• Structural Engineering and Mechanics
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• 제83권4호
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• pp.435-449
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• 2022

Constitutive modeling that could reasonably predict and effectively evaluate the post-peak structural behavior while eliminating the mesh-dependency in numerical simulation remains to be developed for general engineering applications. Based on the previous work, a simple one-dimensional modeling procedure is proposed to predict and evaluate the post-peak response, as characterized by the evolution of localized strain field, of a steel member to monotonically uniaxial tension. The proposed model extends the classic one-dimensional softening with localization model as introduced by (Schreyer and Chen 1986) to account for the localization length, and bifurcation and rupture points. The new findings of this research are as follows. Two types of strain-softening functions (bilinear and nonlinear) are proposed for comparison. The new failure criterion corresponding to the constitutive modeling is formulated based on the engineering strain inside the localization zone at rupture. Furthermore, a new mathematical expression is developed, based on the strain rate inside and outside the localization zone, to describe the displacement field at which bifurcation occurs. The model solutions are compared with the experimental data on four low-carbon cylindrical steel bars of different lengths. For engineering applications, the model solutions are also compared to the experimental data of a cylindrical steel bar system (three steel bars arranged in series). It is shown that the bilinear and nonlinear softening models can predict the energy dissipation in the post-peak regime with an average difference of only 4%.

• Journal of Periodontal and Implant Science
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• 제35권1호
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• pp.251-261
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• 2005

Alveolar ridge defects may limit or restrict placement of implants. The purpose of this study was to evaluate clinical and histopathologic results which occur following guided bone regeneration using platelet-rich plasma, bovine bone powder and e-PTFE membrane in the localized alveolar bone defects. Ten patients who required guided bone regeneration in implant placemnet, were slelected. Alveolar crest height and width were measured at baseline and, afer 2nd surgery 5 months later At 5 months , we obtained histopathological results as follows: 1. Alveolar crest height was an average of $8.20{\pm}3.74$ mm preoperatively and decreased to an average of $7.40{\pm}1.84$ mm postoperatively. There was no significant difference. 2. Alveolar crest width was an average of $4.25{\pm}2.03$ mm preoperatively and significantly increased to an average of $7.20{\pm}2.44$ mm postoperatively (P<0.01) 3. The change of Alveolar crest height and width were $0.80{\pm}1.40$ mm, $2.95{\pm}1.09$ mm 4. Histopathological evaluations revealed new bone formation with graft material and laminated bone containing the presence of osteocyte-like cell In conclusion, guided bone regeneration using platelet-rich plasma, bovine bone powder and e-PTFE membrane would provide a viable therapeutic alternative for implant placement in the localized alveolar defect or implant failure

• Molecules and Cells
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• 제22권2호
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• pp.146-153
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• 2006

Cell polarity is critical for the division, differentiation, migration, and signaling of eukaryotic cells. RAX2 of budding yeast encodes a membrane protein localized at the cell cortex that helps maintain the polarity of the bipolar pattern. Here, we designate SPAC6f6.06c as $rax2^+$ of Schizosaccharomyces pombe, based on its sequence homology with RAX2, and examine its function in cell polarity. S. pombe $rax2^+$ is not essential, but ${\Delta}rax2$ cells are slightly smaller and grow slower than wild type cells. During vegetative growth or arrest at G1 by mutation of cdc10, deletion of $rax2^+$ increases the number of cells failing old end growth just after division. In addition, this failure of old end growth is dramatically increased in ${\Delta}tea1{\Delta}rax2$, pointing to genetic interaction of $rax2^+$ with $tea1^+$. ${\Delta}rax2$ cells contain normal actin and microtubule cytoskeletons, but lack actin cables, and the polarity factor for3p is not properly localized at the growing tip. In ${\Delta}rax2$ cells, and endogenous rax2p is localized at the cell cortex of growing cell tips in an actin- and microtubule-dependent manner. However, ${\Delta}rax2$ cells show no defects in cell polarity during shmoo formation and conjugation. Taken together, these observations suggest that rax2p controls the cell polarity of fission yeast during vegetative growth by regulating for3p localization.

• Radiation Oncology Journal
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• 제34권1호
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• pp.45-51
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• 2016

Purpose: The aim of this work was to assess the efficacy and tolerability of hypofractionated intensity-modulated radiotherapy (IMRT) in patients with localized prostate cancer. Materials and Methods: Thirty-nine patients who received radical hypofractionated IMRT were retrospectively reviewed. Based on a pelvic lymph node involvement risk of 15% as the cutoff value, we decided whether to deliver treatment prostate and seminal vesicle only radiotherapy (PORT) or whole pelvis radiotherapy (WPRT). Sixteen patients (41%) received PORT with prostate receiving 45 Gy in 4.5 Gy per fraction in 2 weeks and the other 23 patients (59%) received WPRT with the prostate receiving 72 Gy in 2.4 Gy per fraction in 6 weeks. The median equivalent dose in 2 Gy fractions to the prostate was 79.9 Gy based on the assumption that the ${\alpha}/{\beta}$ ratio is 1.5 Gy. Results: The median follow-up time was 38 months (range, 4 to 101 months). The 3-year biochemical failure-free survival rate was 88.2%. The 3-year clinical failure-free and overall survival rates were 94.5% and 96.3%, respectively. The rates of grade 2 acute genitourinary (GU) and gastrointestinal (GI) toxicities were 20.5% and 12.8%, respectively. None of the patients experienced grade ${\geq}3$ acute GU and GI toxicities. The grade 2-3 late GU and GI toxicities were found in 8.1% and 5.4% of patients, respectively. No fatal late toxicity was observed. Conclusion: Favorable biochemical control with low rates of toxicity was observed after hypofractionated IMRT, suggesting that our radiotherapy schedule can be an effective treatment option in the treatment of localized prostate cancer.

• Radiation Oncology Journal
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• 제8권2호
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• pp.255-260
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• 1990

1985년 4월부터 1989년 9월까지 경북대학교병원 치료방사선과에서 두경부 악성 임파종으로 진단되어 복합화학요법 및 방사선 병용치료를 받은 26명을 대상으로 치료성적을 분석하였다. 완전관해율은 $88{\%}$, 부분관해율은 $12{\%}$였고 관해율에 영향을 미치는 예후인자는 없었다. 3년 생존율 및 3년무병생존율은 각각 $62.4{\%}$및 $65.2{\%}$였다. 생존율이 높았던 군은 편측성 임파절침범(p<0.05), 방사선량 5000 cGy 이상 (p<0.01), 화학요법 6회 이상 (p=0.06)등이었다. 26예 중 8예 (부분관해 3예 포함)에서 재발을 했으며 재발 양상은 국소재발 1예, 원격 전이 1예, 인접조직에 재발 1예, 국소 재발 및 원격전이 2예 등이었다.

• 터널과지하공간
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• 제18권4호
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• pp.289-299
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• 2008

화강풍화암 및 풍화토층 깍기 비탈면의 붕괴 원인 분석을 위해 수행한 안정성 검토 사례를 통해 화강암을 모암으로 하는 지역에 폭넓게 분포하는 화강풍화암 및 풍화토 깍기 비탈면 설계 시 유념해야 할 사항들을 살펴보았다. 지질 및 지반 조사를 통한 지반특성 파악하였으며 한계평형해석 및 수치해석을 통한 안전율 검토, 강우 및 파괴 이력 비교 분석 등 일련의과정을 비탈면 안정성 검토를 위해 수행하였다. 대상 지역 깍기 비탈면의 안정성 검토 결과로서 비탈면의 붕괴 원인은 주로 집중 강우 시 지반조건상 연약한 상부 지반에서의 전단강도 감소에 기인함을 알 수 있었다. 또한, 지하수 유입 경로와도 밀접한 관련이 있는 것으로 분석되었으며, 이를 기초로 비탈면의 안정화를 위한 대책공을 제시하였다.

• Coupled systems mechanics
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• 제11권1호
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• pp.55-78
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• 2022

The main aim of this paper is the identification of the model parameters for the constitutive model of concrete and concrete-like materials capable of representing full set of 3D failure mechanisms under various stress states. Identification procedure is performed taking into account multi-scale character of concrete as a structural material. In that sense, macro-scale model is used as a model on which the identification procedure is based, while multi-scale model which assume strong coupling between coarse and fine scale is used for numerical simulation of experimental results. Since concrete possess a few clearly distinguished phases in process of deformation until failure, macro-scale model contains practically all important ingredients to include both bulk dissipation and surface dissipation. On the other side, multi-scale model consisted of an assembly micro-scale elements perfectly fitted into macro-scale elements domain describes localized failure through the implementation of embedded strong discontinuity. This corresponds to surface dissipation in macro-scale model which is described by practically the same approach. Identification procedure is divided into three completely separate stages to utilize the fact that all material parameters of macro-scale model have clear physical interpretation. In this way, computational cost is significantly reduced as solving three simpler identification steps in a batch form is much more efficient than the dealing with the full-scale problem. Since complexity of identification procedure primarily depends on the choice of either experimental or numerical setup, several numerical examples capable of representing both homogeneous and heterogeneous stress state are performed to illustrate performance of the proposed methodology.

• 대한토목학회논문집
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• 제30권6C호
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• pp.219-229
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• 2010

우리 나라는 산지가 국토 면적의 약 70%를 차지하고 있기 때문에 장마나 태풍 시 집중 강우에 의하여 다수의 사면 붕괴가 발생하고 있으며, 이러한 사면 붕괴로 인해 많은 인명과 재산피해가 발생되고 있다. 이러한 상황하에서 사면 붕괴로 인한 피해를 경감시키기 위해서는 광범위한 지역에 걸쳐 분포되어 있는 사면을 대상으로 붕괴가 예상되는 위험한 사면부를 추출하여 방재 대책을 강구할 필요성이 있으며, 이를 위해서는 사면의 안정성 또는 위험도의 정량적 평가가 선행되어야 한다. 그러나 국내에는 아직까지 광역의 수많은 사면을 대상으로 강우와 지형적 요인 및 토질공학적 요인을 고려한 위험도 예측모델이 구축되어 있지 않은 실정이다. 따라서, 본 연구에서는 유역 내 지하수위의 시간 변화를 구하는 집수모델과 무한사면의 안정해석모델을 조합한 해석기법을 제안하고, 이를 이용한 해석 사례를 소개하고자 한다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회A
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• pp.114-119
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• 2007

Sulfide stress cracking (SSC) of materials exposed to oilfield environment containing hydrogen sulfide $(H_{2}S)$ has been recognized as a materials failure problem. Laboratory data and field experience have demonstrated that extremely low concentration of $H_{2}S$ may be sufficient to lead to SSC failure of susceptible materials. In some cases, $(H_{2}S)$ can act synergistically with chlorides to produce corrosion and cracking failures. SSC is a form of hydrogen embrittlement that occurs in high strength steels and in localized hard zones in weldment of susceptible materials. In the heat-affected zones adjacent to welds, there are often very narrow hard zones combined with regions of high residual stress that may become embrittled to such an extent by dissolved atomic hydrogen. On the base of understanding on sulfide stress cracking and its mechanism, SSC resistance for the several materials, those are ASTM A106 Gr B using in the oil industries, are evaluated.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.171-178
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• 2005

It is unavoidable to be formed slopes under special circumstance of Korea where 70% of the whole area are composed of mountains when civil engineering projects such as roads, site developments are increased with industrial development and horizontal expansions of urban area. Moreover, stability of the slopes become one of quite important issues under special meteorological characteristics that over two-thirds of annual average rainfall are concentrated in summer season and the localized torrential downpour are getting more frequent recently. Resulting in these circumstances, partial slope failures by debris flow of the high water content soils are occurred frequently in cutting soil slopes. In this case of debris flow slope failure, slope declination method are selected for their stable recovery because it is impossible to recover entirely by existing recovery methods. Seeding or special grass planting methods are followed separately without exception. The method by which entire recover with bigger stability ratio would be possible and grass planting work would be done simultaneously is developed. In this study, the results of the tests including a real construction history in a failed slope using developed method are described