포름알데히드 수지의 열안정성 및 경화거동)

  • Yoon, Sung Bong;Kim, Jin Woo;Cho, Donghwan
    • Journal of Adhesion and Interface
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    • v.7 no.1
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    • pp.16-22
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    • 2006
  • In this work, the effect of cure temperature and time on the thermal stability and the exothermic cure reaction peak of a waterborne resol-type phenol-formaldehyde resin, which may be used for preparing phenolic sheet molding compounds (SMC), has been investigated using a thermogravimetric analyzer and a differential scanning calorimeter. The weight loss of waterborne phenol-formaldehyde resin was mainly occurred at three temperature stages: near $200^{\circ}C,\;400^{\circ}C$, and $500^{\circ}C$. The carbon yield at $750^{\circ}C$ for the cured resin was about 62%~65%. Their thermal stability increased with increasing cure temperature and time. Upon cure, the exothermic reaction was taken placed in the range of $120^{\circ}C{\sim}190^{\circ}C$ and the maximum peak was found in between $165^{\circ}C$ and $170^{\circ}C$. The shape and the maximum of the exothermic curves depended on the given cure temperature and time. To remove $H_2O$ and volatile components, the uncured resin needed a heat-treatment at $100^{\circ}C$ for 60 min at least prior to cure or molding. Curing at $130^{\circ}C$ for 120 min made the exothermic peak of waterborne phenol-formaldehyde resin completely disappeared. And, post-curing at $180^{\circ}C$ for 60 min further improved the thermal stability of the cured resin.

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Evaluation of Durability for Glass fabric/Phenolic Composites under Salt Water Environment (염수환경에 노출된 유리섬유직물/페놀 복합재의 내구성 평가)

  • Yoon, Sung-Ho
    • Composites Research
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    • v.18 no.4
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    • pp.27-34
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    • 2005
  • Salt water spray and immersion tests were experimentally conducted for over 6 months to investigate the durability of glass fabric/phenolic composites under salt water environment. Mechanical properties such as tensile properties, flexural properties, and shear properties were evaluated and thermal analysis properties such as storage shear modulus, loss shear moduls, and tan 6 were obtained through a DMA. A change in chemical structures was analyzed through a FTIR. According to the results, mechanical properties and thermal analysis properties were sensitive to salt water environment and these properties began to degrade in increasing in exposure times. However, tensile and flexural moduli started to decrease and then slightly increase as increasing in exposure times due to plasticization and crosslinking in matrix as well as physical swelling in composites. Beyond a certain exposure times, these properties began to decrease as further increasing in exposure times. Also the shape and location of peaks in FTIR curves were insensitive to exposure times, but the intensity of peaks would be. finally we found that the durability of glass fabric/phenolic composites were affected on salt water immersion environment rather than salt water spray environment.