• Restorative Dentistry and Endodontics
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• 제45권3호
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• pp.31.1-31.20
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• 2020

Matrix metalloproteinases (MMPs) are enzymes that can degrade collagen in hybrid layer and reduce the longevity of adhesive restorations. As scientific understanding of the MMPs has advanced, useful strategies focusing on preventing these enzymes' actions by MMP inhibitors have quickly developed in many medical fields. However, in restorative dentistry, it is still not well established. This paper is an overview of the strategies to inhibit MMPs that can achieve a long-lasting material-tooth adhesion. Literature search was performed comprehensively using the electronic databases: PubMed, ScienceDirect and Scopus including articles from May 2007 to December 2019 and the main search terms were "matrix metalloproteinases", "collagen", and "dentin" and "hybrid layer". MMPs typical structure consists of several distinct domains. MMP inhibitors can be divided into 2 main groups: synthetic (synthetic-peptides, non-peptide molecules and compounds, tetracyclines, metallic ions, and others) and natural bioactive inhibitors mainly flavonoids. Selective inhibitors of MMPs promise to be the future for specific targeting of preventing dentin proteolysis. The knowledge about MMPs functionality should be considered to synthesize drugs capable to efficiently and selectively block MMPs chemical routes targeting their inactivation in order to overcome the current limitations of the therapeutic use of MMPs inhibitors, i.e., easy clinical application and long-lasting effect.

• 대한두개안면성형외과학회지
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• 제24권2호
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• pp.59-65
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• 2023

Background: Fibrous dysplasia (FD) is a localized bone disorder in which fibro-osseous tissue replaces the normal bone structure. Patients with craniofacial FD often present with gradual swelling, deformity, and compromised vision or hearing. We previously introduced "the core extirpation method," a novel surgical technique that is minimally invasive like traditional bone shaving but has longer-lasting effects. This study presents the long-term outcomes of our core extirpation method. Methods: We conducted a retrospective analysis of patients who underwent core extirpation for FD of the zygomaticomaxillary region from 2012 through 2021. Computed tomography (CT) scans were performed 6 to 12 months before the operation, immediately before and after the operation, and during follow-up visits. We performed all operations using the upper gingivobuccal approach, and we extirpated the core of the lesion while preserving the cortical structures of the zygoma and the maxilla to maintain symmetrical facial contour. Results: In 12 patients with lesions in the growth phase, anteroposterior/mediolateral (AP/ML) length discrepancies and the volume increased between preoperative and immediate postoperative CT scans. All patients' immediate postoperative AP/ML discrepancies were stable up to 12-17 months postoperatively. Postoperative volume showed continuous lesion growth; the median volume growth rate was 0.61 cc per month. Conclusion: In this article, we present our experiences managing FD using the minimally invasive core extirpation technique, which entails small expected blood loss and can be performed as day surgery. It provides similar cosmetic outcomes as traditional bone shaving but with longer-lasting results. Although there are some limitations with the study's retrospective nature and small sample size, our 4-year follow-up results show promising results of the core extirpation method in well-indicated patients.

• 토지주택연구
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• 제12권4호
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• pp.103-117
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• 2021

인구 및 기술의 변화속도가 빠른 현재 상황에서 장수명주택인증은 건물의 물리적 및 기능적 수명 연장 견인책이다. 장수명주택 인증요건인 가변성과 수리용이성은 인필요소를 구조와 구분하여 교체 및 변경하도록 유도한다. 이러한 방식은 공업화주택의 특징과도 부합하여 설계 및 시공방법의 변화로 두 가지 주택 유형은 함께 활성화될 수 있을 것이다. 본 연구에서는 이러한 특징을 고려하여 OSC공법을 활용한 공동주택 모델이 장수명주택 인증기준을 충족하도록 계획하였다. 이러한 결과로 평면가변성 및 설비배관의 설치방법, 화장실 공사 방법 등을 습식 공법과는 다른 방식을 적용하여 제시하였다. 가변형 평면은 22m²와 46m²의 두 가지 타입 평면을 확장하여 69m²평면을 만드는 세대통합방법 그리고 가변 가능한 건식패널 벽체를 활용하여 69m²평면을 여러 가지로 계획하는 방법을 제안했다. 이러한 가변성은 9m×10.5m 스팬의 강콘크리트 합성구조 및 일체형 슬래브로 SI시스템 중 서포트 부분을 구성하고 비내력 외벽 및 내벽, 배관 등을 인필부분으로 구분하여 건축구성재를 부품화하는 방식으로 만들 수 있다. 이러한 서포트와 인필 분리 만으로도 시공법과 관련된 기준을 상당부분 충족할 수 있다. 현재 인필요소를 교체 용이하게 하는 기술은 탄소저감 등에서 국가에 편익이 증가할 수 있으므로 활성화를 위해 세제혜택 등의 인센티브 도입을 검토할 필요가 있다.

• International Journal of Costume and Fashion
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• 제14권2호
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• pp.81-96
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• 2014

The meanings of colors vary with time and space. For the most important events in a person's life, such as wedding or funeral, people use color to symbolize their identities or roles. Traditionally, the colors of dress had indicated the wearer's age, class, or marital status in Korea. However, Korea's exposure to western cultures has affected in many dimensions of its modern history. Especially, influenced by social change, the traditional dress has undergone many modifications in forms, silhouettes, materials, and color. However, women's mourning dress has been maintained as a long lasting tradition and the use of white in mourning dress has been regarded as a norm until recently, while men have worn a regular black suit with a black tie. But, the shift from white to black in mourning dress has been observed in recent mourning practices. To examine this change of color in Korean traditional mourning dress, a historical approach utilizing multiple resources, such as interview, observations of events, documents, and archival records was applied.

• 천문학회보
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• 제42권1호
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• pp.31.1-31.1
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• 2017

Spiral structure in disk galaxies is modeled with ncollisionless N-body simulations including live disks, halos, and bulges with a range of masses. Two of these simulations make long-lasting and strong two-arm spiral wave modes that last for about 5 Gyr with constant pattern speed. These two had a light stellar disk and the largest values of the Toomre Q parameter in the inner region at the time the spirals formed, suggesting the presence of a Q-barrier to wave propagation resulting from the bulge. The relative bulge mass in these cases is about 10%. Models with weak two-arm spirals had pattern speeds that followed the radial dependence of the Inner Lindblad Resonance. In addition to these, we also report a few more cases where two-armed spirals are developed and are maintained for a several rotation time scales.

• The Korean Journal of Physiology
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• 제30권1호
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• pp.117-124
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• 1996

This study evaluated the hypothesis that motoneuron collaterals modulate the excitability of ventral spinocerebellar tract neurons. In acute cats, 128 ventral cerebellar tract cells were studied extracellularly to determine the effects of ventral root stimuli. The majority of the cells responded to ventral root stimulation with either short or long latency increases in spike discharge. In many cells with sufficient spontaneous activity ventral root stimulation also evoked a long lasting reduction in activity. In preparations with the dorsal root ganglion removed VSCT neurons had similar response properties. In some cells contralateral ventral root stimulation also evoked excitatory responses. These findings indicate the VSCT can provide the cerebellum with information regarding activity in the final output neurons of the motor system, the alpha motoneurons.

• Molecules and Cells
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• 제39권7호
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• pp.515-523
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• 2016

Long-term immunity to many viral and bacterial pathogens requires$ CD8^+$ memory T cell development, and the induction of long-lasting$ CD8^+$ memory T cells from a $na{\ddot{i}}ve$, undifferentiated state is a major goal of vaccine design. Formation of the memory$ CD8^+$ T cell compartment is highly dependent on the early activation cues received by $na{\ddot{i}ve}$ $CD8^+$ T cells during primary infection. This review aims to highlight the cellularity of various niches within the lymph node and emphasize recent evidence suggesting that distinct types of T cell activation and differentiation occur within different immune contexts in lymphoid organs.

• Journal of the Optical Society of Korea
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• 제15권1호
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• pp.103-108
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• 2011

Recently reported asynchronous-optical-sampling terahertz (THz) time-domain spectroscopy enables high-resolution spectroscopy due to a long time-delay window. However, a long-lasting tail signal following the main pulse is often measured in a time-domain waveform, resulting in spectral fluctuation above a background noise level on a high-resolution THz amplitude spectrum. Here, we adopt the wavelet power spectrum estimation technique (WPSET) to effectively remove the spectral fluctuation without sacrificing spectral features. Effectiveness of the WPSET is verified by investigating a transmission spectrum of water vapor.

• 한국실내디자인학회논문집
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• 제15권6호
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• pp.172-177
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• 2006

Most of the Korean multi-dwelling houses have less than 20 years of lifespan. Because the environmental issues such as energy consumption, limited resources, and demolition waste problems became been more and more critical, we now need to focus on long lasting and adaptable buildings. Korean wall bearing apartment buildings are constructed with site cast concrete for core, exterior, and interior together with pipes varied, so when the buildings are old and life style of the users changes, it is difficult to maintain and renovate these buildings. In this study, to resolve the problems described above, two types of Korean long life multi-dwelling housing models which represent improved durability and adaptability responding user's needs and life style changes were proposed with various methods as follows: Either column and beam structure or flat slab structure was used to utilize space better. To make maintenance easier and renovation economical for both public space and each unit, plumbing pipes, ducts, and conduits were clustered at the cores and public corridors with access doors and light weight partitions with steel studs and raised floors or above-ceiling spaces were used in lieu of site cast concrete walls and floor slabs with varied pipes.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 추계학술대회 논문집
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• pp.211-215
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• 1999

It is well known that a long-term exposure to a loud noise environment affects performance, since it distracts attention, and also is able to evoke stress accompanied by negative emotional states. The purpose of this study was to analyze dynamics of subjective and physiological variables during long-lasting (30 min) exposure to intensive white noise (85 dB[A]). Physiological signals on 23 college students were recorded by BIOPAC, Grass Neurodata systems and AcqKnowledge 3.5 software. Autonomic variables, namely skin conductance level (SCL), non-specific SCR number (N-SCR), inter-beat intervals in ECG (RR intervals), heart rate variability index (HF/LF ratio of HRV), respiration rate (RESP), and skin temperature (SKT) were analyzed on 5 min epoch basis. Psychological assessment (subjective rating of stress level) was also repeated on every 5 min basis. Regression and correlation analyses were employed to trace the time course of the dynamics of the subjective and autonomic physiological variables and their relationship. Results showed that intense noise evokes subjective stress with associated autonomic nervous system responses. However, it was shown that physiological variables endure specific changes in the process of exposure to loud white noise. Discussed are probable psychophysiological mechanisms mediating reactivity to long-term auditory stimulation of high intensity.