• BMB Reports
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• v.50 no.4
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• pp.160-161
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• 2017

Proper maintenance of biological components is crucial for longevity and healthy aging. Although the role of homeostatic maintenance systems for DNA and protein in longevity is established, it remains largely unknown for RNA. In our recent work, we show that nonsense-mediated mRNA decay (NMD) promotes longevity in the roundworm C. elegans by enhancing RNA quality control. We find that the activity of NMD decreases during aging, raising the possibility that RNA quality declines in old animals. We then show that key components of NMD complex are required for prolonged lifespan in C. elegans. In addition, animals with reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS), a representative longevity model, display increased NMD activity. Thus, up-regulation of NMD appears to play crucial roles in longevity conferred by reduced IIS via enhancing mRNA quality control. As both IIS and NMD pathways are evolutionarily conserved, mammals including humans may be equipped with similar RNA quality control systems to achieve longevity.

• BMB Reports
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• v.42 no.3
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• pp.131-135
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• 2009

MicroRNAs control gene expression by inhibiting translation or promoting degradation of their target mRNAs. Since the discovery of the first microRNAs, lin-4 and let-7, in C. elegans, hundreds of microRNAs have been identified as key regulators of cell fate determination, lifespan, and cancer in species ranging from plants to humans. However, while microRNAs have been shown to be particularly abundant in the brain, their role in the development and activity of the nervous system is still largely unknown. In this review, we describe recent advances in our understanding of microRNA function at synapses, the specialized structures required for communication between neurons and their targets. We also propose how these advances might inform the molecular model of memory.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.05a
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• pp.651-652
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• 2006

The choice of suitable hip implant is one of important factors in total hip replacement (THR). In clinical view points, improper adaptation of hip implant might cause abnormal stress distribution to the bone, which can shorten the lifespan of replaced hip implant. Currently, interest in custom-designed hip implants has increased as studies reveals the importance of geometric shape of patient's femur in modeling and designing custom hip implants. In this study, we have developed the custom-designed hip implant models with various sizes in hip implant, and the stress distribution in the bone was analyzed using Finite Elements methods. It was found that minimizing the gap between implant stem and femoral cavity is crucial to minimize stress concentration in the bone.

• Journal of Korean Society of Steel Construction
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• v.14 no.5 s.60
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• pp.627-639
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• 2002

Bridge construction is almost complete in many countries. Thus, the government and highway agencies change their focus from constructing to maintaining. Effectively maintaining bridges require predicting their lifespan using a system reliability viewpoint. Likewise, maintenance models based on the system reliability concept should be developed. Thus, this study developed maintenance models for preventive maintenance and essential maintenance using system reliability and lifetime distributions. The optimal maintenance strategy for an existing bridge was obtained using the developed maintenance models.

• Progress in Superconductivity and Cryogenics
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• v.16 no.3
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• pp.10-14
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• 2014

Due to continuous increase of electric power consumption, couple of resolutions for improving accuracy in power system like line separation are being studied. The increase of the power demand can cause problems such as supply difficulties of the electricity and broadband outages, failure, etc. When a fault occurs in the power system, a fault current also increases. Fault current creates problems like reduction of lifespan and failure on the power system. In order to resolve these problems, the reduction of initial fault current using the characteristics of superconducting element was applied to fault current limiter. We applied the system to high speed fault current limiter. We found that the superconducting element effectively reduced initial fault current and the fault current was limited by changing operation of high speed interrupter.

• Clinical and Experimental Pediatrics
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• v.59 no.9
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• pp.355-361
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• 2016

The menarcheal age of Korean women has been rapidly decreasing for the last 50 years, and the average menarcheal age of women born in the 1990s is approaching 12.6 years. In addition, interest in early puberty has been increasing recently owing to the rapid increase in precocious puberty. Generally, out of concern for short stature and early menarche, idiopathic central precocious puberty in female adolescents is treated with gonadotropin-releasing hormone analogs. Studies to date have described the association between early menarche and psychosocial problems such as delinquency and risky sexual behavior, as well as physical health problems such as obesity, diabetes, cardiovascular diseases, and breast cancer throughout the lifespan of women. However, the pathophysiological mechanism underlying this association has not been clarified thus far. In this article, we review and discuss the existing literature to describe the current understanding of the effects of early menarche on the physical and psychosocial health of adolescent girls and adult women.

• Proceedings of the Korean Society of Applied Entomolohy Conference
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• 2005.05a
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• pp.132-132
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• 2005

• Journal of the Korean Society of Safety
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• v.33 no.4
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• pp.38-45
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• 2018

Bridges are structures where safety must be ensured. Generally, the destruction mechanism of bridge deck shows punching shear. Lately, the high-strength concrete is often used to increase the lifespan of bridges. The benefits of using the high-strength concrete are that it increases the durability and strength. On the contrary, it reduces the cross-section of the bridges. This study suggested the optimal thickness of bridge deck with application of high-strength concrete and the study evaluated its structural performance experimentally. The evaluation result shows that 180 mm and 190 mm of thickness are optimal for 100 MPa and 120 MPa high-strength concrete bridge deck respectively.

• BMB Reports
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• v.41 no.11
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• pp.751-756
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• 2008

Aging and cancer both occur as a result of accumulated cellular damage, and both are related to the regulation of specific genes in the damage response. Recent research has unveiled connections between the mechanisms of aging and cancer, but how to prevent the development of cancer and increase longevity remain unknown. SIRT1 (the mammalian Sir2), which has $NAD^+$-dependent class III histone deacetylase activity, may be a key gene linking the modulation of cancer and aging. SIRT1 has broad biological functions in growth regulation, stress response, tumorigenesis, endocrine signaling, and extended lifespan. Here, we focus on the current knowledge regarding the role of SIRT1 in aging and cancer, and discuss the implications of SIRT1 as a therapeutic target for the optimal balance between anti-aging and anti-cancer activities.

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2005.11a
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• pp.21-21
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• 2005