• Radiation Oncology Journal
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• 제36권1호
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• pp.17-24
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• 2018

Purpose: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. Materials and Methods: In this single arm phase II prospective clinical trial, patients with T3-4 or N+ M0 rectal adenocarcinoma were enrolled. Patients who received induction chemotherapy or previous pelvic radiotherapy were excluded. Study protocol consisted of three-dimensional conformal SRT (25 Gy in 5 fractions in 1 week) with concurrent and consolidation chemotherapies including capecitabine and oxaliplatin. Total mesorectal excision was done at least 8 weeks after the last fraction of radiotherapy. Primary outcome was complete pathologic response and secondary outcomes were treatment related complications. Results: Thirty-three patients completed the planned preoperative chemoradiation and 26 of them underwent surgery (24 low anterior resection and 2 abdominoperineal resection). Acute proctitis grades 2 and 3 were seen in 11 (33.3%) and 7 (21.2%) patients, respectively. There were no grades 3 and 4 subacute hematologic and non-hematologic (genitourinary and peripheral neuropathy) toxicities and perioperative morbidities such as anastomose leakage. Grade 2 or higher late toxicities were observed among 29.6% of the patients. Complete pathologic response was achieved in 8 (30.8%) patients who underwent surgery. The 3-year overall survival and local control rates were 65% and 94%, respectively. Conclusion: This study showed that SRT combined with concurrent and consolidation chemotherapies followed by delayed surgery is not only feasible and tolerable without significant toxicity but also, associated with promising complete pathologic response rates.

• Restorative Dentistry and Endodontics
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• 제24권1호
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• pp.1-12
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• 1999

Bacterial infection of the pulp results in the development of a periapical lesion with the concomitant resorption of periapical bone. The cytokines are believed to play an important role in this matter. The purpose of this study was to find the relationship among the presence of black pigmented bacteria, the levels of cytokines(TNF-${\alpha}$, -${\beta}$, IL-$1{\beta}$, and TGF-${\beta}1$), and the amount of bone resorption in periapical and pulpal diseases. For the purpose, the patients were grouped into chronic apical pathosis, acute apical pathosis, acute pulpitis, and a healthy control group. Root canal samples were taken from periapical tissue exudates during routine endodontic treatment, and the venous blood was taken from each patients. The samples were processed to measure local and systemic levels of the cytokines using enzyme linked immunosorbent assay(ELISA). Bacterial content of Porphyromonas endodontalis, Porphyromonas gingivalis, and Prevotella nigrescens were measured by indirect immunofluorescence method and the size of the periapical lesions were measured from the radiographs. The following results were obtained: 1. The levels of bone resorptive cytokines(TNF-${\alpha}$, TNF-${\beta}$, and IL-$1{\beta}$) in exudates from acute and chronic apical pathoses were significantly higher than those from acute pulpitis and the normal pulps(p<0.05). 2. IL-$1{\beta}$ were the highest among the bone resorptive cytokines in apical pathoses. However, no statistical difference between acute and chronic lesions were found(p>0.05). 3. The levels of TGF-${\beta}1$ in exudates from acute pulpitis and chronic apical pathoses were significantly higher than those from acute apical pathoses and the normal pulps(p<0.05). However, there were no significant correlations among the levels of bone resorptive cytokines. 4. The levels of TNF-${\beta}$ in serum were significantly higher than those from the exudates while serum TGF-${\beta}1$ concentrations were significantly lower(p<0.05). 5. Exudates from the canals in which the P. nigrescens were detected showed significantly higher levels of IL-$1{\beta}$ than those from the canals without the microorganism(p<0.05). 6. There were no significant correlations among the levels of the cytokines, the amount of bone destruction, and the presence of acute and chronic symptoms(p>0.05).

• International Journal of Costume and Fashion
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• 제11권1호
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• pp.63-83
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• 2011

This study aims to prove the changes, development and social background of Korean male cosmetics over the period of 2000-2010. There were total 574 articles written about male make-up and cosmetics in Chosun Daily, Joongang Daily and Donga Daily, which are the top three Korean local daily newspapers in terms of sales revenue for that period. These articles were analyzed together with social background research from various books and daily newspapers. The analysis of articles was divided into different categories; such as foundation cosmetics, color cosmetics, hair, and the social background. It was found that the articles related to foundation cosmetics were written the most, the articles related to male appearance management were second, articles on other items including how to manage the skin being the least. As for the social background of Korean male cosmetics, first of all, a change in social recognition can be pointed out. The traditional understanding of gender roles has changed, men's appearance management has started to be regarded as a competitive talent, and at the same time, the esthetic viewpoint for men also has changed. One example is the newly made popular term, "flower-handsome man", which shows the new trend of favoring males with nice skin. Second, the expansion of mass culture can be pointed out. As consumers can get information and fashion trends easier and faster, the fashion spreads fast, and this has led to the generalization and popularization of the sense of beauty. Third, the development of scientific technology and medical science can be pointed out. Thanks to the progress in those areas. the extension of youthfulness has become possible and the cosmetics industry was also affected greatly, as shown in the market spread of functional products for anti-ageing and wrinkle control as the interest in anti-ageing has grown. There are benefits from the development of scientific technology, but the problem of environmental pollution has appeared due to machinery and industrialization and thus the issue of well-being has been raised. Rising interest in naturalism, pro-environmentalism and organic cosmetics has influenced the cosmetics industry. In addition, the quantity of ultraviolet rays exposed to our skin has increased due to the air pollution caused by the destruction of environment, leading to increased usage of sun block lotion. Lastly, the influence of consumer society and the expansion of consumerism culture can be pointed out. In the modern society, consumption acts not only as the use of products and services but it also has an important role of mediating individuals with others and the society. The market for male cosmetics has been expanding and the number of men putting on make-up has been increasing rapidly. Therefore, this study is meaningful in that the analysis of the mode of change and the social background are an essential process in order to provide a direction for the future market for male cosmetics.

• Asian-Australasian Journal of Animal Sciences
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• 제24권9호
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• pp.1233-1242
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• 2011

The in vivo digestibility of mulberry leaves (Morus alba) and the effects of the partial replacement of cotton seed with fresh mulberry leaf in rations on the performance of growing Vietnamese cattle was investigated. For the in vivo digestibility trial, twenty castrated rams of Phanrang breed (a local prolific breed) with an initial weight of 23-25 kg, were first assigned to four groups according to weight and then randomly assigned to one of four dietary treatments to determine digestibility of nutrients in mulberry leaves (M. alba), natural Bermuda grass (Cynodon dactylon), elephant grass (Pennisetum purpureum) and buffalo grass (Panicum maximum cv. TD 58). All forages were cut and chopped daily before being offered (at 120% maintenance) to the sheep. In the feeding trial, 20 Laisind (Vietnam yellow cows${\times}$Red Sindhy bulls) crossbred bulls averaged 18 month old and 184 kg were used to investigate the effect of partial replacement of cottonseed in the diet by mulberry leaves on live weight gain and feed conversion rate. The experiment was a randomized complete block design with four levels of fresh mulberry leaves which varied from 0 to 15% of total dietary dry mater and five animals per treatment over an 84 day period. The in vivo digestion trial showed the superior quality of mulberry leaves compared with the grasses. Chemical analysis indicated that mulberry leaves had the highest CP and the lowest NDF contents (22.3 and 31.1% DM, respectively) among the four forages tested. Digestibility of DM and OM of the mulberry leaf (66.4 and 71.8%, respectively) was also the highest but that of CP (58.2%) and NDF (58.4%) was the lowest of the four forages evaluated (p<0.05). Consequently, the ME value and therefore net energy (NE) and unit feed for lactation (UFL) values of the mulberry leaves, which was estimated from chemical composition and digestibility values, were the highest among the forages investigated in the present study. Results of the feeding trial showed no treatment effect on average daily gain (ADG) of the cattle. The values were 554, 583, 565 and 568 g/d for animals in the diets of 0, 5, 10, and 15% mulberry leaves inclusion, respectively. Total DM intake of the animal was not affected by the treatment when expressed as kg/animal/d. However, when adjusted for metabolic weight of the animal the DM intake was reduced (p<0.05) as whole cottonseed was replaced by mulberry leaves in the ration. When the level of mulberry leaves in the ration increased from 5 to 15% of dietary DM at the expense of whole cottonseed, CP and ME intakes of the cattle were significantly decreased (p<0.05) and the feed to gain ratio reduced by 8 to 14% as compared with the control diet (p<0.05). Mulberry leaf is a good feed ingredient for ruminants because of its high level of crude protein and high digestibility of nutrients and energy. Mulberry leaves can be efficiently used as a source of protein supplement to replace cottonseed, a more expensive animal feeds ingredient, in the diet for Vietnamese cattle.

• Journal of Chest Surgery
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• 제40권12호
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• pp.855-858
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• 2007

승모판막 치환술 후 발생하는 좌심실파열은 치명적인 합병증이다. 30년 전 국외에서 승모판막에 대한 수술을 받은 병력이 있는 54세 여자 환자가 심한 승모판막 협착증과 심한 삼첨판막 폐쇄부전을 주소로 내원하여 승모판막 치환술 및 삼첨판막륜 성형술을 시행받았다. 심폐기 이탈 후 수술장 내에서 발생한 대량출혈로 심폐기 재가동 상태에서 평가한 결과 좌심방으로부터 3 cm 후방부위의 방실 골짜기에서 발생한 급성 제I형 좌심실 파열로 진단하고 심외막 접근법으로 테프론 펠트를 이용한 일차 봉합술, 심막첨포를 이용한 밀봉 봉합술 및 피브린 접착제를 적용하여 성공적으로 봉합하였으며 환자는 수술 14일째 합병증 없이 퇴원하였다. 이에 승모판막 치환술 후 발생하는 제I형 좌심실 파열에 대한 문헌고찰과 함께 증례를 보고하고자 한다.

• 조명전기설비학회논문지
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• 제18권5호
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• pp.16-26
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• 2004

우리나라의 경우 최근 경관조명의 중요성을 인식하고 많은 건축물과 광장, 조경, 역사적 모뉴멘트 등에 옥외조명이 설치되고 있다. 특히, 최근 쇼핑용 복합건물들은 옥외조명을 설치함으로써 건물의 인지도를 높이고, 그에 따라 매출을 증대시키고자 한다. 그러나, 대형 쇼핑용 복합빌딩에 옥외조명을 과다하게 설치함으로써 광공해를 발생시키고 있다. 이미 광공해에 대하여 선진외국에서는 조명조례와 광공해대책가이드 등을 제정하여 쾌적한 조명환경을 구축하려고 노력하고 있다. 이에 본 연구는 주로 야간에 많이 이용되는 3개의 복합쇼핑 빌딩에 설치된 옥외조명의 광공해의 발생 실태를 조사하였다. 이를 위하여 건물의 표면휘도, 보행도로의 수평면조도 및 연직면조도를 직접 현장에서 측정기구로 측정하여 CIE기준과 비교하였으며, 연구 결과는 다음과 같다. 전반확산형조명기구가 보행도로에 설치됨으로써 눈부심이 부분적으로 발생하고 있으므로 cut-off 조명기구를 설치할 필요가 있는 것으로 나타났다. 또한, 건물외관의 옥외조명은 건물의 인지도와 광고를 강조하기 위하여 휘도값을 크게 설계한 것으로 나타났다. 즉, 도로에 면한 건물표면의 측정휘도값이 CIE기준과 비교했을 때 2배정도 높게 나타났으며, 보도의 연직면 조도비도 권장값보다 크게 나타났다. 아직 우리나라의 경우 광공해에 대한 기준이나 가이드가 없으므로 이에 대한 대책이 절실히 필요하다.

• 한국조경학회지
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• 제39권5호
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• pp.101-110
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• 2011

본 연구의 목적은 근교도시의 녹지경관에 주목하여 그 특성을 살펴보고 향후 근교도시 녹지경관의 보전계획 및 활용방안에 대한 방향성을 고찰하는 것이다. 연구대상지는 일본의 수도 도쿄의 근교도시인 마츠도시이다. 먼저 공간분석과 현장조사를 통해 대상지의 녹지경관을 유형화하고, 다음으로 녹지경관에 대한 설문조사를 실시하여 녹지경관 평가와 요인분석을 실시하였다. 연구 결과, 마츠도시에는 도시계획, 자연지형적 요인, 사회문화적 요인 등이 복합적으로 작용하여 다양한 녹지 형태가 존재하고 있으며, 주된 녹지경관은 20개의 다양한 유형으로 구분할 수 있었다. 각 녹지경관 유형을 대상으로 한 설문조사에서는 시가화조정구역의 하천, 공원 등이 개성 있는 경관으로 높게 평가된 반면, 주거구역의 농지 및 수림지 등은 낮게 평가되었다. 요인분석을 통하여 경관평가의 척도를 분석한 결과 3가지 성분이 추출되었으며, 각 성분은 명료성, 친밀성, 지역성이다. 도시 농지와 수림지는 근교도시의 녹지경관 특징 중 하나이며, 도시이미지 중 친밀성, 지역성과 관련된다. 마지막으로 본 연구의 결과를 바탕으로 근교도시에 있어서 녹지계획과 녹지경관 관리에 시사하는 바를 고찰하였다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2014년도 춘계학술대회
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• pp.73-75
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• 2014

본 연구는 해상교통안전시설 투자로 인한 해양사고 예방의 경제적 효과를 분석하는 것이다. 안전시설 투자의 경제적 효과 분석을 위해, 조건부 가치측정법을 이용하였다. 조건부 가치측정법은 특정 응답자들을 대상으로 설문지 또는 면접을 통해 환경재와 같은 비시장재의 가치를 계량적으로 측정하기 위해서 사용하는 방법이다. VTS는 시장재가 아니므로 VTS 시설투자에 대한 경제적 타당성을 추정하기 위하여 향후 VTS 시설 설치 예정 지역의 어민 및 선사 등을 대상으로 설문조사를 실시하였다. 설문조사를 실시한 결과, 통역지역 VTS 신설로 인해 발생할 수 있는 연간 총편익은 약110억으로 추정되었다. 2014년부터 5년간 소득세의 형태로 지불하게 된다면, 5년 동안 발생하게 되는 편익은 현재가치 기준으로 약473억원이다. 통영 VTS신설에 따른 경제성 분석결과, 편익-비용비율(B/C ratio)이 3.193로 1보다 높게 나왔고, 순현재가치(NPV)가 325억, 그리고 내부수익률(IRR)이 37.4%로 사회적 할인율인 5.5%보다 높아, 경제적 타당성이 있는 것으로 분석되었다.

• 대한교통학회지
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• 제34권5호
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• pp.465-475
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• 2016

최근 일부 도시에서는 도시철도 건설 시 부정확한 수요예측에 따른 재정적 부담으로 많은 갈등을 겪은 바 있는데, 건설비용뿐만 아니라 운영비용을 잘못 예측할 경우에도 지자체 또는 정부에 막대한 예산 낭비를 초래할 우려가 있다. 특히 운영비용은 공공재인 도시철도의 요금정책에도 직접적인 영향을 줄 수 있으므로 도시철도의 현실적인 운영비용을 추정하는 모형 개발이 시급하다. 이에 본 연구에서는 도시철도의 특성을 가장 잘 설명하는 변수와 기존 연구에서 사용된 변수들보다 정확성과 신뢰성을 높일 수 있는 변수를 투입하여 운영비용의 추정모형을 개발하는 것을 목적으로 한다. 먼저 국내 도시철도를 대상으로 최근 5년의 도시철도 운영데이터를 수집하여 운영비용에 영향을 미치는 변수들을 종합적으로 검토하였고 평균 역간거리, 열차 운행 거리, 열차정원, 운전유형(유 무인), 사업유형(재정 민자)을 독립변수로 선정, 더미회귀모형을 구축하여 실질적인 운영비용을 추정하였다.

• Radiation Oncology Journal
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• 제8권2호
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• pp.225-230
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• 1990

1979년부터 1987년까지의 서울대학교병원 치료방사선과에서 흉선암으로 근치목적의 방사선치료를 받은 21명을 대상으로 조사하였다. 전체환자의 3년생존율은 $80.5{\%}$, 3년 무병생존율은 $78.6{\%}$였다. 근무력증을 동반한 환자는 $43.5{\%}$였고 치료후 $40{\%}$ (4/10)에서 증상의 호전을 보였다. 증상의 유무에 따른 3년생존율을 비교하여보면 각각 $90{\%}$, $78.8{\%}$였으며 근무력증이 예후에 나쁜 영향을 주는 인자가 아님을 알 수 있었다. 방사선치료후 완전관해율은 절제술을 시행한 경우는 $100{\%}$(3/3)인 반면, 절제가 불가능한 경우는 $20{\%}$(3/15)였다. 완전관해율 및 부분관해율은($33{\%}$ vs $56{\%}$) $89{\%}$였고 이에 따른 3년생존율은 각각 $89.8{\%},\;81.7{\%}$로 통계학적으로 유의한 차이는 보이지 않았다. 수술정도에 따른 치료실패율을 비교하여보면 절제가 가능한 환자에서는 치료실패가 없었으나, 절제가 불가능하였던 환자 15명중 4명에서 국소실패, 1명이 골전이 소견을 보였다. 국소치료실패가 대부분으로 원격전이율은 낮은 양상을 보였다.