• Biomolecules & Therapeutics
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• v.19 no.3
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• pp.357-363
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• 2011

In relieving local pains, ropivacaine has been widely used. In case of their application such as ointments and creams, it is difficult to expect their effects for a significant period of time, because they are easily removed by wetting, movement and contacting. Therefore, the new formulations that have suitable bioadhesion were needed to enhance local anesthetic effects. The effect of drug concentration and temperature on drug release was studied from the prepared 1.5% Carboxymethyl cellulose (CMC) (150MC) gels using synthetic cellulose membrane at $37{\pm}0.5^{\circ}C$. As the drug concentration and temperature increased, the drug release increased. A linear relationship was observed between the logarithm of the permeability coefficient and the reciprocal temperature. The activation energy of drug permeation was 3.16 kcal/mol for a 1.5% loading dose. To increase the skin permeation of ropivacaine from CMC gel, enhancers such as saturated and unsaturated fatty acids, pyrrolidones, propylene glycol derivatives, glycerides, and non-ionic surfactants were incorporated into the ropivacaine-CMC gels. Among the enhancers used, polyoxyethylene 2-oleyl ether showed the highest enhancing effects. For the efficacy study, the anesthetic action of the formulated ropivacaine gel containing an enhancer and vasoconstrictor was evaluated with the tail-flick analgesimeter. According to the rat tail-flick test, 1.5% drug gels containing polyoxyethylene 2-oleyl ether and tetrahydrozoline showed the best prolonged local analgesic effects. In conclusion, the enhanced local anesthetic gels containing penetration enhancer and vasoconstrictor could be developed using the bioadhesive polymer.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.34 no.1
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• pp.11-18
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• 2022

In order to improve the accuracy of particle tracking prediction techniques near the Korean Strait, this study compared and analyzed a particle tracking model based on a seawater flow numerical model and a machine learning based on a particle tracking model using field observation data. The data used in the study were the surface drifter buoy movement trajectory data observed in the Korea Strait, prediction data by machine learning (linear regression, decision tree) using the tide and wind data from three observation stations (Gageo Island, Geoje Island, Gyoboncho), and prediciton data by numerical models (ROMS, MOHID). The above three data were compared through three error evaluation methods (Correlation Coefficient (CC), Root Mean Square Errors (RMSE), and Normalized Cumulative Lagrangian Separation (NCLS)). As a final result, the decision tree model had the best prediction accuracy in CC and RMSE, and the MOHID model had the best prediction results in NCLS.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.5
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• pp.619-628
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• 2010

Shape Memory Alloy (SMA) has recently received attention in developing implantable surgical equipments and it is expected to lead the future medical device market by adequately imitating surgeons' flexible and delicate hand movement. However, SMA actuators have not been used widely because of their nonlinear behavior called hysteresis, which makes their control difficult. Hence, we propose a parameter, $t_1$, which is necessary for temperature control, by analyzing the open-loop step response between current and temperature and by comparing it with the values of linear differential equations. $t_1$ is a pole of the transfer function in the invariant linear model in which the input and output are current and temperature, respectively; hence, $t_1$ is found to be related to the state variable used for temperature control. When considering the parameter under heat treatment conditions, $T_{max}$ was found to assume the lowest value, and $t_1$ was irrelevant to the heat treatment.

• Korean Journal of Environmental Agriculture
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• v.14 no.2
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• pp.135-143
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• 1995

This study was conducted to investigate the adsorption characteristics, distribution coefficients, and movement of alachlor(2-chloro-2', 6'-dimethyl-N-(methoxymethyl) acetanilide) and chlorothalonil(tetrachloroisophthalonitrile) for the 3 soils sampled from major soil groups in Cheju Island. Namwon, Jeju, and Mureng soils used in this study were classified as black volcanic ash soil, dark brown volcanic ash soil and dark brown nonvolcanic soil, respectively. Organic carbon content and CEC of Namwon soil were very high and those of Mureung soil were very low. Linear and Freundlich adsorption isotherms were the best to fit the adsorption of alachlor and chlorothalonil in the soils. K value, Freundlich coefficient, of alachlor for Namwon soil was 21.38, being 5.4 and 97.2 times higher than that for Jeju and Mureung soils respectively. The values of chlorothalonil for the soils were similar to those of alachlor but were much higher than them. When Mureung, Jeju and Namwon soil columns were leached with a solution containing 10.25 mg/l of alachlor and 1.50 mg/l of chlorothalonil, alachlor was first detected at 0.265, 0.47, and 1.86 pore volume (PV) and chlorothalonil was 3.71, 4.7 and 17.5 PV, respectively. The pore volumes at $C/C_o=1$ of alachlor in the leachates from Mureung, Jeju and Namwon soil columns were 1.1, 3.7 and 6.6 PV and those at $C/C_o=0.2$ of chlorothalonil were 7.5, 8.5 and 27.5, respectively. This means that the deceasing order of the mobility of the chemicals in soils was Mureung soil>Jeju soil${\gg}$Namwon soil. The pore volumes detecting $C/C_o=0.5$ of alachlor and $C/C_o=0.05$ of chlorothalonil in leachate were positively correlated with the distribution coefficients for the soils.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.6B
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• pp.507-514
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• 2011

A numerical model has been developed by employing a finite element method to simulate the depth-averaged 2-D dispersion of the heat pollutant, which is an important pollutant material in natural streams. Among the finite element methods, the Streamline Upwind/Petrov Galerkin (SUPG) method was applied. Also both linear and quadratic elements can be applied so that irregular river boundaries can be easily represented. To show the movement of heat pollutants, the reaction term describing heat transfer was represented as an equation in which sink/source term is proportional to the difference between the equilibrium temperature and water surface temperature. The equation was expressed so that the water surface temperature changes according to the temperature transfer coefficient and the equilibrium temperature. For the calibration of the model developed, analytic and numerical results from a case of rectangular channel with full width continuous injection have been compared in a steady state. The comparisons showed that the numerical results were in good agreement with analytical solutions. The application site was selected from the downstream of Paldang dam to Jamsil submerged weir, and overall length of this site is about 22.5 km. The change of water temperature caused by the discharge from the Guri sewage treatment plant has been simulated, and results were similar to the observed data. Overall it is concluded that the developed model can represent the water temperature changes due to heat transport accurately. But the verification using observed data will further enhance the validity of the model.

• Korean Journal of Agricultural Science
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• v.12 no.2
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• pp.282-291
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• 1985

In order to investigate the settlement characteristics of fill dam with decomposed granite is used as a embankment material instead of conventional clay collected behavoir of Andong dam and analyzed. Andong dam is the use of decomposed granite in the embankment material, and various type of gauges were installed in dam to measure a pore pressure, interval vertical settlement, dam crest settlement, relative settlement, surface settlement and internal horizontal movement. The results were summerized as follows; 1. With the increase of embankment loading, the settlement of core zone during construction increased with linear and under the effective stress $7kg/cm^2$ vertical settlement ratio ranged between 0.1 and 0.8% approximately and showed smaller value than that of fill dam with clay were used as a embankment material. 2. Though embankment loading was increased with about over central part of embankment height, the settlement of core zone in the lower part of the embankment was influenced slightly. 3. Pore pressure responsed sensitively with the increase of coefficient of permeability in core zone and settlement increased with pore pressure were dispersed. 4. During construction relative settlement in the lower part of the embankment has the largest influence on magnitude of the relative density and after construction settlement showed larger value in the core zone which has the largest compression height. 5. Settlement distribution of dam crest showed larger value in the central part, maximum section of dam, but smaller value in near the abutment.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.35 no.4
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• pp.779-789
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• 2015

Because cable-supported bridges have long spans and large members, their movements and geometrical changes by temperatures tend to be bigger than those of small or medium-sized bridges. Therefore, it is important for maintenance engineers to monitor and assess the effect of temperature on the cable-supported bridges. To evaluate how much the superstructure expands or contracts when subjected to changes in temperature is the first step for the maintenance. Thermal movements of a cable-stayed bridge in service are evaluated by using long-term temperatures and displacements data. Displacements data are obtained from extensometers and newly installed GNSS (Global Navigation Satellite System) receivers on the bridge. Based on the statistical data such as air temperatures, each sensor's temperatures, average temperatures and effective temperatures, correlation analysis between temperatures and displacements has been performed. Average temperatures or effective temperatures are most suitable for the evaluation of thermal movements. From linear regression analysis between effective temperatures and displacements, the variation rate's of displacement to temperature have been calculated. From additional regression analysis between expansion length's and variation rate's of displacement to temperature, the thermal expansion coefficient and neutral point have been estimated. Comparing these parameters with theoretical and analytical results, a practical procedure for evaluating the real thermal behaviors of the cable-supported bridges is proposed.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2009.04a
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• pp.108-108
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• 2009

The main object of this research is to minimize the shock effects which frequently result in fatal damage in wind met mast on impact of barge. The collision between wind met mast and barge is generally a complex problem and it is often not practical to perform rigorous finite element analyses to include all effects and sequences during the collision. LS-dyna generally purpose explicit finite element code, which is a product of ANSYS software, is used to model and analyze the non-linear response of the met mast due to barge collision. A significant part of the collision energy is dissipated as strain energy and except for global deformation modes, the contribution from elastic straining can normally be neglected. On applying impact force of a barge to wind met mast, the maximum acceleration, internal energy and plastic strain were calculated for each load cases using the finite element method and then compare it, varying to the velocity of barge, with one varying to the thickness of rubber fender conditions. Hence, we restrict the present research mainly to the wind met mast and also parametric study has been carried out with various velocities of barge, thickness of wind met mast, thickness and Mooney-Rivlin coefficient of rubber fender with experimental data. The equation of motion of the wind met mast is derived under the assumption that it was ignored vertical movement effect of barge on sea water. Such an analyzing method which was developed so far, make it possible to determine the proper size and material properties of rubber fender and the optimal moving conditions of barge, and finally, application method can be suggested in designing process of rubber fender considering barge impact.

• Journal of Radiation Protection and Research
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• v.41 no.1
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• pp.49-55
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• 2016

Background: For the purpose of baseline data collection and enhancement of environmental monitoring the distribution studies of $^{137}Cs$ and $^{90}Sr$ in the soil of Uljin province was performed and the relation between surface soil activities and soil properties (pH, TOC and median of the surface soil) was analyzed. Materials and Methods: For 14 spots within 10 km from the NPP surface soil samples were collected and soils for depth profile were sampled for 3 spots in April 2011. Using ${\gamma}$-ray spectrometry with HPGe detector, the concentrations of $^{137}Cs$ were determined and the concentrations of $^{90}Sr$ were measured by counting ${\beta}$-activity of $^{90}Y$ (in equilibrium with $^{90}Sr$) in a gas flow proportional counter. Results and Discussion: The concentration ranges of $^{137}Cs$ and $^{90}Sr$ were $<0.479-39.6Bq{\cdot}(kg-dry)^{-1}$ (avg. $7.51Bq{\cdot}(kg-dry)^{-1}$) and $0.209-1.85Bq{\cdot}(kg-dry)^{-1}$ (avg. $0.74Bq{\cdot}(kg-dry)^{-1}$) which were similar to the reported values from other regions in Korea. The activity ratio of $^{137}Cs$ to $^{90}Sr$ in surface soils was around 9.67, which is much bigger than the initial value of 1.75 for worldwide fallouts because of faster downward movement of $^{90}Sr$ after fallout than that of $^{137}Cs$. For depth profile studies soils were collected down to 40 cm depth for the locations of Deokgu, Hujeong and Maehwa. The $^{137}Cs$ concentration distribution of the first two showed maximum values at top soils and decreased rapidly in exponential manner, while $^{90}Sr$ showed two local maximum values for soils near top and about 30 cm depth. Through linear fittings between the $^{137}Cs$ and $^{90}Sr$ concentrations of surface soil and pH, TOC and median of the surface soil, the only probable relationship obtained was between $^{137}Cs$ and TOC (determination coefficient $R^2=0.6$). Conclusion: The concentration ranges of $^{137}Cs$ and $^{90}Sr$ in Uljin were similar to the reported values from other regions in Korea. The only probable relationship obtained between activities and soil properties was between $^{137}Cs$ and TOC.