• Bulletin of the Korean Chemical Society
• /
• v.19 no.4
• /
• pp.400-401
• /
• 1998

• Archives of Pharmacal Research
• /
• v.15 no.1
• /
• pp.69-72
• /
• 1992

Pyrimidine bases and their mucleosides were oxidatively iodinated at C-5 position by the reaction of iodine in DMF (dimethylformamide) with MCPBA (m-chloroperbenzoic acid) under mild conditions. For uracil derivatives such as uracil 1a. 1, 3-dimethyluracil 1b, uridine 1c, and 2'-deoxyuridine 1d, the corresponding 5-iodo derivatives were obtained in high yields (71-95%). The iodination of cytidine 3a and 2'-deoxycytidine 3b was achieved in moderate yields (41-56%).