• Molecules and Cells
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• v.43 no.10
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• pp.870-879
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• 2020

Dendrites require precise and timely delivery of protein substrates to distal areas to ensure the correct morphology and function of neurons. Many of these protein substrates are supplied in the form of ribonucleoprotein (RNP) complex consisting of RNA-binding proteins (RBPs) and mRNAs, which are subsequently translated in distal dendritic areas. It remains elusive, however, whether key RBPs supply mRNA according to local demands individually or in a coordinated manner. In this study, we investigated how Drosophila sensory neurons respond to the dysregulation of a disease-associated RBP, Ataxin-2 (ATX2), which leads to dendritic defects. We found that ATX2 plays a crucial role in spacing dendritic branches for the optimal dendritic receptive fields in Drosophila class IV dendritic arborization (C4da) neurons, where both expression level and subcellular location of ATX2 contribute significantly to this effect. We showed that translational upregulation through the expression of eukaryotic translation initiation factor 4E (eIF4E) further enhanced the ATX2-induced dendritic phenotypes. Additionally, we found that the expression level of another disease-associated RBP, fragile X mental retardation protein (FMRP), decreased in both cell bodies and dendrites when neurons were faced with aberrant upregulation of ATX2. Finally, we revealed that the PAM2 motif of ATX2, which mediates its interaction with poly(A)-binding protein (PABP), is potentially necessary for the decrease of FMRP in certain neuronal stress conditions. Collectively, our data suggest that dysregulation of RBPs triggers a compensatory regulation of other functionally-overlapping RBPs to minimize RBP dysregulation-associated aberrations that hinder neuronal homeostasis in dendrites.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.10
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• pp.3885-3892
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• 2010

Safety-Critical systems, such as Plant Protection Systems in nuclear power plant, plays a key role that the facilities can be operated without undue risk to the health and safety of public and environment, and those systems shall be designed, fabricated, installed, and tested to quality standards commensurate with the importance of the functions to be performed. Computer-based Instrumentation and Control Systems to perform the safety-critical function have Real Time Operating Systems to control and monitoring the sub-system and executing the application software. The safety-critical Real Time Operating Systems shall be designed, analyzed, tested and evaluated to have capability to maintain a high integrity and quality. However, local nuclear power plants have applied the real time operating systems on safety critical systems through Commercial Grade Item Dedication method, and this is the reason of lack of detailed methodology on assessing the safety of real time operating systems, expecially to the new developed one. This paper presents the methodology and experiences of safety evaluation on safety-critical Real Time Operating Systems based upon design requirements. This paper may useful to develop and evaluate the safety-critical Real Time Operating Systems in other industry to ensure the safety of public and environment.

• Journal of Bio-Environment Control
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• v.6 no.3
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• pp.159-167
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• 1997

To cope with the mass-production and supply of plug seedling, the supply of transplanters is necessary. In the study, a transplanting test was carried out to find the optimum working condition in the mechanizd transplantation and to acquire the basic data for the improvement of transplanters by the research and analysis of working capacity of the local manual transplanters. The size of hopper affected transplanting stand and rate. Re-irrigation was required for the transplanted seedlings because they wilt 1 day after the transplanting if soil compaction is incomplete. Consequently, back-forth-left-right compaction method was good for soil covering and compaction. It may be thought to increase the amount of irrigation water at the time of transplanting by double-irrigation mechanism, but it needs to increase the larger water tank which makes the operation uneasy. So, assuming the working model by 1 or 2 operators with the machine size as small as possible, it seemed that eliminating of automatic irrigation method was desirable in view of efficiency. Though semiautomatic transplanter needs some structural improvements, it seemed still suitable for transplanting of plug seedlings such as 45-day red pepper seedlings in 128-hole tray and 25-day Chinese cabbage seedling in 128-hole tray. If traveling speed of the transplanter is limited to less than 14 m/min, with the transplanting depth of 2~3cm and transplanting space of 30cm.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.3A
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• pp.209-216
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• 2005

This paper generally relates to the field of wireless local area networks(WLANs), and more particularly, to AP selection and association methods for the performance of a station. In these days, IEEE 802.11 Wireless LAN network is widely deployed and used as an emerging service to connect high-speed Internet in the public wireless environment. But, if there are many users in hot spot area, they suffer a severe decrease of performance. Thus it needs an association and access control mechanism especially when it is used in the public environment. In this paper, we suggest a selection and association method using Beacon or Probe Response frames based IEEE 802.11. Station selects AP using the information of the capacity area in a Beacon or a Probe Response frame. According to the present paper, an association method for a public WLAN service, which includes a WLAN user terminal and an AP for relaying WLAN communications to and from the user terminal, includes the steps of the user terminal asking the AP's states for access to a radio channel; and the station selects and associates with the AP According to the above-described selection in a high speed wireless Internet service based on public WLAN technologies that are currently in operations. Further, it is possible to improve the efficiency of network management.

• The KIPS Transactions:PartC
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• v.17C no.3
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• pp.271-280
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• 2010

For the next generation mobile communication system, diverse wireless network techniques such as beyond 3G LTE, WiMAX/WiBro, and next generation WLAN etc. are proceeding to the form integrated into the All-IP core network. According to this development, Beyond 3G integrated into heterogeneous wireless access technologies must support the vertical handover and network to be used of several radio networks. However, unified management of each network is demanded since it is individually serviced. Therefore, in order to solve this problem this study is introducing the theory of Common Radio Resource Management (CRRM) based on Generic Link Layer (GLL). This study designs the structure and functions to support the vertical handover and propose the vertical handover algorithm of which policy-based and MCDM are composed between LTE and WLAN systems using GLL. Finally, simulation results are presented to show the improved performance over the data throughput, handover success rate, the system service cost and handover attempt number.

• Journal of the Korean association of regional geographers
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• v.17 no.1
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• pp.17-39
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• 2011

As recent inflows of foreign immigrants to relatively advanced countries in Northeast Asia have rapidly increased, Japan in particular uses 'multicultural coexistance' as a key concept for developing both discourse and policies on them. This paper is first of all to suggest a new typology of multicultural societies in the world ill order to differentiate the case of Northeast Asian countries from those of Western countries. And this paper is to suggest that foreign immigrants in Japan have different positions in labor markets and living experiences according to historical and social backgrounds as well as their nationality. The transformation process towards multicultural society is not only historical and social but also geographical and spatial, as foreign immigrants have made different spatial distribution and regional segregation in types. In order to control this socio-spatial process towards multicultural society, Japan has developed the concept of 'multicultural coexistence' similar with that of multiculturalism in Western countries. This concept seems to be quite significant as it has been initiated by local communities for symbiotic relationship between foreign immigrants and native Japanese dwellers. But it can be regarded as a strategic ideology to control foreign immigrants as it targets mainly on Nikkeijin, and is usually concerned with the cultural aspect. Seen from a theoretical point of view, this concept can be seen as closed with liberal multiculturalism as opportunity equity, but far from corporative multiculturalism as outcome equity, and it is on the process transferring from the first stage of tolerance to the second stage of legislation of nondiscrimination, while being distant from the third stage of legislation paradigmization of recognition, and hence appears to be easily reverted to assimilationism.

• Journal of the Korean Society of Food Culture
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• v.14 no.4
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• pp.431-446
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• 1999

The purpose of this study is to examine current foodservice management practices at free congregate meal service for elderly people. Forty seven meal service centers as well as randomly selected Seoul and Kyunggido area were surveyed and interviewed and results were summarized as follows: The cost of each meal(lunch) was ranged from 1,300 won to 1,500 won and 68% of target centers were severed over 100 meals per day. Meal time for lunch begins from 10:30 am to 12:00 because great portion of elderly didn't take breakfast frequently. 52.3% of centers severed meal 5 times per week, just weekdays. 21.3% of centers employeed dietitian, 63.8% of center employeed cook. 95.7% of center were supported labor force by volunteers. Volunteer was important contribution to free meal service. Utilizing the labor force more effectively is thus a major challenge facing manager in each center. Ideal supporting system of free foodstuff, foodbank was still minor source of securing foodstuff. Most of centers(46 centers)served lunch, only one of them served breakfast and lunch. Government was the major financial sponsor, the second of them was religious organization. The large portions of financial support provided only food cost of total meal service budget. Most of center adapted self-service system. Standardized recipes were not developed and meal preparation was controlled under the experience of volunteers. Recording system of nutrition management, production control, storage and inventory control was not adapted by most of sites. It is suggested that in order to meet the change of the patterns of social and family structure, the service of the center should be offended in urban area and it is necessary to develop systematic management models for the center. It was suggested that not only financial support but also systematical support on management by the local government may be necessary to meet the goal of supply nutritionally balanced food at center.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.200-206
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• 2018

The aim of this study was to evaluate the effect of Ropivacaine on pain following laparoscopic surgery. Between March 2015 and June 2017, all 97 patients with renal mass who elected to receive laparoscopic nephrectomy were reviewed, retrospectively. Normal saline (0.9%) was used as a control in 45 patients while Ropivacaine was used for local anesthesia in the instillation group (n=52). Pain score (visual analog scale) of the shoulder and upper abdominal area between the two groups was significantly different between recovery time and 24 h (p<0.05), with no significant differences between 48 and 72 h (both p>0.05). In the instillation group, pain score of shoulder and abdominal pain in the two groups according to the amount of CO2 used was not significantly different between recovery time and 24, 48, and 72 h (all p>0.05). Ropivacaine reduced shoulder and upper abdominal pain that occurred within 24 h after surgery. Effective pain control with Ropivacaine is needed in the early postoperative period when a large amount of CO2 is used in laparoscopic surgery.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.257-265
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• 2020

Parts obsolescence is a component type, in which raw materials or parts that make up a weapons system, are developed and produced according to demand, but they age due to changes in technology or market conditions. The weapon system equipment currently being used by the military is having difficulty in procurement, maintenance, and operation because of the obsolescence of parts. Parts obsolescence during the life cycle of a weapons system affects not only the combat readiness of the military but also the economic loss of material, parts, and equipment manufacturers and suppliers. On the other hand, advanced technology has reduced the life span of electronic components that make up the weapons system. In addition, because of the nature of the weapons system, the obsolescence of components takes decades from development to disposal, which has a serious adverse effect on equipment readiness and life cycle costs. Therefore, it is necessary to manage systematically the parts obsolescence from development until the disposal of the weapons system equipment. This study examined the system of component control in developed countries to present a proper management plan for local situations and propose development plans for the early settlement of component control.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7569-7576
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• 2013

Background: The purpose of this article is to present preliminary results of simultaneous boost irradiation radiotherapy for locally advanced nasopharyngeal carcinoma (NPC). Methods: Fifty-eight patients who underwent simultaneous boost irradiation radiotherapy for NPC in Cancer Center of Sun Yat-sen University between September 2004 and December 2009 were eligible. Acute and late toxicities were scored weekly according to the Radiation Therapy Oncology Group (RTOG) acute and late radiation morbidity scoring schemes. An especial focus was on evidence of post-radiation brain injury. Also quality of life was analysed according to the EORTC (European Organisation for Research and Treatment of Cancer) recommendations. Discrete variables were compared by ${\chi}^2$ test. The Kaplan-Meier method was used to calculate the survival rates and generate survival curves. Results: A total of 58 patients with a mean follow-up time of 36 months completed clinical trials.Fifty-seven patients (98.3) achieved complete remission in the primary sites and cervical lymph nodes, with only one patient (1.7%) showing partial remission.The most frequently observed acute toxicities during the concurrent chemoradiotherapy were mucositis and leucopenia. Four patients (6.9%) had RTOG grade 3 mucositis, whereas four patients (6.9%) had grade 3 leucopenia. No patient had grade 4 acute toxicity. Three (5.17%) of the patients exhibited injury to the brain on routine MRI examination, with a median observation of 32 months (range, 25-42months). All of them were RTOG grade 0. The 3-year overall, regional-free and distant metastasis-free survival rates were 85%, 94% and 91%, respectively. Conclusion: Simultaneous boost irradiation radiotherapy is feasible in patients with locally advanced nasopharyngeal carcinoma. The results showed excellent local control and overall survival, with no significant increase the incidence of radiation brain injury or the extent of damage. A larger population of patients and a longer follow-up period are needed to evaluate ultimate tumor control and late toxicity.