• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.71-71
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• 2012

As the critical dimensions of integrated circuits are scaled down, the line width and spacing between the metal interconnects are made smaller. The dielectric film used as insulation between the metal lines contributes to the resistance-capacitance (RC) time constant that governs the device speed. If the RC time delay, cross talk and lowering the power dissipation are to be reduced, the intermetal dielectric (IMD) films should have a low dielectric constant. The introduction of Cu and low-k dielectrics has incrementally improved the situation as compared to the conventional $Al/SiO_2$ technology by reducing both the resistivity and the capacitance between interconnects. Some of the potential candidate materials to be used as an ILD are organic and inorganic precursors such as hydrogensilsequioxane (HSQ), silsesquioxane (SSQ), methylsilsisequioxane (MSQ) and carbon doped silicon oxide (SiOCH), It has been shown that organic functional groups can dramatically decrease dielectric constant by increasing the free volume of films. Recently, various inorganic precursors have been used to prepare the SiOCH films. The k value of the material depends on the number of $CH_3$ groups built into the structure since they lower both polarity and density of the material by steric hindrance, which the replacement of Si-O bonds with Si-$CH_3$ (methyl group) bonds causes bulk porosity due to the formation of nano-sized voids within the silicon oxide matrix. In this talk, we will be introduce some properties of SiOC(-H) thin films deposited with the dimethyldimethoxysilane (DMDMS: $C_4H_{12}O_2Si$) and oxygen as precursors by using plasma-enhanced chemical vapor deposition with and without ultraviolet (UV) irradiation.

• Fashion & Textile Research Journal
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• v.18 no.3
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• pp.363-373
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• 2016

This study aims to develop an all-fabric integrated smart jacket in order to create a temperature-regulating system based on a user experience design. For this research, previous research technologies of a textile switch interface and a temperature-regulating system were utilized and a unifying technology for the all-fabric integrated smart jacket was developed which can provide the appropriate temperature environments to the human body. A self-heating textile was applied at the areas of the back and hood in the final tested jacket, and an embroidery circuit was developed in the form of a rectangle in the back and in both ears of the hood, taking into account the pattern of the jacket part where it was be applied and the embroidery production method. The textile switch interface was designed in a three-layer structure: an embroidery circuit line in a conductive yarn, an interval material, and a conductive sensing material, and it was made to work with the input and output sensors through the multiple input method. After the all-fabric integrated smart jacket was produced according to the pattern, all of the textile band lines for transmission were gathered and connected with a miniature module for controlling temperature and then integrated into the inside of the left chest pocket of the jacket. After the users put on this jacket, they were asked to assess the wearing satisfaction. Most of them reported a very low level of irritation and discomfort and said that the jacket was as comfortable as everyday clothing.

• Publications of The Korean Astronomical Society
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• v.27 no.4
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• pp.253-256
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• 2012

We present the IRC images of M51, a pair of interacting galaxies. Given the high angular resolution (7.4") and the wide field of view (~ 10') covering almost the entire M51 system, we investigate dust properties and their connection to the spiral arm structure. We have applied image-filtering processes including the wavelet analysis to the N3 image, which traces the total stellar mass best among the IRC bands. From this filtered image, the center, arm, and interarm regions are defined. A color, or flux ratio among the MIR bands, has been measured at each pixel (3.7" in size). We find a wide variety of S7/S11 with a difference between arm and interarm regions. We also find that at some positions S11 seems to be higher than predicted by MW dust models. Estimated contributions from the stellar continuum and gas emission lines to the band are not enough to explain this discrepancy. From these results, we deduce that the PAH ionization condition and its fraction to the total dust mass in M51 are different from those in MW.

• Genomics & Informatics
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• v.19 no.4
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• pp.46.1-46.11
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• 2021

Moringa oleifera is nowadays raising as the most preferred medicinal plant, as every part of the moringa plant has potential bioactive compounds which can be used as herbal medicines. Some bioactive compounds of M. oleifera possess potential anti-cancer properties which interact with the apoptosis protein p53 in cancer cell lines of oral squamous cell carcinoma. This research work focuses on the interaction among the selected bioactive compounds derived from M. oleifera with targeted apoptosis protein p53 from the apoptosis pathway to check whether the bioactive compound will induce apoptosis after the mutation in p53. To check the toxicity and drug-likeness of the selected bioactive compound derived from M. oleifera based on Lipinski's Rule of Five. Detailed analysis of the 3D structure of apoptosis protein p53. To analyze protein's active site by CASTp 3.0 server. Molecular docking and binding affinity were analyzed between protein p53 with selected bioactive compounds in order to find the most potential inhibitor against the target. This study shows the docking between the potential bioactive compounds with targeted apoptosis protein p53. Quercetin was the most potential bioactive compound whereas kaempferol shows poor affinity towards the targeted p53 protein in the apoptosis pathway. Thus, the objective of this research can provide an insight prediction towards M. oleifera derived bioactive compounds and target apoptosis protein p53 in the structural analysis for compound isolation and in-vivo experiments on the cancer cell line.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.46 no.2
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• pp.186-194
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• 2013

We compiled and analyzed long-term time-series data collected in Korea to evaluate changes in oceanographic conditions and marine ecosystems near Jeju Island ($33^{\circ}00^{\prime}-34^{\circ}00^{\prime}\;N$, $125^{\circ}30^{\prime}-127^{\circ}30^{\prime}\;E$) from 1981 to 2010. Environmental data included depth-specific time series of temperature and salinity that have been measured bimonthly since 1961 in water columns at 175 fixed stations along 22 oceanographic lines in Korean waters by the National Fisheries Research & Development Institute, and time series of estimated volume transport of the Tsushima Warm Current (TWC) and Korea Strait Bottom Cold Water (KSBCW) for the period from 1961 to 2008. We analyzed the species composition in terms of biomass of fish species caught by Korean fishing vessels in the waters near Jeju Island (1981-2010). Data were summarized and related to environmental changes using canonical correspondence analysis (CCA). The CCA detected major shifts in fish community structure between 1982 and 1983 and between 1990 and 1992; the dominant species were a filefish during 1981-1992 and chub mackerel from 1992 to 2007. CCA suggested that water temperature and salinity in the mixed layer and the volume transport of the TWC and the KSBCW were significantly related to the long-term changes in the fish community in the waters off Jeju Island. Fish community shifts seemed to be related to the well-established 1989 regime shift in the North Pacific. Further studies are required to elucidate the mechanisms driving climate change effects on the thermal windows and habitat ranges of commercial species to develop fisheries management plans based on reliable projections of long-term changes in the oceanographic conditions in waters off Jeju Island.

• Wind and Structures
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• v.27 no.2
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• pp.71-88
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• 2018

At the University of Western Ontario (UWO), numerical tools represented in semi-closed form solution for the conductors and finite element modeling of the lattice tower were developed and utilized significantly to assess the behavior of transmission lines under downburst wind fields. Although these tools were validated against other finite element analyses, it is essential to validate the findings of those tools using experimental data. This paper reports the first aeroelastic test for a multi-span transmission line under simulated downburst. The test has been conducted at the three-dimensional wind testing facility, the WindEEE dome, located at the UWO. The experiment considers various downburst locations with respect to the transmission line system. Responses obtained from the experiment are analyzed in the current study to identify the critical downburst locations causing maximum internal forces in the structure (i.e., potential failure modes), which are compared with the failure modes obtained from the numerical tools. In addition, a quantitative comparison between the measured critical responses obtained from the experiment with critical responses obtained from the numerical tools is also conducted. The study shows a very good agreement between the critical configurations of the downburst obtained from the experiment compared to those predicted previously by different numerical studies. In addition, the structural responses obtained from the experiment and those obtained from the numerical tools are in a good agreement where a maximum difference of 16% is found for the mean responses and 25% for the peak responses.

• Bulletin of the Korean Chemical Society
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• v.34 no.8
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• pp.2455-2460
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• 2013

Second-order rate constants ($k_N$) have been measured spectrophotometrically for the nucleophilic displacement reactions of 4-nitrophenyl X-substituted-cinnamates (4a-4e) and Y-substituted-phenyl cinnamates (5a-5e) with Z-substituted-phenoxide anions in 80 mol % $H_2O$/20 mol % DMSO at $25.0{\pm}0.1^{\circ}C$. The Hammett plot for the reactions of 4a-4e with 4-chlorophenoxide (4-$ClPhO^-$) consists of two intersecting straight lines, which might be taken as a change in the rate-determining step (RDS). However, it has been concluded that the nonlinear Hammett plot is not due to a change in the RDS but is caused by stabilization of the ground state of substrates possessing an electron-withdrawing group in the cinnamoyl moiety through resonance interactions, since the Yukawa-Tsuno plot exhibits an excellent linear correlation with ${\rho}X=0.89$ and r = 0.58. The Br${\o}$nsted-type plot for the reactions of 4-nitrophenyl cinnamate (4c) with Z-substituted-phenoxides is linear with ${\beta}_{nuc}=0.76$. The Br${\o}$nsted-type plot for the reactions of Y-substituted-phenyl cinnamates (5a-5d) with 4-chlorophenoxides (4-$ClPhO^-$) is also linear with ${\beta}_{lg}=-0.72$. The Hammett plot correlated with ${\sigma}^-$ constants for the reactions of 5a-5d results in a much better linear correlation than that correlated with ${\sigma}^o$ constants, indicating that a partial negative charge develops on the O atom of the leaving aryloxide. Thus, the reactions have been concluded to proceed through a concerted mechanism.

• Journal of the Korean earth science society
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• v.27 no.4
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• pp.425-432
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• 2006

A seismic tomography using refraction waves is applied to provide information on depth of basement rocks and leachate distribution of the Noeun waste landfill site for the stage of preliminary environmental survey. This method is generally applied to civil and environmental areas. Three lines, apparently perpendicular to the potential leachate flow direction in this site, were installed to investigate the waste landfill site in pseudo three dimensional geometry. The results show that the site is composed of 3 layers and depth of basement becomes shallower at the upstream area of the landfill site than that of the downstream area. Moreover, some parts of the second layer and the basement at the down stream area are partially infiltrated by the leachate, probably related to the disturbed distribution of the different velocity materials within the second layer. In Conclusion, refraction wave tomography is found to be one of the most efficient way to investigate waste landfill site.

• Journal of Microbiology and Biotechnology
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• v.33 no.6
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• pp.806-822
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• 2023

In the current study we assessed a new crystallized compound, 5-(1-hydroxybutyl)-4-methoxy-3-methyl-2H-pyran-2-one (C-HMMP), from the endophytic fungus Colletotrichum acutatum residing in the medicinal plant Angelica sinensis for its in vitro antimicrobial, antibiofilm, antioxidant, antimalarial, and anti-proliferative properties. The promising compound was identified as C-HMMP through antimicrobial-guided fraction. The structure of C-HMMP was unambiguously confirmed by 2D NMR and HIRS spectroscopic analysis. Antimicrobial property testing of C-HMMP showed it to be effective against a variety of pathogenic bacteria and fungi with MICs ranging from 3.9 to 31.25 ㎍/ml. The compound displayed excellent antibiofilm activity against C. albicans, S. aureus, and K. pneumonia. Furthermore, the antimalarial and radical scavenging activities of C-HMMP were clearly dosedependent, with IC50 values of 0.15 and 131.2 ㎍/ml. The anti-proliferative activity of C-HMMP against the HepG-2, HeLa, and MCF-7 cell lines in vitro was investigated by MTT assay, revealing notable anti-proliferative activity with IC50 values of 114.1, 90, and 133.6 ㎍/ml, respectively. Moreover, CHMMP successfully targets topoisomerase I and demonstrated beneficial anti-mutagenicity in the Ames test against the reactive carcinogenic mutagen, 2-aminofluorene (2-AF). Finally, the compound inhibited the activity of α-glucosidase and α-amylase with IC50 values of 144.7 and 118.6 ㎍/ml, respectively. To the best of our knowledge, the identified compound C-HMMP was obtained for the first time from C. acutatum of A. sinensis, and this study demonstrated that C-HMMP has relevant biological significance and could provide better therapeutic targets against disease.

• Progress in Medical Physics
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• v.28 no.3
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• pp.83-91
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• 2017

In this work, we investigated the recently proposed phase-contrast x-ray imaging (PCXI) technique, the so-called single grid-based PCXI, which has great simplicity and minimal requirements on the setup alignment. It allows for imaging of smaller features and variations in the examined sample than conventional attenuation-based x-ray imaging with lower x-ray dose. We performed a systematic simulation using a simulation platform developed by us to investigate the image characteristics. We also performed a preliminary PCXI experiment using an established a table-top setup to demonstrate the performance of the simulation platform. The system consists of an x-ray tube ($50kV_p$, 5 mAs), a focused-linear grid (200-lines/inch), and a flat-panel detector ($48-{\mu}m$ pixel size). According to our results, the simulated contrast of phase images was much enhanced, compared to that of the absorption images. The scattering length scale estimated for a given simulation condition was about 117 nm. It was very similar, at least qualitatively, to the experimental contrast, which demonstrates the performance of the simulation platform. We also found that the level of the phase gradient of oriented structures strongly depended on the orientation of the structure relative to that of linear grids.