• IMMUNE NETWORK
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• 제20권3호
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• pp.20.1-20.15
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• 2020

Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.

• 대한지역사회영양학회지
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• 제19권2호
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• pp.142-162
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• 2014

Objectives: To evaluate the critical environmental factors on healthy-aging of Korean people, we investigated the significant factors influencing health status of septuagenarians living in rural area of Jeonla province, known to be one of the representative longevity regions in Korea. Methods: We divided subjects into healthy group (36M/25F) or poor-health group (26M/73F) based on self-reported health status, body mass index, a number of prescription, and blood test data. General characteristics, physical measurements, lifestyle, dietary behavior and nutrient intake, physical health and mental health data were statistically compared between the two groups. Results: Average age was not different between healthy group and poor-health group in men and women, respectively. In men, significantly favorable factors to health were observed to be higher education, regular exercise, higher grip strength and walking function, body mass index (${\geq}18.5kg/m^2$), moderate frequency of drinking and eating-out, non-smoking, normal red blood cell (RBC) count, higher serum dehydroepiandrosterone-sulfate (DHEAS) level, good digestive function and appetite, normal hearing function, regular meals, adequate vegetable and fruit intake, diverse food intake, adequate energy and nutrients (protein, vitamin $B_1$, $B_6$, C and E, folate, niacin, P, Zn and K) intake, higher mini-nutrient status assessment (MNA) score and low level of depression. On the other hand, in women, those were literacy, living arrangement, moderate frequency of drinking, healthy teeth, higher grip strength and walking function, bone mineral density, normal RBC and white blood cell (WBC) count, higher DHEAS concentration, higher MNA score, normal cognition and memory function, having snack and adequate fruit intake. Conclusions: These results could be useful to plan effective strategies to increase health-life expectancy of Korean old people living in rural areas.

• 한국학교보건학회지
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• 제20권1호
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• pp.63-75
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• 2007

Purpose: With economic development and prolonged longevity, the level of health and health disparities have became growing concerns for individual and society as well. Since youth's health status are influenced by households' socioeconomic status and associated with heath status in later stage of life, assessing health inequality in the youth is a significant step toward lessening health disparity and promoting health. We measured health inequality in high school students and decomposed it into health factors. Methods: The subjects included 3,787 high school students of 12th graders from the Korea Education and Employment Panel (KEEP) in 2004. True health status was assumed as a latent variable and estimated by ordered logistic regression model. The predicted health was used as a measure of individual health after rPSraling to [0,1] interval. Total health inequality was then measured by Gini coefficient and was decomposed into health factors. Results: Health inequality in high school students was observed. Of total health inequality, 44% was explained by biological factors such as body mass index (BMI) (32.5%) and gender (13.5%). Behavioral factors such as smoking, drinking, physical activity, hours in bed and hours of computer ussge added to 11.7%. Household income and work experiences explained 5.6% and 8.8%, respectively. School satisfaction explained 14.6%. Other school related factors such as self-assessed achievement and experience of being bullied accounted for 15.5%. Conclusion: Among the health factors, biological factor was the most important contributor in health disparity. Other factors such as health behaviors, socioeconomic factors, school satisfaction and school related factors exhibited somewhat similar magnitude. For policy purposes, it is recommended to look into modifiable factors depending BM, gender and school surroundings.

• 산학경영연구
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• 제14권
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• pp.45-62
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• 2001

이 연구는 전략적 제휴의 존속기간을 결정하는 요소들에 대해 분석한다. 일반적으로 성공하는 전략적 제휴는 오랫동안 지속될 가능성이 맡고, 실패하는 전략적 제휴는 오랫동안 지속될 가능성이 낮다. 국가간의 차이, 산업형태 또는 환경, 파트너와의 전략적 제휴 경험, 다른 기업들과의 전략적 제휴 경험 등이 전략적 제휴들의 지속기간에 미치는 효과들을 조사함으로써 간접적으로 전략적 제휴의 성공, 실패요인을 조사한다. 이 효과를 조사하기 위하여 네델란드의 Limburg의 대학교 연구자들에 수집된 CATI (Cooperative Agreements and Technology Indicators)에서 표본을 추출하여 Cox-Regression을 이용한다. 결과들이 보고되어지고, 어떤 전략적 의미들을 가지는지 조사한다.

• Journal of Preventive Medicine and Public Health
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• 제51권3호
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• pp.154-162
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• 2018

Objectives: Early retirement occurs when one's job satisfaction suffers due to employment mismatch resulting from factors such as inadequate compensation. Medical doctors report high levels of job stress and burnout relative to other professionals. These levels are highest among emergency physicians (EPs), and despite general improvements in their working conditions, early retirement continues to become more common in this population. The purpose of this study was to identify the factors influencing EPs intention to retire early and to develop a probability equation for its prediction. Methods: A secondary analysis of data from the 2015 Korean Society of Emergency Physicians Survey was performed. The variables potentially influencing early retirement were organized into personal characteristics, extrinsic factors, and intrinsic factors. Logistic regression analysis was performed to identify risk factors and to develop a probability equation; these findings were then arranged in a nomogram. Results: Of the 377 survey respondents included in the analysis, 48.0% intended to retire early. Risk factors for early retirement included level of satisfaction with the specialty and its outlook, slanderous reviews, emergency room safety, health status, workload intensity, age, and hospital type. Intrinsic factors (i.e., slanderous reviews and satisfaction with the specialty and its outlook) had a stronger influence on early retirement than did extrinsic factors. Conclusions: To promote career longevity among EPs, it is vital to improve emergency room safety and workload intensity, to enhance medical professionalism through a stronger vision of emergency medicine, and to strengthen the patient-doctor relationship.

• 동의생리병리학회지
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• 제28권4호
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• pp.452-459
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• 2014

The purpose of this study was to examine the correlation between general health condition and biopsychological traits of Sasang typology which determines the disease susceptibility and treatment responses. We had Korean Constitutional Multicenter Bank (KCMB) listed 1156 participants for measuring Sasang Personality Questionnaire (SPQ) and Body Mass Index (BMI) for biopsychological traits of each Sasang types as well as Short Form 12 (SF12) for general health status. All the analysis was performed with consideration of gender and age. We analyzed the differences in general health status between Sasang types and the correlation between general health status and biopsychological traits of Sasang typology. We also analyzed how much the selected SF12 subscales can be explained with biopsychosocial characteristics. There were no generaliszable differences among Sasang type groups in SF12, no significant correlation between biopsychological traits and SF12 Physical and Mental Component Summary. We found that there were significant correlations between SPQ-Behavior subscale and SF12 Vitality, and the regression model with SPQ-Behavior, SPQ-Emotionality, age and sex can predict 15.4% of the total variances in SF12 Vitality. We discussed the possibility that the Sasang typology is not a determinant of general health status but a moderator for the susceptibility and response. This study would contribute to the development of Sasang type-specific life nurturing program focusing on the psychological perspectives.

• 한국식품영양학회지
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• 제27권5호
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• pp.940-955
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• 2014

The purpose of this study was to compare the degree nutrient intake, health status and other characteristics of females aged 65 years and over in a longevity area according to family arrangement. For analysis, 585 female elderly were recruited from the Kugoksoondam area (Kurye, Goksung, Soonchang and Damyang counties), known as the longevity-belt region in Jeonla province, Korea. The subjects were categorized into three groups according to family arrangement (living alone, living with spouse only and living with family). Demographic characteristics were collected, as well as information on physical measurements, blood tests for biochemical indicators, health status and health-related life style, dietary behavior, favorite food groups, consumption frequency of food groups, nutrient intake and mini nutrition assessment. In the group living with their spouse only, the highest education, physical activity, diverse food intake, frequency of eating meats and fish, energy and nutrients intake, and score on the mininutrient status assessment (MNA) were found to be significantly favorable factors. Taken together, these results demonstrated that the group living with their spouse only had relatively superior nutrient intake and the quality of diet. In contrast, the group living alone showed the lowest self-rated economic status, diversity of food intake, and physical activity, with the highest frequency of drinking, smoking and regular exercise for almost everyday compared with the other groups. On the other hand, those living with family demonstrated the lowest intake of supplements or functional foods, and levels of hemoglobin hematocrit MCH, but the highest HBA1c and blood sugar. Therefore, the group living with family was assumed to be at risk of anemia and diabetes. These results could be useful to plan effective strategies to increase the health-life expectancy of Korean elderly people living in rural areas, according to family arrangement.

• 생명과학회지
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• 제30권12호
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• pp.1092-1100
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• 2020

Six-transmembrane epithelial antigen of prostate 4 (Steap4)는 철과 구리를 환원하여 철과 구리의 세포내 유입에 관여하는 금속 환원효소로, 구리 철의 항상성 뿐만 아니라 염증, 포도당 대사, 지질 대사에도 중요한 역할을 한다. 최근에 Steap4가 지방세포의 분화를 촉진한다는 보고가 발표되었으나, 이에 관련된 분자적 기전에 대해서는 알려지지 않았다. 그래서, 본 연구에서는 Steap4에 의한 지방세포분화 촉진에 관련된 기전을 연구하였다. 이를 위해 3T3-L1 백색지방세포, 불멸화된 갈색지방세포(iBA) 및 생쥐의 배아 섬유아 세포인 C3H10T1/3 세포에서 Steap4을 감소시킨 후 지방세포분화 초기단계에 관련된 신호들을 분석하였다. Steap4을 shRNA로 감소시켰을 때 지방세포분화 초기 단계에서 3종류 지방세포의 세포 증식이 억제되었으며, 세포주기 관련 단백질인 cyclin A, cyclin D 그리고 cdk2의 발현은 감소하는 반면 세포주기 저해 단백질인 p21과 p27의 발현은 증가하였다. 또한 세포주기 관련 신호인 p38, ERK 그리고 Akt의 활성화는 억제되었다. 한편 지방세포분화 초기 단계에 관여하는 지방세포분화 전사인자들을 분석하였을 때, Steap4의 감소는 지방세포분화 활성 전사 인자인 C/EBPβ, KLF4의 발현을 저해하는 반면, 지방세포분화 억제 전사 인자인 KLF2, KLF3 그리고 GATA2의 발현은 증가시켰다. 또한 Steap4의 과발현은 C/EBPβ promoter에 존재하는 전사억제 히스톤 표지자인 H3K9me2과 H3K27me3을 감소시켰다. 따라서, 이상의 결과를 종합하면 Steap4는 지방세포분화 초기단계인 mitotic clonal expansion을 촉진하고 지방세포분화 전사인자들의 발현을 조절함으로써, 지방세포분화를 촉진시킴을 알 수 있었다.

• 보건행정학회지
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• 제20권1호
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• pp.37-63
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• 2010

Public expenditures on long-term care are a matter of concern for Korea as in many other countries. The expenditure is expected to accelerate and to put pressure on public budgets, adding to that arising from insufficient retirement schemes and other forms of social spending. This study tried to foresee how much health care spending could increase in the future considering demographic and non-demographic factors as the drivers of expenditure. Previous projections of future long-term expenditure were mainly based on a given relation between spending and age structure. However, although demographic factors will surely put upward pressure on long-term care costs, other non-demographic factors, such as labor cost increase and availability of informal care, should be taken into account as well. Also, the possibility of dynamic link between health status and longevity gains needs to be considered. The model in this study is cell-base and consists of three main parts. The first part estimated the numbers of elderly people with different levels of health status by age group, gender, household type. The second part estimated the levels of long-term care services required, by attaching a probability of receiving long-term care services to each cell using from the sample from current year. The third part of the model estimated long-term care expenditure, along the demographic and non-demographic factors' change in various scenarios. Public spending on long-term care could rise from the current level of 0.2~0.3% of GDP to around 0.44~2.30% by 2040.

• KIEAE Journal
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• 제13권1호
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• pp.141-150
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• 2013

As longevity of human-beings is extended and the population of aged people increases, diverse issues related with the aged people are presented. The neighborhood space for the aged people is required to be designed based upon the understanding of such difficulties of the elderly and the public outdoor environment is an important environmental resource that can enhance the quality of life and promote the health of the elderly in underprivileged area without burdening them economically. This study aims to research the daily life of the elderly in underprivileged urban area and their utilization styles of outdoor environments in order to find out the push factors and pull factors that induce the aged people to use the outdoor environments. For this purpose, this study carried out an interview survey upon 69 elderly residents and surveyed on 363 elderly residents of low income class who are aged 60 and over and living in decaying area in Jeonju. For the analysis of the collected data, a qualitative and a quantitative analysis were accomplished. As results of study, the elderly in underprivileged area use such outdoor environments as resting facilities, exercise equipment, parks, farming gardens and waterfronts, and the push factors for them to use the outdoor environments were sordid indoor spaces, sense of isolation or loneliness, and the desire for maintaining good health. And the pull factors for them to use the outdoor environments were natural factors, opportunities for social interactions, space for exercise. The obstacles that hinder the elderly in using outdoor environments were the bad health of the elderly, lack of facilities, accessibility and weather conditions. Thus, the results of this study are expected to provide basic data for designing the outdoor environments to promote the health of the elderly in urban underprivileged area and to relieve the burdensome problems related with ageing societies.