• 한국환경보건학회지
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• 제12권1호
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• pp.25-38
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• 1986

This paper was intented to charily the cause of an increase of serum guanase activity in rats following injection of $CCI_4$. The cause of increasing serum guanase was focused on the change of guanase activities in both serum and liver, and additionally, these results were compared with the previously known alanine aminotransferase (ALT). Concomitantly the microscopic investigation on the histologic changes, and the determination of lipid peroxides of liver were combined in this experiment for a correlation to observe that the activity of guanase would be effected by the various degree of hepatic injury induced by $CCI_4$. The serum levels of guanase were increased about 2 fold in the fatty change stage (3-12 days), 5.2 fold representing the peak value in necrosis stage (21days), 4.5 fold in early cirrhosis stage (48 days), and 2 fold in severe cirrhosis stage (92 days). These changes of serum guanase activity showed similar patterns to those of ALT activity and lipid peroxides in liver cell. The changes of liver guanase activities showed an increase, whereas ALT activities in liver were markedly decreased. It is likely that the increase of serum guanase activity is based on the excess leaking of guanase into blood by the result of accelerated enzyme synthesis in liver cell of $CCI_4$ intoxicated rats. In addition, the possibility could not be ruled out, however, that the increase of serum guanase activity would be caused by the alteration of membrane permeability.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.4953-4960
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• 2013

Primary liver cancer is one of the most common cancers at the global level, accounting for half of all cancers in some undeveloped countries. This disease tends to occur in livers damaged through alcohol abuse, or chronic infection with hepatitis B and C, on a background of cirrhosis. Various cancer-causing substances are associated with primary liver cancer, including certain pesticides and such chemicals as vinyl chloride and arsenic. The strong association between HBV infection and liver cancer is well documented in epidemiological studies. It is generally acknowledged that the virus is involved through long term chronic infection, frequently associated with cirrhosis, suggesting a nonspecific mechanism triggered by the immune response. Chronic inflammation of liver, continuous cell death, abnormal cell growth, would increase the occurrence rate of genetic alterations and risk of disease. However, the statistics indicated that only about one fifth of HBV carries would develop HCC in lifetime, suggesting that individual variation in genome would also influence the susceptibility of HCC. The goal of this review is to highlight present level of knowledge on the role of viral infection and genetic variation in the development of liver cancer.

• 대한핵의학회지
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• 제15권2호
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• pp.59-66
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• 1981

Serum HBsAg and Anti-HBs obtained by radioimmunoassay were studied in 109 cases of various liver diseases who visited or were admitted to National Medical Center from December, 1980 to July, 1981. The results were as follows; 1) HBsAg was detected in 67.0% of total 109 cases; 71.9% of 32 cases with acute viral hepatitis, 71.4% of 14 cases with chronic hepatitis, 65.2% of 46 cases with liver cirrhosis and 58.8% of 17 cases with hepatoma. 2) Anti-HBs was detected in 32.1% of total 109 cases; 37.0% of 46 cases with liver cirrhosis, 29.4% of 17 cases with hepatoma, 28.6% of 14 cases with chronic hepatitis, 28.1% of 32 cases with acute viral hepatitis. 3) HBsAg or Anti-HBs, the markers of Hepatitis B virus was detected in 89.0% of total 109 cases; 93.6% of 32 cases with acute viral hepatitis, 89.1% of 46 cases with liver cirrhosis, 85.7% of 14 cases with chronic hepatitis and 82.4% of 17 cases with hepatoma, which strongly suggested that the various liver diseases were associated with hepatitis B virus infection.

• 한국방사선학회논문지
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• 제13권4호
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• pp.547-555
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• 2019

본 연구는 일반적인 간 초음파영상에서 형태학적인 분류인 간 표면, 간 가장자리, 간 실질을 점수체계로 이용하여 간 조직검사 결과의 경미한 섬유화(F1), 중증도 섬유화(F2), 심한 섬유화(F3) 및 간병변(F4)으로 나눈 섬유화 단계와 비교하여 유용성을 알아보고자 하였다. 결론적으로 일반적인 초음파 검사는 경미한 섬유화(F1)~심한 섬유화(F3)를 검출할 수 있는 민감한 예측 인자로 간 가장자리>간 실질>간 표면으로 나타났으며, 간경변(F4)를 검출할 수 있는 예측인자로는 간 실질>간 표면>간 가장자리로 나타났다. 일반적인 초음파 검사에서 각각의 변수가 아닌 3가지 변수조합을 활용한다면 간 섬유화 정도와 진행 상태를 평가하는데 더 유용할 것으로 사료된다.

• Korean Journal of Radiology
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• 제23권2호
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• pp.180-188
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• 2022

Objective: To validate the performance of 3T spin-echo echo-planar imaging (SE-EPI) magnetic resonance elastography (MRE) for staging hepatic fibrosis in a large population, using surgical specimens as the reference standard. Materials and Methods: This retrospective study initially included 310 adults (155 undergoing hepatic resection and 155 undergoing donor hepatectomy) with histopathologic results from surgical liver specimens. They underwent 3T SE-EPI MRE ≤ 3 months prior to surgery. Demographic findings, underlying liver disease, and hepatic fibrosis pathologic stage according to METAVIR were recorded. Liver stiffness (LS) was measured by two radiologists, and inter-reader reproducibility was evaluated using the intraclass correlation coefficient (ICC). The mean LS of each fibrosis stage (F0-F4) was calculated in total and for each etiologic subgroup. Comparisons among subgroups were performed using the Kruskal-Wallis test and Conover post-hoc test. The cutoff values for fibrosis staging were estimated using receiver operating characteristic (ROC) curve analysis. Results: Inter-reader reproducibility was excellent (ICC, 0.98; 95% confidence interval, 0.97-0.99). The mean LS values were 1.91, 2.41, 3.24, and 5.41 kPa in F0-F1 (n = 171), F2 (n = 26), F3 (n = 38), and F4 (n = 72), respectively. The discriminating cutoff values for diagnosing ≥ F2, ≥ F3, and F4 were 2.18, 2.71, and 3.15 kPa, respectively, with the ROC curve areas of 0.97-0.98 (sensitivity 91.2%-95.9%, specificity 90.7%-99.0%). The mean LS was significantly higher in patients with cirrhosis (F4) of nonviral causes, such as primary biliary cirrhosis (9.56 kPa) and alcoholic liver disease (7.17 kPa) than in those with hepatitis B or C cirrhosis (4.28 and 4.92 kPa, respectively). There were no statistically significant differences in LS among the different etiologic subgroups in the F0-F3 stages. Conclusion: The 3T SE-EPI MRE demonstrated high interobserver reproducibility, and our criteria for staging hepatic fibrosis showed high diagnostic performance. LS was significantly higher in patients with non-viral cirrhosis than in those with viral cirrhosis.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.308.1-308.1
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• 2003

We underwent this study to know correlation between the amount of portosysternic shunt/hepatic fibrosis and bioavailability parameters such as AUC, Cmax, Tmax and t1 /2 of high extraction ratio drug, propranolol, in CCl4-induced liver cirrhosis model of rats. This study describes the bioavaility study of propranolol(5 mg/kg), Shunt Index using thallium-201 per rectum scintigraphy to to measure the amount of portosystemic shunt indirectly and intrahepatic hydroxyproline content performed in the CCl4-induced liver cirrhosis model of rats. (omitted)

• 한국산학기술학회논문지
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• 제21권5호
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• pp.111-120
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• 2020

본 연구의 목적은 간경변증 환자의 재입원 경험에 미치는 영향요인을 탐색하여 간경변증 재입원을 줄이기 위한 전략을 개발하는데 필요한 기초자료를 제공하기 위함이다. 연구대상자는 2019년 5월부터 6월까지 2개월 동안 S 시 중소병원에 입원한 75명의 간경변증 환자를 대상으로 하였다. 자료는 SPSS(Version 25.0) 통계 프로그램을 사용하였으며, 재입원에 영향을 미치는 요인에 대하여 로지스틱 회귀분석을 하였다. 연구 결과, 자가 간호는 60점 만점에 평균 27.49±10.53점이었고, 사회적 지지는 90점 만점에 평균 52.80±16.44, 음주 거절 효능감은 80점 만점에 평균 42.39±22.76점이었다. 재입원 방법은 계획된 입원과 계획되지 않은 입원으로 분류하였는데, 계획되지 않은 재입원은 계획된 재입원보다 퇴원 후 한 달 이내의 음주 경험(OR: 4.16), 합병증 유무(OR: 5.11)에 따라 차이가 있는 것으로 나타났으며, 설명력은 19.7%이었다. 간경변증 환자에게 조기에 관리하여 합병증의 발생을 줄이고, 음주에 대한 자가 간호와 사회적 지지 및 음주 거절 효능감을 증가시켜 계획되지 않은 재입원을 줄이고 간경변증의 진행과 악화를 예방하는 것이 중요하겠다. 음주 경험과 합병증 발생은 자가 간호, 사회적 지지, 음주 거절 효능감을 증가시키는 중재를 통해 감소시킬 수 있으므로 간경변증 환자에게 음주하지 않도록 하며, 합병증 관리를 하는 간호 전략이 필요하겠다.

• Clinical and Experimental Pediatrics
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• 제48권1호
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• pp.104-107
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• 2005

저자들은 20개월 유아에서 복통이나 담즙정체 등의 특이 증상이 동반되지 않으면서도 간, 비장종대를 동반하고 간 조직검사에서 간경화가 있었으나, 종괴제거 수술 후 간기능검사 뿐 아니라 간, 비장 종대가 급격하게 해결된 총수담관낭을 경험하였다. 총수담관낭을 조기에 발견하여 적절하게 제거하는 것이 간기능 검사의 호전 뿐 아니라 조직학적으로 입증된 간경화를 호전시키는 데에도 중요함을 시사한다고 하겠다.

• 대한핵의학회지
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• 제27권2호
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• pp.309-314
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• 1993

저자등은 33세 남자 환자에서 검사실 소견과 복부 전산화 단층촬영, 간 신티그라피 및 골주사, 복부 초음파 및 수술소견을 통해 알콜성 및 C형 간염에 의한 간경화를 동반한 환자가 교통사고로 복부 외상에 의한 간하부열상을 받아 복강내출혈로 입원한 환자에서 일시적으로 골주사소견에서 비장에 섭취를 보이는 것이 복부 비장의 잠재적 외상으로 인한 것으로 사료되며, 비장 비대 외에는 특이소견이 보이지 않으며 기전이 명확하지 않은 골주사상 비장섭취를 보인 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Nutrition Research and Practice
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• 제13권2호
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• pp.87-94
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• 2019

BACKGROUND/OBJECTIVES: Oxidative stress is a major effector of various diseases; accordingly, antioxidants are frequently ingested in order to prevent or alleviate disease symptoms. Kimchi contains various natural antioxidants, and it is known that the functional activity varies depending on the ingredients and fermentation state. Black raspberries (BR) contain various bioactive compounds with antioxidant effects. This study investigated the antioxidant and liver-protection effects of kimchi supplemented with black raspberry juice powder (BJP). MATERIALS/METHODS: BJP-added kimchi (BAK; at 0.5%, 1%, and 2% concentrations of BJP) and control (without BJP) were prepared and fermented at $4^{\circ}C$ for 4 weeks. Changes in the antioxidant effects of BAK during fermentation were investigated. In addition, the protective activity of BAK against oxidative stress was investigated in a liver cirrhosis-induced animal model in vivo. RESULTS: BAK groups showed the acidity and pH of optimally ripened (OR) kimchi at 2 weeks of fermentation along with the highest lactic acid bacterial counts. Additionally, BAK groups displayed a higher content of phenolic compounds and elevated antioxidant activities relative to the control, with the highest antioxidant effect observed at 2 weeks of fermentation of OR 1% BAK. After feeding the OR 1% BAK to thioacetamide-induced liver cirrhosis rats, we observed decreased glutamate oxaloacetate transaminase and glutamate pyruvate transaminase activities and elevated superoxide dismutase activity. CONCLUSIONS: These findings showed that the antioxidant effects of OR BAK and feeding of OR 1% BAK resulted in liver-protective effects against oxidative stress.