• Journal of Ginseng Research
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• v.44 no.5
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• pp.717-724
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• 2020

Background: Malignant arrhythmias require drug therapy. However, most of the currently available antiarrhythmic drugs have significant side effects. Ginsenoside Rg2 exhibits excellent cardioprotective effects and appears to be a promising candidate for cardiovascular drug development. So far, the oral toxicity and antiarrhythmic effects of Rg2 have not been evaluated. Methods: Acute oral toxicity of Rg2 was assessed by the Limit Test method in mice. Subchronic oral toxicity was determined by repeated dose 28-day toxicity study in rats. Antiarrhythmic activities of Rg2 were evaluated in calcium chloride-induced arrhythmic rats. Antiarrhythmic mechanism of Rg2 was investigated in arrhythmic rats and H9c2 cardiomyocytes. Results: The results of toxicity studies indicated that Rg2 exhibited no single-dose (10 g/kg) acute oral toxicity. And 28-day repeated dose treatment with Rg2 (1.75, 3.5 and 5 g/kg/d) demonstrated minimal, if any, subchronic toxicity. Serum biochemical examination showed that total cholesterol in the high-dose cohort was dramatically decreased, whereas prothrombin time was increased at Day 28, suggesting that Rg2 might regulate lipid metabolism and have a potential anticoagulant effect. Moreover, pretreatment with Rg2 showed antiarrhythmic effects on the rat model of calcium chloride induced arrhythmia, in terms of the reduced duration time, mortality, and incidence of malignant arrhythmias. The antiarrhythmic mechanism of Rg2 might be the inhibition of calcium influx through L-type calcium channels by suppressing the phosphorylation of Ca²⁺/calmodulin-dependent protein kinase II. Conclusion: Our findings support the development of Rg2 as a promising antiarrhythmic drug with fewer side effects for clinical use.

• Parasites, Hosts and Diseases
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• v.50 no.2
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• pp.103-111
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• 2012

Intestinal giant-cystic disease (IGCD) of the Israel carp (Cyprinus carpio nudus) has been recognized as one of the most serious diseases afflicting inland farmed fish in the Republic of Korea, and Thelohanellus kitauei has been identified as the causative agent of the disease. Until now, studies concerning IGCD caused by T. kitauei in the Israel carp have been limited to morphological and histopathological examinations. However, these types of diagnostic examinations are relatively time-consuming, and the infection frequently cannot be detected in its early stages. In this study, we cloned the full-length 18S rRNA gene of T. kitauei isolated from diseased Israel carps, and carried out molecular identification by comparing the sequence with those of other myxosporeans. Moreover, conventional PCR and real-time quantitative PCR (qPCR) using oligonucleotide primers for the amplification of 18S rRNA gene fragment were established for further use as methods for rapid diagnosis of IGCD. Our results demonstrated that both the conventional PCR and real-time quantitative PCR systems applied herein are effective for rapid detection of T. kitauei spores in fish tissues and environmental water.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.4
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• pp.1224-1248
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• 2022

In various sensor network applications, such as climate observation organizations, sensor nodes need to collect information from time to time and pass it on to the recipient of information through multiple bounces. According to field tests, this information corresponds to most of the energy use of the sensor hub. Decreasing the measurement of information transmission in sensor networks becomes an important issue.Compression sensing (CS) can reduce the amount of information delivered to the network and reduce traffic load. However, the total number of classification of information delivered using pure CS is still enormous. The hybrid technique for utilizing CS was proposed to diminish the quantity of transmissions in sensor networks.Further the energy productivity is a test task for the sensor nodes. However, in previous studies, a clustering approach using hybrid CS for a sensor network and an explanatory model was used to investigate the relationship between beam size and number of transmissions of hybrid CS technology. It uses efficient data integration techniques for large networks, but leads to clone attacks or attacks. Here, a new algorithm called SBEA (Snowball Endurance Algorithm) was proposed and tested with a bow. Thus, you can extend the battery life of your WSN by running effective copy detection. Often, multiple nodes, called observers, are selected to verify the reliability of the nodes within the network. Personal data from the source centre (e.g. personality and geographical data) is provided to the observer at the optional witness stage. The trust and reputation system is used to find the reliability of data aggregation across the cluster head and cluster nodes. It is also possible to obtain a mechanism to perform sleep and standby procedures to improve the life of the sensor node. The sniffers have been implemented to monitor the energy of the sensor nodes periodically in the sink. The proposed algorithm SBEA (Snowball Endurance Algorithm) is a combination of ERCD protocol and a combined mobility and routing algorithm that can identify the cluster head and adjacent cluster head nodes.This algorithm is used to yield the network life time and the performance of the sensor nodes can be increased.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.1
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• pp.140-147
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• 2012

Vehicle routing problem is one of the traveling salesman problems with various conditions such as vehicle capacity limits, delivery time windows, as well as time dependent speeds in metropolitan area. In this research hourly vehicle moving speeds information in a typical metropolitan area are analyzed to use the results in the design procedure of VRP heuristic. Quality initial vehicle routing solutions can be obtained with adaption of the analysed results of the time periods with no vehicle speed changes. This strategy makes complicated time dependent vehicle speed simple to solve. Time dependent vehicle speeds are too important to ignore to obtain optimum vehicle routing search for real life logistics systems.

• Journal of Families and Better Life
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• v.8 no.1
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• pp.129-142
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• 1990

The purpose of this study were to investigate : 1) Differences of perceived time pressure according to the employment status of housewife. 2) The differences of housework strategy according to the employment status of housewife. 3) The relation between perceived time pressure and housework performance strategy. The subject of this study were 375 women living in Seoul, the age of youngest child is at least school age. They were composed of non employed housewives, employed professional housewives and employed non professional housewives. Survery methods were questionare and interview. Data analysis strategy were percentile, frequency, one-way ANOVA, scheffe test and MCA. The major findings were : 1) Perceived time pressure and two sub areas, psychological time pressure and time pressure according to the part of housework were significantly different according to the employment status of housewife. The independent influence of employment status of housewives was most po erful in regression analysis. 2) Housework performance strategy was different according to the employment status of housewife. The strategies were divisions of housework amon family members, use of convenience goods, services, appliance, paid help, adjustment of housework performance standard, reduction of leisure and sleep time.

• Journal of Families and Better Life
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• v.7 no.2
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• pp.145-161
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• 1989

The objectives of this study are ; 1) To analyze the time use and the invironments of rural housewives household labor according to the characteristics of agriculture. 2) To investigate the factors influencing household labor time. In this study, the rural areas are divided into two groups according to characteristics of agriculture. One is traditional agricultural area-Seokchon Dong in Youngcheon Kun, and the other is commercial agricultural area-Dongpo 1 Dong in Sungju Kun. Two areas are located in Kyungpook Province. 145 housewives dwelling in above two villiages were interviewed. The statistics used for data analysis were frequency, percentile, T-test, x2-test, and multiple regression analysis. Results are as follows; 1) household labor time had not significant differences Hetween Youngcheon and Sungju. But agricultural labor time was longer in Sungju than in Youngcheon. 2) household labor environments in Sungju were better than those in Youngcheon. 3) household labor time was influenced by agricultural labor time and socio-cultural time.

• Asian Journal for Public Opinion Research
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• v.5 no.3
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• pp.204-227
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• 2018

This paper seeks to interrogate the very assumption of "sociality" in social media at a conceptual level and substantiate it with the help of information collected on aged people's use of conventional media $vis-{\grave{a}}-vis$ so called "social media" from the field work. Although global literature has written the obituary of mass media and promoted the "sociality" of social media, one needs to critically engage with such statement. Such statements have been an outcome of the established status of the "post broadcast" model of media where conventional media is in existence for some time and accessible to everyone in society. Further, this paper seeks to explore the interplay of new media in the life of the aged population in select areas of Kolkata city in the state of West Bengal, India. There are few studies on the ageing population's use of new media in the Indian context. While many of the studies reveal the new media literacy among the youth, this is unimportant as both the new media and the youth are relatively young as a field of research in media studies in India. What is missed in the earlier studies is, how new media plays an important function in the life of the aged population. How do older adults engage with the skilling and deskilling process of media literacy in their everyday life? And finally, do new media provide an extension to their on-going social relations? With the help of substantive details, the present study addresses the aforementioned queries.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.9
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• pp.321-331
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• 2021

This study examines the impact of Information and Communication Technology (ICT) and the role of Malaysian local wisdom called "Ugahari" in managing Work-Life Balance (WLB) during the COVID-19 pandemic in Malaysia. Data was obtained through online and offline surveys which were distributed to the agencies in the public and private sectors spread across Kuala Lumpur, Selangor and Pura Jaya. Overall 466 respondents were found to have given valid and complete responses. This research utilized the Partial Least Squares Structural Equation Modelling. It was found that the use of the ICT during Work from Home (WFH) helped workers to have relatively high flexibility where they could easily expand or contract one domain to meet the demands of another domain. At the same time it also offered high permeability where aspects of one domain entered another domain. This encourages workers to integrate their roles and achieve broad work autonomy. Furthermore, this situation then gives rise to a high level of interference at the boundary between work and family domains. On the other hand Ugahari reduces the level of interference caused by ICT use and encourages workers to compartmentalize their respective roles. Thus, ICT and Ugahari's behavior can play a role and complement each other in the context of realizing worker well-being.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2022.11a
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• pp.49-50
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• 2022

There are continuous cases of fire expansion due to fire door problems around the world, including the 2010 Shanghai Apartment Fire, the 2017 Grenfell Tower Fire in England, and the 2020 Ul-san Residential and Commercial Complex Fire. In order to prevent such fire damage, the country has strengthened the performance standards of fire doors, and recently, efforts have been made to ensure the best performance of fire doors by introducing a quality recognition system. Securing the performance of fire doors is a very important aspect. However, there is a concern that old fire doors may not function normally in the event of fire due to natural deterioration, corrosion, and damage during the use process, but countermeasures are insufficient. Therefore, from a management perspective, it is very important to maintain fire doors and secure an appropriate replacement time. Therefore, the purpose of this study is to determine whether the fire door has durability to prevent fire spread in the process of use through operation probability analysis and expert surveys, and to propose an appropriate useful life of the fire door.

• Korean Journal of Medicinal Crop Science
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• v.18 no.6
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• pp.429-438
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• 2010

The use of cellulolytic lactic acid bacteria in new method to prepare high nutrition complementary foods was investigated. For the screening of cellulolytic lactic acid bacteria, more than 1,150 bacterial colony were isolated from diluted infant feces samples. A typical strain which appeared the most excellent cellulolytic activities was identified novel acidophilic Enterococcus sp. TO-94 through the results of morphological, biochemical and chemotaxonomic characteristics and 16S rDNA sequencing. The optimal lactic acid fermentation conditions of Omija(Schizandra chinensis Baillon) by Enterococcus sp. TO-94 were as follows: pH and temperature were 3.0 and $37^{\circ}C$, respectively, and fermentation time was 20hrs. The fructose and glucose were major free sugar and the contents were 5.83 and 4.30 mg/g after fermentation, respectively. The contents of lactic acid and acetic acid were 9.84 mg/g and 2.08 mg/g after fermentation, respectively. The vitamin $B_1$, $B_2$, niacin, folic acid and C were major vitamin in the fermented broth, the contents were 1.5~3 times higher than those of initial fermentation time. Also, the contents of polyphenol and anthocyanine were 3.8 and 1.2 times higher than those of initial fermentation time.