• 한국대기환경학회지
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• 제32권6호
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• pp.575-582
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• 2016

Seoul city has high population density as well as high traffic congestion, which are vulnerable to exposure of environmental pollutions caused by car traffic. However, recent studies are only on local regions about road traffic and air pollution or health effect of road traffic on residents. Thus, comprehensive study data are needed in terms of overall Seoul regions. In this study utilized the nitrogen dioxide concentration through the national air pollution monitoring network data, 2012 to 2013. It also divided regions into high and low exposure districts via the Origin destination data developed by the Korea transport institute to quantify and evaluate the effect of transport policies and analyzed a correlation of asthma symptoms with high and low exposure districts through raw data of community health survey from the Korea centers for disease control and prevention. Based on the collected data, the pearson's correlation analysis was conducted between air pollution substance concentration and high exposure district and multiple logistic regression analysis was conducted to determine the effect of traffic environment and factors on asthma symptoms of residents. Accordingly, the following results were derived. First, the high exposure district was higher concentrations of nitrogen dioxide ($NO_2$) as per time compared to those of the low exposure district (p<0.01). Second, analysis on correlation between average daily environmental concentration in the air pollution monitoring network and road traffic showed that nitrogen dioxide had a significant positive correlation (p<0.01) with car traffic and total traffic as well as with truck traffic (p<0.05) statistically. Third, an adjusted odds ratio about asthma doctor's diagnosis in the high and low exposure districts was analyzed through the logistic regression analysis. With regard to an adjusted model 2 (adjusted gender, age, health behavior characteristics, and demographic characteristics) odds ratio of asthma doctor's diagnosis in the high exposure district was 1.624 (95% CI: 1.269~2.077) compared to that of the low exposure district, which was significant statistically (p<0.001).

• Radiation Oncology Journal
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• 제33권4호
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• pp.276-283
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• 2015

Purpose: We evaluated the efficacy and toxicity of repeated high dose 3-dimensional conformal radiation therapy (3D-CRT) for patients with unresectable hepatocellular carcinoma. Materials and Methods: Between 1998 and 2011, 45 patients received hepatic re-irradiation with high dose 3D-CRT in Samsung Medical Center. After excluding two ineligible patients, 43 patients were retrospectively reviewed. RT was delivered with palliative or salvage intent, and equivalent dose of 2 Gy fractions for ${\alpha}/{\beta}=10Gy$ ranged from $31.25Gy_{10}$ to $93.75Gy_{10}$ (median, $44Gy_{10}$). Tumor response and toxicity were evaluated based on the modified Response Evaluation Criteria in Solid Tumors criteria and the Common Terminology Criteria for Adverse Events (CTCAE) ver. 4.0. Results: The median follow-up duration was 11.2 months (range, 4.1 to 58.3 months). An objective tumor response rate was 62.8%. The tumor response rates were 81.0% and 45.5% in patients receiving ${\geq}45Gy_{10}$ and $<45Gy_{10}$, respectively (p = 0.016). The median overall survival (OS) of all patients was 11.2 months. The OS was significantly affected by the Child-Pugh class as 14.2 months vs. 6.1 months (Child-Pugh A vs. B, p < 0.001), and modified Union for International Cancer Control (UICC) T stage as 15.6 months vs. 8.3 months (T1-3 vs. T4, p = 0.004), respectively. Grade III toxicities were developed in two patients, both of whom received ${\geq}50Gy_{10}$. Conclusion: Hepatic re-irradiation may be an effective and tolerable treatment for patients who are not eligible for further local treatment modalities, especially in patients with Child-Pugh A and T1-3.

• 대한두경부종양학회지
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• 제23권1호
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• pp.15-20
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• 2007

Background and Objectives：Supraglottic partial laryngectomy is oncologically sound surgical procedure for selected cases of laryngeal cancer which maintains physiologic speech and swallowing without permanent tracheostoma. The purpose of this study is to evaluate the oncologic and functional results of supraglottic partial laryngectomy and neck dissection for supraglottic cancer. Materials and Methods：Between 1991-2005, Twenty-three supraglottic cancer patients, underwent supraglottic partial laryngectomy, were studied retrospectively. There were 5 patients with cT1, 14 with cT2, 4 with cT3 and 11 patients with cN0, 1 with cN1, 10 with cN2, 1 with cN3. All patients underwent neck dissection and postoperative radiotherapy was added to twenty patients. They were reviewed with respect to primary subsites, extended subsites, treatment result, survival rate, factors affecting the prognosis, postoperative complication, time of decannulation and oral diet, and postoperative voice. Results：Among eleven patients with clinically negative node, six patients had pathologically positive nodes. So occult metastasis was 54.5%. Two patients recurred at cervical lymph node and one had distant metastasis to lung. Local and regional control were 100% and 91.3%. The overall 3-year and 5-year survival rate were 84%, 78%, respectively. Nineteen cases were squamous cell carcinomas and four were basaloid squamous cell carcinomas. Basaloid subtype was significantly affected to survival. Decannulation and oral feeding were possible in 100%. Conclusions：Supraglottic partial laryngectomy is oncologically safe and functionally good procedure in supraglottic cancers. Elective neck dissection is beneficial in management of occult cervical metastasis.

• 대한전자공학회논문지SP
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• 제46권1호
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• pp.23-31
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• 2009

최근 출입통제, 금융보안 및 전자여권 등 다양한 분야에서 얼굴인식, 지문인식, 홍채인식 등과 같은 생체인식기술의 적용이 활발히 이루어지고 있다. 또한 최근에는 손가락의 지정맥 패턴정보를 이용하여 개인을 인증하는 연구 역시 활발히 진행 중이다. 일반적으로 획득된 지정맥 영상은 손가락의 두께에 따른 적외선 빛의 투과도 및 카메라의 센서 잡음으로 인하여 정맥과 배경 분리에 많은 어려움이 있다. 이를 해결하기 위하여 본 논문에서는 고속으로 지정맥 영역을 추출하기 위한 새로운 방법을 제안한다. 본 연구는 기존의 방법에 비해 다음과 같은 2가지 장점을 가지고 있다. 첫째, 획득된 지정맥 영상에 적응적 지역 이진화 방법을 적용하여 지정맥 영역을 분리하였다. 둘째, 분리된 영상의 잡음을 열림 및 닫힘 연산을 이용하여 제거하고 최종적으로 골격화하여 지정맥 영역을 추출하였다. 실험결과, 기존의 방법들에서는 영상 잡음을 제거하기 위해 많은 필터를 사용하였으나 제안한 방법에서는 필터를 많이 사용하지 않으면서도 고속으로 정확하게 지정맥 영역을 추출할 수 있음을 보였다.

• Journal of Preventive Medicine and Public Health
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• 제36권4호
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• pp.373-376
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• 2003

Objectives : Peripheral blood-buffy coat fractions (N=14,956) have been stored at $-70^{\circ}C$ in the headquarter of the Korean Multicenter Cancer Cohort (KMCC), since 1993. To study the future molecular etiology of cancers using specimens of the cohort, properly stored specimens are necessary, Therefore, the DNA-viability of the bully coat samples was investigated. Methods : Buffy coat fraction samples were randomly selected from various collection areas and years (N=100). The DNA viability was evaluate from the UV-absorbent ratios at 260/280nm and the PCH for $\beta$-globin was performed with genomic DNA isolated from the buffy coat. Results : PCR products were obtained from 85 and 98% of the C and H area-samples, respectively, using 50 or $100{\mu}l$ of the buffy coat. There were significant differences in the yields of the PCR-amplifications from the C and H areas (p<0.05), which was due to differences in the homogenization of the buffy coat fractions available as aliquots. The PCR-products were obtained from all of the samples (N=7) stored at the C area-local confer, but the other aliquots stored at the headquarter were not PCR-amplified, Therefore, the PCR products in almost all the samples, even including the DNA-degraded samples, were obtained. In addition, an improvement in the DNA isolation, i,e. approx. 1.6 fold, was found after using extra RBC lysis buffer. Conclusions : PCR products for $\beta$-globin were obtained from nearly all of the samples. The regional differences in the PCR amplifications were thought to have originated from the different sample-preparation and homogenization performance. Therefore, the long term-stored buffy coat species at the KMCC can be used for future molecular studies.

• Radiation Oncology Journal
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• 제3권2호
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• pp.131-136
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• 1985

성문암은 술, 담배가 주 원인적 인자로 밝혀져 있다. 성문암은 쉰목소리 등으로 조기발견이 용이하며 대부분 분화도가 좋은 편평상피암이고 해부학적 위치상 조직생검 및 치료경과 관찰이 용이하며, 성운에는 임파절이 없으므로 전이가 적다. 국소 치료인 방사선치료와 수술이 치료의 주종을 이루며 방사선치료는 음성보전 측면에서 효과적이므로 초기병변에는 방사선치료를 진행된 병변의 경우 수술 혹은 수출 및 방사선 복합요법을 사용하고 있다. 저자들은 1979년 3월부터 1982년 9월까지 서울대학교병원 치료방사선과에서 성문암으로 치료받은 환자들을 추적 조사하여 다음과 같은 결과를 얻었다. 1. 방사선치료 후 3년 무병 생존율이 $T_1N_0 :\;78\%T_1N_0;\;60\%T_3N_0:\;50\%$, 2 구제적 수술후 3년 무병생존율이 $T_1N_0 :\;89\%T_2N_0;\;80\%T_3N_0:\;50\%$ 3. 재발은 대개 3년 이내에 하였다.

• Radiation Oncology Journal
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• 제9권1호
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• pp.111-116
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• 1991

1979년부터 1987년까지 서울대학교 병원에서 상기도에 국한된 다형성 세망증으로 근치적 방사선치료를 받은 33명의 환자의 치료성적을 분석하였다. 발열, 체중감소, 도한등의 전신적 증상은 대상 환자중 $48\%$에서 나타났으며 침윤병소로는 비강이 $85\%$로 가장 많았고 븐비동 및 구개부가 각각 $33\%$와 $30\%$이었다. 전체 환자의 5년 및 10년 생존율은 각각 $47\%$와 $40\%$이었다. 방사선 조사야 내에서 재발한 경우와 그렇지 않은 경우간의 방사선 선량 차이는 통계학적으로 유의하였으며 조사야 경계부위에서 재발한 경우는 그렇지 않은 경우에 비해서 조사야 면적이 작았다. 추적 관찰 기간중 악성 임파종 4예, 골수 세망증 1예 등의 전신적 전이가 확인되었다. 따라서 방사선 치료를 시행하여 다형성 세망증의 국소 치료율은 향상시키기 위해서는 최소 4,500 cGy의 선량과 병소주위의 조직을 충분히 포함하는 조사야를 사용해야 하며 전신적 전이를 효과적으로 치료할 화학요법 면에서의 개선이 필요하다고 판단된다.

• 식물병연구
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• 제8권3호
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• pp.146-161
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• 2002

최근 연작장해의 주원인으로 지적되는 토양병해의 발생은 매우 심각한 양상을 띄고 있다. 그 예로 배추 무사마귀병, 마늘 흑색썩음균핵병, 감자의 풋마름병, 고추 역병, 토마토 시들음병 , 수박의 CGMMV 등을 들 수 있으며 이 모두 시급히 해결하지 안되는 현실문제다. 토양병 발생이 이렇게 심각해진 것은 특정작물의 주산단지화 및 주년 생산체계, 시설원예의 보편화에 의한 획일적인 작부체계 내지는 동일작물 연작에 의해 토양환경이 급속히 악화된데 그 근본 원인이 있으며 이외에 수량 및 품질위주의 품종 육성에 의해 작물의 병 저항성을 소홀히 한 점이나 화학비료 위주의 경종방법 등도 토양병 발생을 부추기는 한 원인으로 지적되고 있다. 토양병 발생에 대한대책으로 그 원인을 찾아 제거하는 방법이 가장 효율적이라고 생각되는바 장기적인 대책으로 지역의 현실여건 및 경제성을 고려한 합리적 작부체계의 개발·운용, 작물별로 피해가 심한 다수 병해를 대상으로 한 복합저항성 품종의 육성 ·보급, 농토배양 및 토양개량을 통한 악화된 토양환경의 개선을 들 수 있고 단기적인 대책으로는 간편한 토양소독 기술의 개발·보급, 신속·정확한 토양병 예찰기술의 정립이 긴급하다. 이를 위하여 토양병 전문연구자의 육성 및 현장문제 해결을 위한 공동연구의 활성화 등에 국가적인 차원에서의 적극적인 지원이 요청되고 있다.

• 한국지리정보학회지
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• 제3권2호
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• pp.1-10
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• 2000

본 연구의 목적은 도시내 필지 단위의 지가산정과 그 결과의 시각적 표현을 위한 자동화 시스템을 개발하는 것이다. 현재 필지별 공시지가는 건교부의 ALPAS 프로그램으로 매년 산정 되지만, 시스템이 매우 번잡하고, 도시공간분석과 도시계획을 지원하는 기능을 제공하지 못해 개선되어야 한다. 따라서 본 연구는 지가계산을 위해 뉴럴네트워크(Neural Network)이론을 도입하였으며, Matlab 4.0 어플리케이션으로 계산 프로그램을 작성하였다. 계산 결과의 공간표현을 위해 ArcView GIS를 도입하였으며, 두 어플리케이션의 통합은 DDE(Dynamic Data Exchange)방식으로 통합하였다. 이는 Matlab을 서버로 설정하고, ArcView를 클라이언트로 설정함으로써 가능하였다. 사례연구는 진주시를 대상으로 하였으며, ArcView창의 메뉴에서 동명을 선택하면, Matlab에서 해당 동의 네트워크 모형을 구축하고, 필지 속성자료로 네트워크를 교육한다. 그 다음 ArcView 창에 고도제한, 미관지구, 도로 및 공원지정에 의한 지가 변동을 시뮬레이션할 수 있도록 버튼을 추가하여, 자동적으로 계산과 결과의 시각화가 가능한 시스템을 구축하였다. 이 시스템은 부수적인 보완을 거친다면, 도시계획을 지원하기 위한 시스템(Planning Support System)으로 활용 가능할 것이다.

• Journal of Acupuncture Research
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• 제18권3호
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• pp.154-170
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• 2001

Objective : To broaden understanding about acupuncture and moxibustion therapy on AIDS and to promote base studies and clinical trials Materials and Methods : Analysis was given to more than 30 literatures including acupuncture and moxibustion therapy on AIDS-related sites explored by internet search engine named NAVER from Nov., 2000 to Feb. 20th, 2001 Results : 1. Acupuncture and moxibustion played great role as a complementary therapy in enabling AIDS patients to keep their antiretroviral therapy by enhancing immune system, ameliorating AIDS-related symptoms and side effect of antiretroviral drug 2. Acupuncture and moxibustion therapy had a broad spectrum indication from systemic or local signs of AIDS patients to signs of antiretroviral drug-related side effect 3. Contraindication of acupuncture and moxibustion therapy against AIDS patients include abstraction and moxibustion on the skin lesion, because of their easy exposure to inflammation 4. AIDS patients were regarded as the state of KI-HE(氣虛), EUM-HE(陰虛), YEOL-DOK(熱毒) in general 5. BO-KI(補氣), BO-HYUL(補血), BO-EUM(補陰), CHEONG-YEOL-HAE-DOK(淸熱解毒) were shown as a principle of acupuncture and moxibustion therapy for AIDS patients 6. Principle of selecting acupoints for AIDS patients had characteristics of enhancing immune system, detoxicating detrimental agents and relieving each AIDS related symptom appropriately 7. Acupuncture on 合谷(HAPKOK, LI4), 內關(NAE-GWAN, P6), 足三里(CHOK-SAMNI, S36) were applied to the early stage of AIDS in order to enhance immune system. Acupuncture on 血海(HYOLHAE, SP10), 三陰交(SAMUMGYO, SP6), (KOHWANG, B43) were applied to the intermediate stage of AIDS so as to enhance immune system and eliminate YEOL-DOK(熱毒) in blood. Moxibustion on 湧泉(YONGCHON, K1), 足三里(CHOK-SAMNI, S36) were applied to the late stage owing to enhance immune system more. Conclusion : The efficacy of acupuncture and moxibustion therapy on AIDS has been acknowledged to the world, moreover, it is proved to be significant as a complementary therapy on AIDS patients. Thus, more control group studies of the efficacy of acupuncture and moxibustion therapy on AIDS and clinical trials are considered to be necessary.