• Maxillofacial Plastic and Reconstructive Surgery
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• v.30 no.6
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• pp.529-539
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• 2008

Background and Purpose : Oral squamous cell carcinoma (OSCC) is one of the most aggressive tumors of the head and neck area. OSCC is known to preferentially metastasize via lymphatic system, and resulting cervical lymph node metastasis is the most reliable of treatment failure. But the biological mechanism of the regional nodal metastasis is not clear. So, we determined metastasis-related factors in orthotopic nude mouse models of OSCC. Experimental Design : Two cell lines-KB and YD-10B cells, established from human oral mucosal squamous cell carcinoma, were xenografted into the tissue space of athymic murine mouth floor. The mice were followed for tumor development and growth, the murine tumors were examined histopathologically for local invasion or regional or distant metastasis. Finally, we performed immunohistochemical assays with antiepithelial growth factor (EGF), EGF receptor (EGFR), phosphorylated EGFR (pEGFR), and anti-vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-2, phosphorylated VEGFR-2/3 (pVEGFR-2/3) antibodies. We also determined the microvessel density. Results : Transplantation of human OSCC tumor cells into the mouth floor successfully resulted in the formation of orthotopic tumors. KB cell line showed significantly higher tumor proliferation and higher nodal metastatic potential than YD-10B cell line. Furthermore, immunohistochemical staining demonstrated higher expression of EGFR/pEGFR, VEGF, and pVEGFR-2/3 as well as higher microvessel density in KB murine tumors than in YD-10B murine tumors. Conclusion : An orthotopic model of OSCC in athymic mice was established which copies the cervical lymph nodal metastasis of human OSCC. Our mouth floor model should facillitate the understanding of the molecular pathogenesis of cervical nodal metastasis of OSCC.

• Transactions of Materials Processing
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• v.18 no.4
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• pp.342-346
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• 2009

Forming characteristics for the bundle extrusion of Cu-Ti bimetal wires are investigated, which can identify the process conditions for weak mechanical bonding at the contact surface during the direct extrusion of a Cu-Ti bimetal wire bundle. Bonding mechanism between Cu and Ti is assumed as a cold pressure welding. Then, the plastic deformation at the contact zone causes mechanical bonding and a new bonding criterion for pressure welding is developed as a function of the principal stretch ratio and normal pressure at the contact surface by analyzing micro local extrusion at the contact zone. The averaged deformation behavior of Cu-Ti bimetal wire is adopted as a constitutive behavior at a material point in the finite element analysis of Cu-Ti wire bundle extrusion. Various process conditions for bundle extrusions are examined. The deformation histories at the three points, near the surface, in the middle and near the center, in the cross section of a bundle are traced and the proposed new bonding criterion is applied to predict whether the mechanical bonding at the Cu-Ti contact surface happens. Finally, a process map for the direct extrusion of Cu-Ti bimetal wire bundle is proposed.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.10a
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• pp.393-397
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• 2005

A process map has been developed, which can identify the process conditions for weak mechanical bonding at the contact surface during the direct extrusion of a Cu-Ti bimetal wire bundle. Bonding mechanism between Cu and Ti is assumed as a cold pressure welding. Then, the plastic deformation at the contact zone causes mechanical bonding and a new bonding criterion fur pressure welding is developed as a function of the principal stretch ratio and normal pressure at the contact surface by analyzing micro local extrusion at the contact zone. The averaged deformation behavior of Cu-Ti bimetal wire is adopted as a constitutive behavior at a material point in the finite element analysis of Cu-Ti wire bundle extrusion. Various process conditions for bundle extrusions are examined. The deformation histories at the three points, near the surface, in the middle and near the center, in the cross section of a bundle are traced and the proposed new bonding criterion is applied to predict whether the mechanical bonding at the Cu-Ti contact surface happens. Finally, a process map for the direct extrusion of Cu-Ti bimetal wire bundle is proposed.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.19 no.3
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• pp.326-333
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• 2010

In this study, DAQ and TRA modules were applied to the CFRP single specimen testing method using AE. A method for crack identification in CFRP specimens based on k-mean clustering and wavelet transform analysis are presented. Mode I on DCB under vertical loading and mode II on 3-points ENF testing under share loading have been carried out, thereafter k-mean method for clustering AE data and wavelet transition method per amplitude have been applied to investigate characteristics of interfacial fracture in CFRP composite. It was found that the fracture mechanism of Carbon/Epoxy Composite to estimate of different type of fractures such as matrix(epoxy resin) cracking, delamination and fiber breakage same as AE amplitude distribution using a AE frequency analysis. In conclusion, the presented results provide a foundation for using wavelet analysis as efficient crack detection tool. The advantage of using wavelet analysis is that local features in a displacement response signal can be identified with a desired resolution, provided that the response signal to be analyzed picks up the perturbations caused by the presence of the crack.

• Journal of Medicine and Life Science
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• v.15 no.2
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• pp.56-61
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• 2018

Advances in medical technology has enabled better management of complicated and chronic wounds. Negative-pressure wound therapy (NPWT) is a novel dressing technique that uses negative pressure to drain exudates and blood from wounds. NPWT increases local blood flow and promotes reduction of edema and wound healing and is suitable for a variety of wounds. It is associated with few adverse effects and shows excellent efficacy and cost-effectiveness. NPWT promotes rapid growth of granulation tissue and wound contraction; thus, it is more advantageous than general dressings as it reduces the size skin of grafts or flaps required for repair, and patients with chronic wounds can be treated as outpatients. We investigated the general usage and mechanism of NPWT, its clinical applications and adverse effects.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.17 no.1
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• pp.28-35
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• 2021

The flow accelerated corrosion (FAC) is one of significant aging and degradation mechanism and can affect structural integrity of CANDU feeder pipes. Pipe burst can occur under normal operation pressure (min. 10 MPa) if wall-thinning of the feeder pipe due to FAC is accumulated. Previous studies considered simple shapes of feeder pipe with local wall-thinning in order to conservatively assess structural integrity of wall-thinned feeder pipe. In this paper, a new FE model is developed, having an actual shape of the feeder pipe (double bent) as well as the actual wall-thinning shape and location based on the in-service inspection result. Then, the burst pressure assessment of the wall-thinned feeder pipe is performed using lower bound limit load analysis considering elastic-perfectly plastic material. In addition, an improved formulation to predict the burst pressure of the wall-thinned feeder pipe is presented and the safety margin is compared with an existing assessment method.

• Journal of Korean Society of Steel Construction
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• v.15 no.3
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• pp.261-269
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• 2003

The length of the links in an eccentrically braced frame will dictate the behavior of the frame. Link length controls the yielding mechanism and the ultimate failure mode. For short links, the links' shear forces reach the plastic shear capacity before the end moments reach the plastic moment capacity, and the links yields in the shear, forming a shear hinges. These links are termed "shear links." For long links, the end moments reach the plastic moment capacity before the links' shear forces reach the plastic shear capacity, forming moment hinges. These links are termed moment links." In long links, flexural yielding dominates the response, and very high bending strains are required at the link ends to produce large link deformations. In a shear links, the shear force is constant along the length of the links, and the inelastic shear strain are is uniformly distributed over the length of the links. This permits the development of large inelastic link deformations without the development of excessively high local strains. However, The use of eccentrically braced steel frames for the purpose of architectural cionsiderations such as openings and doors, areis dictating the use of longer links, though. Little data areis available on the behavior of long links under cyclic loading conditions. In This paper documents the results of an experimental program is that was conducted to assess the response of moment links in eccentrically braced frames. Sixteen specimens awere tested using a cyclic load.

• International Journal of Concrete Structures and Materials
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• v.18 no.3E
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• pp.173-181
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• 2006

The objectives of this study are to evaluate the reliability of an existing nonlinear analysis program for predicting the inelastic behavior of reinforced concrete frame with seismic details and to observe the redistribution of the internal forces, which can not be easily measured by an experiment. In order to carry out this task, the nonlinear analysis program of IDARC 2D(3) was run on a 2-bay, 2-story moment-resisting reinforced concrete plane frame with seismic details. (1) The effort to obtain the results of the analysis similar to those of experiment was made by determining the appropriate values of model parameters. The comparison of the analysis results with those of experiment and the observation of the distribution of internal forces obtained through nonlinear analysis points to the following conclusions. (1) The overall relationship between lateral load and lateral displacement given by the analysis is similar to that of experiment. However, the values of initial stiffness and the amount of energy dissipation in the initial displacement steps given by the analysis show larger values than those of experiment. (2) The analysis provided detailed information on the distribution and redistribution of internal forces and proved useful in elucidating the crack pattern, the sequence of the occurrence of plastic hinges, and the failure or yielding mechanism for the whole structure. (3) In spite of the similarity in overall behavior of analysis and experiment, there exists a significant discrepancy in some local behaviors. Furthermore, the hysteresis in the relationship between moment and curvature in some column ends have shown sudden deteriorations in strength, which can not be interpreted satisfactorily at the present time. Therefore, it is necessary to develop a better analytical model to fill this knowledge gap.

• The Korean Journal of Pharmacology
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• v.27 no.2
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• pp.197-205
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• 1991

Local extravasation during intravenous administration of adriamycin (doxorubicin HCl) can cause severe skin ulceration and necrosis. To investigate the mechanism of adriamycin-induced skin toxicity, effects of adriamycin on reactive oxygen radical metabolism using cultured skin cells of fetal rat. Adriamycin produced significant release of lactic dehydrogenase from cultured skin cell preparations dose- and time-dependently. The production of superoxide anion in sonicated suspensions of cultured skin cells was significantly increased by adriamycin under the presence of NADPH and NADH. The drug also stimulated malondialdehyde (MDA) production, an index of lipid peroxidation, in NADPH- and NADH-supported cell preparations. The increased production of MDA was significantly inhibited by oxygen radical scavengers (superoxide dismutase, catalase, thiourea) and antioxidants (butylated hydroxytoluene, ${\alpha}-tocopherol$). Treatment of cultured skin cells with 1, 3,-bis (2-chloroethyl)-1-nitrosourea (BCNU), an inhibitor of glutathione reductase, enhanced the lipid peroxidation induced by adriamycin. The present study suggests that lipid peroxidation which is resulted from the stimulated production of reactive oxygen radical causes cellular damage in adriamycin-treated skin cells of rat.

• Journal of Korean Society of Steel Construction
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• v.16 no.6 s.73
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• pp.781-792
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• 2004

Experiments were performed to study the cyclic behavior of framed steel walls with thin web plates. Five specimens of single-bay and three-story steel plate walls were tested for cyclic lateral load. The parameters for the test specimens included the plate thickness and the column strength. Based on the test results, the strength, deformability, and energy dissipation capacity of the framed steel walls were studied. The test results showed that the behavioral characteristics of the framed steel walls with thin web plates were different in many aspects from those of the conventional braced frame, and the steel wall with a stiffened web plate exhibited cantilever action, high strength, and low ductility. With the framed steel plate walls, local plate buckling and tension-field action developed in the thin web plates, and plastic deformation was uniformly distributed along the wall's height. As a result, the framed steel plate walls exhibited combined flexural and shear deformation, but they also showed high strength and energy dissipation capacity. Moreover, such walls have high deformability, which was equivalent to that of the conventional moment frame. Frame members such as columns and beams, however, must be designed to resist the tension-field action of the thin web plates. If the column does not have sufficient strength, and if its sections are not compact enough, the overall strength of the framed steel wall might be significantly decreased by the development of the soft-story mechanism. The framed steel walls with thin web plates have advantages, such as high deformability and high strength. Therefore, they can be used as ductile elements in earthquake-resistant systems.