• 제목/요약/키워드: loading history

검색결과 343건 처리시간 0.025초

정신분열병에서 연성 신경학적 징후의 가족내 전달에 관한 연구 (The Study About Intra-Familial Transmission of the Neurological Soft Signs in Schizophrenia)

  • 류수정;최영락;이상익;신철진;김시경;손정우
    • 생물정신의학
    • /
    • 제15권2호
    • /
    • pp.83-91
    • /
    • 2008
  • 목 적 연성 신경학적 징후는 정신분열병의 유전과 관계되는 생물학적 표현형으로 여겨져 왔다. 본 연구에서는 연성 신경학적 징후가 유전적 하중과 관련해서 가족 내에서 연관성을 보이는지를 알아보고자 하였다. 대상 및 방법 정신분열병 환자로서 부모 중 한 명은 정신분열병의 가족력이 있고 나머지 한 명은 가족력이 없는 환자가(N=14) 모집되었다. 이들의 부모가 가진 가족력에 따라 유전적 하중을 정하였고 이를 위해 Family Interview for Genetic Studies(FIGS)로 직접 면담을 시행하였다. 환자의 부모에서 환자를 제외한 1차 혹은 2차 친척에서 정신분열병 환자가 있는 부모를 유전적 하중이 있는 '추정 보유자'(presumed carrier)(N=9)로, 그렇지 않은 부모를 '추정 비보유자' (presumed noncarrier)(N=11)로 구분하였다. 또한 정상 대조군은 1차 혹은 2차 친척에서 정신분열병의 가족력이 없는 일반인(N=12)이었다. 이들의 연성 신경학적 징후를 한국어판 신경학적 평가 척도(Neurological Evaluation Scale-Korean version)를 사용하여 평가하였으며 가족내 연관성에 대한 분석 방법으로 급내 상관계수법(Intra-Class Coefficients[ICC]) method)을 이용하였다. 결 과 연성 신경학적 징후의 하위 영역 중 운동 조정 영역에서 환자와 추정 보유자 간에 유의한 연관성이 존재하였고(ICC=.804, p=.016) 환자와 추정 비보유자와는 연관성이 존재하지 않았다. 운동 조정 영역 이외의 다른 하위 영역에서는 유전적 하중과 상관없이 가족내 연관성이 존재하지 않았다. 그러나, 환자군과 정상 대조군의 운동 조정 영역의 점수 간에는 통계적으로 유의한 차이가 존재하지 않았다. 결 론 이번 연구에서는 연성 신경학적 징후들이 정신분열병의 유전적 하중과 같이 유전되는 생물학적 표현형일 가능성이 입증되지 못하였다. 향후 보다 많은 수를 대상으로 한 추시 연구가 필요하다.

  • PDF

극저(極低)사이클 하중하(荷重下)에서 강부재(鋼部材)의 손상도평가(損傷度評價)를 위한 유한요소해석(有限要素解析) (Nonlinear FEM Analysis for Damage Assessment of Steel Members under Very-Low-Cycle Loading)

  • 박연수
    • 대한토목학회논문집
    • /
    • 제14권4호
    • /
    • pp.703-710
    • /
    • 1994
  • 극저사이클 하중하에서 강구조부재의 비선형 유한요소해석을 실험과 더불어 수행하였다. 본 해석은 강진과 같은 반복하중하에서 강구조부재의 균열발생전까지를 유한요소법으로 추적한 것이다. 해석과 실험결과로부터 얻어진 히스테러틱 거동을 비교한 후, 큰 반복변형을 받는 응력집중부에 있어서 국소변형율의 이력을 수치해석에 의해 시뮬레이션하였다. 이 국소변형율의 이력과 극저사이클 파괴설험시의 균열발생 현상과의 관계를 정량적으로 분석하였다. 실험과 수치해석 결과를 바탕으로 강구조부재의 내전안전성 평가를 위한 새로운 방법이 본 논문에서 제시되었다.

  • PDF

액체 로켓 터보 펌프 터빈의 천이 열전달 및 구조 해석 (Transient Heat Transfer and Structural Analyses for the Turbopump Turbine of a Liquid Rocket Engine)

  • 유재한;최지훈;이인;한재흥;전성민;김진한
    • 한국항공우주학회지
    • /
    • 제32권3호
    • /
    • pp.58-65
    • /
    • 2004
  • 유한요소법을 이용하여 액체 로켓 엔진 터보 펌프 터빈의 천이 열전달 및 구조 해석이 수행되었다. 해석 모델은 3차원 8절점 등매개변수 솔리드 요소로 구성되었으며, 전체 모델의 1/80만이 해석되었다. 열 스파이크를 포함하는 시동 조건과 정상상태에서의 하중이 고려되었다. 블레이드 면 위의 열전달 계수는 상용 열유동 해석 프로그램인 Fluent를 이용하였다. 개발된 유한 요소 코드를 이용하여 시동 및 정상상태에서 천이 열전달 응답을 구하였다. 또한, 원심력과 열하중이 가해질 때, 최대 응력 및 슈라우드의 변위를 구하였다.

다중 과하중에 의한 A1 7075-T6 합금의 피로균열 성장지연현상에 관한 연구 (A Study on Fatigue Crack Growth Retardation Phenomena of Al 7075--T6 Alloy under Multiple overload(I))

  • 이택순;이유태
    • 한국해양공학회지
    • /
    • 제6권1호
    • /
    • pp.96-104
    • /
    • 1992
  • Aircraft structures and engineering structures are always subject to variable amplitude loads. Variable amplitude loads include some kind of loading history; for example, constant amplitude load, single peak overload and block overload etc. Crack growth under variable amplitude loading exhibits retardation effect. In this study, the 4 point bending fatigue test was performed by hydrolic servo fatigue testing machine on 7075-T6 Al-alloy. The retardation effect of overload ratio and numbers of overload cycle was quantitatively studied. 1) Change of retardation effect against increment of overload ratio is more evident when the multiple overload is applied than single overload is done. 2) The number of overload cycle is very important factor about the crack growth retardation effect when the overload ratio is more than 1.75; that is not when the overload ratio is less than 1.75. 3) Overload affected zone size increased gradually by increment of crack growth retardation effect. 4) Crack driving force is more greatly reduced when the crack tip branched off two direction than it sloped to one direction.

  • PDF

반복하중을 받는 콘크리트의 누가손상 특성 (Cumulative Damage Characteristics of Concrete Subjected to Variable Amplitude Loadings)

  • 변근주;김문겸;한상훈
    • 대한토목학회논문집
    • /
    • 제7권1호
    • /
    • pp.43-54
    • /
    • 1987
  • 본 논문에서는 압축반복하중을 받는 콘크리트의 피로누가손상 특성이 연구되었다. 압축을 받는 무근콘크리트의 원주형 공시체에 대한 기초실험을 통하여, 콘크리트의 누가손상에는 여러 인자들 중에서 반복적으로 작용되는 응력의 수준과 재하순서가 가장 크게 영향을 마친다는 것을 발견하였다. 이를 기초로 2단계 응력수준 조건하에서의 피로실험을 실시하여, 콘크리트의 누가손상특성은 Miner의 선형이론을 따르기 보다는 오히려 비선형의 상관관계를 가지며, 응력의 재하방법에 따라 누가손상의 특성과 콘크리트의 정적강도가 변화됨을 구명하였다. 또한 본 연구를 통하여 2 단계 응력수준하에서 콘크리트의 피로특성과 콘크리트구조의 잔존수명을 예측하는데 사용될 수 있는 실험공식이 도출되었다.

  • PDF

축소모델과 실모델 면진베어링의 성능실험에 관한 연구 (A Study on Testing of 1/4-scale and Full-size Seismic Isolation Bearings)

  • 정민기;정지만;김두훈
    • 한국소음진동공학회:학술대회논문집
    • /
    • 한국소음진동공학회 1996년도 춘계학술대회논문집; 부산수산대학교, 10 May 1996
    • /
    • pp.194-202
    • /
    • 1996
  • An approach to increase the seismic resistance of large structures is to reduce the seismic forces, to which structures are subjected by base isolation systems. The anti-seismic performance of base-isolated beatings has been verified experimentally by shaking table tests. However, it may be difficult to perform the tests for the full-scale beatings of base-isolated structures. Therefore, the test program was designed to evaluate the reliability and properties of the beatings under a range of loading conditions including axial stress, loading frequency and direction, and temperature. The effects of scale were also evaluated by comparing the results of the 1/4-scale beatings with those from the full-scale bearings, and the ultimate behavior of both types of bearings with evaluated through a series of roll-out tests. This report draws comparisons among the different tests and bearings to determine the importance of various factors including load history, axial stress, and frequency. Comparisons between the 1/4-scale bearings were difficult because of the scaling effects in manufacturing and thermal radiation, but qualitative results from the 1/4-scale bearings can certainly be extrapolated the full-scale bearings.

  • PDF

정지토압계수 측정에 관한 연구 1 (A Study on the Measuring about the Coefficient of Earth Pressure at Rest 1)

  • 송무효
    • 한국해양공학회지
    • /
    • 제15권4호
    • /
    • pp.92-100
    • /
    • 2001
  • It is very important to determine the coefficient of earth pressure at rest accurately in order to estimate the behavior of soil structure. For estimation of K/sub 0/-value depending upon the stress history of dry sand, a new type of K/sub 0/-oedeometer apparatus is devised, and the horizontal earth pressure is accurately measured. For this study, 2 types of one-cyclic K/sub 0/-Loading/unloading models have been studied experimentally using four relative densities of the sand. The results obtained in this test are as follows : K/sub on'/ the coefficient of earth pressure at - rest for virgin loading is a function of the angle of internal friction Φ' of the sand and is determined as K/sub on/=1 - 0.914 sin Φ', K/sub ou'/ the coefficient of earth pressure at rest for virgin unloading is a function of K/sub on/ and over consolidation ratio(OCR), and is determined as K/sub ou/=K/sub on/(OCR)K/sup a/. The exponent α, increases as the relative density increases. K/sub or'/ the coefficient of earth pressure at rest for virgin reloading decreases in hyperbola type as the vertical stress, σ/sub v/’, increases. And, the stress path at virgin reloading leads to the maximum prestress point, independent upon the value of the minimum unloading stress. The gradient of this curve, m/sub r/ increases as OCR increases.

  • PDF

Acceleration-based neural networks algorithm for damage detection in structures

  • Kim, Jeong-Tae;Park, Jae-Hyung;Koo, Ki-Young;Lee, Jong-Jae
    • Smart Structures and Systems
    • /
    • 제4권5호
    • /
    • pp.583-603
    • /
    • 2008
  • In this study, a real-time damage detection method using output-only acceleration signals and artificial neural networks (ANN) is developed to monitor the occurrence of damage and the location of damage in structures. A theoretical approach of an ANN algorithm that uses acceleration signals to detect changes in structural parameters in real-time is newly designed. Cross-covariance functions of two acceleration responses measured before and after damage at two different sensor locations are selected as the features representing the structural conditions. By means of the acceleration features, multiple neural networks are trained for a series of potential loading patterns and damage scenarios of the target structure for which its actual loading history and structural conditions are unknown. The feasibility of the proposed method is evaluated using a numerical beam model under the effect of model uncertainty due to the variability of impulse excitation patterns used for training neural networks. The practicality of the method is also evaluated from laboratory-model tests on free-free beams for which acceleration responses were measured for several damage cases.

임플란트 보철의 생역학과 교합 (Biomechanics and Occlusion for Implant-Supported Prosthesis)

  • 구철인;곽종하;정재헌
    • 구강회복응용과학지
    • /
    • 제18권2호
    • /
    • pp.127-144
    • /
    • 2002
  • There is an increasing appreciation of the vital role that biomechanics play in the performance of oral implant. The aim of this article is to provide some basic principles that will allow a clinician to formulate a biomechanically valid treatment plan. However, at this point in the history of oral implantology, the clinician should realize that we do not know enough to provide absolute biomechanical rules that will guarantee success of all implants in all situations. To examine the biomechanical questions, one must begin with an analysis of the distribution of biting forcess to implants. Related topics, such as stress transfer to surrounding tissues and interrelationships between bone biology and mechanical loading are major subjects, deserving a separate discussion. Once rigid fixation, angulation, crestal bone level, contour, and gingival health are achieved, stress beyond physiologic limits is the primary cause of initial bone loss around implants. The restoring dentist has specific responsibilities to reduce overload to the bone-implant interface. These include proper diagnosis, leading to a treatment plan designed with adequate retention and form, and progressive loading to improve the amount and density of bone and further reduce the risk of stress beyond physiologic limits. The major remaining factor is the development of occlusal concept in harmony with the rest of the stomagnetic system.

Seismic base isolation of precast wall system using high damping rubber bearing

  • Tiong, Patrick L.Y.;Adnan, Azlan;Rahman, Ahmad B.A.;Mirasa, Abdul K.
    • Earthquakes and Structures
    • /
    • 제7권6호
    • /
    • pp.1141-1169
    • /
    • 2014
  • This study is aimed to investigate the seismic performance of low-rise precast wall system with base isolation. Three types of High Damping Rubber Bearing (HDRB) were designed to provide effective isolation period of 2.5 s for three different kinds of structure in terms of vertical loading. The real size HDRB was manufactured and tested to obtain the characteristic stiffness as well as damping ratio. In the vertical stiffness test, it was revealed that the HDRB was not an ideal selection to be used in isolating lightweight structure. Time history analysis using 33 real earthquake records classified with respective peak ground acceleration-to-velocity (a/v) ratio was performed for the remaining two types of HDRB with relatively higher vertical loading. HDRB was observed to show significant reduction in terms of base shear and floor acceleration demand in ground excitations having a/v ratio above $0.5g/ms^{-1}$, very much lower than the current classification of $0.8g/ms^{-1}$. In addition, this study also revealed that increasing the damping ratio of base isolation system did not guarantee better seismic performance particularly in isolation of lightweight structure or when the ground excitation was having lower a/v ratio.