• Journal of the Society of Disaster Information
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• v.15 no.2
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• pp.292-300
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• 2019

Purpose: To reduce the noise and vibration of reinforced concrete slab structures, the damping performance is to be performed experimentally after installing hollow core or filling it with liquid. Method: Using the hollow rate as an experimental variable, the damping ratio and stiffness of each test specimen at impact load are obtained to determine the difference between the damping ratio and stiffness of the numerical analysis. In addition, the damping effects are reviewed by comparing the difference in the damping ratio and stiffness of a test specimen filled with liquid 50% of the study. Results: Since the difference in resistance between a specimen with or without hollow core is 5%, it is judged that there is no structural problem, and the injection of liquid into the hollow core can increase the damping ratio, which can reduce noise or vibration. Conclusion: At less than 20% of hollow rate, there was little damping effect, and at 30%, damping effect was found. However, if liquid is injected into the hollow core of the specimen, damping rate is shown to increase, and the injection of liquid into the hollow part is believed to reduce noise or vibration.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.1
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• pp.339-346
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• 2019

Various studies have been conducted to evaluate the probabilistic fatigue life of steel railway bridges, but many of them are based on a relatively simple model of crack propagation. The model assumes zero minimum stress and constant loading amplitude, which is not appropriate for the fatigue life evaluation of railway bridges. Thus, this study proposes a new probabilistic method employing an advanced crack propagation model that considers the live-dead load ratio for the fatigue life evaluation of steel railway bridges. In addition, by using the rainflow cycle counting algorithm, it can handle variable-amplitude loading, which is the most common loading pattern for railway bridges. To demonstrate the proposed method, it was applied to a numerical example of a steel railway bridge, and the fatigue lives of the major components and structural system were estimated. Furthermore, the effects of various ratios of live-dead loads on bridge fatigue life were examined through a parametric study. As a result, with the increasing live-dead stress ratio from 0 to 5/6, the fatigue lives can be reduced by approximately 30 years at both the component and system levels.

• Journal of Korean Society on Water Environment
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• v.34 no.6
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• pp.688-702
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• 2018

Since the 1970s regulations against the pollution of drinking water have been introduced in Lake Paldang watershed area. To understand the effects of water environment management policies and the impacts of climate changes on Lake Paldang, a long-term comprehensive study of this watershed and the changes in its water environment is required. In this study, we analyzed changes in the weather, hydrology, sources of pollution, water quality, and algal development from 2000 to 2015 year based on the statistical data provided by several national information systems. While the population and amount of sewage in the Lake Paldang watershed increased by about 1.5 times, the amount of animal manure showed a decreasing trend during the same period. The wastewater also increased by about 1.5 times while the amount of water intakes rose by about 1.14 times. The water quality in front of the Paldang Dam, which is the representative monitoring site of the Lake Paldang, was stable. The annual average BOD concentration remained within 2 mg/L, which is a "Good (lb)" level according to the environment standards of Republic of Korea. The development of phytoplankton and harmful cyanobacteria were largely influenced by meteorological factors.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.35 no.11
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• pp.25-34
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• 2019

It is important to design windows in a reasonable way considering the performance characteristics of the elements of the window rather than just to increase the thermal energy performance of the window. In this study, the Heat-transfer Coefficient as insulation performance of the windows and together with the grade of the glass's SHGC (Solar Heat Gain Coefficient) were analyzed to relate to the energy efficiency performance of the building by azimuth angle. Based on this basic study, the Heat-transfer Coefficient of windows and the SHGC rating of glass were applied to the unit plan of apartment building, and the Heating and Cooling Demand were analyzed by azimuth angle. Apartment plan types were divided into 2 types of Non-extension and extension of balcony. The designPH analysis data derived from the variant of the Heat-transfer Coefficient and SHGC, were put into PHPP(Passive House Planning Package) to analyze precisely the energy efficiency(Heating and Cooling Demands) of the building by azimuth angle. In addition, assuming the 'ㅁ' shape layout, energy efficiency performance and potential of PV Panel installation also were analyzed by floors and azimuth angle, reflecting the shading effects by surrounding buildings. As the results of the study, the effect of Heat Gain by SHGC was greater than Heat Loss due to the Heat-transfer Coefficient. So it is more effective to increase SHGC to satisfy the same Heating Demand, and increasing SHGC made possible to design windows with low Heat-transfer Coefficient. It was also revealed that the difference in annual Heating and Cooling Demands between the low, mid and high floor households is significantly high. In addition to it, the installation of PV Panel in the form of a shading canopy over the window reduces the Cooling Load while at the same time producing electricity, and also confirmed that absolute thermal energy efficiency could not be maximized without controlling the thermal bridge and ventilation problems as important heat loss factors.

• Journal of Microbiology and Biotechnology
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• v.31 no.5
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• pp.667-675
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• 2021

Streptococcus agalactiae is an important bacterial pathogen and causative agent of diseases including neonatal sepsis and meningitis, as well as infections in healthy adults and pregnant women. Although antibiotic treatments effectively relieve symptoms, the emergence and transmission of multidrug-resistant strains indicate the need for an effective immunotherapy. Effector T helper (Th) 17 cells are a relatively newly discovered subpopulation of helper CD4⁺ T lymphocytes, and which, by expressing interleukin (IL)-17A, play crucial roles in host defenses against a variety of pathogens, including bacteria and viruses. However, whether S. agalactiae infection can induce the differentiation of CD4⁺ T cells into Th17 cells, and whether IL-17A can play an effective role against S. agalactiae infections, are still unclear. In this study, we analyzed the responses of CD4⁺ T cells and their defensive effects after S. agalactiae infection. The results showed that S. agalactiae infection induces not only the formation of Th1 cells expressing interferon (IFN)-γ, but also the differentiation of mouse splenic CD4⁺ T cells into Th17 cells, which highly express IL-17A. In addition, the bacterial load of S. agalactiae was significantly increased and decreased in organs as determined by antibody neutralization and IL-17A addition experiments, respectively. The results confirmed that IL-17A is required by the host to defend against S. agalactiae and that it plays an important role in effectively eliminating S. agalactiae. Our findings therefore prompt us to adopt effective methods to regulate the expression of IL-17A as a potent strategy for the prevention and treatment of S. agalactiae infection.

• Animal Bioscience
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• v.35 no.12
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• pp.1871-1880
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• 2022

Objective: The primary goal was to identify the effectiveness of chemical or biological additives in delaying the deterioration of early-harvested wilted rye silage after exposure to air. Methods: Rye harvested as a whole plant at the early heading stage was wilted for 24 h. The wilted forage was divided into treatments including sodium diacetate (SDA) at 3 (SDA3) and 6 g/kg (SDA6), Lactobacillus plantarum (LP), L. buchneri (LB), or their equal mixture (LP+LB) at 1×10⁶ colony-forming unit/g fresh matter. Results: After 60 d of conservation in 20-L silos, lactic acid was greater in LP and LP+LB silages than other treatments (102 vs 90.2 g/kg dry matter [DM]). Acetic acid was greatest in SDA6 (32.0 g/kg DM) followed by LB (26.1 g/kg DM) and was lowest in LP treatment (4.73 g/kg DM). Silage pH was lower with microbial inoculation and the lowest and highest values were observed in LP and untreated silages, respectively. After 60 d, neutral detergent fiber concentration was lowest in SDA6 silages, resulting in the greatest in vitro DM digestibility (846 g/kg DM). Aerobic stability was longest in SDA6 (176 h) followed by LB treatment (134 h). Instability after aerobiosis was greatest in LP silages (68 h), about 8 h less than untreated silages. After aerobic exposure, yeast and mold numbers were lowest in SDA6 silages, resulting in DM loss minimization. Exhaustion of acetic acid and lactic acid after aerobic exposure was lowest with SDA6 but greatest with untreated and LP silages. Conclusion: Treatment of early-cut wilted rye forage with SDA at 6 g/kg resulted in silages with higher feeding value and fermentation quality, and substantially delayed deterioration after aerobic exposure, potentially qualifying SDA at this load for promotion of silage quality and delaying aerobic spoilage of early-harvested (low DM) rye forage.

• Earthquakes and Structures
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• v.23 no.5
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• pp.445-462
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• 2022

To investigate and evaluate the seismic damage behaviors of steel reinforced recycled concrete (SRRC) filled circular steel tube composite columns, in this study, the cyclic loading tests of 11 composite columns was carried out by using the load-displacement joint control method. The seismic damage process, hysteretic curves and performance indexes of composite columns were observed and obtained. The effects of replacement rates of recycled coarse aggregate (RCA), diameter thickness ratio, axial compression ratio, profile steel ratio and section form of profile steel on the seismic damage behaviors of composite columns were also analyzed in detail. The results show that the failure model of columns is a typical bending failure under the combined action of horizontal loads and vertical loads, and the columns have good energy dissipation capacity and ductility. In addition, the replacement rates of RCA have a certain adverse effect on the seismic bearing capacity, energy consumption and ductility of columns. The seismic damage characteristics of composite columns are revealed according to the failure modes and hysteretic curves. A modified Park-Ang seismic damage model based on the maximum displacement and cumulative energy consumption was proposed, which can consider the adverse effect of RAC on the seismic damage of columns. On this basis, the performance levels of composite columns are divided into five categories, The interlayer displacement angle and damage index are used as the damage quantitative indicators of composite columns, and the displacement angle limits of composite columns at different performance levels under 80% assurance rate are calculated as 1/105, 1/85, 1/65, 1/28, and 1/25 respectively. On this basis, the damage index limits corresponding to each performance level are calculated as 0.045, 0.1, 0.48, 0.8, and 1.0 respectively. Finally, the corresponding relations among the performance levels, damage degrees, interlayer displacement angles and damage indexes of composite columns are established. The conclusions can provide reference for the seismic design of SRRC filled circular steel tube composite columns, it fills the vacancy in the research on seismic damage of steel reinforced recycled concrete (SRRC) filled circular steel tube composite columns.

• Journal of Life Science
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• v.33 no.2
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• pp.199-207
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• 2023

To prepare for the threat of a future epidemic in the post-COVID-19 era, research based on the one-health concept (i.e., the health of humans, animals, and the environment as "one") is essential. Cross-species infections are being identified as a result of the high infection rate and viral load of SARS-CoV-2 in humans. The possibility of transmission of SARS-CoV-2 from humans to mink has been determined. In addition, the transmission of SARS-CoV-2 from humans to cats through contact has been considered possible. The data so far show that livestock and poultry are less likely to be infected with SARS-CoV-2. However, if infections are established through a new mutation, the resulting diseases are expected to have enormous ripple effects on various fields, such as human food security, the economy, and trade. In addition, there are concerns about the endemic prospect of SARS-CoV-2 and the high accessibility of companion animals. This is because the evolution of the virus likely occurs in animal hosts. Once SARS-CoV-2 is established in other species, they might serve as intermediate hosts for the re-emergence of the virus in the human population. Thus, it is necessary to ensure a rapid response to future outbreaks by accumulating research data on the animal infection of SARS-CoV-2. These data can have implications for the development of animal models for vaccines and therapeutics against SARS-CoV-2. Therefore, in this study, epidemiological reviews were analyzed, and response strategies against SARS-CoV-2 infection in animals were presented using the One-health approach.

• Nuclear Engineering and Technology
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• v.17 no.3
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• pp.211-215
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• 1985

The effects of temperature and strain rate on the I-SCC behaviors of Zircaloy-4 were investigated by constant load test at 30$0^{\circ}C$ and constant elongation rate test at 300, 350 and 40$0^{\circ}C$ in 3.34mg $I_2$/㎤. The results showed that I-SCC susceptibility increased as the strain rate decreased or the temperature increased. The empirical relation between the stress and the time to failure at 30$0^{\circ}C$ was given by 1/ $t_{f}$∝exp (0.3$\sigma$/$\sigma$$_{UTS}$-31.5) When the I-SCC susceptibility was expressed by the ratio of fracture energy in iodine atmosphere to that in the inert atmosphere, severe I-SCC susceptibility was found near 7.6$\times$10$^{-6}$ sec at 30$0^{\circ}C$ and the maximum point of I-SCC susceptibility tended to shift to the higher strain rate with increasing the temperature. The quasi-cleavage fracture was observed in I-SCC fracture surface. From these results, it was certain that the film repture step was involved as an important process in the I-SCC mechanism of Zircaloy-4.4.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.2
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• pp.105-112
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• 2023

Leucine-rich repeat kinase 2 (LRRK2) is known to play a crucial role in the pathophysiology of neurodegenerative disorders such as Parkinson's disease. LRRK2 is predominantly expressed in the lung as well as the brain. However, it is unclear whether LRRK2 expression correlates with the pathogenesis of lung squamous cell carcinoma (LUSC). This study analyzes the prognostic significance of LRRK2 in LUSC using the Kaplan-Meier plotter tool. High expression of LRRK2 is known to be associated with a bad prognosis in patients with LUSC. Patients with high LRRK2 expression, tumor mutational burden, high neoantigen load, and even gender correlation reportedly have the worse survival rates. In the gene expression profiling interactive analysis (GEPIA) database, the severity of pathogenesis in LUSC with high LRRK2 expression positively corresponds to a high expression of anti-inflammatory cytokines but not inflammatory cytokines. Similarly, the increased expression of interleukin (IL)10-related genes was shown to be significantly linked in LRRK2-high LUSC patients having a poor prognosis. Moreover, the tumor immune estimation resource (TIMER) database suggests that macrophages are one of the cellular sources of IL10 in LRRK2-high LUSC patients. Collectively, our results demonstrate that the postulated LRRK2-IL10 axis is a potential therapeutic target and prognostic biomarker for LUSC.