• Clinics in Shoulder and Elbow
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• v.24 no.4
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• pp.224-230
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• 2021

Background: Local anesthetics often are used in rotator cuff tears as therapeutic tools, although some cases have reported that they have detrimental effects. Neurotropin (NTP) is used widely in Japan as a treatment for various chronic pain conditions and is shown to have protective effects on cartilage and nerve cells. In this study, we investigated the protective effect of NTP against lidocaine-induced cytotoxicity. Methods: Tenocytes from rotator cuff tendons were incubated with lidocaine, NTP, lidocaine with NTP, and a control medium. Cell viability was evaluated using the WST-8 assay. Cell apoptosis was detected via annexin V staining using flow cytometry. The expression of BCL-2 and cytochrome c, which are involved in the intrinsic mitochondrial pathway of apoptosis, was evaluated via Western blotting and immunohistochemical staining. Results: In the cell viability assay, lidocaine decreased cell viability in a dose-dependent manner, and NTP did not affect cell viability. Moreover, NTP significantly inhibited the cytotoxic effect of lidocaine. The flow cytometry analysis showed that lidocaine significantly induced apoptosis in tenocytes, and NTP considerably inhibited this lidocaine-induced apoptosis. Western blotting experiments showed that lidocaine decreased the protein expression of BCL-2, and that NTP conserved the expression of BCL-2, even when used with lidocaine. Immunohistochemical staining for cytochrome c showed that 0.1% lidocaine increased cytochrome c-positive cells, and NTP suppressed lidocaine-induced cytochrome c expression. Conclusions: NTP suppresses lidocaine-induced apoptosis of tenocytes by inhibiting the mitochondrial apoptotic pathway. Intra-articular/bursal injection of NTP with lidocaine could protect tenocytes in rotator cuff tendons against lidocaine-induced apoptosis.

• 한국신재생에너지학회:학술대회논문집
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• 2005.11a
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• pp.648-654
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• 2005

The performance prediction of a planar-type solid oxide fuel ceil is conducted by a computational analysis. The transport processes are formulated with the help of a simplified treatment of heat generation by the electrochemical reaction. From the result of the computational analysis, it is shown that the electrochemical reaction is closely related to the transport phenomena inside a solid oxide fuel cell. Transport phenomena including heat and mass transfer have influence on the distribution of local current density and as a result, on the performance characteristics of the fuel cell. Computational analysis is also extended to the parametric study to investigate the performance behavior of the fuel cell with different amount of supplied fuel flow rates. It is also demonstrated that the mathematical formulation and computational procedures proposed in this study can be applied to prove the importance of the specific TPB(Three-Phase-Boundary) area in the manufacturing process of electrodes in a solid oxide fuel cell.

• Journal of the Korean Ceramic Society
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• v.42 no.12 s.283
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• pp.846-853
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• 2005

For the performance prediction of a planar-type solid oxide fuel cell, the computational analysis of transport phenomena with a simplified treatment of heat generation by the electrochemical reaction is conducted. From the result of the computational analysis, it is shown that the electrochemical reaction is closely related to the transport phenomena inside a solid oxide fuel cell. Transport phenomena including heat and mass transfer influences on the distribution of local current density and, as a result, on the performance characteristics of the fuel cell. Computational analysis is also extended to the parametric study to investigate the performance behavior of the fuel cell with different amount of supplied fuel flow rates. It is also demonstrated that the mathematical formulation and computational procedures proposed in this study can be applied to prove the importance of the specific TPB area in the manufacturing process of electrodes in solid oxide fuel cells.

• Nuclear Engineering and Technology
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• v.16 no.2
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• pp.47-57
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• 1984

Mathematically-rigorous time-volume averaged conservation equations were simplified to established the differential equations of THERMIT-6S, which is a two-fluid 3-D code. The difference equations of THERMIT-6S were obtained by discretizing the proceeding set of differential equations. The spatial discretization is characterized by a first-order spatial scheme, donor cell method, and staggered mesh layout. For time discretization, a first order semi-implicit scheme treats implictly sonic terms and terms relating to local transport phenomena and explicitly convective terms. The results were linearized by the Newton-Raphson method. In order to construct the reduced pressure equation, the linearized equations were manipulated so that all variables are coupled between mesh cells through only the pressure variable. By simulating numerically the OPERA-15 experiment, it was found that THERMIT-6S is a very powerful code in predicting reactor behavior after sodium boiling including flow coastdown, reversal flow and flow oscillation.

• Journal of computational fluids engineering
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• v.7 no.2
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• pp.8-16
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• 2002

A numerical study on the use of the momentum interpolation method for flows with a large body force is presented. The inherent problems of the momentum interpolation method are discussed first. The origins of problems of the momentum interpolation methods are the validity of linear assumptions employed for the evaluation of the cell-face velocities, the enforcement of mass conservation for the cell-centered velocities and the specification of pressure and pressure correction at the boundary. Numerical experiments are performed for a typical flow involving a large body force. The numerical results are compared with those by the staggered grid method. The fact that the momentum interpolation method may result in physically unrealistic solutions is demonstrated. Numerical experiments changing the numerical grid have shown that a simple way of removing the physically unrealistic solution is a proper grid refinement where there is a large pressure gradient. An effective way of specifying the pressure and pressure correction at the boundary by a local mass conservation near the boundary is proposed, and it is shown that this method can effectively remove the inherent problem of the specification of pressure and pressure correction at the boundary when one uses the momentum interpolation method.

• Journal of Mechanical Science and Technology
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• v.14 no.7
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• pp.789-795
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• 2000

Free-surface flows with an arbitrary deformation, induced by a submerged hydrofoil, are simulated numerically, considering two-fluid flows of both water and air. The computation is performed by a finite volume method using unstructured meshes and an interface capturing scheme to determine the shape of the free surface. The method uses control volumes with an arbitrary number of faces and allows cell wise local mesh refinement. The integration in space is of second order, based on midpoint rule integration and linear interpolation. The method is fully implicit and uses quadratic interpolation in time through three time levels. The linear equations are solved by conjugate gradient type solvers, and the non-linearity of equations is accounted for through Picard iterations. The solution method is of pressure-correction type and solves sequentially the linearized momentum equations, the continuity equation, the conservation equation of one species, and the equations for two turbulence quantities. Finally, a comparison is quantitatively made at the same speed between the computation and experiment in which the grid sensitivity is numerically checked.

• Journal of Advanced Marine Engineering and Technology
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• v.29 no.2
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• pp.209-216
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• 2005

Thermo-chromic Liquid Crystal(TLC) particles were used as temperature sensor for thermal fluid flow. 1K $\times$ 1K CCD color camera and Xenon Lamp(500w) were used for the visualization of a Hele-Shaw cell The characteristic between the reflected colors from the TLC and their corresponding temperature shows strong non-linearity A neural network known as having strong mapping capability for non-linearity is adopted to quantify the temperature field using the image of the flow. Improvements of color-to-temperature mapping was attained by using the local color luminance (Y) and hue (H) information as the inputs for the constructed neural network.

• Physical Therapy Rehabilitation Science
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• v.1 no.1
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• pp.6-12
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• 2012

Objective: Coenzyme (CoQ10) is an enzymatic co factor used in normal cellular metabolism. Recent evidence shows that in people with heart disease it can reverse endothelial cell damage in the blood vessels. It is also a potent antioxidant. Design: One group pretest-posttest design. Methods: In the present study, endothelial function was evaluated using the response to occlusion and heat before and 2 weeks after administration of CoQ10, 300 mg/day. Thirty Eight subjects, who are physical therapy students, participated in a series of experiments to see if taking 300 mg of CoQ10 daily for 2 weeks would impact resting blood flow in the forearm skin and the blood flow response to 4 minutes of vascular occlusion and the response to local heat ($42^{\circ}C$) for 6 minutes. Results: The results showed that, for this population, there was no difference in the response to heat. However, the response to occlusion was improved after administration of CoQ10. Conclusions: It would appear that in a young population CoQ10 has no effect on the nitric oxide vasodilator pathway in skin but does influence other vasodilator pathways.

• International Journal of Fluid Machinery and Systems
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• v.7 no.3
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• pp.86-93
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• 2014

This paper describes performance enhancement of a regenerative blower used for a 20 kW fuel cell system. Two design variables, bending angle of an impeller and blade thickness of an impeller tip, which are used to define an impeller shape, are introduced to enhance the blower performance. Internal flow of the regenerative blower has been analyzed with three-dimensional Navier-Stokes equations to obtain the blower performance. General analysis code, CFX, is introduced in the present work. SST turbulence model is employed to estimate the eddy viscosity. Throughout the numerical analysis, it is found that the thickness of impeller tip is effective to increase the blower efficiency in the present blower. Pressure is successfully increased up to 2.8% compared to the reference blower at the design flow condition. And efficiency is also enhanced up to 2.98 % compared to the reference one. It is noted that low velocity region disturbs to make strong recirculation flow inside the blade passages, thus increases local pressure loss. Detailed flow field inside the regenerative blower is also analyzed and compared.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1999.11a
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• pp.453-456
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• 1999

The Si-SiO$_2$interface trap and nitride bulk trap distribution of SONOSFET(polysilicon-oxide-nitride-oxide-semiconductor)NVSM(nonvolatile semiconductor memory) cell were investigated by single charge pumping method. The used device was fabricated by 0.35 7m standard logic fabrication including the ONO cell process. This ONO dielectric thickness is tunnel oxide 24 $\AA$, nitride 74 $\AA$, blocking oxide 25 $\AA$, respectively. Keeping the pulse base level in accumulation and pulsing the surface into inversion with increasing amplitudes, the charge pumping current flow from the single junction. Using the obtained I$_{cp}$-V$_{h}$ curve, the local V$_{t}$ distribution, doping concentration, lateral interface trap distribution and lateral memory trap distribution were extracted. The maximum N$_{it}$($\chi$) of 1.62$\times$10$^{19}$ /cm$^2$were determined.mined.d.